Interactions on record — worth a quick check against your medications. Based on 7 of 23 ingredients. Check your meds →
Dietary supplement

Digestech Ingredients & Drug Interactions

by Onnit

Digestech label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Digestech against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Digestech is a dietary supplement by Onnit with 23 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.Based on those ingredients, 1,100 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Ginger (root) extract, organic Fennel, Astragalus (root) extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Digestech by Onnit

Ask about any prescription or over-the-counter medication and we check it for interactions with Digestech by Onnit — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Digestech by Onnit

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 4 of its 23 active ingredients.
  • “AstraZyme” is listed as a grouped ingredient — the label gives one combined amount (50 mg) without saying how much of each component you get.
  • “DigesTech Power Blend” is a proprietary blend — the label gives one combined amount (500 mg) without saying how much of each component you get.

Digestech contains 23 ingredients total, including digestive enzymes and herbal extracts. The active enzymes are Protease, Lipase, Lactase, Acid Protease, Pepsin, and a blend of others (Amylase, Serratiopeptidase, Cellulase, Invertase, Glucoamylase, Alpha-Galactosidase, Xylanase, Pectinase, Maltase, Beta-Glucanase, and Hemicellulase) that help break down different components of food.

You'll also find herbal extracts of organic Fennel, Astragalus root, organic Ginger root, and Tienchi root, plus Trace Minerals. The inactive ingredients are vegetarian capsule material, rice hull concentrate, and maltodextrin.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: digestion and digestive enzyme support.
  • We looked for evidence on: Colic, Constipation, Dyspepsia, Diarrhea, Flatulence, Irritable bowel syndrome (IBS) — and 4 related terms.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.
  • Also on file: Fennel is rated "Insufficient Reliable Evidence To Rate" for Constipation, Dyspepsia, Flatulence, Irritable bowel syndrome (IBS), and more.

Evidence for Digestech's active ingredients is mixed. Lactase is effective for lactose intolerance.

Ginger is possibly effective for pregnancy nausea, menstrual cramps, and osteoarthritis. Fennel is possibly effective for menstrual cramps.

Tienchi is possibly effective for angina and stroke. However, for most of the other conditions these ingredients are used for — including inflammatory bowel disease, general dyspepsia, anxiety, and bronchitis — the evidence is insufficient to rate them.

The data we hold does not establish effectiveness for the product as a whole for digestive support.

The evidence, ingredient by ingredient Proteolytic Enzymes (proteases) Fennel Ginger Astragalus Panax Notoginseng Lipase Lactase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of the enzymes in Digestech are generally well tolerated, but proteases (Protease, Acid Protease, Pepsin) may cause digestive upset or allergic reactions, and rarely can trigger allergic rhinitis or asthma with exposure. Lactase is also generally well tolerated.

Lipase should be used only under medical guidance if you have serious digestive conditions. Fennel is generally safe as a food but concentrated amounts may cause gastrointestinal discomfort, sensitivity to sunlight, or rarely seizures.

Astragalus is generally well tolerated short-term but has limited human safety data. Ginger at typical supplement doses is generally well tolerated; side effects at higher doses include heartburn, diarrhea, and burning in the mouth.

Tienchi may cause dry mouth, insomnia, nausea, rash, or nervousness.

Side effects, ingredient by ingredient Proteolytic Enzymes (proteases) Fennel Ginger Astragalus Panax Notoginseng Lipase Lactase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 7 matched ingredients can interact with medications — Fennel, Panax Notoginseng, Ginger, Astragalus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 1,101 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take blood thinners (anticoagulants like warfarin) or antiplatelet drugs, diabetes medications, hormonal contraceptives or hormone replacement therapy, immunosuppressants, lithium, cancer drugs (especially those processed by your liver), heart medications like nifedipine or losartan, the antibiotic ciprofloxacin, or tamoxifen, run them through the interaction checker on this page before starting Digestech. The Moderate interactions with these drug types are the biggest concern.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Digestech is an enzyme and herbal blend designed to support digestion. It's generally well tolerated for most adults, but the herbal ingredients — especially Fennel, Ginger, Astragalus, and Tienchi — interact with many medications, including blood thinners, diabetes drugs, hormonal contraceptives, and immunosuppressants.

Before you start this product, check your exact medications with the tool on this page, and talk with your doctor or pharmacist about whether it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 10 of 23 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 23, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Digestech, straight from the product label.

Brand Onnit
Barcode (UPC) 819444011080
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Oct 23, 2019
DSLD ID 208612
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Digestech by Onnit, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
819444011080
IngredientAmount% DV
Amylase0 NP--
Protease0 NP--
Serratiopeptidase250 mg--
Lipase0 NP--
Lactase0 NP--
Cellulase0 NP--
Invertase0 NP--
Glucoamylase0 NP--
Alpha-Galactosidase0 NP--
Xylanase0 NP--
Pectinase0 NP--
Maltase0 NP--
Acid Protease0 NP--
Beta-Glucanase0 NP--
Proteases0 NP--
Hemicellulase0 NP--
Trace Minerals0 NP--
Pepsin130 mg--
organic Fennel125 mg--
Astragalus (root) extract0 NP--
Amylase0 NP--
organic Ginger (root) extract125 mg--
AstraZyme50 mg--
Tienchi (root) extract0 NP--
DigesTech Power Blend500 mg--

Other ingredients: Vegetarian Capsule, Rice hull concentrate, Maltodextrin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Maximizes nutrient intake Increases enzyme levels Helps digestive distress

Formula

Our flagship proteolytic enzyme blend, DigesTech offers assistance with the digestion of all five major categories: fats, protein, dairy, fiber and carbohydrates.

Full-spectrum Digestive enzymes Nutrient Absorption with AstraZyme & Serratiopeptidase

Suggested/Recommended/Usage/Directions

Suggested Use: For adults, as a dietary supplement, take two capsules with at start of your meal. Do not exceed six capsules in a 24-hour period unless otherwise recommended by a health care practitioner.

Precautions

Do not exceed six capsules in a 24-hour period unless otherwise recommended by a health care practitioner.

Consult a medical doctor before taking this or any other nutritional supplement if you are pregnant, nursing, have or suspect a medical condition, or are taking any medications.

Keep out of reach of children

Storage

Store in a cool, dry place.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Gluten free Soy free Dye free

Formulation

Gluten free Soy free Dye free

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Digestech by Onnit label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Digestech label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Digestech by Onnit

These are the 23 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Serratiopeptidase

250 mg per serving

Pepsin

No known
interactions
130 mg per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Pepsin monograph & interactions

Organic Fennel

Interacts with
740 drugs
125 mg per serving

Fennel is a Mediterranean herb widely used as a food and spice, and traditionally taken for digestive complaints, colic, and menstrual cramps. Some sm...

Organic Fennel monograph & interactions

Organic Ginger (root) extract

Interacts with
1,007 drugs
125 mg per serving

Ginger is a widely used culinary spice with a long history in traditional medicine, and it has the strongest evidence for helping with nausea and vomi...

Organic Ginger (root) extract monograph & interactions

AstraZyme

50 mg per serving

DigesTech Power Blend

500 mg per serving
  • › Amylase
  • › Protease
  • › Lipase
  • › Lactase
  • › Cellulase
  • › Invertase
  • › Glucoamylase
  • › Alpha-Galactosidase
  • › Xylanase
  • › Pectinase
  • › Maltase
  • › Acid Protease
  • › Beta-Glucanase
  • › Hemicellulase
  • › Amylase

Other (inactive) ingredients: Vegetarian Capsule, Rice hull concentrate, Maltodextrin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Digestech by Onnit Drug Interactions

Want to check YOUR meds against Digestech?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,100Drugs
1,034 Moderate 66 Minor

Ingredients driving the most interactions

organic Ginger (root) extract 1,007
organic Fennel 740
Astragalus (root) extract 208
Tienchi (root) extract 207

Individual Drug Interactions

The ingredients in Digestech interact with 1,100 drugs. Click any drug to see the details.

4 of the 23 ingredients in Digestech interact with drugs. Each result below shows which ingredient is responsible. organic Ginger (root) extract organic Fennel Astragalus (root) extract Tienchi (root) extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Digestech with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

organic Ginger (root) extract14 drug types · 1,007 drugs

Anticoagulant/Antiplatelet Drugs

Ginger may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs. However, research is conflicting.
Laboratory research suggests that ginger inhibits thromboxane synthetase and decreases platelet aggregation. However, this has not been demonstrated unequivocally in humans, with mixed results from clinical trials. Theoretically, excessive amounts of ginger might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, taking ginger with antidiabetes drugs might increase the risk of hypoglycemia.
Animal and human research suggests that ginger might increase insulin levels and/or decrease blood glucose levels.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Ginger might increase or decrease the levels of CYP3A4 substrates.
In vitro research and some case reports suggest that ginger inhibits CYP3A4 activity. Three case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking ginger and cancer medications that are CYP3A4 substrates (imatinib, dabrafenib, and crizotinib). However, the causality of this interaction is unclear due to the presence of multiple interacting drugs and routes of administration.
Conversely, other in vitro research suggests that ginger induces CYP3A4 activity, leading to reduced levels of CYP3A4 substrates. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Losartan (Cozaar)

Theoretically, ginger might increase levels of losartan and the risk of hypotension.
In animal research, ginger increased the levels and hypotensive effects of a single dose of losartan. It is not clear if ginger alters the concentration or effects of losartan when taken continuously. Additionally, this interaction has not been shown in humans.

Likelihood Possible Evidence D
Nifedipine (Procardia)

Ginger may have antiplatelet effects and increase the risk of bleeding if used with nifedipine.
Clinical research shows that combined treatment with ginger 1 gram plus nifedipine 10 mg significantly inhibits platelet aggregation when compared to nifedipine or ginger alone.

Likelihood Possible Evidence B
P-Glycoprotein Substrates

Ginger might increase the absorption and blood levels of P-glycoprotein (P-gp) substrates.
In vitro research and case reports suggest that ginger inhibits drug efflux by P-gp, potentially increasing absorption and serum levels of P-gp substrates. Two case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking ginger and cancer medications that are P-gp substrates (trametinib, crizotinib). However, the causality of this interaction is unclear due to the presence of multiple interacting drugs and routes of administration.

Likelihood Possible Evidence D
Phenprocoumon (Marcoumar, Others)

Ginger might increase the risk of bleeding with phenprocoumon.
Phenprocoumon, a warfarin-related anticoagulant, might increase the international normalized ratio (INR) when taken with ginger. There is one case report of a 76-year-old woman with a stable INR on phenprocoumon that increased to greater than 10 when she began consuming dried ginger and ginger tea.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Ginger might increase the risk of bleeding with warfarin.
Laboratory research suggests that ginger might inhibit thromboxane synthetase and decrease platelet aggregation. In one case report, ginger increased the INR when taken with phenprocoumon, which has similar pharmacological effects as warfarin. In another case report, ginger increased the INR when taken with a combination of warfarin, hydrochlorothiazide, and acetaminophen. A longitudinal analysis suggests that taking ginger increases the risk of bleeding in patients taking warfarin for at least 4 months. However, research in healthy people suggests that ginger has no effect on INR, or the pharmacokinetics or pharmacodynamics of warfarin. Until more is known, monitor INRs closely in patients taking large amounts of ginger.

Likelihood Possible Evidence B
Calcium Channel Blockers

Theoretically, taking ginger with calcium channel blockers might increase the risk of hypotension.
Some animal and in vitro research suggests that ginger has hypotensive and calcium channel-blocking effects. Another animal study shows that concomitant administration of ginger and the calcium channel blocker amlodipine leads to greater reductions in blood pressure when compared with amlodipine alone.

Likelihood Unlikely Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, when taken prior to cyclosporine, ginger might decrease cyclosporine levels.
In an animal model, ginger juice taken 2 hours prior to cyclosporine administration reduced the maximum concentration and area under the curve of cyclosporine by 51% and 40%, respectively. This effect was not observed when ginger juice and cyclosporine were administered at the same time.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ginger might increase the levels of CYP1A2 substrates.
In vitro research shows that ginger inhibits CYP1A2 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, ginger might increase the levels of CYP2B6 substrates.
In vitro research shows that ginger inhibits CYP2B6 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, ginger might increase the levels of CYP2C9 substrates.
In vitro research shows that ginger inhibits CYP2C9 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Metronidazole (Flagyl)

Theoretically, ginger might increase levels of metronidazole.
In an animal model, ginger increased the absorption and plasma half-life of metronidazole. In addition, the elimination rate and clearance of metronidazole was significantly reduced.

Likelihood Possible Evidence D
organic Ginger (root) extract full monograph & interactions

organic Fennel6 drug types · 740 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, fennel might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.

Animal research suggests that fennel oil has antithrombotic and antiplatelet effects.

Likelihood Possible Evidence D
Ciprofloxacin (Cipro)

Theoretically, fennel might decrease the levels and clinical effects of ciprofloxacin.

Animal research shows that fennel reduces ciprofloxacin bioavailability by nearly 50%, possibly due to the metal cations such as calcium, iron, and magnesium contained in fennel. This study also found that fennel increased tissue distribution and slowed elimination of ciprofloxacin.

Likelihood Probable Evidence D
Contraceptive Drugs

Theoretically, taking large amounts of fennel might decrease the effects of contraceptive drugs due to competition for estrogen receptors.

Some constituents of fennel have estrogenic activity.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.

In vitro research suggests that fennel inhibits CYP3A4 enzyme activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, taking large amounts of fennel might interfere with hormone replacement therapy due to competition for estrogen receptors.

Some constituents of fennel have estrogenic activity.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, taking large amounts of fennel might decrease the antiestrogenic effect of tamoxifen.

Some constituents of fennel have estrogenic activity, which may interfere with the antiestrogenic activity of tamoxifen.

Likelihood Possible Evidence D
organic Fennel full monograph & interactions

Astragalus (root) extract4 drug types · 208 drugs

Antidiabetes Drugs

Theoretically, taking astragalus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research in humans shows that astragalus might have hypoglycemic effects. Theoretically, taking astragalus, especially in combination with other hypoglycemic agents, might increase the risk of hypoglycemia.

Likelihood Probable Evidence A
Cyclophosphamide

Theoretically, astragalus might interfere with cyclophosphamide therapy.
Evidence regarding the effect of astragalus on immunosuppression caused by cyclophosphamide is conflicting. Some animal research suggests that astragalus reverses cyclophosphamide-induced immunosuppression. However, other animal research shows no effect.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, astragalus might interfere with immunosuppressive therapy.
Astragalus seems to stimulate immune function. Theoretically, taking astragalus might decrease the effects of immunosuppressive therapy.

Likelihood Possible Evidence D
Lithium

Theoretically, astragalus might increase levels and adverse effects of lithium.
Animal research suggests that astragalus has diuretic properties. Theoretically, due to this diuretic effect, astragalus might reduce excretion and increase levels of lithium.

Likelihood Probable Evidence D
Astragalus (root) extract full monograph & interactions

Tienchi (root) extract4 drug types · 207 drugs

Aspirin

Theoretically, taking Panax notoginseng concomitantly with aspirin may increase the risk of adverse effects from both products.
Animal research shows that taking Panax notoginseng extract with aspirin increases blood levels of salicylic acid by approximately 50% and blood levels of Panax notoginseng by 75% to 196%. This effect may be due to increased absorption of both products.

Likelihood Possible Evidence D
Caffeine

Theoretically, taking Panax notoginseng may decrease the levels and clinical effects of caffeine.
Animal research shows that administering Panax notoginseng intravenously for 7 days before intraperitoneal injection of caffeine can decrease maximal blood levels of caffeine by 37%. This interaction is attributed to the ability of Panax notoginseng to increase the activity of cytochrome P450 1A2 (CYP1A2) enzymes.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, taking Panax notoginseng might reduce the levels and clinical effects of CYP1A2 substrates.
Animal research shows that administering Panax notoginseng intravenously for 7 days before intraperitoneal injection of caffeine can decrease maximal blood levels of caffeine by 37%. This interaction was attributed to the ability of Panax notoginseng to increase the activity of CYP1A2.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, taking Panax notoginseng concomitantly with warfarin may increase the risk of bleeding.
Animal research shows that taking Panax notoginseng concomitantly with warfarin increases plasma warfarin levels, prothrombin time, and international normalized ratio when compared with control. In vitro research also suggests that Panax notoginseng may downregulate expression of cytochrome P450 3A4 enzymes, which may affect warfarin metabolism.

Likelihood Possible Evidence D
Tienchi (root) extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Digestech, from the product label.

Onnit

See all Onnit products
Name
Onnit Labs, LLC
City
Austin
State
Texas
ZipCode
78744
Phone Number
(855) 666-4899
Pharmacist Counseling Corner

Digestech by Onnit: Common Questions

Does Digestech by Onnit interact with any medications?
Yes. Based on its ingredients, Digestech has a known interaction with 1,100 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Digestech contains 23 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is lactase in this product safe for someone with lactose intolerance?
Yes — lactase is effective for lactose intolerance and is generally well tolerated. If you're lactose intolerant, this enzyme can help you digest dairy products more comfortably.
Can I take this if I'm pregnant?
It depends on which ingredients. Lactase and Ginger are likely safe in moderate amounts during pregnancy, but Fennel, Astragalus, and Tienchi should be avoided because there isn't enough safety data or there are specific concerns. Talk with your doctor or pharmacist about your individual situation before starting.
Can I take this if I'm breastfeeding?
Lactase and small food amounts of Ginger are likely okay, but Fennel medicinal doses, Astragalus, and Tienchi are not well studied or should be avoided while breastfeeding. Check with your doctor or pharmacist first.
What does Lactase in this product do?
Lactase breaks down lactose, the natural sugar in milk and dairy products. It helps people who are lactose intolerant digest dairy without discomfort.
What does Ginger do in this formula?
Ginger may help reduce nausea, menstrual cramps, and soreness from exercise. However, it can interact with several medications, especially blood thinners and diabetes drugs, so check your medications before taking this product.
Will this help with general digestion if I don't have lactose intolerance?
The enzymes here break down different food components — fats, proteins, carbohydrates — which may help digestion generally. However, the data we hold doesn't establish that the product works for common digestive complaints like bloating or dyspepsia overall.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Digestech is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Digestech label
Go deeper

The Full Monographs Behind Digestech’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Fennel

Interacts with 740 drugs

Fennel is a Mediterranean herb widely used as a food and spice, and traditionally taken for digestive complaints, colic, and menstrual cramps. Some small studies suggest possible benefit for...

Read the full Fennel monograph → Herb & supplement monograph

Ginger

Interacts with 1,007 drugs

Ginger is a widely used culinary spice with a long history in traditional medicine, and it has the strongest evidence for helping with nausea and vomiting, including from motion sickness, pr...

Read the full Ginger monograph → Herb & supplement monograph

Astragalus

Interacts with 208 drugs

Astragalus is a root used for centuries in traditional Chinese medicine, mainly to support the immune system and help the body cope with stress. While early studies are interesting, strong h...

Read the full Astragalus monograph → Herb & supplement monograph

Panax Notoginseng

Interacts with 207 drugs

Panax notoginseng (sanqi or tienchi ginseng) is a traditional Chinese herb most often used to help with bleeding, bruising, and circulation. Human evidence for these uses is limited and most...

Read the full Panax Notoginseng monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Lactase

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...

Read the full Lactase monograph →
Sources

Sources & How We Checked

Digestech's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 114 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
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Fennel 17 references
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Astragalus 13 references
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Ginger 64 references
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Panax Notoginseng 15 references
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