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Dietary supplement

Spirulina AstaBlue Complex Ingredients & Drug Interactions

by California Gold Nutrition

Spirulina AstaBlue Complex label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Spirulina AstaBlue Complex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Spirulina AstaBlue Complex is a dietary supplement by California Gold Nutrition with 2 active ingredients. Its ingredients are commonly taken for general nutrition and energy, antioxidant support, cholesterol and metabolic health.Based on those ingredients, 931 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Spirulina AstaBlue Complex Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Spirulina AstaBlue Complex by California Gold Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Spirulina AstaBlue Complex by California Gold Nutrition — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Spirulina AstaBlue Complex by California Gold Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Spirulina AstaBlue Complex Blend” is a proprietary blend — the label gives one combined amount (1 Gram(s)) without saying how much of each component you get.

This product contains three active ingredients. Astaxanthin is a carotenoid antioxidant derived from algae.

Spirulina is a blue-green algae packed with protein and nutrients. Phycocyanin is a pigment naturally present in spirulina.

The product also contains inactive ingredients — hydroxypropyl methylcellulose (a capsule binder), natural flavors, and silicon dioxide (an anti-caking agent).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Hypertension — rated "Possibly Effective" (Blue-green Algae) (Natural Medicines).

For astaxanthin, the evidence we hold is insufficient to rate whether it works for age-related cognitive decline, age-related macular degeneration, aging skin, Alzheimer disease, athletic performance, or carpal tunnel syndrome. For spirulina, the data suggests it is possibly effective for high blood pressure (hypertension).

Evidence is insufficient to rate its use for acne, hay fever, iron-deficiency anemia, or arsenic poisoning. Neither ingredient's effectiveness for other health claims is established in the data we hold.

The evidence, ingredient by ingredient Blue-green Algae Astaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Astaxanthin is generally well tolerated, though long-term safety data are limited. The most common side effects are abdominal pain, diarrhea, and red-colored stools.

At higher doses (40 mg daily), severe abdominal pain has been reported in a small number of people. Spirulina is generally well tolerated, but side effects can include abdominal cramps, bloating, diarrhea, dizziness, fatigue, flatulence, headache, nausea, and vomiting.

Rare allergic reactions, including anaphylaxis, have occurred. A critical safety note: quality varies widely in spirulina products, and some can be contaminated with toxins or heavy metals.

For astaxanthin, there isn't enough safety data to know if it's safe in pregnancy or while breastfeeding — talk with your doctor or pharmacist for personalized advice. For spirulina, the same applies: safety data are insufficient, and contamination risk is a concern — your doctor or pharmacist can help you decide.

Side effects, ingredient by ingredient Blue-green Algae Astaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Blue-green Algae, Astaxanthin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 932 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you use blood thinners or antiplatelet drugs (moderate severity), diabetes medications (moderate severity), immunosuppressants (moderate severity), or drugs broken down by CYP3A4 or CYP2B6 liver enzymes (moderate severity). We also could not check phycocyanin for interactions because no data are on file for it.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

If you take blood thinners, diabetes medications, or immunosuppressants, talk with your doctor or pharmacist before starting this product — the interactions are documented, and your healthcare provider can weigh the risks and benefits for you. Spirulina products can vary widely in quality and purity, so source matters.

This is worth a conversation with your healthcare provider before you add it to your routine, especially if you're pregnant, breastfeeding, or taking any medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Spirulina AstaBlue Complex, straight from the product label.

Brand California Gold Nutrition
Barcode (UPC) 898220018574
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD Nov 22, 2023
DSLD ID 299707
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), No Allergies, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Spirulina AstaBlue Complex by California Gold Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
30
UPC/BARCODE
898220018574
IngredientAmount% DV
Protein1 Gram(s)1%
Astaxanthin0 NP--
Spirulina0 NP--
Phycocyanin0 NP--
Spirulina AstaBlue Complex Blend1 Gram(s)--

Other ingredients: Hydroxypropyl Methylcellulose, Natural Flavors, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Take 2 tablets daily, with food. Best when taken as directed by a qualified healthcare professional.

Precautions

Warnings: Keep out of reach of children. Keep out of reach of children. Pregnant or lactating women, the chronically ill, elderly, individuals under the age of 18, those taking prescription medications (e.g., blood thinners) as well as those with a physician-diagnosed medical condition should consult with a physician, pharmacist, naturopath or other qualified healthcare professional prior to taking dietary supplements.

Pregnant or lactating women, the chronically ill, elderly, individuals under the age of 18, those taking prescription medications (e.g., blood thinners) as well as those with a physician-diagnosed medical condition should consult with a physician, pharmacist, naturopath or other qualified healthcare professional prior to taking dietary supplements.

Sealed for your protection. Do not use if seal is missing or broken.

Not manufactured with milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, soy, sesame, or gluten. Produced in an FDA-registered, third-party audited, and cGMP-compliant facility that may process other products that contain these allergens or ingredients.

Storage

Store in a cool, dry place. Protect from heat, light, and moisture.

Formula

Our Organic Spirulina, Phycocyanin, and Astaxanthin are sourced from Parry Nutraceuticals.

Brand IP Statement(s)

California Gold Nutrition is a registered trademark of Madre Labs, LLC

Formulation

Formulated Without: Gluten GMOs Soy

Not manufactured with milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, soy, sesame, or gluten.

Our Organic Spirulina, Phycocyanin, and Astaxanthin are sourced from Parry Nutraceuticals.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Spirulina AstaBlue Complex by California Gold Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Spirulina AstaBlue Complex label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Spirulina AstaBlue Complex by California Gold Nutrition

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Protein

1 Gram(s) per serving

Spirulina AstaBlue Complex Blend

Interacts with
327 drugs
1 Gram(s) per serving

Blue-green algae are nutrient-rich aquatic microorganisms (such as spirulina and Klamath Lake algae) taken as a supplement for energy, nutrition, and...

Spirulina AstaBlue Complex Blend monograph & interactions

Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Natural Flavors, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Spirulina AstaBlue Complex by California Gold Nutrition Drug Interactions

Want to check YOUR meds against Spirulina AstaBlue Complex?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
931Drugs
931 Moderate

Ingredients driving the most interactions

Spirulina AstaBlue Complex Blend 327

Individual Drug Interactions

The ingredients in Spirulina AstaBlue Complex interact with 931 drugs. Click any drug to see the details.

1 of the 2 ingredients in Spirulina AstaBlue Complex interact with drugs. Each result below shows which ingredient is responsible. Spirulina AstaBlue Complex Blend

Each ingredient & the kinds of drugs it affects

For each ingredient in Spirulina AstaBlue Complex with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Spirulina AstaBlue Complex Blend3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs. However, this is unlikely.
Spirulina blue-green algae have shown antiplatelet and anticoagulant effects in vitro. However, one preliminary study in 24 patients receiving spirulina blue-green algae 2.3 grams daily for 2 weeks showed no effect on platelet activation or measures of clotting time.

Likelihood Unlikely Evidence D
Antidiabetes Drugs

Theoretically, taking blue-green algae with antidiabetes drugs might increase the risk of hypoglycemia.
Human research shows that spirulina blue-green algae can have hypoglycemic effects in patients with diabetes, at least some of whom were using antidiabetes drugs. However, blue-green algae does not seem to improve glycated hemoglobin (HbA1c) levels in patients with diabetes. A meta-analysis of animal studies also suggests that spirulina blue-green algae have hypoglycemic effects.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, concurrent use of blue-green algae might interfere with immunosuppressive therapy.
Blue-green algae have been shown to stimulate the immune system.

Likelihood Possible Evidence D
Spirulina AstaBlue Complex Blend full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Spirulina AstaBlue Complex, from the product label.

California Gold Nutrition

See all California Gold Nutrition products
Name
Madre Labs, LLC
Street Address
301 North Lake Avenue, Suite 500
City
Pasadena
State
CA
ZipCode
91101
Web Address
www.calgn.com
Pharmacist Counseling Corner

Spirulina AstaBlue Complex by California Gold Nutrition: Common Questions

Does Spirulina AstaBlue Complex by California Gold Nutrition interact with any medications?
Yes. Based on its ingredients, Spirulina AstaBlue Complex has a known interaction with 931 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Spirulina AstaBlue Complex contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does spirulina do in this supplement?
Spirulina is a nutrient-dense blue-green algae used in this product for its potential health-supporting properties. Research suggests it may help with high blood pressure, though evidence for other uses like acne or anemia is still insufficient.
Is this safe to take while I'm pregnant?
There isn't enough safety data on either astaxanthin or spirulina to know whether they're safe during pregnancy. Talk with your doctor or pharmacist — they can help you decide what's right for your situation.
What are the most common side effects?
For astaxanthin, the most common effects are abdominal pain, diarrhea, and red-colored stools. For spirulina, they include abdominal cramps, bloating, diarrhea, nausea, and headache. Both are generally well tolerated, but individual responses vary.
Can this product be contaminated?
Yes. Spirulina quality varies widely, and some products can contain toxins or heavy metals. Choose a reputable brand and look for third-party testing when possible.
Will this help with my cognitive decline or memory?
There isn't enough reliable evidence yet to know whether astaxanthin works for age-related cognitive decline or Alzheimer disease. The research so far is inconclusive.
Is this safe to take while breastfeeding?
There isn't enough safety data on either astaxanthin or spirulina to know whether they're safe while breastfeeding. Talk with your doctor or pharmacist for guidance on your specific situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Spirulina AstaBlue Complex is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Spirulina AstaBlue Complex label
Go deeper

The Full Monographs Behind Spirulina AstaBlue Complex’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Blue-green Algae

Interacts with 327 drugs

Blue-green algae are nutrient-rich aquatic microorganisms (such as spirulina and Klamath Lake algae) taken as a supplement for energy, nutrition, and general wellness. Evidence for most heal...

Read the full Blue-green Algae monograph → Herb & supplement monograph

Astaxanthin

Interacts with 671 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph →
Sources

Sources & How We Checked

Spirulina AstaBlue Complex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 25 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Astaxanthin 3 references
  1. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

See these in context on the Astaxanthin monograph →

Blue-green Algae 22 references
  1. Jensen GS, Ginsberg DJ, Huerta P, et al. Consumption of Aphanizomenon flos-aquae has rapid effects on the circulation and function of immune cells in humans. A novel approach to nutritional mobilization of the immune system. JANA 2000;2:50-6.
  2. Iwasa M, Yamamoto M, Tanaka Y, et al. Spirulina-associated hepatotoxicity. Am J Gastroenterol 2002;97:3212-13. PubMed
  3. Hayashi O, Katoh T, Okuwaki Y. Enhancement of antibody production in mice by dietary Spirulina platensis. J Nutr Sci Vitaminol (Tokyo) 1994;40:431-41.. PubMed
  4. Vitale S, Miller NR, Mejico LJ, et al. A randomized, placebo-controlled, crossover clinical trial of super blue-green algae in patients with essential blepharospasm or Meige syndrome. Am J Ophthalmol 2004;138:18-32. PubMed
  5. Mani UV, Desai S, Iyer U. Studies on the long-term effect of spirulina supplementation on serum lipid profile and glycated proteins in NIDDM patients. J Nutraceut 2000;2(3):25-32. DOI
  6. Chiu HF, Yang SP, Kuo YL, et al. Mechanisms involved in the antiplatelet effect of C-phycocyanin. Br J Nutr 2006;95:435-40. PubMed
  7. Hsiao G, Chou PH, Shen MY, et al. C-phycocyanin, a very potent and novel platelet aggregation inhibitor from Spirulina platensis. J Agric Food Chem 2005;53:7734-40.
  8. Katz M, Levine AA, Kol-Degani H, Kav-Venaki L. A compound herbal preparation (CHP) in the treatment of children with ADHD: a randomized controlled trial. J Atten Disord 2010;14:281-91. PubMed
  9. Madhyastha, H. K., Radha, K. S., Sugiki, M., Omura, S., and Maruyama, M. Purification of c-phycocyanin from Spirulina fusiformis and its effect on the induction of urokinase-type plasminogen activator from calf pulmonary endothelial cells. Phytomedicine PubMed
  10. Mazokopakis, E. E., Karefilakis, C. M., Tsartsalis, A. N., Milkas, A. N., and Ganotakis, E. S. Acute rhabdomyolysis caused by Spirulina (Arthrospira platensis). Phytomedicine. 2008;15(6-7):525-527. PubMed
  11. Halidou, Doudou M., Degbey, H., Daouda, H., Leveque, A., Donnen, P., Hennart, P., and Dramaix-Wilmet, M. [The effect of spiruline during nutritional rehabilitation: systematic review]. Rev.Epidemiol.Sante Publique 2008;56(6):425-431.
  12. Konno, T., Umeda, Y., Umeda, M., Kawachi, I., Oyake, M., and Fujita, N. [A case of inflammatory myopathy with widely skin rash following use of supplements containing Spirulina]. Rinsho Shinkeigaku 2011;51(5):330-333. PubMed
  13. Le TM, Knulst AC, Röckmann H. Anaphylaxis to Spirulina confirmed by skin prick test with ingredients of Spirulina tablets. Food Chem Toxicol 2014;74:309-10. PubMed
  14. Rzymski P, Niedzielski P, Kaczmarek N, Jurczak T, Klimaszyk P. The multidisciplinary approach to safety and toxicity assessment of microalgae-based food supplements following clinical cases of poisoning. Harmful Algae 2015;46:34-42. DOI
  15. Petrus M, Culerrier R, Campistron M, et al. First case report of anaphylaxis to spirulin: identification of phycocyanin as responsible allergen. Allergy 2010;65(7):924-5. PubMed
  16. Marles RJ, Barrett ML, Barnes J, et al. United States Pharmacopeia safety evaluation of spirulina. Crit Rev Food Sci Nutr 2011;51(7):593-604. PubMed
  17. Majdoub H, Ben Mansour M, Chaubet F, et al. Anticoagulant activity of a sulfated polysaccharide from the green alga Arthrospira platensis. Biochim Biophys Acta 2009;1790(10):1377-81. PubMed
  18. Cha BG, Kwak HW, Park AR, et al. Structural characteristics and biological performance of silk fibroin nanofiber containing microalgae spirulina extract. Biopolymers 2014;101(4):307-18. PubMed
  19. Jensen GS, Drapeau C, Lenninger M, Benson KF. Clinical safety of a high dose of phycocyanin-enriched aqueous extract from Arthrospira (Spirulina) platensis: results from a randomized, double-Blind, placebo-controlled study with a focus on anticoagulant ac
  20. Hamedifard Z, Milajerdi A, Reiner Z, Taghizadeh M, Kolahdooz F, Asemi Z. The effects of spirulina on glycemic control and serum lipoproteins in patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized con
  21. Moradi S, Zobeiri M, Feizi A, Clark CCT, Entezari MH. The effects of spirulina (Arthrospira platensis) supplementation on anthropometric indices, blood pressure, sleep quality, mental health, fatigue status and quality of life in patients with ulcerative
  22. Ghanbari F, Amerizadeh A, Behshood P, Moradi S, Asgary S. Effect of microalgae arthrospira on biomarkers of glycemic control and glucose metabolism: a systematic Review and meta-analysis. Curr Probl Cardiol 2022;47(10):100942. PubMed

See these in context on the Blue-green Algae monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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