Spirulina 500 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Spirulina 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Spirulina 500 mg is a dietary supplement by Vitamin World with 2 active ingredients. Its ingredients are commonly taken for preventing or treating copper deficiency, supporting red blood cell formation, bone and connective tissue health.Based on those ingredients, 358 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Spirulina, Copper. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Spirulina 500 mg by Vitamin World
Ask about any prescription or over-the-counter medication and we check it for interactions with Spirulina 500 mg by Vitamin World — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Spirulina 500 mg by Vitamin World
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This tablet contains 2 active ingredients: spirulina (a blue-green algae) and copper (an essential mineral). Spirulina is included for its potential benefits to blood pressure and other health outcomes.
Copper supports normal body functions and is used to prevent or treat copper deficiency. The product also contains several inactive ingredients — povidone, vegetable cellulose, silica, dicalcium phosphate, and vegetable magnesium stearate — which are fillers, binders, and flow agents that help form and stabilize the tablet.
Does it work?
Strong evidence
Spirulina is possibly effective for high blood pressure. For other conditions — acne, allergic rhinitis (hay fever), iron deficiency anemia, and arsenic poisoning — the evidence isn't established enough to rate it.
Copper is likely effective for copper deficiency. For Alzheimer disease and acne, copper is rated possibly ineffective and insufficiently researched, respectively, so the data we hold doesn't support its use for those purposes.
How safe is it?
Well-documented data
Spirulina is generally well tolerated when taken by mouth, though some people report abdominal cramps, bloating, diarrhea, dizziness, fatigue, flatulence, headache, nausea, and vomiting. Rare allergic reactions including rashes, itching, and in one case anaphylaxis have been reported; mild gum bleeding and bruising occurred in a small number of trial participants.
A significant caution: spirulina quality varies widely, and some products can be contaminated with toxins or heavy metals — this is an important reason to buy from reputable sources. Copper is safe at the levels found in food and standard supplements, but excess copper can be toxic.
Contact dermatitis from copper has been reported rarely. There's evidence that people with diabetes have higher blood copper than others, though it's unclear whether elevated copper worsens diabetes itself.
Meds to double-check
Moderate interaction found
Before you start, double-check these medication types with your pharmacist: blood thinners and antiplatelet drugs (warfarin, aspirin, clopidogrel — Moderate severity), diabetes medications (Moderate severity), immunosuppressants (Moderate severity), penicillamine (Moderate severity), and oral contraceptives (Minor severity).
The bottom line
Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
Consider this product if you're looking for spirulina's possible blood pressure support or to correct copper deficiency — but if you take blood thinners, diabetes drugs, immune-suppressing medications, or penicillamine, check with your pharmacist first. Buy from a trusted brand, since spirulina supplements can be contaminated.
Talk to your pharmacist or doctor about whether this is right for your health situation and medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2013.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Spirulina 500 mg, straight from the product label.
| Brand | Vitamin World |
|---|---|
| Barcode (UPC) | 074312732850 |
| Net contents | 500 Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Apr 25, 2013 |
| DSLD ID | 20801 |
| Product type | Other Combinations |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Spirulina 500 mg by Vitamin World, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Copper | 0.36 mg | 18% |
| Spirulina | 1500 mg | -- |
Other ingredients: Povidone, Vegetable Cellulose, Silica, Dicalcium Phosphate, Vegetable Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General
PROD. #3285 B3280 12F
Brand IP Statement(s)
(C)2012 Vitamin World, Inc.
General Statements
Get healthy.
General Health*
Spirulina is a blue/green algae that can be found in the world’s oceans and lakes. In addition, our product promotes general health and wellness.*
This product has been developed, manufactured and packaged by Vitamin World. Our world-class facilities allow us to control exactly what goes into each product. It is your assurance that you are getting the highest quality and freshest products. You have our guarantee!
FDA Statement of Identity
VEGETARIAN DIETARY SUPPLEMENT
Suggested/Recommended/Usage/Directions
DIRECTIONS: For adults, take three (3) tablets three times daily, preferably with meals.
Formulation
No Artificial Color, Flavor or Sweetener, No Preservatives, No Sugar, No Starch, No Milk, No Lactose, No Soy, No Gluten, No Wheat, No Yeast, No Fish.
Precautions
WARNING: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.
Discontinue use and consult your doctor if any adverse reactions occur.
Keep out of reach of children.
Do not use if seal under cap is broken or missing.
Storage
Store at room temperature.
FDA Disclaimer Statement
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Seals/Symbols
QA QUALITY ASSURED
Formula
Blue-Green Algae
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Spirulina 500 mg by Vitamin World label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Spirulina 500 mg by Vitamin World
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size3 Tablet(s) Dosage formTablet Or Pill Servings per container166 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Copper
Interacts with31 drugs
Copper is an essential trace mineral your body needs in small amounts for making red blood cells, supporting nerves and bones, and helping enzymes wor...
Copper monograph & interactionsSpirulina
Interacts with327 drugs
Blue-green algae are nutrient-rich aquatic microorganisms (such as spirulina and Klamath Lake algae) taken as a supplement for energy, nutrition, and...
Spirulina monograph & interactionsOther (inactive) ingredients: Povidone, Vegetable Cellulose, Silica, Dicalcium Phosphate, Vegetable Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Spirulina 500 mg by Vitamin World Drug Interactions
HelloPharmacist Interaction Report
Vitamin World's Spirulina 500 mg contains two active ingredients — spirulina and copper — and both have documented interactions with medications.
The most serious concern is spirulina's interaction with blood thinners and antiplatelet drugs (such as warfarin, aspirin, or clopidogrel). Spirulina has shown anticoagulant effects in lab studies and carries a Moderate severity rating; if you're on these medications, talk to your pharmacist before starting.
Read the full breakdown — every affected drug type, severity by severity
Spirulina also interacts with drugs that suppress the immune system (Moderate severity) — it stimulates immunity, which could work against immunosuppressive therapy — and with diabetes medications (Moderate severity). If you take diabetes drugs, there's a theoretical risk of low blood sugar (hypoglycemia), though the evidence is mixed on whether spirulina meaningfully lowers blood sugar in real patients.
Copper in this product has a Moderate interaction with penicillamine (a heavy metal chelator), which can reduce penicillamine's absorption; if you take it, separate dosing by at least 2 hours. Copper also has a Minor interaction with oral contraceptives — birth control can raise copper levels in your blood, and some people may end up above the normal range.
Altogether, these interactions span 353 individual medications. Use the medication checker below to look up your exact drugs before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Spirulina 500 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Spirulina 500 mg interact with 358 drugs. Click any drug to see the details.
2 of the 2 ingredients in Spirulina 500 mg interact with drugs. Each result below shows which ingredient is responsible. Spirulina Copper
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Spirulina 500 mg — through 1 ingredient. Tap an ingredient for the detail:
SpirulinaImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of blue-green algae might interfere with immunosuppressive therapy.
Read the full Spirulina + 6-mercaptopurine interactionAbciximabReoPro
How Abciximab interacts with Spirulina 500 mg — through 1 ingredient. Tap an ingredient for the detail:
SpirulinaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs.
Read the full Spirulina + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Spirulina 500 mg — through 1 ingredient. Tap an ingredient for the detail:
SpirulinaAnticoagulant/antiplatelet Drugs, Immunosuppressants Moderate
Interaction Summary
Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs.
Read the full Spirulina + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Spirulina 500 mg — through 1 ingredient. Tap an ingredient for the detail:
SpirulinaAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking blue-green algae with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Spirulina + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Spirulina 500 mg — through 1 ingredient. Tap an ingredient for the detail:
SpirulinaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs.
Read the full Spirulina + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Spirulina 500 mg — through 1 ingredient. Tap an ingredient for the detail:
SpirulinaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs.
Read the full Spirulina + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Spirulina 500 mg — through 1 ingredient. Tap an ingredient for the detail:
SpirulinaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs.
Read the full Spirulina + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Spirulina 500 mg — through 1 ingredient. Tap an ingredient for the detail:
SpirulinaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs.
Read the full Spirulina + Acetaminophen, Ibuprofen interactionAcetohexamideDymelor
How Acetohexamide interacts with Spirulina 500 mg — through 1 ingredient. Tap an ingredient for the detail:
SpirulinaAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking blue-green algae with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Spirulina + Acetohexamide interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Spirulina 500 mg — through 1 ingredient. Tap an ingredient for the detail:
SpirulinaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs.
Read the full Spirulina + Acetylsalicylic Acid interactionAdalimumabHumira
How Adalimumab interacts with Spirulina 500 mg — through 1 ingredient. Tap an ingredient for the detail:
SpirulinaImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of blue-green algae might interfere with immunosuppressive therapy.
Read the full Spirulina + Adalimumab interactionAdalimumab-adazHyrimoz
How Adalimumab-adaz interacts with Spirulina 500 mg — through 1 ingredient. Tap an ingredient for the detail:
SpirulinaImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of blue-green algae might interfere with immunosuppressive therapy.
Read the full Spirulina + Adalimumab-adaz interactionAdalimumab-adbmCyltezo
How Adalimumab-adbm interacts with Spirulina 500 mg — through 1 ingredient. Tap an ingredient for the detail:
SpirulinaImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of blue-green algae might interfere with immunosuppressive therapy.
Read the full Spirulina + Adalimumab-adbm interactionAdalimumab-afzbAbrilada
How Adalimumab-afzb interacts with Spirulina 500 mg — through 1 ingredient. Tap an ingredient for the detail:
SpirulinaImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of blue-green algae might interfere with immunosuppressive therapy.
Read the full Spirulina + Adalimumab-afzb interactionAdalimumab-attoAmjevita
How Adalimumab-atto interacts with Spirulina 500 mg — through 1 ingredient. Tap an ingredient for the detail:
SpirulinaImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of blue-green algae might interfere with immunosuppressive therapy.
Read the full Spirulina + Adalimumab-atto interactionAdalimumab-bwwdHadlima
How Adalimumab-bwwd interacts with Spirulina 500 mg — through 1 ingredient. Tap an ingredient for the detail:
SpirulinaImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of blue-green algae might interfere with immunosuppressive therapy.
Read the full Spirulina + Adalimumab-bwwd interactionAdalimumab-fkjpHulio
How Adalimumab-fkjp interacts with Spirulina 500 mg — through 1 ingredient. Tap an ingredient for the detail:
SpirulinaImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of blue-green algae might interfere with immunosuppressive therapy.
Read the full Spirulina + Adalimumab-fkjp interactionAlbiglutideTanzeum
How Albiglutide interacts with Spirulina 500 mg — through 1 ingredient. Tap an ingredient for the detail:
SpirulinaAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking blue-green algae with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Spirulina + Albiglutide interactionAlefaceptAmevive
How Alefacept interacts with Spirulina 500 mg — through 1 ingredient. Tap an ingredient for the detail:
SpirulinaImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of blue-green algae might interfere with immunosuppressive therapy.
Read the full Spirulina + Alefacept interactionAlemtuzumabCampath
How Alemtuzumab interacts with Spirulina 500 mg — through 1 ingredient. Tap an ingredient for the detail:
SpirulinaImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of blue-green algae might interfere with immunosuppressive therapy.
Read the full Spirulina + Alemtuzumab interactionAlogliptinNesina
How Alogliptin interacts with Spirulina 500 mg — through 1 ingredient. Tap an ingredient for the detail:
SpirulinaAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking blue-green algae with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Spirulina + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Spirulina 500 mg — through 1 ingredient. Tap an ingredient for the detail:
SpirulinaAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking blue-green algae with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Spirulina + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Spirulina 500 mg — through 1 ingredient. Tap an ingredient for the detail:
SpirulinaAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking blue-green algae with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Spirulina + Alogliptin, Pioglitazone interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Spirulina 500 mg — through 1 ingredient. Tap an ingredient for the detail:
SpirulinaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs.
Read the full Spirulina + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Spirulina 500 mg — through 1 ingredient. Tap an ingredient for the detail:
SpirulinaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs.
Read the full Spirulina + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Spirulina 500 mg — through 1 ingredient. Tap an ingredient for the detail:
SpirulinaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs.
Read the full Spirulina + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAnacaulase-bcdbNexoBrid
How Anacaulase-bcdb interacts with Spirulina 500 mg — through 1 ingredient. Tap an ingredient for the detail:
SpirulinaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs.
Read the full Spirulina + Anacaulase-bcdb interactionAnagrelideAgrylin
How Anagrelide interacts with Spirulina 500 mg — through 1 ingredient. Tap an ingredient for the detail:
SpirulinaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs.
Read the full Spirulina + Anagrelide interactionAnifrolumab-fniaSaphnelo
How Anifrolumab-fnia interacts with Spirulina 500 mg — through 1 ingredient. Tap an ingredient for the detail:
SpirulinaImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of blue-green algae might interfere with immunosuppressive therapy.
Read the full Spirulina + Anifrolumab-fnia interactionAnisindioneMiradon
How Anisindione interacts with Spirulina 500 mg — through 1 ingredient. Tap an ingredient for the detail:
SpirulinaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs.
Read the full Spirulina + Anisindione interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Spirulina 500 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Spirulina
Anticoagulant/Antiplatelet Drugs
Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs. However, this is unlikely.
Spirulina blue-green algae have shown antiplatelet and anticoagulant effects in vitro. However, one preliminary study in 24 patients receiving spirulina blue-green algae 2.3 grams daily for 2 weeks showed no effect on platelet activation or measures of clotting time.
Antidiabetes Drugs
Theoretically, taking blue-green algae with antidiabetes drugs might increase the risk of hypoglycemia.
Human research shows that spirulina blue-green algae can have hypoglycemic effects in patients with diabetes, at least some of whom were using antidiabetes drugs. However, blue-green algae does not seem to improve glycated hemoglobin (HbA1c) levels in patients with diabetes. A meta-analysis of animal studies also suggests that spirulina blue-green algae have hypoglycemic effects.
Immunosuppressants
Theoretically, concurrent use of blue-green algae might interfere with immunosuppressive therapy.
Blue-green algae have been shown to stimulate the immune system.
Copper
Penicillamine (Cuprimine, Depen)
Theoretically, taking copper with penicillamine might decrease the absorption of penicillamine; separate dosing by at least 2 hours.
Copper chelates penicillamine, which decreases its absorption and may reduce its clinical effects.
Contraceptive Drugs
Theoretically, taking copper with contraceptive drugs might increase the levels and toxic effects of copper.
A meta-analysis of clinical studies suggests that chronic use of oral contraceptives increases serum copper levels by a mean of 57 mcg/dL. In most people, this resulted in levels above the normal reference range for copper.
Brand information
Manufacturer and brand details for Spirulina 500 mg, from the product label.
Vitamin World
See all Vitamin World products- Phone Number
- 1-800-228-4533
- Web Address
- www.vitaminworld.com
Spirulina 500 mg by Vitamin World: Common Questions
Does Spirulina 500 mg by Vitamin World interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is spirulina safe during pregnancy or breastfeeding?
What are the most common side effects?
What is spirulina, and what is it used for?
Why is copper in this supplement?
Does this product contain just spirulina and copper, or are there fillers?
What's the concern about spirulina quality?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Spirulina 500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Spirulina 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Copper
Interacts with 31 drugsCopper is an essential trace mineral your body needs in small amounts for making red blood cells, supporting nerves and bones, and helping enzymes work. Most people get enough copper from fo...
Read the full Copper monograph → Herb & supplement monographBlue-green Algae
Interacts with 327 drugsBlue-green algae are nutrient-rich aquatic microorganisms (such as spirulina and Klamath Lake algae) taken as a supplement for energy, nutrition, and general wellness. Evidence for most heal...
Read the full Blue-green Algae monograph →Sources & How We Checked
Spirulina 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 33 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Copper 11 references
- Murry JJ, Healy MD. Drug-mineral interactions: a new responsibility for the hospital dietician. J Am Diet Assoc 1991;91:66-73.
- Campbell IA, Elmes PC. Ethambutol and the eye: zinc and copper (letter). Lancet 1975;2:711. DOI
- Segal S, Kaminski S. Drug-nutrient interactions. American Druggist 1996 Jul;42-8.
- Kozak SF, Inderlied CB, Hsu HY, et al. The role of copper on ethambutol's antimicrobial action and implications for ethambutol-induced optic neuropathy. Diag Microbiol Infect Dis 1998;30:83-7. PubMed
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
- Cantilena LR, Klaassen CD. The effect of chelating agents on the excretion of endogenous metals. Toxicol Appl Pharmacol 1982;63:344-50.
- Babic Z, Tariba B, Kovacic J, Pizent A, Varnai VM, Macan J. Relevance of serum copper elevation induced by oral contraceptives: a meta-analysis. Contraception. 2013 Jun;87(6):790-800. PubMed
- Qui Q, Zhang F, Zhu W, Wu J, Liang M. Copper in diabetes mellitus: a meta-analysis and systematic review of plasma and serum studies. Biol Trace Elem Res 2017;177(1):53-63.
- Walker-Smith PK, Keith DJ, Kennedy CT, Sansom JE. Allergic contact dermatitis caused by copper. Contact Dermatitis 2016;75(3):186-7. PubMed
- Gallentine A. Third-degree burn on the neuropathic lower extremity in a patient with diabetes while wearing a copper-containing compression sock: a case report. Wound Manag Prev 2021;67(12):26-29. DOI
- Chung KJ, Chin YM, Wong MS, Sanmugam A, Singaravel S, Nah SA. Effectiveness of table salt versus copper sulphate in treating umbilical granuloma: A pilot randomized controlled trial. J Pediatr Surg 2022;57(2):261-265. PubMed
Blue-green Algae 22 references
- Jensen GS, Ginsberg DJ, Huerta P, et al. Consumption of Aphanizomenon flos-aquae has rapid effects on the circulation and function of immune cells in humans. A novel approach to nutritional mobilization of the immune system. JANA 2000;2:50-6.
- Iwasa M, Yamamoto M, Tanaka Y, et al. Spirulina-associated hepatotoxicity. Am J Gastroenterol 2002;97:3212-13. PubMed
- Hayashi O, Katoh T, Okuwaki Y. Enhancement of antibody production in mice by dietary Spirulina platensis. J Nutr Sci Vitaminol (Tokyo) 1994;40:431-41.. PubMed
- Vitale S, Miller NR, Mejico LJ, et al. A randomized, placebo-controlled, crossover clinical trial of super blue-green algae in patients with essential blepharospasm or Meige syndrome. Am J Ophthalmol 2004;138:18-32. PubMed
- Mani UV, Desai S, Iyer U. Studies on the long-term effect of spirulina supplementation on serum lipid profile and glycated proteins in NIDDM patients. J Nutraceut 2000;2(3):25-32. DOI
- Chiu HF, Yang SP, Kuo YL, et al. Mechanisms involved in the antiplatelet effect of C-phycocyanin. Br J Nutr 2006;95:435-40. PubMed
- Hsiao G, Chou PH, Shen MY, et al. C-phycocyanin, a very potent and novel platelet aggregation inhibitor from Spirulina platensis. J Agric Food Chem 2005;53:7734-40.
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- Madhyastha, H. K., Radha, K. S., Sugiki, M., Omura, S., and Maruyama, M. Purification of c-phycocyanin from Spirulina fusiformis and its effect on the induction of urokinase-type plasminogen activator from calf pulmonary endothelial cells. Phytomedicine PubMed
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