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Dietary supplement

Skullcap 375 mg Ingredients & Drug Interactions

by Eclectic Herb

Skullcap 375 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Skullcap 375 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Skullcap 375 mg is a dietary supplement by Eclectic Herb with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, trouble sleeping, nervous tension.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Skullcap, Freeze-Dried. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Skullcap 375 mg by Eclectic Herb

Ask about any prescription or over-the-counter medication and we check it for interactions with Skullcap 375 mg by Eclectic Herb — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Skullcap 375 mg by Eclectic Herb

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: freeze-dried skullcap at 375 mg per capsule. Skullcap is an herb traditionally used to support relaxation and calm, though the evidence for those claims is limited.

The capsule itself is made from hypromellose, an inert material that holds the herb and helps it dissolve in your digestive tract.

Does it work?

No specific claim
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
General wellness

This Skullcap product is marketed for general wellness, not a specific health condition, so there's no single claim to grade — see Skullcap's own graded uses on its monograph.

Why this rating?
  • The label markets general wellness (“Antioxidant support”), not a specific health condition, so there is no single claim to grade against clinical-evidence data.

The data we hold on skullcap shows insufficient reliable evidence to rate it for epilepsy, stress, stroke, spasticity, contact dermatitis, or premenstrual dysphoric disorder. In other words, we don't have enough solid research to say whether it works for any of these uses.

If you're considering it for a specific condition, talk with your doctor about whether the evidence supports it for your situation.

The evidence, ingredient by ingredient Skullcap

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Skullcap is often used short-term, but evidence on its long-term safety is limited and product quality varies—so use it with care. The most common side effects reported are sedation, cognitive impairment, and digestive upset.

In one small trial, about 9% of people taking 350 mg three times daily for two weeks experienced mild digestive disturbances. One person reported vivid dreams at that same dose, though it's unclear whether skullcap was responsible.

A single 100 mg dose didn't cause noticeable CNS effects in testing, but higher doses—like the 200 mg studied—did trigger sedation and cognitive impairment. The safety data advises against skullcap during pregnancy and while breastfeeding.

If you're pregnant, planning to become pregnant, or nursing, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Skullcap

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Skullcap.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check whether you're on any CNS depressants—medications that cause drowsiness or slow your thinking, such as benzodiazepines, sleep aids, narcotic pain relievers, or sedating antidepressants. A moderate interaction is documented: skullcap may intensify their sedating and cognitive effects.

Confirm with your doctor or pharmacist that it's safe to combine.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula marketed for general wellness rather than one specific gradeable purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Skullcap may be worth considering if you're looking for herbal relaxation support and you don't take medications that slow your brain and nervous system. If you do take CNS depressants—sleep aids, anxiety medications, pain relievers, or sedating antidepressants—be cautious and check with your doctor or pharmacist first.

Avoid it during pregnancy and breastfeeding. The evidence for what it treats is weak, so manage expectations and talk it over with your healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 18, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Skullcap 375 mg, straight from the product label.

Brand Eclectic Herb
Barcode (UPC) 023363309313
Net contents 90 Veg Cap(s)
Market status On market
Date entered into DSLD Jul 18, 2023
DSLD ID 294855
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Skullcap 375 mg by Eclectic Herb, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
90
UPC/BARCODE
023363309313
IngredientAmount% DV
Skullcap, Freeze-Dried350 mg--

Other ingredients: Hypromellose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Antioxidant Whole herbs

100% Kosher.

Formulation

Raw Naturally concentrated US grown

Gluten free Non gmo

Vegan

Freeze dried fresh for peak plant power

Freeze-drying is the best method of preservation as it naturally concentrates the nutrients in the plant by removing only the water.

Nothing artificial - no fillers or additives.

Concentrated 6 X through freeze-drying

General Statements

Our aronia berries are locally grown and fresh freeze-dried in-house in small batches. @eclecticherb

FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: Take 1 - 3 capsules per day.

Precautions

Keep out of reach of children.

Discontinue use if unusual symptoms occur.

Consult your health care advisor regarding herbs with pregnancy, infants or prescription drugs.

Consult your health care advisor regarding herbs with pregnancy, infants or prescription drugs.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Skullcap 375 mg by Eclectic Herb label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Skullcap 375 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Skullcap 375 mg by Eclectic Herb

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Skullcap, Freeze-Dried

Interacts with
248 drugs
350 mg per serving Form: Scutellaria lateriflora, Scutellaria lateriflora

American skullcap is an herb traditionally used to calm anxiety and promote relaxation, but solid human evidence is very limited. It is generally cons...

Skullcap, Freeze-Dried monograph & interactions

Other (inactive) ingredients: Hypromellose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Skullcap 375 mg by Eclectic Herb Drug Interactions

Want to check YOUR meds against Skullcap 375 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
248 Moderate

Ingredients driving the most interactions

Skullcap, Freeze-Dried 248

Individual Drug Interactions

The ingredients in Skullcap 375 mg interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in Skullcap 375 mg interact with drugs. Each result below shows which ingredient is responsible. Skullcap, Freeze-Dried

Each ingredient & the kinds of drugs it affects

For each ingredient in Skullcap 375 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Skullcap, Freeze-Dried1 drug type · 248 drugs

Cns Depressants

Theoretically, skullcap can have additive effects when used with other CNS depressants.
Animal and clinical research suggests that skullcap can cause sedation and cognitive impairment.

Likelihood Possible Evidence D
Skullcap, Freeze-Dried full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Skullcap 375 mg, from the product label.

Eclectic Herb

See all Eclectic Herb products
Name
Eclectic Herb
Street Address
755 NE 6th St.
City
Gresham
State
Oregon
ZipCode
97030
Phone Number
503.668.4120
Web Address
www.eclecticherb.com
Pharmacist Counseling Corner

Skullcap 375 mg by Eclectic Herb: Common Questions

Does Skullcap 375 mg by Eclectic Herb interact with any medications?
Yes. Based on its ingredients, Skullcap 375 mg has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Skullcap 375 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
No. The safety data advises against skullcap during pregnancy and while breastfeeding because there isn't enough evidence to know it's safe in those situations. Talk with your doctor or pharmacist before taking it if you're pregnant, planning to become pregnant, or nursing.
What are the most common side effects?
The most common ones are sedation, cognitive impairment, and digestive upset. In one trial at the 350 mg dose taken three times daily, about 9% of people reported mild digestive disturbances. One person on that same regimen had vivid dreams, though it's not certain skullcap caused it.
Is there good evidence that skullcap works for stress, sleep, or seizures?
No. We don't have enough reliable research to say skullcap is effective for stress, epilepsy, stroke, spasticity, contact dermatitis, or premenstrual dysphoric disorder. If you're considering it for a specific condition, ask your doctor whether the evidence supports it.
Does skullcap make you drowsy?
Yes. Research suggests skullcap can cause sedation and cognitive impairment—especially at higher doses. A single 100 mg dose didn't cause noticeable CNS effects, but 200 mg and higher did. This product is 375 mg, so drowsiness is possible, and it could be worse if you also take sleep aids or other sedating medications.
What is skullcap used for traditionally?
Skullcap is an herb traditionally used to support relaxation and calm. However, the evidence for those uses is limited, so we can't say reliably that it works. It's also been used historically for spasticity, epilepsy, and skin conditions, but the data doesn't support those claims either.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Skullcap 375 mg label
Go deeper

The Full Monographs Behind Skullcap 375 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Skullcap

Interacts with 248 drugs

American skullcap is an herb traditionally used to calm anxiety and promote relaxation, but solid human evidence is very limited. It is generally considered relatively safe for short-term us...

Read the full Skullcap monograph →
Sources

Sources & How We Checked

Skullcap 375 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Skullcap 3 references
  1. Wolfson P, Hoffmann DL. An investigation into the efficacy of Scutellaria lateriflora in healthy volunteers. Altern Ther Health Med 2003;9:74-8.
  2. Awad, R., Arnason, J. T., Trudeau, V., Bergeron, C., Budzinski, J. W., Foster, B. C., and Merali, Z. Phytochemical and biological analysis of skullcap (Scutellaria lateriflora L.): a medicinal plant with anxiolytic properties. Phytomedicine. 2003;10(8):6 PubMed
  3. Brock C, Whitehouse J, Tewfik I, Towell T. American skullcap (Scutellaria lateriflora): a randomised, double-blind placebo-controlled crossover study of its effects on mood in healthy volunteers. Phytother Res 2014;28(5):692-8.

See these in context on the Skullcap monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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