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Dietary supplement

Skullcap Ingredients & Drug Interactions

by Herbal Terra

Skullcap label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Skullcap against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Skullcap is a dietary supplement by Herbal Terra with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, trouble sleeping, nervous tension.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are certified organic Skullcap (Scutellaria lateriflora) dried herb liquid extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Skullcap by Herbal Terra

Ask about any prescription or over-the-counter medication and we check it for interactions with Skullcap by Herbal Terra — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Skullcap by Herbal Terra

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: certified organic Skullcap (Scutellaria lateriflora) dried herb liquid extract. The other ingredient listed is menstruum, which is the liquid used to extract and preserve the herb — an inactive component, not a therapeutic one.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Skullcap product and its label doesn't state a use — see Skullcap's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold on skullcap doesn't support a reliable rating for any of its traditional uses. Claims for epilepsy, stress, stroke, spasticity, contact dermatitis, and premenstrual dysphoric disorder (PMDD) all show insufficient reliable evidence to rate.

That means research hasn't yet established whether it works for these purposes — not that it definitely doesn't, just that we don't have solid proof either way.

The evidence, ingredient by ingredient Skullcap

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Skullcap is often used only short-term, but the safety data are limited and product quality varies, so use it with care. The most common side effects reported are sedation, cognitive impairment, and digestive disturbances.

A single 100 mg dose does not appear to cause CNS effects, but higher doses — 200 mg or more — may trigger sedation and mental fog. Around 9% of people taking 350 mg three times daily for 2 weeks reported mild digestive upset.

One person on that same dose reported vivid dreams, though it's unclear if skullcap caused it. During pregnancy, there isn't enough safety data, so it's best avoided.

Breastfeeding safety is unknown as well, so avoid it while nursing. Talk with your doctor or pharmacist before using skullcap if you're pregnant, breastfeeding, or planning either.

Side effects, ingredient by ingredient Skullcap

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Skullcap.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Skullcap by Herbal Terra, check any CNS depressants you're on — that includes sleeping pills (like zolpidem), sedatives, anti-anxiety medications (like benzodiazepines), and opioid pain relievers. Skullcap can add to their sedating and mind-fogging effects.

Run your medications through the interaction checker on this page, and confirm with your doctor or pharmacist before combining.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Skullcap may appeal to you if you're interested in traditional herbal approaches to stress or sleep, but the evidence for it doesn't yet support those uses. Be careful if you take any medication that slows your nervous system — including sleeping pills, sedatives, or anxiety drugs — because skullcap may add to that effect.

Check your exact medications with your doctor or pharmacist before starting, and let them know about any cognitive changes or digestive issues once you do.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Skullcap, straight from the product label.

Brand Herbal Terra
Barcode (UPC) 0606595847459
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Sep 25, 2020
DSLD ID 234459
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Organic, Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Skullcap by Herbal Terra, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
Servings per container
120
UPC/BARCODE
0606595847459
IngredientAmount% DV
certified organic Skullcap (Scutellaria lateriflora) dried herb liquid extract970 mg--

Other ingredients: Menstruum

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Origin of plant material: USA.

Manufactured in the USA in an FDA registered facility

Sugar free

Dried herb/menstruum ratio: 1:3 Expertly extracted Laboratory tested 330 mg/1 mL Premium product Super concentrated liquid herbal extract

Non GMO

No artificial ingredients, GMO, gluten, color additives, fillers, preservatives or binders. Natural Gluten Free

Suggested/Recommended/Usage/Directions

Direction Shake well before use. Adults take up to 30 drops (1 mL, one full squeeze of the dropper bulb) in 3-4 fl. oz of juice or water up to 4 times a day. We recommend to seek expert medical advice before taking this or any other herbal supplements.

FDA Disclaimer Statement

Notice This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Caution May have contraindications.

Do not use if you are allergic to any ingredients.

Consult a physician before using during pregnancy, if nursing, or if you are on any medications.

Keep out of the reach of children.

Storage

Store in a cool, dry, dark place.

Formula

Scutellaria lateriflora

FDA Statement of Identity

Herbal Supplement

Seals/Symbols

Made in USA Made in an FDA registered facility Natural Gluten Free

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Skullcap by Herbal Terra label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Skullcap label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Skullcap by Herbal Terra

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.

Certified organic Skullcap (Scutellaria lateriflora) dried herb liquid extract

Interacts with
248 drugs
970 mg per serving

American skullcap is an herb traditionally used to calm anxiety and promote relaxation, but solid human evidence is very limited. It is generally cons...

Certified organic Skullcap (Scutellaria lateriflora) dried herb liquid extract monograph & interactions

Other (inactive) ingredients: Menstruum. These complete the product’s ingredient list but are not active constituents.

Interaction report

Skullcap by Herbal Terra Drug Interactions

Want to check YOUR meds against Skullcap?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
248 Moderate

Ingredients driving the most interactions

certified organic Skullcap (Scutellaria lateriflora) dried herb liquid extract 248

Individual Drug Interactions

The ingredients in Skullcap interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in Skullcap interact with drugs. Each result below shows which ingredient is responsible. certified organic Skullcap (Scutellaria lateriflora) dried herb liquid extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Skullcap with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

certified organic Skullcap (Scutellaria lateriflora) dried herb liquid extract1 drug type · 248 drugs

Cns Depressants

Theoretically, skullcap can have additive effects when used with other CNS depressants.
Animal and clinical research suggests that skullcap can cause sedation and cognitive impairment.

Likelihood Possible Evidence D
certified organic Skullcap (Scutellaria lateriflora) dried herb liquid extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Skullcap, from the product label.

Herbal Terra

See all Herbal Terra products
Name
Herbal Terra
Pharmacist Counseling Corner

Skullcap by Herbal Terra: Common Questions

Does Skullcap by Herbal Terra interact with any medications?
Yes. Based on its ingredients, Skullcap has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Skullcap contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is skullcap used for?
Skullcap has been used traditionally for epilepsy, stress, stroke, spasticity, contact dermatitis, and premenstrual dysphoric disorder (PMDD). However, we don't yet have solid evidence that it works for any of these — all the claims we hold data on show insufficient reliable evidence to rate.
Will skullcap make me drowsy?
Yes, sedation is one of the most commonly reported side effects. A single 100 mg dose doesn't seem to cause CNS effects, but 200 mg or higher doses can trigger sedation and cognitive impairment — difficulty thinking clearly. If you're sensitive to sedating herbs or take other sleep-slowing medications, be especially cautious.
Is skullcap safe to take while pregnant or breastfeeding?
No — there isn't enough safety data during pregnancy, so it's best avoided then. Breastfeeding safety is also unknown, so avoid it while nursing. Talk with your doctor or pharmacist about whether this product is right for you in those situations.
What side effects might I notice?
The most common ones are sedation, cognitive impairment, and digestive disturbances. Around 9% of people taking higher doses reported mild digestive upset. One person reported vivid dreams, though it's unclear if the product caused it. Information on other side effects is limited.
Can I take skullcap with my sleeping pill or anti-anxiety medication?
Not without checking first. Skullcap has documented moderate interactions with CNS depressants, meaning it can add to their sedating and mind-fogging effects. Run your specific medications through the checker on this page, and confirm with your doctor or pharmacist before combining.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Skullcap label
Go deeper

The Full Monographs Behind Skullcap’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Skullcap

Interacts with 248 drugs

American skullcap is an herb traditionally used to calm anxiety and promote relaxation, but solid human evidence is very limited. It is generally considered relatively safe for short-term us...

Read the full Skullcap monograph →
Sources

Sources & How We Checked

Skullcap's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Skullcap 3 references
  1. Wolfson P, Hoffmann DL. An investigation into the efficacy of Scutellaria lateriflora in healthy volunteers. Altern Ther Health Med 2003;9:74-8.
  2. Awad, R., Arnason, J. T., Trudeau, V., Bergeron, C., Budzinski, J. W., Foster, B. C., and Merali, Z. Phytochemical and biological analysis of skullcap (Scutellaria lateriflora L.): a medicinal plant with anxiolytic properties. Phytomedicine. 2003;10(8):6 PubMed
  3. Brock C, Whitehouse J, Tewfik I, Towell T. American skullcap (Scutellaria lateriflora): a randomised, double-blind placebo-controlled crossover study of its effects on mood in healthy volunteers. Phytother Res 2014;28(5):692-8.

See these in context on the Skullcap monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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