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Dietary supplement

Serrapeptase Ingredients & Drug Interactions

by Source Naturals

Serrapeptase label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Serrapeptase against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Serrapeptase is a dietary supplement by Source Naturals with 1 active ingredient. Its ingredients are commonly taken for inflammation and swelling, sinus and respiratory congestion, pain after surgery or injury.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Serrapeptase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Serrapeptase by Source Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with Serrapeptase by Source Naturals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Serrapeptase by Source Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

This product contains one active ingredient: serrapeptase, an enzyme derived from the silkworm. It's included in the capsule along with several inactive ingredients (maltodextrin, hypromellose, ethylcellulose, and others) that serve as fillers and binders to form and protect the capsule.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Serrapeptase's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: support healthy inflammation response and mucus viscosity.
  • We looked for evidence on: Postoperative swelling, Rhinosinusitis, Chronic bronchitis, Bronchiectasis, Asthma, Back pain — and 4 related terms.
  • The closest evidence on file: Serrapeptase is rated "Insufficient Reliable Evidence To Rate" for Chronic bronchitis (Natural Medicines).
  • Also on file: Serrapeptase is rated "Insufficient Reliable Evidence To Rate" for Asthma, Back pain, Carpal tunnel syndrome, Fibromyalgia, and more.

The evidence we hold does not establish serrapeptase as effective for any of its common uses. Studies on chronic bronchitis, asthma, atherosclerosis, back pain, and osteoporosis all show insufficient reliable evidence to rate it.

That doesn't mean it doesn't work — just that the data available to us isn't conclusive enough to make that call. Talk with your pharmacist about what the latest research shows for your specific interest.

The evidence, ingredient by ingredient Serrapeptase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Serrapeptase is generally well tolerated in the short term. The most common side effects — epigastric pain (pain in the upper abdomen), general gastrointestinal upset, and nausea — occur at rates similar to placebo, so most people don't experience them.

Long-term safety has not been well studied, so caution is warranted with extended use. During pregnancy, the safety data is not sufficient, so it's best avoided.

The same goes for breastfeeding — there isn't reliable safety information available, so avoid use while nursing. If you're pregnant or breastfeeding and interested in serrapeptase, talk with your doctor or pharmacist for personalized guidance.

Side effects, ingredient by ingredient Serrapeptase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Serrapeptase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting this product, check with your pharmacist if you take any anticoagulants or antiplatelets (blood thinners like warfarin, clopidogrel, or high-dose aspirin). The enzyme can theoretically increase bleeding risk, and that's a Moderate-severity concern.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Serrapeptase is generally well tolerated in the short term, but if you're on a blood thinner or antiplatelet medication, you need to check with your pharmacist first — the combination could raise bleeding risk. The evidence for its effectiveness isn't established in our data.

Pregnant or breastfeeding? Skip it and talk with your healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Serrapeptase, straight from the product label.

Brand Source Naturals
Barcode (UPC) 021078019480
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Aug 22, 2017
DSLD ID 77516
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Serrapeptase by Source Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
15
UPC/BARCODE
021078019480
IngredientAmount% DV
Serrapeptase0 NP--

Other ingredients: Maltodextrin, Hypromellose, purified Water, Ethylcellulose, Sodium Carboxymethylcellulose, Talc, Polydextrose, Ammonium Hydroxide, Medium Chain Triglycerides, Oleic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Whole body systemic vegetarian and enteric-coated enzyme

Serrapeptase is provided as a vegetarian capsule with enteric coating designed to provide the most benefit.

FDA Statement of Identity

Dietary Supplement

General Statements

SPU (Serrapeptase units)

Serrapeptase is an enzyme that preliminary evidence suggests is active systemically and may support a healthy inflammation response. Preliminary evidence also suggests that when taken orally, this enzyme may reduce the viscosity of mucus in the respiratory tract.

Suggested/Recommended/Usage/Directions

Suggested Use: 1 to 2 capsules twice daily as needed on an empty stomach with at least 8 ounces of water.

Storage

Store in a cool, dry place.

Precautions

Caution: Do not take if you are pregnant, may become pregnant, breastfeeding, or if you suffer from any gastrointestinal disorders such as ulcers. Consult your health care professional before taking this product if you are taking any drug that affects blood coagulation such as prescription vitamin K, heparin, warfarin (Coumadin), or aspirin.

Discontinue use if nausea, diarrhea, or other intestinal discomfort occurs.

Do not use if either tamper-evident seal is broken or missing.

Keep out of the reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

SN1948 REV C161-B

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Serrapeptase by Source Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Serrapeptase label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Serrapeptase by Source Naturals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container15 Amounts shown are per serving.

Serrapeptase

Interacts with
122 drugs
0 NP per serving

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you...

Serrapeptase monograph & interactions

Other (inactive) ingredients: Maltodextrin, Hypromellose, Purified Water, Ethylcellulose, Sodium Carboxymethylcellulose, Talc, Polydextrose, Ammonium Hydroxide, Medium Chain Triglycerides, Oleic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Serrapeptase by Source Naturals Drug Interactions

Want to check YOUR meds against Serrapeptase?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Serrapeptase 122

Individual Drug Interactions

The ingredients in Serrapeptase interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Serrapeptase interact with drugs. Each result below shows which ingredient is responsible. Serrapeptase

Each ingredient & the kinds of drugs it affects

For each ingredient in Serrapeptase with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Serrapeptase1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking serrapeptase with drugs that have antiplatelet or anticoagulant effects might increase the risk of bruising and bleeding.
In vitro research shows that serrapeptase has fibrinolytic activity.

Likelihood Possible Evidence D
Serrapeptase full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Serrapeptase, from the product label.

Source Naturals

Name
Source Naturals, Inc.
Street Address
P. O. Box 2118
City
Santa Cruz
State
CA
ZipCode
95062
Web Address
www.sourcenaturals.com
Pharmacist Counseling Corner

Serrapeptase by Source Naturals: Common Questions

Does Serrapeptase by Source Naturals interact with any medications?
Yes. Based on its ingredients, Serrapeptase has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Serrapeptase contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What exactly is serrapeptase?
It's an enzyme that comes from silkworms. It has fibrinolytic activity, meaning it can break down fibrin, a protein involved in blood clots. That's why it's been studied for conditions related to inflammation and circulation, though the evidence for its effectiveness isn't conclusive.
Will serrapeptase give me side effects?
Most people tolerate it well. The side effects that do occur — stomach pain, nausea, or general digestive upset — show up at about the same rate as placebo in studies. Rare serious side effects have been reported, but they're uncommon.
Is serrapeptase safe to take long-term?
Short-term use is generally well tolerated, but long-term safety hasn't been well studied. If you're thinking about using it regularly for months, talk with your pharmacist about what we do and don't know.
Can I take serrapeptase if I'm pregnant or breastfeeding?
No — there isn't enough safety data. It's best avoided during pregnancy and while breastfeeding. If you're interested in it during either time, talk with your doctor or pharmacist for personalized advice.
Does serrapeptase actually work?
The evidence we hold shows insufficient reliable data to say it's effective for any of its common uses, including chronic bronchitis, asthma, back pain, and others. That doesn't mean it doesn't work — just that the studies available aren't conclusive enough for us to rate it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Serrapeptase is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Serrapeptase label
Go deeper

The Full Monographs Behind Serrapeptase’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Serrapeptase

Interacts with 122 drugs

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you want to try it, choose an enteric-coate...

Read the full Serrapeptase monograph →
Sources

Sources & How We Checked

Serrapeptase's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Serrapeptase 2 references
  1. Tachibana M, Mizukoshi O, Harada Y, et al. A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling. Pharmatherapeutica 1984;3:526-30..
  2. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res 1990;18:379-88.. PubMed

See these in context on the Serrapeptase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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