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Dietary supplement

Serrapeptase 40,000 IU Ingredients & Drug Interactions

by AN Amazing Nutrition Amazing Formulas

Serrapeptase 40,000 IU label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Serrapeptase 40,000 IU against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Serrapeptase 40,000 IU is a dietary supplement by AN Amazing Nutrition Amazing Formulas with 1 active ingredient. Its ingredients are commonly taken for inflammation and swelling, sinus and respiratory congestion, pain after surgery or injury.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Serrapeptase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Serrapeptase 40,000 IU by AN Amazing Nutrition Amazing Formulas

Ask about any prescription or over-the-counter medication and we check it for interactions with Serrapeptase 40,000 IU by AN Amazing Nutrition Amazing Formulas — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Serrapeptase 40,000 IU by AN Amazing Nutrition Amazing Formulas

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This supplement contains one active ingredient: serrapeptase, an enzyme derived from silkworm cocoons that your body cannot produce on its own. The formula is filled out with inactive ingredients — a plant-based capsule (DRcaps), microcrystalline cellulose, magnesium stearate, and silicon dioxide — which are standard excipients used for texture, flow, and capsule integrity.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Serrapeptase's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: cardiovascular health immune system joint connective tissue.
  • We looked for evidence on: Atherosclerosis, Cardiovascular disease (CVD), Osteoarthritis, Rheumatoid arthritis (RA), Back pain, Carpal tunnel syndrome — and 4 related terms.
  • The closest evidence on file: Serrapeptase is rated "Insufficient Reliable Evidence To Rate" for Atherosclerosis (Natural Medicines).
  • Also on file: Serrapeptase is rated "Insufficient Reliable Evidence To Rate" for Back pain, Cardiovascular disease (CVD), Carpal tunnel syndrome, Osteoarthritis, and more.

The evidence for serrapeptase is insufficient to rate whether it works for any of the conditions it's marketed for — chronic bronchitis, asthma, atherosclerosis, back pain, and osteoporosis. That means we don't have reliable study data showing it's effective for these purposes.

Before you buy it hoping for a specific benefit, talk with your doctor or pharmacist about what the current evidence actually supports.

The evidence, ingredient by ingredient Serrapeptase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Serrapeptase appears well tolerated in short-term use, though long-term safety hasn't been thoroughly studied. The most common side effects reported are epigastric pain (upper abdominal discomfort), gastrointestinal upset, and nausea — though these occurred at the same rate as placebo in trials, suggesting they may not be directly caused by the supplement.

A rare serious side effect, bullous pemphigoid (a blistering skin condition), has been reported, but this is uncommon. The safety data advises against taking serrapeptase during pregnancy or while breastfeeding because there isn't enough information to know whether it's safe for you or your baby in those situations.

Talk with your doctor or pharmacist for personalized guidance if you're pregnant, planning to become pregnant, or nursing.

Side effects, ingredient by ingredient Serrapeptase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Serrapeptase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start serrapeptase, check with your doctor or pharmacist if you take any blood thinners or antiplatelet drugs — including prescription medications like warfarin or clopidogrel, as well as over-the-counter aspirin. The enzyme may amplify their blood-thinning effect and raise your risk of bruising or bleeding.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Serrapeptase is generally well tolerated in the short term, but the evidence that it actually works for any condition is lacking. If you take blood thinners or antiplatelet medications, you'll need to clear this with your doctor or pharmacist first because of the potential for increased bleeding risk.

Pregnancy and breastfeeding are times to avoid it because safety data aren't available for those situations.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Serrapeptase 40,000 IU, straight from the product label.

Brand AN Amazing Nutrition Amazing Formulas
Net contents 270 Capsule(s)
Market status On market
Date entered into DSLD Oct 22, 2021
DSLD ID 256149
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Serrapeptase 40,000 IU by AN Amazing Nutrition Amazing Formulas, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
270
IngredientAmount% DV
Serrapeptase40000 IU--

Other ingredients: DRcaps, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

We believe that Amazing Nutrition is the key for healthy living. We are passionate about bringing you the finest selection of products which can perfectly complement a healthy diet and active lifestyle.

Shop online at: amazingnutrition.com Call toll-free: 1-800-526-0177

Formula

Amazing Nutrition Serrapeptase is a proteolytic enzyme isolated from a microorganism in silkworms. Serrapeptase may support cardiovascular health, immune system functions, joint health, and connective tissues.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Caution: Do not exceed recommended dose.

Do not use this product if you are taking blood platelet inhibitors such as Ticlid, Palvix or Coumadin. Pregnant or nursing mothers, children under 18 and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Pregnant or nursing mothers, children under 18 and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Storage

Store in a cool, dry place.

FDA Statement of Identity

Dietary Supplement

Formulation

Delayed release Supports immune system health Supports cardiovascular health Delayed release capsules (DRCaps)

Contains No: Artificial preservatives, colors, flavors or sweeteners, sugar, starch, milk, lactose, soy, gluten, wheat, yeast, fish or sodium.

Seals/Symbols

Made in USA GMP Good Manufacturing Practice Quality Product

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, adults take one (1) capsule daily, preferably with a meal or as directed by a health care professional.

Brand IP Statement(s)

DRCaps is a registered trademark of Capsugel.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Serrapeptase 40,000 IU by AN Amazing Nutrition Amazing Formulas label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Serrapeptase 40,000 IU label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Serrapeptase 40,000 IU by AN Amazing Nutrition Amazing Formulas

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container270 Amounts shown are per serving.

Serrapeptase

Interacts with
122 drugs
40000 IU per serving

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you...

Serrapeptase monograph & interactions

Other (inactive) ingredients: DRcaps, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Serrapeptase 40,000 IU by AN Amazing Nutrition Amazing Formulas Drug Interactions

Want to check YOUR meds against Serrapeptase 40,000 IU?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Serrapeptase 122

Individual Drug Interactions

The ingredients in Serrapeptase 40,000 IU interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Serrapeptase 40,000 IU interact with drugs. Each result below shows which ingredient is responsible. Serrapeptase

Each ingredient & the kinds of drugs it affects

For each ingredient in Serrapeptase 40,000 IU with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Serrapeptase1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking serrapeptase with drugs that have antiplatelet or anticoagulant effects might increase the risk of bruising and bleeding.
In vitro research shows that serrapeptase has fibrinolytic activity.

Likelihood Possible Evidence D
Serrapeptase full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Serrapeptase 40,000 IU, from the product label.

AN Amazing Nutrition Amazing Formulas

See all AN Amazing Nutrition Amazing Formulas products
Name
Amazing Nutrition
City
Jersey City
State
NJ
ZipCode
07310
Phone Number
1-800-526-0177
Web Address
amazingnutrition.com
Pharmacist Counseling Corner

Serrapeptase 40,000 IU by AN Amazing Nutrition Amazing Formulas: Common Questions

Does Serrapeptase 40,000 IU by AN Amazing Nutrition Amazing Formulas interact with any medications?
Yes. Based on its ingredients, Serrapeptase 40,000 IU has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Serrapeptase 40,000 IU contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is serrapeptase?
Serrapeptase is an enzyme originally discovered in silkworm cocoons. It breaks down fibrin, a protein involved in blood clotting and scar tissue formation. Your body doesn't make it naturally, so it only comes from supplements.
Can I take serrapeptase if I'm pregnant or breastfeeding?
No — the safety data advises against it during both pregnancy and breastfeeding because there isn't enough reliable information to know whether it's safe for you or your baby. Talk with your doctor or pharmacist about your individual situation if you're in either of those stages.
What are the side effects?
Most commonly, people report epigastric pain (discomfort in the upper belly), general stomach upset, and nausea. Interestingly, these happened at the same rate in placebo groups during trials, suggesting they may not be directly caused by the supplement. A rare serious side effect — a blistering skin condition called bullous pemphigoid — has been reported, but it's very uncommon.
Does serrapeptase actually work for back pain, asthma, or the other conditions listed?
The evidence isn't established in our data. We have insufficient reliable evidence to rate whether it works for chronic bronchitis, asthma, atherosclerosis, back pain, or osteoporosis. Before you buy it for a specific reason, ask your doctor what the current research actually supports.
How long has serrapeptase been studied for safety?
Short-term use appears well tolerated, but long-term safety hasn't been thoroughly studied. If you're thinking about taking it regularly over months or years, that's worth discussing with your pharmacist or doctor.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Serrapeptase 40,000 IU is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Serrapeptase 40,000 IU label
Go deeper

The Full Monographs Behind Serrapeptase 40,000 IU’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Serrapeptase

Interacts with 122 drugs

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you want to try it, choose an enteric-coate...

Read the full Serrapeptase monograph →
Sources

Sources & How We Checked

Serrapeptase 40,000 IU's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Serrapeptase 2 references
  1. Tachibana M, Mizukoshi O, Harada Y, et al. A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling. Pharmatherapeutica 1984;3:526-30..
  2. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res 1990;18:379-88.. PubMed

See these in context on the Serrapeptase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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