Stars 'N Pipes Let's Make 'Merica Grape Again Ingredients & Drug Interactions
by 'Merica Labz
What is this page for?
First and foremost: checking Stars 'N Pipes Let's Make 'Merica Grape Again against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Stars 'N Pipes Let's Make 'Merica Grape Again is a dietary supplement by 'Merica Labz with 3 active ingredients. Its ingredients are commonly taken for exercise performance, muscle soreness and fatigue, blood flow and circulation.Based on those ingredients, 178 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Citrulline. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Stars 'N Pipes Let's Make 'Merica Grape Again by 'Merica Labz
Ask about any prescription or over-the-counter medication and we check it for interactions with Stars 'N Pipes Let's Make 'Merica Grape Again by 'Merica Labz — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Stars 'N Pipes Let's Make 'Merica Grape Again by 'Merica Labz
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This powder has 3 active ingredients. L-citrulline is an amino acid that your body converts to another amino acid called arginine, which supports blood vessel relaxation and blood flow — that's why it's used for athletic performance.
Betaine anhydrous is a compound that helps with cellular function and is effective for a rare condition called homocystinuria. HydroMax is glycerol, a humectant that draws water into your system and is used for athletic hydration and to ease constipation.
The powder also contains inactive ingredients like silica, citric acid, malic acid, natural and artificial flavoring, sucralose, and acesulfame potassium for taste and texture.
Does it work?
Moderate evidence
L-citrulline is possibly effective for athletic performance. Betaine anhydrous is effective for homocystinuria (a rare metabolic condition) and possibly effective for high homocysteine levels.
Glycerol is likely effective for constipation and possibly effective for athletic performance. For other uses listed — like cardiovascular disease, heart failure, or diabetes — the evidence we hold is insufficient to rate these ingredients, meaning the data isn't established yet.
How safe is it?
Well-documented data
L-citrulline is generally well tolerated in healthy adults, though long-term safety hasn't been fully studied. The most common side effects are gastrointestinal discomfort and heartburn.
Betaine anhydrous is also generally well tolerated, with occasional reports of body odor, diarrhea, nausea, and GI distress. Glycerol is well tolerated orally, though it can cause bloating, nausea, diarrhea, headache, and dizziness at higher doses.
During pregnancy, the safety data for L-citrulline and betaine anhydrous advises against use — there isn't enough data to know if they're safe. Glycerol has no specific pregnancy rating on file here.
While breastfeeding, safety is unknown for L-citrulline and glycerol; betaine safety while breastfeeding is not well established. Talk to your doctor or pharmacist before using this product if you're pregnant or nursing.
Meds to double-check
Moderate interaction found
Check your medications against this product if you take a blood pressure drug (antihypertensive) — L-citrulline may add to its effect and lower your pressure too much. Also double-check if you use erectile dysfunction medication (phosphodiesterase-5 inhibitors like sildenafil).
Both are Moderate-severity interactions.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This is a pre-workout supplement aimed at athletic performance, built around L-citrulline for blood flow and glycerol for hydration. If you take a blood pressure medication or an erectile dysfunction drug, you need to check with your pharmacist first — L-citrulline can interact with both.
Pregnant or breastfeeding? The safety data isn't there yet, so discuss it with your doctor.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 26, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Stars 'N Pipes Let's Make 'Merica Grape Again, straight from the product label.
| Brand | 'Merica Labz |
|---|---|
| Barcode (UPC) | 602573098677 |
| Net contents | 14.2 Ounce(s); 403.4 Gram(s) |
| Market status | On market |
| Date entered into DSLD | Feb 26, 2020 |
| DSLD ID | 213464 |
| Product type | Other Combinations |
| Supplement form | Powder |
| Dietary claims / uses | Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Stars 'N Pipes Let's Make 'Merica Grape Again by 'Merica Labz, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Citrulline | 6000 mg | -- |
| Betaine Anhydrous | 5000 mg | -- |
| HydroMax | 5000 mg | -- |
Other ingredients: Silica, Citric Acid, Malic Acid, Natural and Artificial flavoring, Sucralose, Acesulfame Potassium
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Few things scream 'Merica - or freedom - like crushing a workout while wearing a pair of American flag sweatpants and a bald eagle bandana. Considering that's your everyday workout attire, that essentially makes you a freedom fighter, son. And freedom fighters can't contribute to the fight for freedom with a couple of puny small arms - they need the KABOOM! Big munitions. Well, freedom fighter, meet your best weapon in the fight against skinny arms: Stars 'N Pipes, a stim-free explosive pump agent fit for a real 'Merican hero. Stars 'N Pipes is like mixing a couple hundred lbs of TNT with Bruce Willis from Die Hrd, throwing some fruit in there, and putting it all in a powder. Yeah...it's that good.
Never Big Enough
High Explosive Pump Agent
Precautions
Warning: This product is only intended for use in healthy adults 18 years of age or older.
Pregnant or nursing women should not use this product. Consult your healthcare provider before using this product, especially if you are taking any prescription, over the counter medication, dietary supplement product, or if you have any pre-existing medical condition including but not limited to: high or low blood pressure, cardiac arrhythmia, stroke, heart, liver, kidney or thyroid disease, seizure disorder, psychiatric disease, diabetes, difficulty urinating due to prostate enlargement or if you are taking a MAOI (Monoamine Oxidase Inhibitor) or any other medication.
Immediately discontinue use and consult your health care professional if you experience adverse reaction to this product. Do not exceed recommended serving. Do not use if safety seal is broken or missing.
Keep out of reach of children.
Suggested/Recommended/Usage/Directions
Directions: Mix 1 scoop with 10-16 ounces of water and consume approximately 15-30 minutes prior to your workout.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Formulation
Naturally & Artificially Flavored
Manufactured in a U.S. cGMP Facility
FDA Statement of Identity
Dietary Supplement
Brand IP Statement(s)
HydroMax is a registered trademark of Glanbia plc.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Stars 'N Pipes Let's Make 'Merica Grape Again by 'Merica Labz label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Stars 'N Pipes Let's Make 'Merica Grape Again by 'Merica Labz
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size20.2 Gram(s) Dosage formPowder Servings per container20 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
L-Citrulline
Interacts with178 drugs
L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. I...
L-Citrulline monograph & interactionsBetaine Anhydrous
No knowninteractions
Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and a...
Betaine Anhydrous monograph & interactionsHydroMax
No knowninteractions
Glycerol (glycerin) is a sweet, syrupy compound made naturally in the body and widely used in foods, skin products, and medicines. It is well establis...
HydroMax monograph & interactionsOther (inactive) ingredients: Silica, Citric Acid, Malic Acid, Natural and Artificial flavoring, Sucralose, Acesulfame Potassium. These complete the product’s ingredient list but are not active constituents.
Stars 'N Pipes Let's Make 'Merica Grape Again by 'Merica Labz Drug Interactions
HelloPharmacist Interaction Report
'Merica Labz Let's Make 'Merica Grape Again contains L-citrulline, which does interact with some medications.
The main concern is with blood pressure drugs (antihypertensives). L-citrulline converts to arginine in your body, which relaxes blood vessels — and if you're already taking a blood pressure medication, the two effects can add up and lower your pressure more than intended.
This is a Moderate-severity interaction.
Read the full breakdown — every affected drug type, severity by severity
L-citrulline also has a Moderate interaction with erectile dysfunction drugs (phosphodiesterase-5 inhibitors, like sildenafil). Again, it's the vasodilation effect — taking it with those drugs might push blood pressure down further than either would alone.
The other two active ingredients — betaine anhydrous and glycerol (HydroMax) — have no documented interactions with medications in our data.
Additionally, run your exact medications through the checker on this page before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Stars 'N Pipes Let's Make 'Merica Grape Again?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Stars 'N Pipes Let's Make 'Merica Grape Again interact with 178 drugs. Click any drug to see the details.
1 of the 3 ingredients in Stars 'N Pipes Let's Make 'Merica Grape Again interact with drugs. Each result below shows which ingredient is responsible. L-Citrulline
AcebutololRhotral, Sectral
How Acebutolol interacts with Stars 'N Pipes Let's Make 'Merica Grape Again — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Acebutolol interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Stars 'N Pipes Let's Make 'Merica Grape Again — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Acetazolamide interactionAliskirenTekturna
How Aliskiren interacts with Stars 'N Pipes Let's Make 'Merica Grape Again — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Aliskiren interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Stars 'N Pipes Let's Make 'Merica Grape Again — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Ambrisentan interactionAmilorideAmilamont, Midamor
How Amiloride interacts with Stars 'N Pipes Let's Make 'Merica Grape Again — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Amiloride interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Stars 'N Pipes Let's Make 'Merica Grape Again — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Amiloride, Hydrochlorothiazide interactionAmlodipineNorliqva
How Amlodipine interacts with Stars 'N Pipes Let's Make 'Merica Grape Again — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with Stars 'N Pipes Let's Make 'Merica Grape Again — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Amlodipine Benzoate interactionAmlodipine BesilateIstin
How Amlodipine Besilate interacts with Stars 'N Pipes Let's Make 'Merica Grape Again — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Amlodipine Besilate interactionAmlodipine BesylateNorvasc
How Amlodipine Besylate interacts with Stars 'N Pipes Let's Make 'Merica Grape Again — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Amlodipine Besylate interactionAmlodipine Besylate, BenazeprilLotrel
How Amlodipine Besylate, Benazepril interacts with Stars 'N Pipes Let's Make 'Merica Grape Again — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Amlodipine Besylate, Benazepril interactionAmlodipine, CelecoxibConsensi
How Amlodipine, Celecoxib interacts with Stars 'N Pipes Let's Make 'Merica Grape Again — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Amlodipine, Celecoxib interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with Stars 'N Pipes Let's Make 'Merica Grape Again — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Ammonium Chloride interactionAprocitentanTryvio
How Aprocitentan interacts with Stars 'N Pipes Let's Make 'Merica Grape Again — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Aprocitentan interactionAtenololAtenix, Tenormin
How Atenolol interacts with Stars 'N Pipes Let's Make 'Merica Grape Again — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Atenolol interactionAtenolol, ChlortalidoneAtenixCo, Tenoret 50, Totaretic
How Atenolol, Chlortalidone interacts with Stars 'N Pipes Let's Make 'Merica Grape Again — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Atenolol, Chlortalidone interactionAtenolol, ChlorthalidoneTenoretic
How Atenolol, Chlorthalidone interacts with Stars 'N Pipes Let's Make 'Merica Grape Again — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Atenolol, Chlorthalidone interactionAvanafilStendra
How Avanafil interacts with Stars 'N Pipes Let's Make 'Merica Grape Again — through 1 ingredient. Tap an ingredient for the detail:
L-citrullinePhosphodiesterase-5 Inhibitors Moderate
Interaction Summary
Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
Read the full L-citrulline + Avanafil interactionAzilsartanEdarbi
How Azilsartan interacts with Stars 'N Pipes Let's Make 'Merica Grape Again — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Azilsartan interactionAzilsartan, ChlorthalidoneEdarbyclor
How Azilsartan, Chlorthalidone interacts with Stars 'N Pipes Let's Make 'Merica Grape Again — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Azilsartan, Chlorthalidone interactionBenazeprilLotensin
How Benazepril interacts with Stars 'N Pipes Let's Make 'Merica Grape Again — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Benazepril interactionBenazepril, HydrochlorothiazideLotensin HCT
How Benazepril, Hydrochlorothiazide interacts with Stars 'N Pipes Let's Make 'Merica Grape Again — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Benazepril, Hydrochlorothiazide interactionBendroflumethiazideAprinox, Naturetin, Neo-NaClex
How Bendroflumethiazide interacts with Stars 'N Pipes Let's Make 'Merica Grape Again — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Bendroflumethiazide interactionBendroflumethiazide, NadololCorzide
How Bendroflumethiazide, Nadolol interacts with Stars 'N Pipes Let's Make 'Merica Grape Again — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Bendroflumethiazide, Nadolol interactionBendroflumethiazide, Rauwolfia SerpentinaRauzide
How Bendroflumethiazide, Rauwolfia Serpentina interacts with Stars 'N Pipes Let's Make 'Merica Grape Again — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Bendroflumethiazide, Rauwolfia Serpentina interactionBenzthiazideExna
How Benzthiazide interacts with Stars 'N Pipes Let's Make 'Merica Grape Again — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Benzthiazide interactionBetaxololBetoptic, Kerlone
How Betaxolol interacts with Stars 'N Pipes Let's Make 'Merica Grape Again — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Betaxolol interactionBisoprololZebeta
How Bisoprolol interacts with Stars 'N Pipes Let's Make 'Merica Grape Again — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Bisoprolol interactionBisoprolol, HydrochlorothiazideZiac
How Bisoprolol, Hydrochlorothiazide interacts with Stars 'N Pipes Let's Make 'Merica Grape Again — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Bisoprolol, Hydrochlorothiazide interactionBosentanTracleer
How Bosentan interacts with Stars 'N Pipes Let's Make 'Merica Grape Again — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Bosentan interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Stars 'N Pipes Let's Make 'Merica Grape Again with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
L-Citrulline
Antihypertensive Drugs
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.
Phosphodiesterase-5 Inhibitors
Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.
Brand information
Manufacturer and brand details for Stars 'N Pipes Let's Make 'Merica Grape Again, from the product label.
'Merica Labz
- Name
- 'Merica Labz, LLC.
- City
- Virginia
- Web Address
- www.MericaLabz.com
Stars 'N Pipes Let's Make 'Merica Grape Again by 'Merica Labz: Common Questions
Does Stars 'N Pipes Let's Make 'Merica Grape Again by 'Merica Labz interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will this lower my blood pressure if I'm already taking medication for it?
Can I take this with my erectile dysfunction medication?
What are the most common side effects?
Is this safe to use while I'm pregnant?
Can I breastfeed while taking this?
Does this product actually improve athletic performance?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Stars 'N Pipes Let's Make 'Merica Grape Again is safe with your meds?
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Stars 'N Pipes Let's Make 'Merica Grape Again’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
L-citrulline
Interacts with 178 drugsL-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. It is popular for exercise performance an...
Read the full L-citrulline monograph → Herb & supplement monographBetaine Anhydrous
Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and as a prescription medicine for a rare gen...
Read the full Betaine Anhydrous monograph → Herb & supplement monographGlycerol
Glycerol (glycerin) is a sweet, syrupy compound made naturally in the body and widely used in foods, skin products, and medicines. It is well established as a laxative and a skin and eye moi...
Read the full Glycerol monograph →Sources & How We Checked
Stars 'N Pipes Let's Make 'Merica Grape Again's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 27 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
L-citrulline 8 references
- Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
- Schwedhelm E, Maas R, Freese R, et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol 2008;65:51-9. PubMed
- Romero MJ, Platt DH, Caldwell RB, Caldwell RW. Therapeutic use of citrulline in cardiovascular disease. Cardiovasc Drug Rev 2006;24:275-90. PubMed
- Balderas-Munoz K, Castillo-Martínez L, Orea-Tejeda A, et al. Improvement of ventricular function in systolic heart failure patients with oral L-citrulline supplementation. Cardiol J 2012;19:612-7. PubMed
- Sharif Kashani B, Tahmaseb Pour P, Malekmohammad M, et al. Oral l-citrulline malate in patients with idiopathic pulmonary arterial hypertension and Eisenmenger Syndrome: a clinical trial. J Cardiol 2014;64:231-5. PubMed
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