Interactions on record — worth a quick check against your medications. Based on 3 of 5 ingredients. Check your meds →
Dietary supplement

Macula Plus Ingredients & Drug Interactions

by SuperSmart

Macula Plus label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Macula Plus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Macula Plus is a dietary supplement by SuperSmart with 5 active ingredients. Its ingredients are commonly taken for eye health, age-related macular degeneration, cataract prevention.Based on those ingredients, 751 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Astaxanthin, Zeaxanthin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Macula Plus by SuperSmart

Ask about any prescription or over-the-counter medication and we check it for interactions with Macula Plus by SuperSmart — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Macula Plus by SuperSmart

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Macula Plus is a 5-ingredient softgel formula centered on eye-health carotenoids. The active ingredients are lutein, zeaxanthin, astaxanthin, meso-zeaxanthin, and cyanidin-3-glucosides — pigments found naturally in plants and algae that accumulate in the eye's macula.

The softgel also contains inactive ingredients: beeswax, soy lecithin, and soy oil, which help deliver the lipid-soluble carotenoids.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Eye health and macular support.
  • We looked for evidence on: Age-related macular degeneration (AMD), Asthenopia (eye strain), Cataracts, Central serous retinopathy, Choroideremia, Diabetic retinopathy — and 4 related terms.
  • The strongest evidence on file: Lutein is rated "Possibly Effective" for Age-related macular degeneration (AMD) (Natural Medicines).
  • Also on file: Lutein is rated "Possibly Effective" for Cataracts.
  • Also on file: Zeaxanthin is rated "Possibly Effective" for Age-related macular degeneration (AMD).

Lutein and meso-zeaxanthin are both rated possibly effective for age-related macular degeneration (AMD) and cataracts, based on the evidence we hold. Zeaxanthin is also rated possibly effective for AMD.

Astaxanthin and cyanidin-3-glucosides do not have effectiveness ratings established in our data for eye health or any other condition covered here. The evidence for the other ingredients in slowing cognitive decline, Alzheimer disease, or other age-related conditions is insufficient to rate.

The evidence, ingredient by ingredient Lutein Zeaxanthin Astaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lutein is generally well tolerated at typical doses, with doses up to 20 mg daily showing no adverse effects in the data we hold. It's rated likely safe in pregnancy and lactation, though supplement-dose safety during breastfeeding isn't well studied.

Zeaxanthin and meso-zeaxanthin are generally well tolerated at typical supplement amounts and rated likely safe in pregnancy and lactation, though concentrated supplement safety during pregnancy and breastfeeding hasn't been thoroughly studied — the data suggests caution and a conversation with your doctor. Astaxanthin is generally well tolerated in studies, but long-term safety is limited.

The most common adverse effects are abdominal pain, diarrhea, and red fecal color; higher doses (40 mg daily) have caused severe stomach pain in some cases. Safety data are insufficient for pregnancy and lactation, so these are best avoided during those periods.

We hold no safety data for cyanidin-3-glucosides.

Side effects, ingredient by ingredient Lutein Zeaxanthin Astaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Astaxanthin, Zeaxanthin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 752 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Macula Plus, check if you use any drugs metabolized by the liver's CYP3A4 or CYP2B6 enzymes — astaxanthin may lower their levels (Moderate severity). Also check if you take any antidiabetes drugs or insulin, as zeaxanthin and meso-zeaxanthin may theoretically increase the risk of low blood sugar (Moderate severity).

If you're not sure whether your medications fall into these categories, use the search tool on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Macula Plus is aimed at supporting eye health, particularly for AMD, using well-known carotenoids. If you have diabetes or take medications processed by your liver, check your exact prescriptions here before starting — the interactions are documented and worth verifying.

Talk with your pharmacist about whether this product makes sense for you and your medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Macula Plus, straight from the product label.

Brand SuperSmart
Barcode (UPC) 5453003822677
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Jun 25, 2025
DSLD ID 332394
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Macula Plus by SuperSmart, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
60
UPC/BARCODE
5453003822677
IngredientAmount% DV
Lutein10 mg--
Zeaxanthin2.5 mg--
Astaxanthin2 mg--
Meso-Zeaxanthin2.5 mg--
Cyanidin-3-Glucosides4 mg--

Other ingredients: Beeswax, Soy Lecithin, Soy Oil

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Nutri-Mz - Hward Foundation, UK. US Patents #6,218,436 & 6,329,432, European Patent# 0 831 797.

Formulation

Eye health

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommended use: Adults. Take one softgel per day, during one meal.

Precautions

Contains soy derivatives.

Precautions: Do not exceed the recommended daily dose. This product is a nutritional supplement and should not replace a varied, balanced diet.

Keep out of children's reach.

As with any nutritional supplement, you should consult a health professional before taking this product if you are pregnant, breastfeeding or have a health problem.

Storage

Store away from direct light, heat and humidity.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Macula Plus by SuperSmart label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Macula Plus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Macula Plus by SuperSmart

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lutein

No known
interactions
10 mg per serving

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help...

Lutein monograph & interactions

Zeaxanthin

Interacts with
86 drugs
2.5 mg per serving

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The stron...

Zeaxanthin monograph & interactions

Astaxanthin

Interacts with
671 drugs
2 mg per serving

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise...

Astaxanthin monograph & interactions

Meso-Zeaxanthin

Interacts with
86 drugs
2.5 mg per serving

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The stron...

Meso-Zeaxanthin monograph & interactions

Cyanidin-3-Glucosides

4 mg per serving Form: Tagetes erecta Extract

Other (inactive) ingredients: Beeswax, Soy Lecithin, Soy Oil. These complete the product’s ingredient list but are not active constituents.

Interaction report

Macula Plus by SuperSmart Drug Interactions

Want to check YOUR meds against Macula Plus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
751Drugs
751 Moderate

Ingredients driving the most interactions

Astaxanthin 671
Zeaxanthin 86

Individual Drug Interactions

The ingredients in Macula Plus interact with 751 drugs. Click any drug to see the details.

2 of the 5 ingredients in Macula Plus interact with drugs. Each result below shows which ingredient is responsible. Astaxanthin Zeaxanthin

Each ingredient & the kinds of drugs it affects

For each ingredient in Macula Plus with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Astaxanthin2 drug types · 671 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Astaxanthin full monograph & interactions

Zeaxanthin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.
In an animal diabetic model, zeaxanthin has hypoglycemic effects. However, population research has found that increasing intake of dietary zeaxanthin plus lutein does not decrease the risk of developing type 2 diabetes.

Likelihood Possible Evidence D
Zeaxanthin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Macula Plus, from the product label.

SuperSmart

See all SuperSmart products
Name
SN Worldwide Unipessoal, Lda
Street Address
Avenida Do Infante 66, Edificio Quinta Avenida 1 C
City
Funchal
ZipCode
9000-015
Pharmacist Counseling Corner

Macula Plus by SuperSmart: Common Questions

Does Macula Plus by SuperSmart interact with any medications?
Yes. Based on its ingredients, Macula Plus has a known interaction with 751 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Macula Plus contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Macula Plus if I'm pregnant or breastfeeding?
Lutein, zeaxanthin, and meso-zeaxanthin are rated likely safe in pregnancy and lactation, though concentrated supplement safety during breastfeeding hasn't been well studied — talk with your doctor. Astaxanthin has insufficient safety data and is best avoided during pregnancy and breastfeeding. We don't have safety information on file for cyanidin-3-glucosides.
Does this really help with cataracts and macular degeneration?
Lutein and meso-zeaxanthin are both rated possibly effective for age-related macular degeneration and cataracts based on our data. Zeaxanthin is possibly effective for macular degeneration. Astaxanthin doesn't have an established rating for eye conditions in the evidence we hold.
What's the difference between zeaxanthin and meso-zeaxanthin?
Both are carotenoids that accumulate in your eye and protect the macula. Meso-zeaxanthin is a specific form found at the center of the macula; zeaxanthin is the broader category. They share the same interactions and safety profile in this product.
What side effects might I experience from astaxanthin?
Astaxanthin is generally well tolerated, but the most common side effects are abdominal pain, diarrhea, and red-colored stool. At higher doses (40 mg daily), some people have reported severe stomach pain. Start at the dose on the label and talk with your pharmacist if you experience any of these.
What is cyanidin-3-glucosides and why is it in this formula?
Cyanidin-3-glucosides is a plant pigment (anthocyanin) that may support eye health, but we hold no data on its effectiveness or interactions, so we can't provide details. Your pharmacist or the product's manufacturer can tell you more about why it was included.
Is there soy in this product?
Yes — the inactive ingredients include soy lecithin and soy oil. If you have a soy allergy, this product isn't right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Macula Plus label
Go deeper

The Full Monographs Behind Macula Plus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lutein

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help slow progression of age-related macular...

Read the full Lutein monograph → Herb & supplement monograph

Zeaxanthin

Interacts with 86 drugs

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The strongest evidence relates to slowing progres...

Read the full Zeaxanthin monograph → Herb & supplement monograph

Astaxanthin

Interacts with 671 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph →
Sources

Sources & How We Checked

Macula Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lutein 2 references
  1. Brown L, Rimm EB, Seddon JM, et al. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr 1999;70:517-24. PubMed
  2. Chasan-Taber L, Willett WC, Seddon JM, et al. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr 1999;70:509-16. PubMed

See these in context on the Lutein monograph →

Zeaxanthin 4 references
  1. Montonen J, Knekt P, Jarvinen R, Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 2004;27:362-6. PubMed
  2. Leermakers ET, Darweesh SK, Baena CP, et al. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Am J Clin Nutr 2016;103(2):481-94. PubMed
  3. Kou L, Du M, Zhang C, Dai Z, Li X, Zhang B. The Hypoglycemic, Hypolipidemic, and Anti-Diabetic Nephritic Activities of Zeaxanthin in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Appl Biochem Biotechnol 2017;182(3):944-955. PubMed
  4. Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. Milk and Plasma Lutein and Zeaxanthin Concentrations in Chinese Breast-Feeding Mother-Infant Dyads With Healthy Maternal Fruit and Vegetable Intake. J Am Coll Nutr 2019;38(2):179-184. PubMed

See these in context on the Zeaxanthin monograph →

Astaxanthin 3 references
  1. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

See these in context on the Astaxanthin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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