Siberian Elixir of Life Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Siberian Elixir of Life against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Siberian Elixir of Life is a dietary supplement by Health Republic with 5 active ingredients. Its ingredients are commonly taken for cold sores and herpes lesions (topical), sore throat and mouth sores, wound and skin healing.Based on those ingredients, 1,036 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Propolis, Sea Buckthorn Seed Oil Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Siberian Elixir of Life by Health Republic
Ask about any prescription or over-the-counter medication and we check it for interactions with Siberian Elixir of Life by Health Republic — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Siberian Elixir of Life by Health Republic
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This liquid supplement contains 4 ingredients, including three actives: propolis, cedar nut oil (cold pressed), and sea buckthorn seed oil extract. Propolis is a bee product—a resin-like mixture bees use in the hive.
Cedar nut oil is extracted from the nuts of cedar trees. Sea buckthorn is a berry known for its oils and fruit extract.
The product contains no inactive fillers or binding agents listed.
Does it work?
Moderate evidence
The evidence backing these ingredients is mixed. Propolis is possibly effective for oral mucositis (mouth inflammation) and herpes labialis (cold sores), and possibly effective for diabetes support, though the strength of evidence varies.
Sea buckthorn is possibly effective for burns but was rated possibly ineffective for eczema. For dyslipidemia (abnormal cholesterol), aging skin, cancer, and dengue fever, the evidence we hold is either insufficient or too limited to establish how well it works.
How safe is it?
Well-documented data
Propolis is generally well tolerated in the short term, though allergic reactions are possible—especially if you're sensitive to bee products. The most common side effect reported is mild headache; in one trial, about 7% of people taking propolis 250 mg twice daily for 4 months reported it.
Serious allergic reactions are rare but can happen. Sea buckthorn is also generally well tolerated as a food, but supplement safety hasn't been fully studied.
High doses may cause yellow staining of the skin, and topical use can cause dryness, irritation, or rash in some people. There isn't enough safety data on either ingredient for pregnancy or breastfeeding, so these are best avoided in those periods.
Meds to double-check
Moderate interaction found
Check your medications against these drug types before starting: blood thinners and antiplatelet drugs (both propolis and sea buckthorn can increase bleeding risk), blood pressure medications (sea buckthorn may lower it further), warfarin specifically (propolis may reduce its effect), and any drug metabolized by your liver's CYP enzymes—especially CYP3A4, CYP2C9, CYP2D6, CYP2C19, CYP1A2, or CYP2E1 (propolis may raise blood levels at high doses). Use the medication checker on this page to look up your exact drugs.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
If you take medications for blood pressure, blood clotting, or those processed by your liver, check with your pharmacist before starting this product—the interactions are real. People sensitive to bee products should be cautious with propolis.
This supplement may be worth considering for cold sores or mouth sores if you've cleared it with your doctor, but talk to your pharmacist first.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 24, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Siberian Elixir of Life, straight from the product label.
| Brand | Health Republic |
|---|---|
| Barcode (UPC) | 4630004760738 |
| Net contents | 3.52 Fluid Ounce(s); 100 mL |
| Market status | On market |
| Date entered into DSLD | Jan 24, 2024 |
| DSLD ID | 304011 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Siberian Elixir of Life by Health Republic, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Protein | 0 Gram(s) | -- |
| Total Fat | 0.6 Gram(s) | 0.75% |
| Calories | 5.4 Gram(s) | -- |
| Total Carbohydrates | 0.05 Gram(s) | 0.01% |
| Sugars | 0 Gram(s) | -- |
| Propolis | 0 NP | -- |
| Cedar Nut Oil, Cold Pressed | 0 NP | -- |
| Sea Buckthorn Seed Oil Extract | 0 NP | -- |
| Cedar | 0 NP | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
All product ingredients are collected by Contracted Beekeeping and Woodsmen to assure the highest quality and traceability from our hives to your table. Our products are also tested for their purity, biological activity and compliance with food safety standards.
Not GMO
Collected from Siberian Wilderness 5% Naturally Preserved Bio Active
Not a significant source of calories from fat, saturated fat, trans fat, cholesterol, dietary fiber, sugars, vitamin A and C, calcium, iron.
Product of Russia
Given by Nature, Proven for Centuries All 4 ingredients of such unique product have been collected from wild Siberian forest and processed according to the ancient Russian Siberia territory explorers recipe go back to 16th Century.
No MGO. No Sugar Added.
Suitable for Vegetarians.
The manufacturing facility FDA Registration #15012542486
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement, take 20 drops one or two times a day or more if needed, preferable between meals.
Suggested Use: As a dietary supplement, take 20 drops one or two times a day or more if needed, preferable before meals.
Precautions
Caution: Bee products may cause an allergic reaction in some sensitive people.
Unsuitable for infants under 1 years old.
Do not buy if the security seal is broken.
Storage
This product can be stored at room temperature (24C/75F) in its original container without excess heat.
General Statements
Bio
From Russia with Love
Formula
OleoResin Compound
Siberian Cedar Elixir of Life
The main ingredients of the oil blend "Siberian Cedar Elixir of Life" is cold pressed Cedar Kernel Nuts Oil and Cedar Sap both are natural occurring components of a Cedar tree growing wild in Siberia. Another two ingredients being blended with are Sea Berry Seeds Oil and Bee Propolis that finish the uniqueness of nutrition properties of the Elixir. Propolis is a resinous material collected by bees from bud and exudates of the plants, which is transformed in the presence of bee enzymes. Its color varies from green, red to dark brown. Propolis has a characteristic smell and shows adhesive properties because it strongly interacts with oils and proteins of the skin. In general, propolis in nature is composed of 30% wax, 50% resin and vegetable balsam, 10% essential and aromatic oils, 5% pollen, and other substances (Burdock, 1998).
FDA Statement of Identity
Dietary Supplement
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Siberian Elixir of Life by Health Republic label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Siberian Elixir of Life by Health Republic
These are the 5 active ingredients this product is made of. Select any to open its full monograph.
Serving size0.7 mL Dosage formLiquid Servings per container143 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Protein
Propolis
Interacts with921 drugs
Propolis is a natural, resin-like substance made by bees that has antimicrobial and anti-inflammatory properties in lab studies. Early research sugges...
Propolis monograph & interactionsCedar Nut Oil, Cold Pressed
Sea Buckthorn Seed Oil Extract
Interacts with289 drugs
Sea buckthorn is a berry-bearing shrub rich in vitamins, carotenoids, and fatty acids that people use for skin, eye, digestive, and heart health. Earl...
Sea Buckthorn Seed Oil Extract monograph & interactionsCedar
Siberian Elixir of Life by Health Republic Drug Interactions
HelloPharmacist Interaction Report
Siberian Elixir of Life by Health Republic contains two ingredients we've checked for drug interactions, and both have documented interactions with medications.
Propolis is the one with the most serious concern: at high doses, it may inhibit several liver enzymes (CYP2C19, CYP2D6, CYP1A2, CYP2C9, CYP3A4, and CYP2E1) and theoretically increase blood levels of drugs metabolized by these pathways—all rated Moderate severity. Additionally, propolis may increase bleeding risk with blood thinners (anticoagulants and antiplatelet drugs) and may decrease the effectiveness of warfarin specifically, also Moderate.
Read the full breakdown — every affected drug type, severity by severity
Sea buckthorn seed oil extract carries Moderate interactions with blood pressure drugs (antihypertensive medications) and anticoagulants or antiplatelet drugs. It may lower your blood pressure further or raise your bleeding risk if you're already on these medications.
We could not check cedar nut oil and cedar because we hold no interaction data for them. Altogether, these interactions span 1,025 individual medications.
Because the list is extensive, use the medication checker on this page to search your exact drugs before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Siberian Elixir of Life?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Siberian Elixir of Life interact with 1,036 drugs. Click any drug to see the details.
2 of the 5 ingredients in Siberian Elixir of Life interact with drugs. Each result below shows which ingredient is responsible. Propolis Sea Buckthorn Seed Oil Extract
Ado-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Siberian Elixir of Life — through 1 ingredient. Tap an ingredient for the detail:
PropolisCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Propolis + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Siberian Elixir of Life — through 2 ingredients. Tap an ingredient for the detail:
Sea Buckthorn Seed Oil ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, sea buckthorn may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Sea Buckthorn Seed Oil Extract + Abciximab interactionPropolisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, propolis might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
Read the full Propolis + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Siberian Elixir of Life — through 1 ingredient. Tap an ingredient for the detail:
PropolisCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Propolis + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Siberian Elixir of Life — through 1 ingredient. Tap an ingredient for the detail:
PropolisCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Propolis + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Siberian Elixir of Life — through 1 ingredient. Tap an ingredient for the detail:
PropolisCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Propolis + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Siberian Elixir of Life — through 2 ingredients. Tap an ingredient for the detail:
Sea Buckthorn Seed Oil ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, sea buckthorn may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Sea Buckthorn Seed Oil Extract + Abrocitinib interactionPropolisCytochrome P450 2c9 (cyp2c9) Substrates, Anticoagulant/antiplatelet Drugs +1 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C9.
Read the full Propolis + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Siberian Elixir of Life — through 1 ingredient. Tap an ingredient for the detail:
PropolisCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Propolis + Acalabrutinib interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Siberian Elixir of Life — through 1 ingredient. Tap an ingredient for the detail:
Sea Buckthorn Seed Oil ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking sea buckthorn with antihypertensive drugs might increase the risk of hypotension.
Read the full Sea Buckthorn Seed Oil Extract + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Siberian Elixir of Life — through 2 ingredients. Tap an ingredient for the detail:
Sea Buckthorn Seed Oil ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, sea buckthorn may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Sea Buckthorn Seed Oil Extract + Acenocoumarol interactionPropolisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, propolis might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
Read the full Propolis + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Siberian Elixir of Life — through 1 ingredient. Tap an ingredient for the detail:
PropolisCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Propolis + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Siberian Elixir of Life — through 2 ingredients. Tap an ingredient for the detail:
PropolisCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs +1 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Propolis + Acetaminophen, Aspirin interactionSea Buckthorn Seed Oil ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, sea buckthorn may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Sea Buckthorn Seed Oil Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Siberian Elixir of Life — through 2 ingredients. Tap an ingredient for the detail:
Sea Buckthorn Seed Oil ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, sea buckthorn may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Sea Buckthorn Seed Oil Extract + Acetaminophen, Aspirin, Caffeine interactionPropolisAnticoagulant/antiplatelet Drugs, Cytochrome P450 2e1 (cyp2e1) Substrates +2 Moderate
Interaction Summary
Theoretically, propolis might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
Read the full Propolis + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Siberian Elixir of Life — through 1 ingredient. Tap an ingredient for the detail:
PropolisCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Propolis + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Siberian Elixir of Life — through 1 ingredient. Tap an ingredient for the detail:
PropolisCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Propolis + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Siberian Elixir of Life — through 1 ingredient. Tap an ingredient for the detail:
PropolisCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +1 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Propolis + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Siberian Elixir of Life — through 1 ingredient. Tap an ingredient for the detail:
PropolisCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Propolis + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Siberian Elixir of Life — through 1 ingredient. Tap an ingredient for the detail:
PropolisCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Propolis + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Siberian Elixir of Life — through 1 ingredient. Tap an ingredient for the detail:
PropolisCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +1 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.
Read the full Propolis + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Siberian Elixir of Life — through 1 ingredient. Tap an ingredient for the detail:
PropolisCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Propolis + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Siberian Elixir of Life — through 1 ingredient. Tap an ingredient for the detail:
PropolisCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Propolis + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Siberian Elixir of Life — through 1 ingredient. Tap an ingredient for the detail:
PropolisCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.
Read the full Propolis + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Siberian Elixir of Life — through 1 ingredient. Tap an ingredient for the detail:
PropolisCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Propolis + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Siberian Elixir of Life — through 1 ingredient. Tap an ingredient for the detail:
PropolisCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +1 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Propolis + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Siberian Elixir of Life — through 1 ingredient. Tap an ingredient for the detail:
PropolisCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Propolis + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Siberian Elixir of Life — through 1 ingredient. Tap an ingredient for the detail:
PropolisCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Propolis + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Siberian Elixir of Life — through 1 ingredient. Tap an ingredient for the detail:
PropolisCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Propolis + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Siberian Elixir of Life — through 1 ingredient. Tap an ingredient for the detail:
PropolisCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.
Read the full Propolis + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Siberian Elixir of Life — through 1 ingredient. Tap an ingredient for the detail:
PropolisCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Propolis + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Siberian Elixir of Life — through 1 ingredient. Tap an ingredient for the detail:
PropolisCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Propolis + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Siberian Elixir of Life — through 1 ingredient. Tap an ingredient for the detail:
PropolisCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Propolis + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Siberian Elixir of Life with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Propolis
Anticoagulant/Antiplatelet Drugs
Theoretically, propolis might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
In vitro research shows that propolis water extract and the propolis constituent, caffeic acid phenethyl ester, can inhibit platelet aggregation. Additionally, evidence from an animal model shows that taking propolis in addition to warfarin decreases INR, suggesting that propolis can decrease the effectiveness of warfarin.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
In vitro research shows that propolis extract can inhibit CYP1A2. However, animal research shows that propolis extract does not significantly affect CYP1A2 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP1A2 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C19.
In vitro research shows that propolis extract can inhibit CYP2C19. However, animal research shows that propolis extract does not significantly affect CYP2C19 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2C19 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C9.
In vitro research shows that propolis extract can inhibit CYP2C9. However, animal research shows that propolis extract does not significantly affect CYP2C9 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2C9 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.
In vitro research shows that propolis extract can inhibit CYP2D6. However, animal research shows that propolis extract does not significantly affect CYP2D6 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2D6 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.
Cytochrome P450 2E1 (Cyp2E1) Substrates
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
In vitro research shows that propolis can inhibit CYP2E1. This effect has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Some in vitro research shows that propolis extract can inhibit CYP3A4; however, other in vitro research shows that propolis has no effect on CYP3A4 activity. Furthermore, animal research shows that propolis extract does not significantly affect CYP3A4 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that might in inhibit CYP3A4 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.
Warfarin (Coumadin)
Theoretically, propolis might decrease the effectiveness of warfarin.
Animal research shows that taking propolis in addition to warfarin decreases the international normalized ratio (INR). This effect has not been reported in humans.
Sea Buckthorn Seed Oil Extract
Anticoagulant/Antiplatelet Drugs
Theoretically, sea buckthorn may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Clinical research suggests that sea buckthorn fruit extracts can inhibit platelet aggregation and adhesion to collagen and fibrinogen.
Antihypertensive Drugs
Theoretically, taking sea buckthorn with antihypertensive drugs might increase the risk of hypotension.
Taking sea buckthorn appears to reduce blood pressure in some patients.
Brand information
Manufacturer and brand details for Siberian Elixir of Life, from the product label.
Health Republic
See all Health Republic products- Name
- Carte Blanche WCA, Inc.
- City
- Brooklyn
- State
- NY
- ZipCode
- 11229
- Phone Number
- 1-646-402-4558
- Web Address
- www.beemagicusa.com
Siberian Elixir of Life by Health Republic: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Siberian Elixir of Life’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Propolis
Interacts with 921 drugsPropolis is a natural, resin-like substance made by bees that has antimicrobial and anti-inflammatory properties in lab studies. Early research suggests it may help with cold sores, mouth so...
Read the full Propolis monograph → Herb & supplement monographSea Buckthorn
Interacts with 289 drugsSea buckthorn is a berry-bearing shrub rich in vitamins, carotenoids, and fatty acids that people use for skin, eye, digestive, and heart health. Early research is promising for a few uses l...
Read the full Sea Buckthorn monograph →Sources & How We Checked
Siberian Elixir of Life's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 28 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Propolis 21 references
- Hay KD, Greig DE. Propolis allergy: a cause of oral mucositis with ulceration. Oral Surg Oral Med Oral Pathol 1990;70:584-6. PubMed
- Li YJ, Lin JL, Yang CW, Yu CC. Acute renal failure induced by a Brazilian variety of propolis. Am J Kidney Dis 2005;46:e125-9. PubMed
- Jensen CD, Andersen KE. Allergic contact dermatitis from cera alba (purified propolis) in a lip balm and candy. Contact Dermatitis 2006;55:312-3. PubMed
- Chen, T. G., Lee, J. J., Lin, K. H., Shen, C. H., Chou, D. S., and Sheu, J. R. Antiplatelet activity of caffeic acid phenethyl ester is mediated through a cyclic GMP-dependent pathway in human platelets. Chin J Physiol 6-30-2007;50(3):121-126.
- Hsu, C. Y., Chiang, W. C., Weng, T. I., Chen, W. J., and Yuan, A. Laryngeal edema and anaphalactic shock after topical propolis use for acute pharyngitis. Am J Emerg.Med 2004;22(5):432-433. PubMed
- Black, R. J. Vulval eczema associated with propolis sensitization from topical therapies treated successfully with pimecrolimus cream. Clin Exp.Dermatol. 2005;30(1):91-92. PubMed
- Matos D, Serrano P, Brandao FM. A case of allergic contact dermatitis caused by propolis-enriched honey. Contact Dermatitis 2015;72(1):59-60. PubMed
- Naramoto K, Kato M, Ichihara K. Effects of an ethanol extract of Brazilian green propolis on human cytochrome P450 enzyme activities in vitro. J Agric Food Chem 2014;62(46):11296-302. PubMed
- Nyman G, Hagvall L. A case of allergic contact cheilitis caused by propolis and honey. Contact Dermatitis 2016;74(3):186-7. PubMed
- Ryu CS, Oh SJ, Oh JM, et al. Inhibition of cytochrome P450 by propolis in human liver microsomes. Toxicol Res 2016;32(3):207-13. PubMed
- Akbay E, Özenirler Ç, Çelemli ÖG, Durukan AB, Onur MA, Sorkun K. Effects of propolis on warfarin efficacy. Kardiochir Torakochirurgia Pol. 2017;14(1):43-46. PubMed
- Lamoureux A, Meharon M, Durand AL, Darrigade AS, Doutre MS, Milpied B. A first case of erythema multiforme-like contact dermatitis caused by propolis. Contact Dermatitis. 2017;77(4):263-264. PubMed
- Piredda M, Facchinetti G, Biagioli V, et al. Propolis in the prevention of oral mucositis in breast cancer patients receiving adjuvant chemotherapy: A pilot randomised controlled trial. Eur J Cancer Care (Engl). 2017;26(6). PubMed
- Zhang YX, Yang TT, Xia L, Zhang WF, Wang JF, Wu YP. Inhibitory Effect of Propolis on Platelet Aggregation In Vitro. J Healthc Eng. 2017;2017:3050895. PubMed
- Nyman GSA, Tang M, Inerot A, Osmancevic A, Malmberg P, Hagvall L. Contact allergy to beeswax and propolis among patients with cheilitis or facial dermatitis. Contact Dermatitis 2019;81(2):110-6. PubMed
- Igarashi G, Segawa T, Akiyama N, et al. Efficacy of Brazilian propolis supplementation for japanese lactating women for atopic sensitization and nonspecific symptoms in their offspring: a randomized, double-blind, placebo-controlled trial. Evid Based Comp PubMed
- Soleimani D, Rezaie M, Rajabzadeh F, et al. Protective effects of propolis on hepatic steatosis and fibrosis among patients with nonalcoholic fatty liver disease (NAFLD) evaluated by real-time two-dimensional shear wave elastography: a randomized clinical
- D'Ercole MC. Prolonged use of propolis can increase liver enzymes. J Gastrointestin Liver Dis 2020;29(3):468-9. PubMed
- Cho E, Lee JD, Cho SH. Systemic contact dermatitis from propolis ingestion. Ann Dermatol. 2011;23(1):85-88. PubMed
- Hallajzadeh J, Milajerdi A, Amirani E, Attari VE, Maghsoudi H, Mirhashemi SM. Effects of propolis supplementation on glycemic status, lipid profiles, inflammation and oxidative stress, liver enzymes, and body weight: a systematic review and meta-analysis
- Gheflati A, Dehnavi Z, Ghannadzadeh Yazdi A, Khorasanchi Z, Raeisi-Dehkordi H, Ranjbar G. The effects of propolis supplementation on metabolic parameters: a systematic review and meta-analysis of randomized controlled clinical trials. Avicenna J Phytomed
Sea Buckthorn 7 references
- Johansson AK, Korte H, Yang B, et al. Sea buckthorn berry oil inhibits platelet aggregation. J Nutr Biochem 2000;11:491-5.. PubMed
- Grad, S. C., Muresan, I., and Dumitrascu, D. L. Generalized yellow skin caused by high intake of sea buckthorn. Forsch.Komplementmed. 2012;19(3):153-156. PubMed
- Vlasov, V. V. [Hippophae oil in the treatment of superficial skin burns]. Vestn.Dermatol Venerol. 1970;44(6):69-72.
- Chang BB, Wang F Xu TY Zhang QQ He J Zhang XJ Li J. Total flavones of Hippophae rhamnoides L. for essential hypertension: a systematic review of randomized controlled trials. Chinese Journal of Evidence-Based Medicine. 2009;9(11):1207-1213. DOI
- Olas B, Kontek B, Szczesna M, et al. Inhibition of blood platelet adhesion by phenolics rich fraction of Hippophae rhamnoides L. fruits. J Physiol Pharmacol. 2017;68(2):223-9.
- Larmo P, Järvinen R, Laihia J, et al. Effects of a sea buckthorn oil spray emulsion on dry eye. Cont Lens Anterior Eye. 2019;42(4):428-433. PubMed
- De Seta F, Caruso S, Di Lorenzo G, Romano F, Mirandola M, Nappi RE. Efficacy and safety of a new vaginal gel for the treatment of symptoms associated with vulvovaginal atrophy in postmenopausal women: A double-blind randomized placebo-controlled study. Ma PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC