Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

Shark Cartilage Ingredients & Drug Interactions

by Herb Xtra

Shark Cartilage label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Shark Cartilage against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Shark Cartilage is a dietary supplement by Herb Xtra with 3 active ingredients. Its ingredients are commonly taken for joint and bone health, skin, hair, and nail support, source of dietary protein.Based on those ingredients, 121 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Shark Cartilage. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Shark Cartilage by Herb Xtra

Ask about any prescription or over-the-counter medication and we check it for interactions with Shark Cartilage by Herb Xtra — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Shark Cartilage by Herb Xtra

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.

This product contains 3 active ingredients. Shark cartilage is the key component; gelatin (a protein derived from animal collagen) rounds out the formula.

Water is also listed but we hold no interaction data for it. Neither gelatin nor shark cartilage has established roles in treating the conditions they're sometimes marketed for — the evidence on file doesn't support their use for cancer, osteoarthritis, psoriasis, or other common claims.

Gelatin is rated possibly ineffective for diarrhea and has insufficient evidence for aging skin, brittle nails, uterine fibroids, and beta-thalassemia.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

The label doesn't state a purpose we can grade — see each ingredient's own graded uses on its monograph instead.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold doesn't establish that shark cartilage works for any of the conditions it's used for. It's rated likely ineffective for cancer and has insufficient evidence for age-related macular degeneration, diabetic retinopathy, Kaposi sarcoma, osteoarthritis, and psoriasis.

Gelatin is rated possibly ineffective for diarrhea. For aging skin, brittle nails, uterine fibroids, and beta-thalassemia, the evidence is too thin to rate either way.

If you're considering this product for a specific reason, chat with your doctor or pharmacist — they can help you weigh what the science actually shows.

The evidence, ingredient by ingredient Gelatin Shark Cartilage

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Gelatin is widely eaten in foods and is generally well tolerated when taken by mouth. Common minor side effects include belching, bloating, and indigestion.

Rare allergic reactions (swelling, hives, wheezing, or anaphylaxis) are possible, especially if you have a known gelatin sensitivity — gelatin is used in some vaccines like MMR and DPT, so mention this if you've had vaccine reactions. Shark cartilage is often poorly studied.

Common side effects include constipation, nausea, vomiting, indigestion, dizziness, and taste disturbance. Rare serious effects reported include hepatitis, abnormal blood sugar, weakness, and peripheral swelling.

The safety data for shark cartilage in pregnancy and while breastfeeding is too limited — the facts advise against it in both situations. Talk with your doctor or pharmacist before taking this product if you're pregnant, planning pregnancy, or breastfeeding.

Side effects, ingredient by ingredient Gelatin Shark Cartilage

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Shark Cartilage.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 121 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take immunosuppressants (medications that weaken the immune system for transplant, autoimmune conditions, or other reasons), check your exact drugs on this page and clear this product with your doctor or pharmacist first. No other medication interactions are documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product combines shark cartilage and gelatin, neither of which has proven effective for the conditions they're marketed for. The main caution is a moderate interaction with immunosuppressants — if you take any immune-dampening drug, check your specific medications and discuss this product with your doctor or pharmacist before starting.

Avoid it if you're pregnant or breastfeeding unless your healthcare provider advises otherwise.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Shark Cartilage, straight from the product label.

Brand Herb Xtra
Barcode (UPC) 777949999688
Net contents 60 Capsule(s); 750 mg
Market status On market
Date entered into DSLD Jan 25, 2013
DSLD ID 17563
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Shark Cartilage by Herb Xtra, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
UPC/BARCODE
777949999688
IngredientAmount% DV
Gelatin0 NP--
Shark Cartilage0 NP--
Water0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Use: As a Herbal Supplement: 2 to 3 capsules 3 times daily with a glass of water.

Precautions

Caution: Not recommended for pregnant or nursing women.

In case of cardio-vascular problems consult a physician.

General

H310000

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Shark Cartilage by Herb Xtra label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Shark Cartilage label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Shark Cartilage by Herb Xtra

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Gelatin

No known
interactions
0 NP per serving

Gelatin is a protein made from animal collagen, used as a food, a capsule ingredient, and a supplement for joint, skin, and bone health. For most heal...

Gelatin monograph & interactions

Shark Cartilage

Interacts with
121 drugs
0 NP per serving

Shark cartilage is a supplement made from the skeletal tissue of sharks that was heavily promoted for cancer and joint conditions, but good-quality cl...

Shark Cartilage monograph & interactions

Water

0 NP per serving
Interaction report

Shark Cartilage by Herb Xtra Drug Interactions

Want to check YOUR meds against Shark Cartilage?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
121Drugs
121 Moderate

Ingredients driving the most interactions

Shark Cartilage 121

Individual Drug Interactions

The ingredients in Shark Cartilage interact with 121 drugs. Click any drug to see the details.

1 of the 3 ingredients in Shark Cartilage interact with drugs. Each result below shows which ingredient is responsible. Shark Cartilage

Each ingredient & the kinds of drugs it affects

For each ingredient in Shark Cartilage with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Shark Cartilage1 drug type · 121 drugs

Immunosuppressants

Theoretically, shark cartilage might interfere with immunosuppressive therapy.
In vitro evidence suggests that shark cartilage might stimulate immune responses. This effect has not been reported in humans.

Likelihood Possible Evidence D
Shark Cartilage full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Shark Cartilage, from the product label.

Herb Xtra

See all Herb Xtra products
Name
GOURMET NUTRITION F.B. INC.
City
Ste-Julie
State
Quebec
ZipCode
J3E 1Z2
Pharmacist Counseling Corner

Shark Cartilage by Herb Xtra: Common Questions

Does Shark Cartilage by Herb Xtra interact with any medications?
Yes. Based on its ingredients, Shark Cartilage has a known interaction with 121 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Shark Cartilage contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does gelatin do in this product?
Gelatin is a protein that fills out the formula, but it's not established to treat any condition. It's rated possibly ineffective for diarrhea and has insufficient evidence for other uses like skin health or brittle nails.
Will this help with arthritis or joint pain?
There's insufficient evidence to rate shark cartilage for osteoarthritis. The data we hold doesn't show it works for joint conditions, so talk with your doctor about what the science actually supports for your situation.
What are the most common side effects?
Shark cartilage can cause constipation, nausea, vomiting, indigestion, dizziness, and taste disturbance. Gelatin may cause belching, bloating, and indigestion. Most people tolerate it without serious problems, but these are worth watching for.
Is this safe during pregnancy or while breastfeeding?
The safety data on shark cartilage in pregnancy and lactation is too limited, and the facts advise against it in both. Gelatin is rated likely or possibly safe in pregnancy and likely safe while breastfeeding, but because this product contains shark cartilage, talk with your doctor or pharmacist before use.
Are there any fillers or inactive ingredients?
No inactive ingredients (fillers, binders, capsule materials) are listed for this product. The 3 active ingredients are gelatin, shark cartilage, and water.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Shark Cartilage is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Shark Cartilage label
Go deeper

The Full Monographs Behind Shark Cartilage’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Gelatin

Gelatin is a protein made from animal collagen, used as a food, a capsule ingredient, and a supplement for joint, skin, and bone health. For most health uses, the evidence is limited or mixe...

Read the full Gelatin monograph → Herb & supplement monograph

Shark Cartilage

Interacts with 121 drugs

Shark cartilage is a supplement made from the skeletal tissue of sharks that was heavily promoted for cancer and joint conditions, but good-quality clinical trials have not shown meaningful...

Read the full Shark Cartilage monograph →
Sources

Sources & How We Checked

Shark Cartilage's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 23 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Gelatin 11 references
  1. Lewis CJ. Letter to reiterate certain public health and safety concerns to firms manufacturing or importing dietary supplements that contain specific bovine tissues. FDA. Available at: www.cfsan.fda.gov/~dms/dspltr05.html.
  2. Schwick HG, Heide K. Immunochemistry and immunology of collagen and gelatin. Bibl Haematol 1969;33:111-25. PubMed
  3. Moskowitz RW. Role of collagen hydrolysate in bone and joint disease.Semin Arthritis Rheum 2000;30:87-99. PubMed
  4. Kelso JM. The gelatin story. J Allergy Clin Immunol 1999;103:200-2.
  5. Nakayama T, Aizawa C, Kuno-Sakai H. A clinical analysis of gelatin allergy and determination of its causal relationship to the previous administration of gelatin-containing acellular pertussis vaccine combined with diphtheria and tetanus toxoids. J Allerg PubMed
  6. Sakaguchi M, Inouye S. Anaphylaxis to gelatin-containing rectal suppositories. J Allergy Clin Immunol 2001;108:1033-4. PubMed
  7. PDR Electronic Library. Montvale, NJ: Medical Economics Company, Inc., 2001.
  8. de la Fuente Tornero E, Vega Castro A, de Sierra Hernández PÁ, et al. Kounis syndrome during anesthesia: Presentation of indolent systemic mastocytosis: A case report. A Case Rep. 2017;8(9):226-228. PubMed
  9. Ventura Spagnolo E, Calapai G, Minciullo PL, Mannucci C, Asmundo A, Gangemi S. Lethal anaphylactic reaction to intravenous gelatin in the course of surgery. Am J Ther. 2016;23(6):e1344-e1346. PubMed
  10. Li Y, He H, Yang L, Li X, Li D, Luo S. Therapeutic effect of Colla corii asini on improving anemia and hemoglobin compositions in pregnant women with thalassemia. Int J Hematol. 2016;104(5):559-565. PubMed
  11. Coury JR, Skaggs KF, Marciano GF, et al. Intraoperative Anaphylaxis to the Bovine Flowable Gelatin Matrix: A Report of 2 Cases. JBJS Case Connect 2022;12(1). PubMed

See these in context on the Gelatin monograph →

Shark Cartilage 12 references
  1. Ashar B, Vargo E. Shark cartilage-induced hepatitis [letter]. Ann Intern Med 1996;125:780-1. PubMed
  2. Lane IW, Comac L. Sharks don't get cancer. Garden City, NY: Avery Publishing Group; 1992.
  3. Miller DR, Anderson GT, Stark JJ, et al. Phase I/II trial of the safety and efficacy of shark cartilage in the treatment of advanced cancer. J Clin Oncol 1998;16:3649-55. PubMed
  4. Leitner SP, Rothkopf MM, Haverstick L, et al. Two phase II studies of oral dry shark cartilage powder (SCP) in patients (pts) with either metastatic breast or prostate cancer refractory to standard treatment. Proc Am Soc Clinical Oncol 1998;17:A240.
  5. Batist G, Patenaude F, Champagne P, et al. Neovastat (AE-941) in refractory renal cell carcinoma patients: report of a phase II trial with two dose levels. Ann Oncol 2002;13:1259-63..
  6. Merly, L., Simjee, S., and Smith, S. L. Induction of inflammatory cytokines by cartilage extracts. Int Immunopharmacol. 2007;7(3):383-391. PubMed
  7. Bargahi, A., Hassan, Z. M., Rabbani, A., Langroudi, L., Noori, S. H., and Safari, E. Effect of shark cartilage derived protein on the NK cells activity. Immunopharmacol.Immunotoxicol. 2011;33(3):403-409. PubMed
  8. Leitner SP, Rothkopf MM, Haverstick DD, and et al. Two phase II studies of oral dry shark cartilage powder (SCP) in patients with either metastatic breast or prostate cancer refractory to standard treatment. Amer Soc Clin Oncol 1998;17:A240.
  9. Milner M. A guide to the use of shark cartilage in the treatment of arthritis and other inflammatory joint diseases. Amer Chiropractor 1999;21:40-42.
  10. Rosenbluth, RJ, Jennis, AA, Cantwell, S, and et al. Oral shark cartilage in the treatment of patients with advanced primary brain tumors. A phase II pilot study (meeting abstract). Proc Annu Meet Am Soc Clin Oncol 1999;18:A554.
  11. Saad F, Klotz L, Babaian R, Lacombe L, Champagne P, and Dupont E. Phase I/II trial on AE-941 (Neovastat) in patients with metastatic refractory prostate cancer (abstract presentation). Canadian Urological Association Annual Meeting (June 24-27, 2001).
  12. Merly L, Smith SL. Pro-inflammatory properties of shark cartilage supplement. Immunopharmacol Immunotoxicol. 2015;37(2):140-7. PubMed

See these in context on the Shark Cartilage monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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