Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Stars 'N Pipes Let's Make 'Merica Grape Again Ingredients & Drug Interactions

by 'Merica Labz

Powder Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Stars 'N Pipes Let's Make 'Merica Grape Again is a dietary supplement by 'Merica Labz with 3 active ingredients. Its ingredients are commonly taken for exercise performance, muscle soreness and fatigue, blood flow and circulation.Based on those ingredients, 178 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Citrulline. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Stars 'N Pipes Let's Make 'Merica Grape Again by 'Merica Labz

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This powder has 3 active ingredients. L-citrulline is an amino acid that your body converts to another amino acid called arginine, which supports blood vessel relaxation and blood flow — that's why it's used for athletic performance.

Betaine anhydrous is a compound that helps with cellular function and is effective for a rare condition called homocystinuria. HydroMax is glycerol, a humectant that draws water into your system and is used for athletic hydration and to ease constipation.

The powder also contains inactive ingredients like silica, citric acid, malic acid, natural and artificial flavoring, sucralose, and acesulfame potassium for taste and texture.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: athletic performance and workout support.
  • We looked for evidence on: Athletic performance, Muscle strength, exercise endurance, muscle recovery, workout intensity.
  • The strongest evidence on file: Glycerol is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: L-citrulline is rated "Possibly Effective" for Athletic performance.
  • Also on file: Betaine Anhydrous is rated "Insufficient Reliable Evidence To Rate" for Athletic performance.

L-citrulline is possibly effective for athletic performance. Betaine anhydrous is effective for homocystinuria (a rare metabolic condition) and possibly effective for high homocysteine levels.

Glycerol is likely effective for constipation and possibly effective for athletic performance. For other uses listed — like cardiovascular disease, heart failure, or diabetes — the evidence we hold is insufficient to rate these ingredients, meaning the data isn't established yet.

The evidence, ingredient by ingredient L-citrulline Betaine Anhydrous Glycerol

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-citrulline is generally well tolerated in healthy adults, though long-term safety hasn't been fully studied. The most common side effects are gastrointestinal discomfort and heartburn.

Betaine anhydrous is also generally well tolerated, with occasional reports of body odor, diarrhea, nausea, and GI distress. Glycerol is well tolerated orally, though it can cause bloating, nausea, diarrhea, headache, and dizziness at higher doses.

During pregnancy, the safety data for L-citrulline and betaine anhydrous advises against use — there isn't enough data to know if they're safe. Glycerol has no specific pregnancy rating on file here.

While breastfeeding, safety is unknown for L-citrulline and glycerol; betaine safety while breastfeeding is not well established. Talk to your doctor or pharmacist before using this product if you're pregnant or nursing.

Side effects, ingredient by ingredient L-citrulline Betaine Anhydrous Glycerol

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 3 matched ingredients can interact with medications — L-citrulline.
  • The most serious interaction on file is rated Moderate.
  • For scale: 178 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications against this product if you take a blood pressure drug (antihypertensive) — L-citrulline may add to its effect and lower your pressure too much. Also double-check if you use erectile dysfunction medication (phosphodiesterase-5 inhibitors like sildenafil).

Both are Moderate-severity interactions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a pre-workout supplement aimed at athletic performance, built around L-citrulline for blood flow and glycerol for hydration. If you take a blood pressure medication or an erectile dysfunction drug, you need to check with your pharmacist first — L-citrulline can interact with both.

Pregnant or breastfeeding? The safety data isn't there yet, so discuss it with your doctor.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 26, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Stars 'N Pipes Let's Make 'Merica Grape Again, straight from the product label.

Brand 'Merica Labz
Barcode (UPC) 602573098677
Net contents 14.2 Ounce(s); 403.4 Gram(s)
Market status On market
Date entered into DSLD Feb 26, 2020
DSLD ID 213464
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Stars 'N Pipes Let's Make 'Merica Grape Again by 'Merica Labz, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
20.2 Gram(s)
Maximum serving Sizes:
20.2 Gram(s)
Servings per container
20
UPC/BARCODE
602573098677
IngredientAmount% DV
L-Citrulline6000 mg--
Betaine Anhydrous5000 mg--
HydroMax5000 mg--

Other ingredients: Silica, Citric Acid, Malic Acid, Natural and Artificial flavoring, Sucralose, Acesulfame Potassium

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Few things scream 'Merica - or freedom - like crushing a workout while wearing a pair of American flag sweatpants and a bald eagle bandana. Considering that's your everyday workout attire, that essentially makes you a freedom fighter, son. And freedom fighters can't contribute to the fight for freedom with a couple of puny small arms - they need the KABOOM! Big munitions. Well, freedom fighter, meet your best weapon in the fight against skinny arms: Stars 'N Pipes, a stim-free explosive pump agent fit for a real 'Merican hero. Stars 'N Pipes is like mixing a couple hundred lbs of TNT with Bruce Willis from Die Hrd, throwing some fruit in there, and putting it all in a powder. Yeah...it's that good.

Never Big Enough

High Explosive Pump Agent

Precautions

Warning: This product is only intended for use in healthy adults 18 years of age or older.

Pregnant or nursing women should not use this product. Consult your healthcare provider before using this product, especially if you are taking any prescription, over the counter medication, dietary supplement product, or if you have any pre-existing medical condition including but not limited to: high or low blood pressure, cardiac arrhythmia, stroke, heart, liver, kidney or thyroid disease, seizure disorder, psychiatric disease, diabetes, difficulty urinating due to prostate enlargement or if you are taking a MAOI (Monoamine Oxidase Inhibitor) or any other medication.

Immediately discontinue use and consult your health care professional if you experience adverse reaction to this product. Do not exceed recommended serving. Do not use if safety seal is broken or missing.

Keep out of reach of children.

Suggested/Recommended/Usage/Directions

Directions: Mix 1 scoop with 10-16 ounces of water and consume approximately 15-30 minutes prior to your workout.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Naturally & Artificially Flavored

Manufactured in a U.S. cGMP Facility

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

HydroMax is a registered trademark of Glanbia plc.

See for yourself

Stars 'N Pipes Let's Make 'Merica Grape Again by 'Merica Labz label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Stars 'N Pipes Let's Make 'Merica Grape Again by 'Merica Labz

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size20.2 Gram(s) Dosage formPowder Servings per container20 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Citrulline

Interacts with
178 drugs
6000 mg per serving

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. I...

L-Citrulline monograph & interactions

Betaine Anhydrous

No known
interactions
5000 mg per serving

Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and a...

Betaine Anhydrous monograph & interactions

HydroMax

No known
interactions
5000 mg per serving Form: Glycerol

Glycerol (glycerin) is a sweet, syrupy compound made naturally in the body and widely used in foods, skin products, and medicines. It is well establis...

HydroMax monograph & interactions

Other (inactive) ingredients: Silica, Citric Acid, Malic Acid, Natural and Artificial flavoring, Sucralose, Acesulfame Potassium. These complete the product’s ingredient list but are not active constituents.

Interaction report

Stars 'N Pipes Let's Make 'Merica Grape Again by 'Merica Labz Drug Interactions

Want to check YOUR meds against Stars 'N Pipes Let's Make 'Merica Grape Again?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
178Drugs
178 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Stars 'N Pipes Let's Make 'Merica Grape Again with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Citrulline2 drug types · 178 drugs

Antihypertensive Drugs

Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.

Likelihood Possible Evidence B
Phosphodiesterase-5 Inhibitors

Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Stars 'N Pipes Let's Make 'Merica Grape Again, from the product label.

'Merica Labz

Name
'Merica Labz, LLC.
City
Virginia
Web Address
www.MericaLabz.com
Pharmacist Counseling Corner

Stars 'N Pipes Let's Make 'Merica Grape Again by 'Merica Labz: Common Questions

Does Stars 'N Pipes Let's Make 'Merica Grape Again by 'Merica Labz interact with any medications?
Yes. Based on its ingredients, Stars 'N Pipes Let's Make 'Merica Grape Again has a known interaction with 178 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Stars 'N Pipes Let's Make 'Merica Grape Again contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this lower my blood pressure if I'm already taking medication for it?
L-citrulline can have additive effects with blood pressure drugs and theoretically increase the risk of your pressure dropping too far. Talk to your pharmacist or doctor before starting — they may need to monitor your blood pressure or adjust your medication.
Can I take this with my erectile dysfunction medication?
Both L-citrulline and ED drugs like sildenafil work partly by relaxing blood vessels, so taking them together could cause your blood pressure to drop more than either alone. Check with your pharmacist before combining them.
What are the most common side effects?
L-citrulline most often causes heartburn or gastrointestinal discomfort. Betaine can cause body odor, nausea, or diarrhea. Glycerol may cause bloating, dizziness, nausea, or diarrhea, especially at higher doses.
Is this safe to use while I'm pregnant?
The safety data for L-citrulline and betaine anhydrous during pregnancy advises against use — there isn't enough information to know if they're safe. Talk with your doctor or pharmacist before using this product if you're pregnant or planning to become pregnant.
Can I breastfeed while taking this?
The safety data for L-citrulline and glycerol while breastfeeding is unknown or not well established. Discuss this with your doctor or pharmacist to decide what's right for you and your baby.
Does this product actually improve athletic performance?
L-citrulline is possibly effective for athletic performance, and glycerol is also possibly effective. The evidence supports their use, though results vary from person to person.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Stars 'N Pipes Let's Make 'Merica Grape Again is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Stars 'N Pipes Let's Make 'Merica Grape Again label
Sources

Sources & How We Checked

Stars 'N Pipes Let's Make 'Merica Grape Again's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 27 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

L-citrulline 8 references
  1. Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
  2. Schwedhelm E, Maas R, Freese R, et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol 2008;65:51-9. PubMed
  3. Romero MJ, Platt DH, Caldwell RB, Caldwell RW. Therapeutic use of citrulline in cardiovascular disease. Cardiovasc Drug Rev 2006;24:275-90. PubMed
  4. Balderas-Munoz K, Castillo-Martínez L, Orea-Tejeda A, et al. Improvement of ventricular function in systolic heart failure patients with oral L-citrulline supplementation. Cardiol J 2012;19:612-7. PubMed
  5. Sharif Kashani B, Tahmaseb Pour P, Malekmohammad M, et al. Oral l-citrulline malate in patients with idiopathic pulmonary arterial hypertension and Eisenmenger Syndrome: a clinical trial. J Cardiol 2014;64:231-5. PubMed
  6. Pérez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res 2010;24:1215-22. PubMed
  7. Mirenayat MS, Moradi S, Mohammadi H, Rouhani MH. Effect of L-citrulline supplementation on blood pressure: a systematic review and meta-analysis of clinical trials. Curr Hypertens Rep. 2018;20(11):98. PubMed
  8. Xu Z, Liu C, Liu S, Zhou Z. Comparison of efficacy and safety of daily oral L-arginine and PDE5Is alone or combination in treating erectile dysfunction: A systematic review and meta-analysis of randomised controlled trials. Andrologia. 2021:e14007. PubMed

See these in context on the L-citrulline monograph →

Betaine Anhydrous 11 references
  1. Cystadane (betaine anhydrous for oral solution) Package insert. Orphan Medical, Inc. Minnetonka, MN. November 2005.
  2. Abdelmalek MF, Angulo P, Jorgensen RA, et al. Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study. Am J Gastroenterol 2001;96:2711-7.. PubMed
  3. Schwab U, Torronen A, Toppinen L, et al. Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects. Am J Clin Nutr 2002;76:961-7. PubMed
  4. McGregor DO, Dellow WJ, Robson RA, et al. Betaine supplementation decreases post-methionine hyperhomocysteinemia in chronic renal failure. Kidney Int 2002;61:1040-6. PubMed
  5. Olthof MR, van Vliet T, Verhoef P, et al. Effect of homocysteine-lowering nutrients on blood lipids: results from four randomised, placebo-controlled studies in healthy humans. PloS Med 2005;2:e135. PubMed
  6. Knopman, D. and Patterson, M. An open-label, 24-week pilot study of the methyl donor betaine in Alzheimer disease patients. Alzheimer Dis.Assoc.Disord. 2001;15(3):162-165. PubMed
  7. Moat, S. J., Madhavan, A., Taylor, S. Y., Payne, N., Allen, R. H., Stabler, S. P., Goodfellow, J., McDowell, I. F., Lewis, M. J., and Lang, D. High- but not low-dose folic acid improves endothelial function in coronary artery disease. Eur J Clin Invest 2 PubMed
  8. Abdelmalek, M. F., Sanderson, S. O., Angulo, P., Soldevila-Pico, C., Liu, C., Peter, J., Keach, J., Cave, M., Chen, T., McClain, C. J., and Lindor, K. D. Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial. Hepa PubMed
  9. Ashtary-Larky D, Bagheri R, Ghanavati M, et al. Effects of betaine supplementation on cardiovascular markers: a systematic review and meta-analysis. Crit Rev Food Sci Nutr. 2021 Mar 25:1-18. PubMed
  10. Zawieja EE, Zawieja B, Chmurzynska A. Betaine supplementation moderately increases total cholesterol levels: a systematic review and meta-analysis. J Diet Suppl. 2021;18(1):105-117. PubMed
  11. Imbard A, Toumazi A, Magréault S, et al. Efficacy and pharmacokinetics of betaine in CBS and cblC deficiencies: a cross-over randomized controlled trial. Orphanet J Rare Dis 2022;17(1):417. PubMed

See these in context on the Betaine Anhydrous monograph →

Glycerol 8 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Wagner DR. Hyperhydrating with glycerol: implications for athletic performance. J Am Diet Assoc 1999;99:207-12. PubMed
  3. Yu YL, Kumana CR, Lauder IJ, et al. Treatment of acute cortical infarct with intravenous glycerol. A double-blind, placebo-controlled randomized trial. Stroke 1993;24:1119-24. PubMed
  4. Frei A, Cottier C, Wunderlich P, Ludin E. Glycerol and dextran combined in the therapy of acute stroke. A placebo-controlled, double-blind trial with a planned interim analysis. Stroke 1987;18:373-9. PubMed
  5. Balaskas E, Szepietowski JC, Bessis D, Ioannides D, Ponticelli C, Ghienne C, Taberly A, Dupuy P. Randomized, double-blind study with glycerol and paraffin in uremic xerosis. Clin J Am Soc Nephrol. 2011 Apr;6(4):748-52. PubMed
  6. Blanchet-Bardon C, Tadini G, Machado Matos M, Delarue A. Association of glycerol and paraffin in the treatment of ichthyosis in children: an international, multicentric, randomized, controlled, double-blind study. J Eur Acad Dermatol Venereol. 2012 Aug;26 PubMed
  7. Kajita N, Kanamori K, Yamamoto S, Yoshida K. Generalized Urticaria Caused by a Glycerin Enema in an Infant. J Investig Allergol Clin Immunol 2022;32(4):318-319. PubMed
  8. Suzuki R, Fukuyama K, Miyazaki Y, Namiki T. Contact urticaria syndrome and protein contact dermatitis caused by glycerin enema. JAAD Case Reports. 2016;2:108-10. PubMed

See these in context on the Glycerol monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring