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Dietary supplement

Serrapeptase Ingredients & Drug Interactions

by Source Naturals

Serrapeptase label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Serrapeptase against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Serrapeptase is a dietary supplement by Source Naturals with 1 active ingredient. Its ingredients are commonly taken for inflammation and swelling, sinus and respiratory congestion, pain after surgery or injury.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Serrapeptase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Serrapeptase by Source Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with Serrapeptase by Source Naturals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Serrapeptase by Source Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

This product contains one active ingredient: serrapeptase, an enzyme. The other ingredients are inactive — they're part of the capsule and help it hold together and dissolve properly.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Serrapeptase's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: support healthy inflammation response and mucus viscosity.
  • We looked for evidence on: Back pain, Carpal tunnel syndrome, Chronic bronchitis, Fibromyalgia, Laryngitis, Osteoarthritis — and 4 related terms.
  • The closest evidence on file: Serrapeptase is rated "Insufficient Reliable Evidence To Rate" for Chronic bronchitis (Natural Medicines).
  • Also on file: Serrapeptase is rated "Insufficient Reliable Evidence To Rate" for Back pain, Carpal tunnel syndrome, Fibromyalgia, Osteoarthritis, and more.

The evidence for serrapeptase isn't established in the data we hold. Our monograph lists several conditions it's been studied for — including chronic bronchitis, asthma, atherosclerosis, back pain, and osteoporosis — but the rating for each is insufficient reliable evidence to rate.

That means the research so far hasn't been strong enough to say whether it works.

The evidence, ingredient by ingredient Serrapeptase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Short-term, serrapeptase appears to be generally well tolerated. The most common side effects reported in trials were epigastric pain (pain in the upper belly), stomach upset, and nausea — though these occurred at about the same rate as placebo, suggesting they may not be directly caused by the supplement.

A rare serious side effect, bullous pemphigoid (a blistering skin condition), has been reported. Long-term safety hasn't been well studied.

There isn't enough safety data to know whether serrapeptase is safe in pregnancy or while breastfeeding. Talk with your doctor or pharmacist for personalized advice if you're pregnant, planning pregnancy, or breastfeeding.

Side effects, ingredient by ingredient Serrapeptase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Serrapeptase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take blood thinners or antiplatelet medications (like warfarin, aspirin, clopidogrel, or apixaban), double-check with your doctor or pharmacist before starting serrapeptase — there's a moderate risk that combining them could increase bleeding and bruising. No other medication interactions are documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Serrapeptase may appeal to you if you're exploring options for chronic bronchitis, asthma, or other conditions it's been studied for — but the evidence so far is too thin to say it works. If you take blood thinners or antiplatelet drugs, check with your doctor or pharmacist before adding this supplement, since the combination could theoretically increase bleeding risk.

For personalized advice about whether it's right for you, talk it over with your own healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Serrapeptase, straight from the product label.

Brand Source Naturals
Barcode (UPC) 021078019480
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Aug 22, 2017
DSLD ID 77516
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Serrapeptase by Source Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
15
UPC/BARCODE
021078019480
IngredientAmount% DV
Serrapeptase0 NP--

Other ingredients: Maltodextrin, Hypromellose, purified Water, Ethylcellulose, Sodium Carboxymethylcellulose, Talc, Polydextrose, Ammonium Hydroxide, Medium Chain Triglycerides, Oleic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Whole body systemic vegetarian and enteric-coated enzyme

Serrapeptase is provided as a vegetarian capsule with enteric coating designed to provide the most benefit.

FDA Statement of Identity

Dietary Supplement

General Statements

SPU (Serrapeptase units)

Serrapeptase is an enzyme that preliminary evidence suggests is active systemically and may support a healthy inflammation response. Preliminary evidence also suggests that when taken orally, this enzyme may reduce the viscosity of mucus in the respiratory tract.

Suggested/Recommended/Usage/Directions

Suggested Use: 1 to 2 capsules twice daily as needed on an empty stomach with at least 8 ounces of water.

Storage

Store in a cool, dry place.

Precautions

Caution: Do not take if you are pregnant, may become pregnant, breastfeeding, or if you suffer from any gastrointestinal disorders such as ulcers. Consult your health care professional before taking this product if you are taking any drug that affects blood coagulation such as prescription vitamin K, heparin, warfarin (Coumadin), or aspirin.

Discontinue use if nausea, diarrhea, or other intestinal discomfort occurs.

Do not use if either tamper-evident seal is broken or missing.

Keep out of the reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

SN1948 REV C161-B

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Serrapeptase by Source Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Serrapeptase label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Serrapeptase by Source Naturals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container15 Amounts shown are per serving.

Serrapeptase

Interacts with
122 drugs
0 NP per serving

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you...

Serrapeptase monograph & interactions

Other (inactive) ingredients: Maltodextrin, Hypromellose, Purified Water, Ethylcellulose, Sodium Carboxymethylcellulose, Talc, Polydextrose, Ammonium Hydroxide, Medium Chain Triglycerides, Oleic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Serrapeptase by Source Naturals Drug Interactions

Want to check YOUR meds against Serrapeptase?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Serrapeptase 122

Individual Drug Interactions

The ingredients in Serrapeptase interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Serrapeptase interact with drugs. Each result below shows which ingredient is responsible. Serrapeptase

Each ingredient & the kinds of drugs it affects

For each ingredient in Serrapeptase with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Serrapeptase1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking serrapeptase with drugs that have antiplatelet or anticoagulant effects might increase the risk of bruising and bleeding.
In vitro research shows that serrapeptase has fibrinolytic activity.

Likelihood Possible Evidence D
Serrapeptase full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Serrapeptase, from the product label.

Source Naturals

Name
Source Naturals, Inc.
Street Address
P. O. Box 2118
City
Santa Cruz
State
CA
ZipCode
95062
Web Address
www.sourcenaturals.com
Pharmacist Counseling Corner

Serrapeptase by Source Naturals: Common Questions

Does Serrapeptase by Source Naturals interact with any medications?
Yes. Based on its ingredients, Serrapeptase has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Serrapeptase contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is serrapeptase?
Serrapeptase is an enzyme — a protein that breaks down other molecules. It's been studied for conditions like chronic bronchitis and asthma, though the evidence so far isn't strong enough to say it works for any of them.
Can I take this if I'm pregnant or breastfeeding?
The safety data isn't there either way. There's not enough information to know if serrapeptase is safe during pregnancy or while breastfeeding, so talk with your doctor or pharmacist before taking it if you're pregnant, planning pregnancy, or nursing.
What side effects might I experience?
Most people tolerate it well. The side effects reported in trials — stomach pain, upset stomach, and nausea — showed up at about the same rate as placebo. A rare serious side effect, a blistering skin condition called bullous pemphigoid, has been reported in very few cases.
How long has the long-term safety been studied?
Long-term safety isn't well studied. We have decent short-term safety data, but we don't know much about what happens if you take it for months or years.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Serrapeptase is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Serrapeptase label
Go deeper

The Full Monographs Behind Serrapeptase’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Serrapeptase

Interacts with 122 drugs

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you want to try it, choose an enteric-coate...

Read the full Serrapeptase monograph →
Sources

Sources & How We Checked

Serrapeptase's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Serrapeptase 2 references
  1. Tachibana M, Mizukoshi O, Harada Y, et al. A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling. Pharmatherapeutica 1984;3:526-30..
  2. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res 1990;18:379-88.. PubMed

See these in context on the Serrapeptase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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