Interactions on record — worth a quick check against your medications. Based on 4 of 5 ingredients. Check your meds →
Dietary supplement

Sleep Response Ingredients & Drug Interactions

by Innate Response Formulas

Sleep Response label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Sleep Response against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Sleep Response is a dietary supplement by Innate Response Formulas with 5 active ingredients. Its ingredients are commonly taken for stress and anxiety, sleep problems, fatigue and low energy.Based on those ingredients, 1,430 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sensoril Ashwagandha root & leaf extract, organic Reishi, Lemon Balm. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Sleep Response by Innate Response Formulas

Ask about any prescription or over-the-counter medication and we check it for interactions with Sleep Response by Innate Response Formulas — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Sleep Response by Innate Response Formulas

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 4 of its 5 active ingredients.

Sleep Response contains 5 active ingredients. Sensoril Ashwagandha (an extract of root and leaf) is an adaptogen traditionally used to ease stress and anxiety.

Organic Reishi is a mushroom used to support relaxation. Skullcap and Lemon Balm are herbal extracts with a history of calming use.

The product also contains inactive ingredients — Rice Bran, Vegetable Cellulose, Guar Gum, Vegetable Lubricant, and Silica — which serve as binders and capsule material.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Support restful sleep and relaxation.
  • We looked for evidence on: Anxiety, Generalized anxiety disorder (GAD), Insomnia, Fatigue, Sleep quality, Stress management — and 1 related terms.
  • The strongest evidence on file: Lemon Balm is rated "Possibly Effective" for Stress (Natural Medicines).
  • Also on file: Ashwagandha is rated "Possibly Effective" for Anxiety, Generalized anxiety disorder (GAD), Insomnia, Stress.
  • Also on file: Lemon Balm is rated "Insufficient Reliable Evidence To Rate" for Anxiety, Insomnia.

Ashwagandha in this product is rated Possibly Effective for insomnia, anxiety, stress, and generalized anxiety disorder (GAD), though the evidence is preliminary. Lemon Balm is Possibly Effective for stress and depression.

Reishi showed Possibly Ineffective results for cholesterol (hyperlipidemia) in the studies we have. Skullcap's effectiveness for its traditional uses — including stress — is rated Insufficient Reliable Evidence To Rate, meaning the data we hold doesn't establish whether it works.

Ashwagandha for ADHD is also Insufficient Reliable Evidence To Rate.

The evidence, ingredient by ingredient Ashwagandha Reishi Mushroom Skullcap Lemon Balm

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Ashwagandha is generally well tolerated short-term in healthy adults, but long-term safety data are limited. The most common side effects — diarrhea, nausea, and stomach upset — are uncommon at typical doses.

Rare but serious concerns include acute liver damage; a case of overactive thyroid (hyperthyroidism) has been reported after years of use, and one case of intracranial bleeding and blood vessel narrowing was reported, though the link to ashwagandha alone is unclear. Reishi and Skullcap are generally well tolerated short-term; common mild effects include dizziness, stomach upset, and headache.

Lemon Balm is generally well tolerated; dizziness and sedation don't occur more often than with placebo, though one case of heart rhythm disturbance was reported with a multi-ingredient product containing lemon balm. Ashwagandha is rated Likely Unsafe in pregnancy — the data advises against it due to traditional concerns about miscarriage — and there isn't enough safety information to use it while breastfeeding.

Reishi and Skullcap have insufficient safety data for pregnancy and breastfeeding, so they're best avoided. Lemon Balm has insufficient data for pregnancy (talk with your doctor before use) and limited information for breastfeeding, so check with your doctor or pharmacist first.

Side effects, ingredient by ingredient Ashwagandha Reishi Mushroom Skullcap Lemon Balm

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Lemon Balm, Reishi Mushroom, Ashwagandha, Skullcap.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,431 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Sleep Response, check your medications against these drug types: immunosuppressants (ashwagandha may weaken their effects); CNS depressants like sedatives and opioids (Ashwagandha, Reishi, Skullcap, and Lemon Balm may increase sedation); blood pressure medications (Ashwagandha, Reishi, and Lemon Balm may lower blood pressure further); benzodiazepines like Valium or Klonopin (ashwagandha may add sedative effects); diabetes medications (ashwagandha and reishi may lower blood sugar); thyroid hormone (ashwagandha and lemon balm may interfere); blood thinners (reishi at higher doses); and liver-toxic drugs (ashwagandha may increase liver risk). If you take any of these, confirm it's okay with your doctor or pharmacist.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Sleep Response may help with stress, anxiety, and sleep, based on the Possibly Effective rating for ashwagandha and lemon balm in these areas. It's not for you if you take immunosuppressants, are pregnant, breastfeeding, or have liver disease.

If you're on blood pressure medication, sedating drugs, diabetes medication, thyroid hormone, blood thinners, or any prescription, check with your doctor or pharmacist before starting — the interactions here matter.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sleep Response, straight from the product label.

Brand Innate Response Formulas
Barcode (UPC) 051494401170
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD Aug 23, 2013
DSLD ID 24541
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sleep Response by Innate Response Formulas, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
60
UPC/BARCODE
051494401170
IngredientAmount% DV
100% Whole Food Nutrients0 NP--
Sensoril Ashwagandha root & leaf extract200 mg--
organic Reishi500 mg--
Skullcap200 mg--
Lemon Balm200 mg--

Other ingredients: Vegetable Cellulose, Rice Bran, Guar Gum, Vegetable Lubricant, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

organically grown foods & herbs

Please Recycle

Broad Spectrum Multi-Component Finished Good Tested

Formulation

- Nothing Artificial or Synthetic - Tested Free of Gluten, Dairy and Soy

- Suitable for Vegetarians

Free of Herbicides, Pesticides & Corn

General Statements

- GMP Compliant

EXCEPTIONALLY PURE 100% WHOLE FOOD NUTRIENTS

Made in USA

603-216-0899

vis medicatrix naturae

100% WHOLE FOOD Whole Plant Extracted Live Foods Tested & Assayed for Potecy & Purity

Clinical Strength - Professional Use Only

FDA Statement of Identity

Dietary Supplement

General

Product Code #400117 F1312B-10 Rev: 4 8/09

Brand IP Statement(s)

Sensoril(R) is protected under the US Patent Nos. 6,153,198 and 6,713,092 and is a registered trademark of Natreon, Inc

Suggested/Recommended/Usage/Directions

Suggested Use: 1-2 tablets daily, one hour prior to going to bed, or as directed by your healthcare practitioner.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Sleep Response by Innate Response Formulas label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Sleep Response label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Sleep Response by Innate Response Formulas

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

100% Whole Food Nutrients

0 NP per serving

Sensoril Ashwagandha root & leaf extract

Interacts with
1,372 drugs
200 mg per serving

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evid...

Sensoril Ashwagandha root & leaf extract monograph & interactions

Organic Reishi

Interacts with
375 drugs
500 mg per serving

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits...

Organic Reishi monograph & interactions

Skullcap

Interacts with
248 drugs
200 mg per serving

American skullcap is an herb traditionally used to calm anxiety and promote relaxation, but solid human evidence is very limited. It is generally cons...

Skullcap monograph & interactions

Lemon Balm

Interacts with
264 drugs
200 mg per serving

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold so...

Lemon Balm monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose, Rice Bran, Guar Gum, Vegetable Lubricant, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sleep Response by Innate Response Formulas Drug Interactions

Want to check YOUR meds against Sleep Response?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,430Drugs
1,002 Moderate 428 Minor

Ingredients driving the most interactions

Sensoril Ashwagandha root & leaf extract 1,372
organic Reishi 375
Lemon Balm 264
Skullcap 248

Individual Drug Interactions

The ingredients in Sleep Response interact with 1,430 drugs. Click any drug to see the details.

4 of the 5 ingredients in Sleep Response interact with drugs. Each result below shows which ingredient is responsible. Sensoril Ashwagandha root & leaf extract organic Reishi Lemon Balm Skullcap

Each ingredient & the kinds of drugs it affects

For each ingredient in Sleep Response with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sensoril Ashwagandha root & leaf extract10 drug types · 1,372 drugs

Antidiabetes Drugs

Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.

Likelihood Possible Evidence D
Benzodiazepines

Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.

Likelihood Possible Evidence D
Thyroid Hormone

Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Serotonergic Drugs

Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]

Likelihood Possible Evidence C
Sensoril Ashwagandha root & leaf extract full monograph & interactions

organic Reishi3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.

Likelihood Possible Evidence D
organic Reishi full monograph & interactions

Lemon Balm2 drug types · 264 drugs

Cns Depressants

Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Lemon balm seems to have CNS depressant activity in animals and in humans.

Likelihood Possible Evidence B
Thyroid Hormone

Theoretically, lemon balm might interfere with thyroid hormone replacement therapy.
In vitro, constituents of lemon balm extract bind to thyroid stimulating hormone (TSH), preventing TSH receptor-binding and leading to the inhibition of TSH-stimulated adenylate cyclase activity. In animals, lemon balm extract has been shown to decrease levels of circulating TSH and inhibit thyroid secretion.

Likelihood Possible Evidence D
Lemon Balm full monograph & interactions

Skullcap1 drug type · 248 drugs

Cns Depressants

Theoretically, skullcap can have additive effects when used with other CNS depressants.
Animal and clinical research suggests that skullcap can cause sedation and cognitive impairment.

Likelihood Possible Evidence D
Skullcap full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Sleep Response, from the product label.

Innate Response Formulas

See all Innate Response Formulas products
Name
BioSan Laboratories, Inc.
Street Address
8 Bowers Road
City
Derry
State
NH
ZipCode
03038
Phone Number
800-634-6342
Web Address
www.innateresponse.com
Pharmacist Counseling Corner

Sleep Response by Innate Response Formulas: Common Questions

Does Sleep Response by Innate Response Formulas interact with any medications?
Yes. Based on its ingredients, Sleep Response has a known interaction with 1,430 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sleep Response contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this make me drowsy during the day?
Ashwagandha, Reishi, Skullcap, and Lemon Balm all have sedating properties and are intended to promote relaxation. Drowsiness, dizziness, and cognitive effects are possible, especially at higher doses. Take it at bedtime to minimize daytime impact, and talk with your pharmacist if you're concerned about how it will affect you.
Is this product safe to take long-term?
All four herbal ingredients are generally well tolerated short-term, but long-term safety data are limited across the board. The data we hold doesn't establish whether months or years of use is safe. Discuss long-term use with your doctor or pharmacist.
Can I take this if I'm pregnant or breastfeeding?
No — ashwagandha is rated Likely Unsafe in pregnancy due to traditional concerns about miscarriage. Reishi and Skullcap have insufficient safety data for pregnancy and breastfeeding. Lemon Balm has insufficient data for pregnancy and limited information for breastfeeding. Talk with your doctor or pharmacist about safer options during pregnancy and while nursing.
What's Sensoril Ashwagandha, and how is it different from regular ashwagandha?
Sensoril is a standardized extract of ashwagandha root and leaf made by a specific manufacturer. Standardized extracts aim for consistent levels of active compounds. The interactions and effectiveness data for ashwagandha apply to this form — it still affects the same medications and has the same safety profile.
Can I take this with alcohol?
The product contains multiple sedating herbs (ashwagandha, Reishi, Skullcap, Lemon Balm), and alcohol is also sedating. Taking them together could make you much drowsier or impair cognition more than either alone. It's best to avoid or use extreme caution — ask your pharmacist.
What are the inactive ingredients, and are there fillers?
The inactive ingredients are Rice Bran, Vegetable Cellulose, Guar Gum, Vegetable Lubricant, and Silica. These are common binders, thickeners, and capsule materials that hold the tablet or pill together — they're standard in most supplements.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sleep Response label
Go deeper

The Full Monographs Behind Sleep Response’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Ashwagandha

Interacts with 1,372 drugs

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evidence is still limited. It is generally w...

Read the full Ashwagandha monograph → Herb & supplement monograph

Reishi Mushroom

Interacts with 375 drugs

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should...

Read the full Reishi Mushroom monograph → Herb & supplement monograph

Skullcap

Interacts with 248 drugs

American skullcap is an herb traditionally used to calm anxiety and promote relaxation, but solid human evidence is very limited. It is generally considered relatively safe for short-term us...

Read the full Skullcap monograph → Herb & supplement monograph

Lemon Balm

Interacts with 264 drugs

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold sores. Early studies are promising but gen...

Read the full Lemon Balm monograph →
Sources

Sources & How We Checked

Sleep Response's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 64 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ashwagandha 32 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Upton R, ed. Ashwagandha Root (Withania somnifera): Analytical, quality control, and therapuetic monograph. Santa Cruz, CA: American Herbal Pharmacopoeia 2000:1-25.
  3. Davis L, Kuttan G. Effect of Withania somnifera on cyclophosphamide-induced urotoxicity. Cancer Lett 2000;148:9-17. PubMed
  4. Davis L, Kuttan G. Suppressive effect of cyclophosphamide-induced toxicity by Withania somnifera extract in mice. J Ethnopharmacol 1998;62:209-14. PubMed
  5. Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Altern Med Rev 2000;5:334-46. DOI
  6. Andallu B, Radhika B. Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root. Indian J Exp Biol 2000;38:607-9.
  7. Kulkarni RR, Patki PS, Jog VP, et al. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. J Ethnopharmacol 1991;33:91-5. PubMed
  8. Ahumada F, Aspee F, Wikman G, Hancke J. Withania somnifera exract. Its effects on arterial blood pressure in anaesthetized dogs. Phytother Res 1991;5:111-14.
  9. Panda S, Kar A. Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. J Ethnopharmacol 1999;67:233-39. PubMed
  10. Panda S, Kar A. Changes in thyroid hormone concentrations after administration of ashwagandha root extract to adult male mice. J Pharm Pharmacol 1998;50:1065-68. PubMed
  11. Sehgal, V. N., Verma, P., and Bhattacharya, S. N. Fixed-drug eruption caused by ashwagandha (Withania somnifera): a widely used Ayurvedic drug. Skinmed. 2012;10(1):48-49.
  12. Agnihotri AP, Sontakke SD, Thawani VR, Saoji A, Goswami VS. Effects of Withania somnifera in patients of schizophrenia: a randomized, double blind, placebo controlled pilot trial study. Indian J Pharmacol. 2013;45(4):417-8. PubMed
  13. Biswal BM, Sulaiman SA, Ismail HC, Zakaria H, Musa KI. Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients. Integr Cancer Ther. 2013;12(4):312-22.
  14. Sharma AK, Basu I, Singh S. Efficacy and safety of Ashwagandha root extract in subclinical hypothyroid patients: a double-blind, randomized placebo-controlled trial. J Altern Complement Med. 2018 Mar;24(3):243-248. PubMed
  15. Durg S, Bavage S, Shivaram SB. Withania somnifera (Indian ginseng) in diabetes mellitus: A systematic review and meta-analysis of scientific evidence from experimental research to clinical application. Phytother Res. 2020;34(5):1041-1059.
  16. Björnsson HK, Björnsson ES, Avula B, et al. Ashwagandha-induced liver injury: A case series from Iceland and the US Drug-Induced Liver Injury Network. Liver Int. 2020;40(4):825-829. PubMed
  17. Tharakan A, Shukla H, Benny IR, Tharakan M, George L, Koshy S. Immunomodulatory Effect of Withania somnifera (Ashwagandha) Extract-A Randomized, Double-Blind, Placebo Controlled Trial with an Open Label Extension on Healthy Participants. J Clin Med 2021;1 PubMed
  18. Ireland PJ, Hardy T, Burt AD, Donnelly MC. Drug-induced hepatocellular injury due to herbal supplement ashwagandha. J R Coll Physicians Edinb. 2021;51(4):363-365. PubMed
  19. Kamal HI, Patel K, Brdak A, Heffernan J, Ahmad N. Ashwagandha as a unique cause of thyrotoxicosis presenting with supraventricular tachycardia. Cureus. 2022 Mar 25;14(3):e23494. PubMed
  20. Suryawanshi G, Abdallah M, Thomson M, Desai N, Chauhan A, Lim N. Ashwagandha-Associated Acute Liver Failure Requiring Liver Transplantation. Am J Ther 2023;30(1):e80-e83. PubMed
  21. Pusec CM, Wolsky R, Llerena C, Sura P. A Case of Supplement-Induced Hepatitis. Cureus 2022;14(10):e30433. PubMed
  22. Ajgaonkar A, Jain M, Debnath K. Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract for Improvement of Sexual Health in Healthy Women: A Prospective, Randomized, Placebo-Controlled Study. Cureus 2022;14(10):e30787. PubMed
  23. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
  24. Lubarska M, Halasinski P, Hryhorowicz S, et al. Liver Dangers of Herbal Products: A Case Report of Ashwagandha-Induced Liver Injury. Int J Environ Res Public Health 2023;20(5):3921. PubMed
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Reishi Mushroom 17 references
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Skullcap 3 references
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Lemon Balm 12 references
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  2. Akhondzadeh S, Noroozian M, Mohammadi M, et al. Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomised, placebo controlled trial. J Neurol Neurosurg Psychiatry 2003;74:863-6. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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