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Dietary supplement

Serrapeptase 60,000 Units of Activity Ingredients & Drug Interactions

by NOW

Serrapeptase 60,000 Units of Activity label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Serrapeptase 60,000 Units of Activity against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Serrapeptase 60,000 Units of Activity is a dietary supplement by NOW with 1 active ingredient. Its ingredients are commonly taken for inflammation and swelling, sinus and respiratory congestion, pain after surgery or injury.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Serrapeptase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Serrapeptase 60,000 Units of Activity by NOW

Ask about any prescription or over-the-counter medication and we check it for interactions with Serrapeptase 60,000 Units of Activity by NOW — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Serrapeptase 60,000 Units of Activity by NOW

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: serrapeptase, a protease enzyme sourced from the bacteria Serratia marcescens. The inactive ingredients are rice bran, microcrystalline cellulose, and hypromellose (a capsule material).

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Serrapeptase's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: supports respiratory health and immune function.
  • We looked for evidence on: Asthma, Chronic bronchitis, Laryngitis, Pharyngitis, Rhinosinusitis, Bronchiectasis — and 2 related terms.
  • The closest evidence on file: Serrapeptase is rated "Insufficient Reliable Evidence To Rate" for Chronic bronchitis (Natural Medicines).
  • Also on file: Serrapeptase is rated "Insufficient Reliable Evidence To Rate" for Asthma, Pharyngitis, Rhinosinusitis, Bronchiectasis, and more.

The evidence for serrapeptase is not established in our data. The effectiveness ratings we hold show insufficient reliable evidence for chronic bronchitis, asthma, atherosclerosis, back pain, and osteoporosis — so we don't know whether it works for any of these uses based on current research.

The evidence, ingredient by ingredient Serrapeptase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Serrapeptase is generally well tolerated in the short term, but long-term safety has not been well studied. The most common side effects reported in trials — epigastric pain (upper belly discomfort), gastrointestinal upset, and nausea — appear to occur at about the same rate as placebo.

A rare serious side effect, bullous pemphigoid (a blistering skin condition), has been reported but is uncommon. The safety data advises against use during pregnancy and while breastfeeding.

If you're pregnant, planning to become pregnant, or breastfeeding, talk with your pharmacist or doctor before taking this supplement.

Side effects, ingredient by ingredient Serrapeptase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Serrapeptase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take blood thinners or antiplatelet drugs — such as warfarin, aspirin, clopidogrel, or other anticoagulants — you should check your exact medications with the tool on this page before starting serrapeptase. The risk of increased bruising and bleeding is Moderate.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Serrapeptase might be worth considering if you're looking for enzyme support and don't take blood thinners. If you're on any blood thinner or antiplatelet medication — including aspirin, warfarin, or clopidogrel — check with your pharmacist first.

Long-term safety isn't well studied, so this is best used short-term and under guidance.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 20, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Serrapeptase 60,000 Units of Activity, straight from the product label.

Brand NOW
Barcode (UPC) 733739029737
Net contents 60 Veg Capsule(s)
Market status On market
Date entered into DSLD Jun 20, 2024
DSLD ID 314074
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Serrapeptase 60,000 Units of Activity by NOW, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veg Capsule(s)
Maximum serving Sizes:
1 Veg Capsule(s)
Servings per container
60
UPC/BARCODE
733739029737
IngredientAmount% DV
Serrapeptase33 mg--

Other ingredients: Rice Bran, Microcrystalline Cellulose, Hypromellose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Usage: Take 1 capsule daily on an empty stomach with 8 oz. of water. Continuous use of this product for more than 30 days is not recommended except under the supervision of a physician.

Formula

Serrapeptase (serratiopeptidase) is a protein-digesting enzyme isolated from the friendly bacterium Serratia marcescens. Studies indicate that serrapeptase is absorbed intact from the digestive tract and that it acts systemically to support healthy immune system functions and promote the body's normal healing processes. Some evidence suggests that serrapeptase may support respiratory health by helping to maintain normal mucus secretions.

Systemic Proteolytic Enzymes

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Caution: For adults only. Keep out of reach of children.

Consult physician if pregnant/nursing taking medication (especially blood thinning medications), or have a medical condition.

Not for long-term use.

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish, or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Formulation

Healthy Immune Function Promotes Respiratory Health

Vegetarian/Vegan

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish, or tree nut ingredients.

Natural color variation may occur in this product.

FDA Statement of Identity

A Dietary Supplement

General Statements

Digestive Family owned since 1968.

Storage

Store in a cool, dry place after opening.

Seals/Symbols

GMP Quality Assured.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Serrapeptase 60,000 Units of Activity by NOW label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Serrapeptase 60,000 Units of Activity label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Serrapeptase 60,000 Units of Activity by NOW

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Veg Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Serrapeptase

Interacts with
122 drugs
33 mg per serving

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you...

Serrapeptase monograph & interactions

Other (inactive) ingredients: Rice Bran, Microcrystalline Cellulose, Hypromellose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Serrapeptase 60,000 Units of Activity by NOW Drug Interactions

Want to check YOUR meds against Serrapeptase 60,000 Units of Activity?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Serrapeptase 122

Individual Drug Interactions

The ingredients in Serrapeptase 60,000 Units of Activity interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Serrapeptase 60,000 Units of Activity interact with drugs. Each result below shows which ingredient is responsible. Serrapeptase

Each ingredient & the kinds of drugs it affects

For each ingredient in Serrapeptase 60,000 Units of Activity with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Serrapeptase1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking serrapeptase with drugs that have antiplatelet or anticoagulant effects might increase the risk of bruising and bleeding.
In vitro research shows that serrapeptase has fibrinolytic activity.

Likelihood Possible Evidence D
Serrapeptase full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Serrapeptase 60,000 Units of Activity, from the product label.

NOW

See all NOW products
Name
NOW Foods
Street Address
395 S. Glen Ellyn Rd.
City
Bloomingdale
State
IL
ZipCode
60108
Web Address
nowfoods.com
Pharmacist Counseling Corner

Serrapeptase 60,000 Units of Activity by NOW: Common Questions

Does Serrapeptase 60,000 Units of Activity by NOW interact with any medications?
Yes. Based on its ingredients, Serrapeptase 60,000 Units of Activity has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Serrapeptase 60,000 Units of Activity contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does serrapeptase do?
Serrapeptase is a protease enzyme — a protein that breaks down other proteins. Lab research shows it can break down fibrin, a substance involved in clotting. But we don't have reliable evidence it works for the conditions it's often marketed for, like back pain or asthma.
Is serrapeptase safe to take long-term?
Short-term use is generally well tolerated, but long-term safety hasn't been well studied. If you're thinking of taking it regularly over weeks or months, talk with your pharmacist first.
What are the side effects?
The most common ones are epigastric pain, gastrointestinal upset, and nausea — but they appear to happen at about the same rate as placebo in trials. A rare serious side effect, bullous pemphigoid, has been reported.
Can I take serrapeptase if I'm pregnant or breastfeeding?
No, the safety data advises against it during pregnancy and while breastfeeding. There isn't enough safety information, so talk with your doctor or pharmacist for personalized advice.
What are the inactive ingredients?
Rice bran, microcrystalline cellulose, and hypromellose — the last one is the capsule material. These are inert fillers and binders.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Serrapeptase 60,000 Units of Activity is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Serrapeptase 60,000 Units of Activity label
Go deeper

The Full Monographs Behind Serrapeptase 60,000 Units of Activity’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Serrapeptase

Interacts with 122 drugs

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you want to try it, choose an enteric-coate...

Read the full Serrapeptase monograph →
Sources

Sources & How We Checked

Serrapeptase 60,000 Units of Activity's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Serrapeptase 2 references
  1. Tachibana M, Mizukoshi O, Harada Y, et al. A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling. Pharmatherapeutica 1984;3:526-30..
  2. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res 1990;18:379-88.. PubMed

See these in context on the Serrapeptase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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