Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Standardized Uva Ursi Ingredients & Drug Interactions

by Nature's Way

Standardized Uva Ursi label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Standardized Uva Ursi against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Standardized Uva Ursi is a dietary supplement by Nature's Way with 2 active ingredients. Its ingredients are commonly taken for urinary tract infections, urinary discomfort, mild diuretic.Based on those ingredients, 803 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Uva Ursi. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Standardized Uva Ursi by Nature's Way

Ask about any prescription or over-the-counter medication and we check it for interactions with Standardized Uva Ursi by Nature's Way — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Standardized Uva Ursi by Nature's Way

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 2 active ingredients: uva ursi and uva ursi leaf extract — two forms of the same plant. Uva ursi is a leaf used traditionally in herbal medicine.

The product also includes plant-derived capsule material and magnesium stearate (a binder) as inactive ingredients.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: Urinary tract health and tonic.
  • We looked for evidence on: Urinary tract infections (UTIs), urinary discomfort, urinary frequency, bladder health.
  • The closest evidence on file: Uva Ursi is rated "Possibly Ineffective" for Urinary tract infections (UTIs) (Natural Medicines).

The evidence for uva ursi is thin. For urinary tract infections (UTIs), it's rated possibly ineffective.

For bronchitis and benign prostate enlargement (BPH), there isn't enough reliable evidence to rate it either way. If you're considering it for one of these conditions, talk with your pharmacist or doctor about whether the data supports it for your situation.

The evidence, ingredient by ingredient Uva Ursi

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Uva ursi is generally well tolerated at low doses for short-term use. At normal doses, the most common side effects are diarrhea, nausea, stomach upset, and vomiting.

At very high doses — 20 grams or more of dried herb — it can cause serious effects like convulsions, delirium, and shortness of breath; doses of 30 grams or more have been reported to be fatal. The facts advise against use during pregnancy (it may stimulate the uterus) and while breastfeeding (not enough safety data).

Long-term use is not recommended because of toxicity risk with prolonged exposure.

Side effects, ingredient by ingredient Uva Ursi

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Uva Ursi.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium.
  • For scale: 804 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, check whether you're on any drugs broken down by CYP2C19 or CYP3A4 (many common medications), drugs metabolized by glucuronidation, lithium, urinary acidifiers, or P-glycoprotein substrates. Your pharmacist can search your exact medications on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a short-term herbal option for urinary tract support, though evidence for UTI relief is weak. If you take any prescription medications — especially ones for mood, heart rhythm, or blood thinning — check them against the interaction tool before starting.

Avoid it if you're pregnant or breastfeeding, and don't use it long-term. Talk to your pharmacist about whether this product is right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Standardized Uva Ursi, straight from the product label.

Brand Nature's Way
Barcode (UPC) 033674633007
Net contents 60 Veg. Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2016
DSLD ID 62300
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Standardized Uva Ursi by Nature's Way, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
033674633007
IngredientAmount% DV
Total Carbohydrates1 Gram(s)1%
Uva Ursi300 mg--
Uva Ursi leaf extract666 mg--

Other ingredients: plant-derived Capsule, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Urinary Tonic* Our Standardized Uva Ursi Extract is carefully tested and produced to superior quality standards.

Premium Extract

Urinary tonic

Precautions

Keep out of reach of children.

Safety sealed with printed outer shrinkwrap and inner seal. Do not use if either is broken or missing.

Caution: Do not use if pregnant, nursing or under the age of 12.

Caution: Do not use if pregnant, nursing or under the age of 12. If you are taking medications or have kidney disease, consult a healthcare professional before use.

This product should not be taken for more than 14 days continuously unless otherwise recommended by a healthcare professional.

Formulation

Gluten free. No sugar, salt, yeast, wheat, soy, dairy products, artificial colors, flavors, or preservatives.

VEGETARIAN

Brand IP Statement(s)

2016 Nature’s Way Brands, LLC

Seals/Symbols

CERTIFIED AUTHENTIC TRU-ID

VEGETARIAN

General

LN63300.A01 BLK8337A

FDA Disclaimer Statement

This statement has not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

20% Arbutins

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommendation: Take 2 capsules two times daily, preferably with food.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Standardized Uva Ursi by Nature's Way label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Standardized Uva Ursi label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Standardized Uva Ursi by Nature's Way

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Uva Ursi

Interacts with
803 drugs
300 mg per serving

Uva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial...

Uva Ursi monograph & interactions

Uva Ursi leaf extract

Interacts with
803 drugs
666 mg per serving Form: Arbutins

Uva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial...

Uva Ursi leaf extract monograph & interactions

Other (inactive) ingredients: Plant-derived Capsule, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Standardized Uva Ursi by Nature's Way Drug Interactions

Want to check YOUR meds against Standardized Uva Ursi?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
803Drugs
740 Moderate 63 Minor

Ingredients driving the most interactions

Uva Ursi 803

Individual Drug Interactions

The ingredients in Standardized Uva Ursi interact with 803 drugs. Click any drug to see the details.

1 of the 2 ingredients in Standardized Uva Ursi interact with drugs. Each result below shows which ingredient is responsible. Uva Ursi

Each ingredient & the kinds of drugs it affects

For each ingredient in Standardized Uva Ursi with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Uva Ursi6 drug types · 803 drugs

Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, uva ursi may decrease the metabolism of CYP2C19 substrates.
In vitro, uva ursi appears to inhibit cytochrome CYP2C19. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
In vitro, uva ursi appears to inhibit CYP3A4. This effect has not been reported in humans.

Likelihood Possible Evidence D
Glucuronidated Drugs

Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
In vitro, uva ursi extract appears to strongly inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1). However, uva ursi extract does not appear to inhibit UGT1A1 in animal models. This effect has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, uva ursi may increase lithium levels, necessitating a decrease in dose.
Uva ursi may have diuretic properties. Diuretics may increase lithium reabsorption with sodium in the proximal tubule of the kidney. Theoretically, uva ursi might reduce excretion and increase levels of lithium.

Likelihood Probable Evidence D
Urinary Acidifying Agents

Effects of uva ursi in the urinary tract may be reduced by urinary acidifying agents.
Uva ursi seems to work best in alkaline urine. Theoretically, taking uva ursi with medications known to acidify the urine may decrease any effects of uva ursi on the urinary tract.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
In vitro, uva ursi appears to inhibit the multi-drug transporter protein, P-glycoprotein. This effect has not been reported in humans.

Likelihood Possible Evidence D
Uva Ursi full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Standardized Uva Ursi, from the product label.

Nature's Way

See all Nature's Way products
Name
Nature's Way Brands, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1-800-962-8873
Web Address
naturesway.com
Pharmacist Counseling Corner

Standardized Uva Ursi by Nature's Way: Common Questions

Does Standardized Uva Ursi by Nature's Way interact with any medications?
Yes. Based on its ingredients, Standardized Uva Ursi has a known interaction with 803 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Standardized Uva Ursi contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's the difference between the two ingredients in this product?
Both are uva ursi — one is the whole leaf and one is an extract. They come from the same plant and have the same interactions and effects. The product includes both forms.
Can I take this long-term?
No. The safety notes advise against prolonged use because uva ursi can be toxic with long-term exposure. It's meant for short-term use only.
What are the most common side effects?
At normal doses, diarrhea, nausea, stomach upset, and vomiting are the most common. At high doses it can cause much more serious effects, which is why staying within recommended doses matters.
Is this proven to work for UTIs?
No. The data rates uva ursi as possibly ineffective for urinary tract infections. If you're treating a UTI, talk with your doctor about treatments with stronger evidence.
Can I take this if I'm pregnant or breastfeeding?
No. You should avoid it during pregnancy because it may stimulate the uterus and lacks safety data. It's also not recommended while breastfeeding due to insufficient safety information.
Why do I need to check this against my medications if the interactions haven't happened in humans?
Lab studies show uva ursi can slow how your liver processes several common medications, even though that effect hasn't been documented in actual patients yet. Because the risk is real in theory, it's worth checking your specific drugs to be sure.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Standardized Uva Ursi is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Standardized Uva Ursi label
Go deeper

The Full Monographs Behind Standardized Uva Ursi’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Uva Ursi

Interacts with 803 drugs

Uva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial effects in the urine. Evidence in people...

Read the full Uva Ursi monograph →
Sources

Sources & How We Checked

Standardized Uva Ursi's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Uva Ursi 8 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Wang L, Del Priore LV. Bull's-eye maculopathy secondary to herbal toxicity from uva ursi. Am J Ophthalmol 2004;137:1135-7. PubMed
  5. Beaux, D., Fleurentin, J., and Mortier, F. Effect of extracts of Orthosiphon stamineus Benth, Hieracium pilosella L., Sambucus nigra L. and Arctostaphylos uva-ursi (L.) Spreng. in rats. Phytother.Res 1999;13(3):222-225.
  6. de Arriba SG, Naser B, Nolte KU. Risk assessment of free hydroquinone derived from Arctostaphylos Uva-ursi folium herbal preparations. Int J Toxicol. 2013;32(6):442-453.
  7. Park JB, Kim D, Min JS, et al. Identification and characterization of in vitro inhibitors against UDP-glucuronosyltransferase 1A1 in uva-ursi extracts and evaluation of in vivo uva-ursi-drug interactions. Food Chem Toxicol. 2018;120:651-661. PubMed
  8. Chauhan B, Yu C, Krantis A, et al. In vitro activity of uva-ursi against cytochrome P450 isoenzymes and P-glycoprotein. Can J Physiol Pharmacol. 2007;85(11):1099-107.

See these in context on the Uva Ursi monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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