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Dietary supplement

Serrapeptase 120,000 IU Ingredients & Drug Interactions

by SuperSmart

Serrapeptase 120,000 IU label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Serrapeptase 120,000 IU against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Serrapeptase 120,000 IU is a dietary supplement by SuperSmart with 1 active ingredient. Its ingredients are commonly taken for inflammation and swelling, sinus and respiratory congestion, pain after surgery or injury.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Serrapeptase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Serrapeptase 120,000 IU by SuperSmart

Ask about any prescription or over-the-counter medication and we check it for interactions with Serrapeptase 120,000 IU by SuperSmart — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Serrapeptase 120,000 IU by SuperSmart

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

This product contains one active ingredient: serrapeptase, an enzyme derived from silkworm pupae. Serrapeptase is marketed for its potential to break down fibrin and other proteins in the body.

The capsule also contains acacia, an inactive ingredient used in the formulation.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Serrapeptase's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Proteolytic enzyme for inflammation and swelling.
  • We looked for evidence on: Back pain, Carpal tunnel syndrome, Fibromyalgia, Osteoarthritis, Postoperative swelling, Rheumatoid arthritis (RA) — and 4 related terms.
  • The closest evidence on file: Serrapeptase is rated "Insufficient Reliable Evidence To Rate" for Back pain (Natural Medicines).
  • Also on file: Serrapeptase is rated "Insufficient Reliable Evidence To Rate" for Carpal tunnel syndrome, Fibromyalgia, Osteoarthritis, Rheumatoid arthritis (RA), and more.

The evidence for serrapeptase is limited. The data we hold shows insufficient reliable evidence to rate its effectiveness for chronic bronchitis, asthma, atherosclerosis, back pain, and osteoporosis — the main conditions people ask about.

That doesn't mean it doesn't work; it means the research hasn't yet been robust enough to establish whether it does. If you're considering it for one of these purposes, your pharmacist or doctor can talk through what's known and what remains uncertain.

The evidence, ingredient by ingredient Serrapeptase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Serrapeptase is generally well tolerated for short-term use, though long-term safety hasn't been studied much. The most common side effects reported are stomach pain, gastrointestinal upset, and nausea — though in trials these occurred at about the same rate as placebo, so they may not be directly caused by the supplement.

A rare serious side effect called bullous pemphigoid (blistering skin condition) has been reported. During pregnancy, there isn't enough safety data, so it's best avoided.

The same goes for breastfeeding — no reliable safety information exists, so it should be skipped.

Side effects, ingredient by ingredient Serrapeptase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Serrapeptase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take blood thinners or antiplatelet drugs — including warfarin, aspirin, clopidogrel, or similar medications — check them against the interaction tool before starting this product. Serrapeptase may increase your bleeding and bruising risk with these drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Serrapeptase is generally well tolerated short-term, but its effectiveness for common conditions isn't well established in the data we hold. The main caution is if you take blood thinners or antiplatelet medications — this supplement could theoretically increase bleeding risk.

Check your exact medications with the tool on this page, and talk with your pharmacist before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Serrapeptase 120,000 IU, straight from the product label.

Brand SuperSmart
Barcode (UPC) 5453003825531
Net contents 90 Drcaps Hypromellose Capsule(s)
Market status On market
Date entered into DSLD Jun 25, 2025
DSLD ID 332747
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Serrapeptase 120,000 IU by SuperSmart, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
45
UPC/BARCODE
5453003825531
IngredientAmount% DV
Serrapeptase0 NP--

Other ingredients: Acacia

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Serrapeptase Bioactive enzyme 120,000 IU per day

Each capsule contains gastroresistant granules providing 60,000 international units of the proteolytic enzyme serrapeptase.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommended use: Adults. Take one capsule twice a day on an empty stomach.

Precautions

Precautions: Contains lactose.

Do not exceed the recommended daily dose. This product is a nutritional supplement and should not replace a varied, balanced diet.

Keep out of childrens' reach.

As with any nutritional supplement, you should consult a health professional before taking this product if you are pregnant, breastfeeding or have a health problem.

Storage

Store away from direct light, heat and humidity.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Serrapeptase 120,000 IU by SuperSmart label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Serrapeptase 120,000 IU label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Serrapeptase 120,000 IU by SuperSmart

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Serrapeptase

Interacts with
122 drugs
0 NP per serving

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you...

Serrapeptase monograph & interactions

Other (inactive) ingredients: Acacia. These complete the product’s ingredient list but are not active constituents.

Interaction report

Serrapeptase 120,000 IU by SuperSmart Drug Interactions

Want to check YOUR meds against Serrapeptase 120,000 IU?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Serrapeptase 122

Individual Drug Interactions

The ingredients in Serrapeptase 120,000 IU interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Serrapeptase 120,000 IU interact with drugs. Each result below shows which ingredient is responsible. Serrapeptase

Each ingredient & the kinds of drugs it affects

For each ingredient in Serrapeptase 120,000 IU with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Serrapeptase1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking serrapeptase with drugs that have antiplatelet or anticoagulant effects might increase the risk of bruising and bleeding.
In vitro research shows that serrapeptase has fibrinolytic activity.

Likelihood Possible Evidence D
Serrapeptase full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Serrapeptase 120,000 IU, from the product label.

SuperSmart

See all SuperSmart products
Name
SN Worldwide Unipessoal, Lda
Street Address
Avenida Do Infante 66, Edificio Quinta Avenida 1 C
City
Funchal
ZipCode
9000-015
Pharmacist Counseling Corner

Serrapeptase 120,000 IU by SuperSmart: Common Questions

Does Serrapeptase 120,000 IU by SuperSmart interact with any medications?
Yes. Based on its ingredients, Serrapeptase 120,000 IU has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Serrapeptase 120,000 IU contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take serrapeptase while pregnant?
No — there isn't enough safety data, so it's best avoided during pregnancy. Talk with your doctor or pharmacist about alternatives if you're considering it.
Is it safe while breastfeeding?
No — there's no reliable safety information available, so it should be avoided while breastfeeding. Your pharmacist or doctor can suggest other options if you need something for a specific condition.
What are the common side effects?
The most common side effects reported are stomach pain, gastrointestinal upset, and nausea. However, in trials these side effects occurred at about the same rate as placebo, suggesting they may not be directly caused by serrapeptase itself.
How long is it safe to take serrapeptase?
It's generally well tolerated for short-term use, but long-term safety hasn't been well studied. If you're thinking about using it long-term, discuss that with your pharmacist.
Does serrapeptase work for back pain?
The evidence isn't established — we hold insufficient reliable evidence to rate whether it works for back pain. Your pharmacist or doctor can discuss what the current research suggests and whether it's worth trying for your situation.
What is serrapeptase?
Serrapeptase is an enzyme derived from silkworm pupae. It's marketed for its ability to break down fibrin and other proteins in the body, though as mentioned, strong evidence for its effectiveness is lacking.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Serrapeptase 120,000 IU is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Serrapeptase 120,000 IU label
Go deeper

The Full Monographs Behind Serrapeptase 120,000 IU’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Serrapeptase

Interacts with 122 drugs

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you want to try it, choose an enteric-coate...

Read the full Serrapeptase monograph →
Sources

Sources & How We Checked

Serrapeptase 120,000 IU's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Serrapeptase 2 references
  1. Tachibana M, Mizukoshi O, Harada Y, et al. A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling. Pharmatherapeutica 1984;3:526-30..
  2. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res 1990;18:379-88.. PubMed

See these in context on the Serrapeptase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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