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Dietary supplement

Single Herbs Feverfew Leaf & Flower Ingredients & Drug Interactions

by Gaia Herbs Single Herbs

Single Herbs Feverfew Leaf & Flower label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Single Herbs Feverfew Leaf & Flower against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Single Herbs Feverfew Leaf & Flower is a dietary supplement by Gaia Herbs Single Herbs with 2 active ingredients. Its ingredients are commonly taken for migraine prevention, headache, fever (traditional).Based on those ingredients, 929 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are total alcohol free Feverfew extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Single Herbs Feverfew Leaf & Flower by Gaia Herbs Single Herbs

Ask about any prescription or over-the-counter medication and we check it for interactions with Single Herbs Feverfew Leaf & Flower by Gaia Herbs Single Herbs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Single Herbs Feverfew Leaf & Flower by Gaia Herbs Single Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • “Validated Full Spectrum Profile” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

This product contains 2 active ingredients: a validated full spectrum profile of feverfew (as a total alcohol free extract) and parthenolide. Feverfew leaf and flower has been used traditionally, though the extract form here removes alcohol.

The capsule also contains vegetable glycerin as an inactive ingredient.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: migraine and headache support.
  • We looked for evidence on: Tension headache, migraine, fever, menstrual discomfort.
  • The closest evidence on file: Feverfew is rated "Insufficient Reliable Evidence To Rate" for Tension headache (Natural Medicines).

The evidence we hold does not establish feverfew's effectiveness for the conditions listed — tension headache, prurigo nodularis, psoriasis, and rheumatoid arthritis all show insufficient reliable evidence to rate. That doesn't mean it doesn't work; it means the research we have on file isn't robust enough to make a claim either way.

Talk with your doctor or pharmacist about what the broader research landscape shows if you're considering it for a specific condition.

The evidence, ingredient by ingredient Feverfew

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Feverfew is generally well tolerated in the short term, though some people experience allergic reactions or mouth irritation. The most common side effects are gastrointestinal — abdominal pain, bloating, constipation, diarrhea, flatulence, heartburn, and nausea.

Chewing fresh feverfew leaves is more likely to cause mouth ulcers and other mouth problems than commercial preparations. One thing to know: stopping feverfew after long-term use may trigger "post-feverfew syndrome," with symptoms like anxiety, headaches, and trouble sleeping.

Avoid this product during pregnancy — it may stimulate the uterus and its safety isn't established. Similarly, safety information is insufficient for breastfeeding, so it's best avoided then too.

Side effects, ingredient by ingredient Feverfew

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Feverfew.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 930 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take blood thinners (anticoagulants) or antiplatelet drugs — feverfew may increase bleeding risk. Additionally, ask about any medications metabolized by the liver enzymes CYP2C19, CYP2D6, CYP1A2, CYP2C9, CYP3A4, or CYP2C8, as feverfew may theoretically raise their levels.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Feverfew may help with certain conditions, but the evidence we hold isn't solid enough to confirm effectiveness. The main concern is its potential to raise blood levels of many medications and increase bleeding risk if you're on blood thinners.

If you take any prescription drugs — especially those metabolized by the liver or blood thinners — check them against the search tool on this page and talk with your doctor or pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Single Herbs Feverfew Leaf & Flower, straight from the product label.

Brand Gaia Herbs Single Herbs
Barcode (UPC) 751063145787
Net contents 60 Vegetarian Liquid Phyto-Cap(s)(TM)
Market status On market
Date entered into DSLD Jun 25, 2012
DSLD ID 9934
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Single Herbs Feverfew Leaf & Flower by Gaia Herbs Single Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
751063145787
IngredientAmount% DV
Calories20 {Calories}--
Validated Full Spectrum Profile0 NP--
total alcohol free Feverfew extract665 mg--
Parthenolide2 mg--

Other ingredients: Vegetable Glycerin, Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use Take 1 capsule 2 times daily between meals

Use only as directed on label.

Precautions

Not to be used during pregnancy or lactation.

Keep away from children.

Safety sealed for your protection.

If you have a medical condition or take pharmaceutical drugs please consult with your doctor before using this product.

Brand IP Statement(s)

meetyourherbs(R) Enter ID # at GaiaHerbs.com

U.S. Patent No. 6,238,696 B1

General Statements

Laboratory tested for purity

Natural separation may occur. This does not affect product quality.

The Gaia Difference

Supports a healthy inflammatory response*

BEST BY

Formulation

Free of heavy-metal toxicity

100% vegetarian, dairy free, no gluten-containing ingredients

Formula

Feverfew

High potency, easy absorption Alcohol-free, Liquid Phyto-Caps(TM)

Plant-derived capsule

Storage

Keep bottle capped at all times and store in a cool dry place.

FDA Statement of Identity

DIETARY SUPPLEMENT

General

[001] 1228-0511

FDA Disclaimer Statement

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Single Herbs Feverfew Leaf & Flower by Gaia Herbs Single Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Single Herbs Feverfew Leaf & Flower label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Single Herbs Feverfew Leaf & Flower by Gaia Herbs Single Herbs

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Validated Full Spectrum Profile

0 NP per serving
  • › Parthenolide

Total alcohol free Feverfew extract

Interacts with
929 drugs
665 mg per serving

Feverfew is a daisy-family herb best known for migraine prevention, where some studies suggest it may modestly lower how often migraines occur, though...

Total alcohol free Feverfew extract monograph & interactions

Other (inactive) ingredients: Vegetable Glycerin, Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Single Herbs Feverfew Leaf & Flower by Gaia Herbs Single Herbs Drug Interactions

Want to check YOUR meds against Single Herbs Feverfew Leaf & Flower?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
929Drugs
929 Moderate

Ingredients driving the most interactions

total alcohol free Feverfew extract 929

Individual Drug Interactions

The ingredients in Single Herbs Feverfew Leaf & Flower interact with 929 drugs. Click any drug to see the details.

1 of the 2 ingredients in Single Herbs Feverfew Leaf & Flower interact with drugs. Each result below shows which ingredient is responsible. total alcohol free Feverfew extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Single Herbs Feverfew Leaf & Flower with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

total alcohol free Feverfew extract7 drug types · 929 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, feverfew might have additive effects and increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Laboratory research suggests that feverfew may inhibit platelet aggregation. Additionally, in one case report, a 36-year-old patient taking feverfew 2400 mg daily for 3 months experienced vaginal bleeding and a prolonged menstrual cycle, with a modest increase in partial thromboplastin time (PTT) and prothrombin time (PT).

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP1A2.
Laboratory research shows that feverfew might inhibit CYP1A2. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP2C19.
Laboratory research shows that feverfew might inhibit CYP2C19. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C8 (Cyp2C8) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP2C8.
Laboratory research shows that feverfew might inhibit CYP2C8. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP2C9.
Laboratory research shows that feverfew might inhibit CYP2C9. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP2D6.
Laboratory research shows that feverfew might inhibit CYP2D6. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP3A4.
Laboratory research shows that feverfew might inhibit CYP3A4. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
total alcohol free Feverfew extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Single Herbs Feverfew Leaf & Flower, from the product label.

Gaia Herbs Single Herbs

See all Gaia Herbs Single Herbs products
Name
Gaia Herbs, Inc.
Street Address
101 Gaia Herbs Dr.
City
Brevard
State
NC
ZipCode
28712
Web Address
GaiaHerbs.com
Pharmacist Counseling Corner

Single Herbs Feverfew Leaf & Flower by Gaia Herbs Single Herbs: Common Questions

Does Single Herbs Feverfew Leaf & Flower by Gaia Herbs Single Herbs interact with any medications?
Yes. Based on its ingredients, Single Herbs Feverfew Leaf & Flower has a known interaction with 929 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Single Herbs Feverfew Leaf & Flower contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
The safety data advises against feverfew during pregnancy because it may stimulate the uterus. While breastfeeding, there isn't enough reliable safety information, so it's best avoided. Talk with your doctor or pharmacist about whether this product is right for you in either situation.
What are the most common side effects?
Most people experience gastrointestinal symptoms like nausea, heartburn, diarrhea, bloating, constipation, abdominal pain, or flatulence. Skin rashes can occur in sensitive individuals. If you chew fresh feverfew leaves instead of taking a commercial preparation, you're more likely to get mouth ulcers or tongue irritation.
What happens if I stop taking it after using it for a long time?
Stopping feverfew after long-term use may cause "post-feverfew syndrome" — symptoms like anxiety, headaches, and insomnia. This is something to be aware of if you've been taking it regularly.
Will this help my tension headaches?
The evidence we hold on feverfew for tension headaches is insufficient to say either way. Talk with your doctor about whether it might be worth trying for your situation.
Why do I need to check my medications against this product?
Feverfew may slow how your liver clears certain drugs, which could raise their blood levels and cause problems. It also has a theoretical risk of increasing bleeding if you're on anticoagulants or antiplatelet drugs. Your doctor or pharmacist can tell you if any of your specific medications are affected.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Single Herbs Feverfew Leaf & Flower is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Single Herbs Feverfew Leaf & Flower label
Go deeper

The Full Monographs Behind Single Herbs Feverfew Leaf & Flower’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Feverfew

Interacts with 929 drugs

Feverfew is a daisy-family herb best known for migraine prevention, where some studies suggest it may modestly lower how often migraines occur, though the evidence is mixed. It is generally...

Read the full Feverfew monograph →
Sources

Sources & How We Checked

Single Herbs Feverfew Leaf & Flower's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 18 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Feverfew 18 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Awang DVC. Prescribing therapeutic feverfew (Tancetum pathrnium (L.) Schultz Bip., syn. Chrysanthemumparthenium (L.) Bernh). Int Med 1998;1:11-3.
  3. Heptinstall S, Groenewegen WA, Spangenberg P, Loesche W. Extracts of feverfew may inhibit platelet behaviour via neutralization of sulphydryl groups. J Pharm Pharmacol 1987;39:459-65. PubMed
  4. Heptinstall S, White A, Williamson L, Mitchell JR. Extracts of feverfew inhibit granule secretion in blood platelets and polymorphonuclear leucocytes. Lancet 1985;1:1071-4. PubMed
  5. Makheja AN, Bailey JM. A platelet phospholipase inhibitor from the medicinal herb feverfew (Tanacetum parthenium). Prostaglandins Leukot Med 1982;8:653-60.
  6. Groenewegen WA, Heptinstall S. A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in-vitro. J Pharm Pharmacol 1990;42:553-7. PubMed
  7. Heptinstall S, Groenewegen WA, Spangenberg P, Losche W. Inhibition of platelet behaviour by feverfew: a mechanism of action involving sulphydryl groups. Folia Haematol Int Mag Klin Morphol Blutforsch 1988;115:447-9.
  8. Biggs MJ, Johnson ES, Persaud NP, Ratcliffe DM. Platelet aggregation in patients using feverfew for migraine. Lancet 1982;2:776. PubMed
  9. Lamminpaa A, Estlander T, Jolanki R, Kanerva L. Occupational allergic contact dermatitis caused by decorative plants. Contact Dermatitis 1996;34:330-5. PubMed
  10. Johnson ES, Kadam NP, Hylands DM, Hylands PJ. Efficacy of feverfew as prophylactic treatment of migraine. Br Med J (Clin Res Ed) 1985;291:569-73. PubMed
  11. Pittler MH, Ernst E. Feverfew for preventing migraine. Cochrane Database Syst Rev 2004;(1):CD002286. PubMed
  12. Ernst E, Pittler MH. The efficacy and safety of feverfew (Tanacetum parthenium L.): an update of a systematic review. Public Health Nutr 2000;3:509-14.
  13. Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
  14. Sil'vestrov VP, Kinitin AV, and Chesnokova, IV. [Immunological and metabolic disorders and the means for their correction in patients with chronic bronchitis]. Ter.Arkh. 1991;63:7-11.
  15. Cady RK, Goldstein J, Nett R, et al. A double-blind placebo-controlled pilot study of sublingual feverfew and ginger (LipiGesic M) in the treatment of migraine. Headache 2011;51:1078-86.
  16. Jovanovic, M. and Poljacki, M. [Compositae dermatitis]. Med Pregl. 2003;56(1-2):43-49. PubMed
  17. Burry, J. N. Compositae dermatitis in South Australia: contact dermatitis from Chrysanthemum parthenium. Contact Dermatitis 1980;6(6):445.
  18. Alenzi KA, Alharbi FH, Tawhari FM, Fradees GS. Alteration of Coagulation Test Results and Vaginal Bleeding Associated With the Use of Feverfew (Tanacetum parthenium). J Med Cases 2021;12(1):9-12.

See these in context on the Feverfew monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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