Interactions on record — worth a quick check against your medications. Based on 4 of 11 ingredients. Check your meds →
Dietary supplement

SIBOZyme Ingredients & Drug Interactions

by Priority One Nutritional Supplements

SIBOZyme label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking SIBOZyme against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

SIBOZyme is a dietary supplement by Priority One Nutritional Supplements with 11 active ingredients. Its ingredients are commonly taken for lactose intolerance, gas and bloating after dairy, diarrhea from dairy foods.Based on those ingredients, 36 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Betaine Hydrochloride. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against SIBOZyme by Priority One Nutritional Supplements

Ask about any prescription or over-the-counter medication and we check it for interactions with SIBOZyme by Priority One Nutritional Supplements — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of SIBOZyme by Priority One Nutritional Supplements

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 8 of its 11 active ingredients.
  • “Pancreatin” is listed as a grouped ingredient — the label gives one combined amount (400 mg) without saying how much of each component you get.

SIBOZyme contains 11 active ingredients—mostly digestive enzymes that help break down different types of food. Protease breaks down proteins; lipase breaks down fats; lactase breaks down milk sugar; and amylase, maltase, and sucrase break down carbohydrates.

The formula also includes betaine hydrochloride (which increases stomach acid), ox bile (a digestive fluid), pancreatin (a blend of multiple digestive enzymes), and prolyl endopeptidase (another protein-digesting enzyme). The inactive ingredients are rice flour, hypromellose (a capsule material), and purified water.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Digestive enzyme support for digestion.
  • We looked for evidence on: Dyspepsia, Lactose intolerance, Diarrhea, Bloating and gas, Indigestion, Pancreatic enzyme insufficiency.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.
  • Also on file: Betaine Hydrochloride is rated "Insufficient Reliable Evidence To Rate" for Diarrhea, Dyspepsia.

The evidence for most of these ingredients in SIBOZyme is not well established in the data we hold. Lactase is effective for lactose intolerance—if that's why you're taking it, this ingredient can help.

For the others—protease, lipase, and betaine hydrochloride—the research doesn't yet show they work reliably for the digestive complaints they're meant to address. If you're considering this product for a specific condition, talk with your pharmacist about what the science actually supports.

The evidence, ingredient by ingredient Lactase Betaine Hydrochloride Proteolytic Enzymes (proteases) Lipase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The digestive enzymes in SIBOZyme are generally well tolerated by most adults, but a few cautions apply. Protease can rarely trigger allergic reactions; lipase should be used only under medical guidance if you have serious digestive conditions; and lactase is generally safe but has caused contact allergies in rare cases.

Betaine hydrochloride is the biggest concern—it irritates the stomach and should not be used if you have ulcers, gastritis, or true acid reflux, as it may make those worse. We don't have enough safety data to recommend betaine hydrochloride during pregnancy or breastfeeding.

For the other ingredients, safety data in pregnancy or breastfeeding is either limited or not on file; talk with your doctor before regular use if you're pregnant or nursing.

Side effects, ingredient by ingredient Lactase Betaine Hydrochloride Proteolytic Enzymes (proteases) Lipase

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 4 matched ingredients can interact with medications — Betaine Hydrochloride.
  • The most serious interaction on file is rated Minor.
  • For scale: 36 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take H2-blockers, antacids, or proton pump inhibitors (PPIs) for heartburn or acid reflux, check your specific medications with the tool on this page—betaine hydrochloride in SIBOZyme may weaken their effects. For the other ingredients we could check, no interactions are documented in our data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with clinical evidence supporting its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

SIBOZyme is a multi-enzyme formula that's generally well tolerated in adults without digestive ulcers or severe acid reflux. If you take acid-reducing medications (H2-blockers, antacids, or PPIs), check your exact drugs on this page before starting—betaine hydrochloride may reduce their effects.

If you're pregnant, nursing, or have a serious digestive condition, run this by your pharmacist or doctor first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 11 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about SIBOZyme, straight from the product label.

Brand Priority One Nutritional Supplements
Barcode (UPC) 815354021720
Net contents 180 Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2024
DSLD ID 310784
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for SIBOZyme by Priority One Nutritional Supplements, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Vegetarian Capsule(s)
Maximum serving Sizes:
3 Vegetarian Capsule(s)
Servings per container
60
UPC/BARCODE
815354021720
IngredientAmount% DV
Amylase0 NP--
L-Glutamic Acid220 mg--
Protease0 NP--
Lipase0 NP--
Lactase100 mg--
Maltase100 mg--
Betaine Hydrochloride220 mg--
Pancreatin400 mg--
Sucrase100 mg--
Ox Bile300 mg--
Prolyl Endopeptidase25 mg--
Amylase60 mg--

Other ingredients: Rice Flour, Hypromellose, Water, Purified

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Warning: If you are pregnant or breast feeding, consult your physician before using this product.

Keep out of reach of children.

For professional use only

Suggested/Recommended/Usage/Directions

Recommendations: Take three (3) capsules two times daily before meals or as directed by your physician.

Storage

Keep container tightly closed, store in a cool, dry place.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Contains no preservatives. Bisphenol-A (BPA) & Phthalate free

Non-GMO

General Statements

Formulated by: Dr. Mona Morstein

FDA Statement of Identity

A Dietary Supplement

Brand IP Statement(s)

Tolerase G is a trademark of DSM

Priority One Nutritional Supplements Inc. Since 1988

Seals/Symbols

GMP Certified

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

SIBOZyme by Priority One Nutritional Supplements label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

SIBOZyme label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in SIBOZyme by Priority One Nutritional Supplements

These are the 11 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Vegetarian Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Glutamic Acid

220 mg per serving

Lactase

No known
interactions
100 mg per serving

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can red...

Lactase monograph & interactions

Maltase

100 mg per serving

Betaine Hydrochloride

Interacts with
36 drugs
220 mg per serving

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is l...

Betaine Hydrochloride monograph & interactions

Pancreatin

400 mg per serving

Sucrase

100 mg per serving

Ox Bile

300 mg per serving

Prolyl Endopeptidase

25 mg per serving Form: Aspergillus niger

Amylase

60 mg per serving

Other (inactive) ingredients: Rice Flour, Hypromellose, Water, Purified. These complete the product’s ingredient list but are not active constituents.

Interaction report

SIBOZyme by Priority One Nutritional Supplements Drug Interactions

Want to check YOUR meds against SIBOZyme?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
36Drugs
36 Minor

Ingredients driving the most interactions

Betaine Hydrochloride 36

Individual Drug Interactions

The ingredients in SIBOZyme interact with 36 drugs. Click any drug to see the details.

1 of the 11 ingredients in SIBOZyme interact with drugs. Each result below shows which ingredient is responsible. Betaine Hydrochloride

Each ingredient & the kinds of drugs it affects

For each ingredient in SIBOZyme with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Betaine Hydrochloride3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D
Betaine Hydrochloride full monograph & interactions
The maker

Brand information

Manufacturer and brand details for SIBOZyme, from the product label.

Priority One Nutritional Supplements

See all Priority One Nutritional Supplements products
Name
Priority One Nutritional Supplements, Inc.
Web Address
www.priorityonevitamins.com
Pharmacist Counseling Corner

SIBOZyme by Priority One Nutritional Supplements: Common Questions

Does SIBOZyme by Priority One Nutritional Supplements interact with any medications?
Yes. Based on its ingredients, SIBOZyme has a known interaction with 36 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
SIBOZyme contains 11 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will SIBOZyme help my lactose intolerance?
Yes—lactase, one of the enzymes in this product, is effective for lactose intolerance. That said, the other enzymes in the formula don't have strong evidence behind them yet, so talk with your pharmacist about whether the whole product is right for you.
Can I take SIBOZyme if I have acid reflux?
No, this product isn't a good fit for you. It contains betaine hydrochloride, which raises stomach acid and can make reflux and heartburn worse. It's also not safe if you have ulcers or gastritis.
What should I do if I take antacids or omeprazole?
Check your exact medications in the tool on this page before starting SIBOZyme. Betaine hydrochloride in the formula may reduce how well your acid-reducing drugs work.
Is it safe to take while breastfeeding?
Safety data during breastfeeding isn't well established for most of the ingredients here. Talk with your doctor or pharmacist first—they can weigh the risks and benefits for your situation.
What does ox bile do in this formula?
Ox bile is a digestive fluid that helps your body break down fats. We don't have interaction data on file for it, but it's included to support overall digestion.
Are there any side effects I should know about?
Most people tolerate these enzymes well, but digestive upset is possible. Rarely, protease can trigger allergies. If you have a known sensitivity to enzymes or detergents, mention that to your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

SIBOZyme label
Go deeper

The Full Monographs Behind SIBOZyme’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactase

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...

Read the full Lactase monograph → Herb & supplement monograph

Betaine Hydrochloride

Interacts with 36 drugs

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...

Read the full Betaine Hydrochloride monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph →
Sources

Sources & How We Checked

SIBOZyme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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