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Dietary supplement

Stars 'N Pipes 'Merican Made Ingredients & Drug Interactions

by 'Merica Labz

Stars 'N Pipes 'Merican Made label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Stars 'N Pipes 'Merican Made against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Stars 'N Pipes 'Merican Made is a dietary supplement by 'Merica Labz with 3 active ingredients. Its ingredients are commonly taken for exercise performance, muscle soreness and fatigue, blood flow and circulation.Based on those ingredients, 178 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Citrulline. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Stars 'N Pipes 'Merican Made by 'Merica Labz

Ask about any prescription or over-the-counter medication and we check it for interactions with Stars 'N Pipes 'Merican Made by 'Merica Labz — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Stars 'N Pipes 'Merican Made by 'Merica Labz

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Stars 'N Pipes contains 3 active ingredients. L-citrulline is an amino acid that your body converts to another compound that increases blood vessel relaxation and blood flow — it's used to support athletic performance.

Betaine anhydrous is a compound naturally found in foods; it's used primarily to help manage high levels of a compound called homocysteine in your blood. The third ingredient, HydroMax, is a branded form of another compound meant to support hydration and performance, though we hold no detailed data on it.

The powder also contains several inactive ingredients — silica, citric acid, malic acid, sucralose, and natural and artificial flavoring — which are fillers and flavorings.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: exercise performance and muscle strength.
  • We looked for evidence on: Athletic performance, Muscle strength, Muscular dystrophy, Sarcopenia, endurance, exercise capacity — and 1 related terms.
  • The strongest evidence on file: L-citrulline is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: L-citrulline is rated "Possibly Ineffective" for Sarcopenia.
  • Also on file: Betaine Anhydrous is rated "Insufficient Reliable Evidence To Rate" for Athletic performance.

L-citrulline is possibly effective for athletic performance, meaning there's some evidence it may help, though more research would strengthen the case. For sarcopenia (age-related muscle loss), the evidence leans toward it being possibly ineffective.

For cardiovascular disease, heart failure, Reye syndrome, and diabetes, we don't have enough reliable evidence to rate it either way. Betaine anhydrous is effective for homocystinuria, a rare genetic condition, and possibly effective for high homocysteine levels.

For nonalcoholic fatty liver disease, adenomas, depression, and acid reflux, the evidence is insufficient to rate. We hold no effectiveness data for HydroMax.

The evidence, ingredient by ingredient L-citrulline Betaine Anhydrous

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-citrulline is generally well tolerated in healthy adults, though long-term safety isn't fully studied. The most common side effects are gastrointestinal discomfort and heartburn.

A small number of people with pulmonary hypertension reported cough. Betaine anhydrous is also generally well tolerated at studied doses, but may cause body odor, diarrhea, nausea, vomiting, and GI distress; cerebral swelling (cerebral edema) has been reported rarely.

For pregnancy, there isn't enough safety data for L-citrulline, so the safety data advises against it. The same applies to betaine anhydrous.

For breastfeeding, safety data for L-citrulline while nursing is unknown and should be avoided, and safety for betaine anhydrous while breastfeeding isn't well established, so caution is advised. Talk with your doctor or pharmacist before using this product if you're pregnant or nursing.

Side effects, ingredient by ingredient L-citrulline Betaine Anhydrous

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — L-citrulline.
  • The most serious interaction on file is rated Moderate.
  • For scale: 178 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check your exact medications against our tool if you're on blood pressure drugs or PDE-5 inhibitors like sildenafil — both have Moderate interactions with L-citrulline. Blood pressure medication combined with L-citrulline could lower your pressure too much; PDE-5 inhibitors plus L-citrulline could cause dangerous blood vessel relaxation and a severe blood pressure drop.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may appeal to athletes looking to support performance, but it's not for everyone. If you take blood pressure medication or erectile dysfunction medication, you need to check with your pharmacist first — the L-citrulline could interact.

Pregnant or nursing individuals should avoid it. Talk to your pharmacist about your medications and health before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 26, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Stars 'N Pipes 'Merican Made, straight from the product label.

Brand 'Merica Labz
Barcode (UPC) 602573098684
Net contents 14.17 Ounce(s); 401.6 Gram(s)
Market status On market
Date entered into DSLD Feb 26, 2020
DSLD ID 213467
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Stars 'N Pipes 'Merican Made by 'Merica Labz, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
20.1 Gram(s)
Maximum serving Sizes:
20.1 Gram(s)
Servings per container
20
UPC/BARCODE
602573098684
IngredientAmount% DV
L-Citrulline6000 mg--
Betaine Anhydrous5000 mg--
HydroMax5000 mg--

Other ingredients: Silica, Citric Acid, Malic Acid, Sucralose, Natural and Artificial flavoring

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Few things scream 'Merica - or freedom - like crushing a workout while wearing a pair of American flag sweatpants and a bald eagle bandana. Considering that's your everyday workout attire, that essentially makes you a freedom fighter, son. And freedom fighters can't contribute to the fight for freedom with a couple of puny small arms - they need the KABOOM! Big munitions. Well, freedom fighter, meet your best weapon in the fight against skinny arms: Stars 'N Pipes, a stim-free explosive pump agent fit for a real 'Merican hero. Stars 'N Pipes is like mixing a couple hundred lbs of TNT with Bruce Willis from Die Hrd, throwing some fruit in there, and putting it all in a powder. Yeah...it's that good.

Never Big Enough

High Explosive Pump Agent

Precautions

Warning: This product is only intended for use in healthy adults 18 years of age or older.

Pregnant or nursing women should not use this product. Consult your healthcare provider before using this product, especially if you are taking any prescription, over the counter medication, dietary supplement product, or if you have any pre-existing medical condition including but not limited to: high or low blood pressure, cardiac arrhythmia, stroke, heart, liver, kidney or thyroid disease, seizure disorder, psychiatric disease, diabetes, difficulty urinating due to prostate enlargement or if you are taking a MAOI (Monoamine Oxidase Inhibitor) or any other medication.

Immediately discontinue use and consult your health care professional if you experience adverse reaction to this product. Do not exceed recommended serving. Do not use if safety seal is broken or missing.

Keep out of reach of children.

Suggested/Recommended/Usage/Directions

Directions: Mix 1 scoop with 10-16 ounces of water and consume approximately 15-30 minutes prior to your workout.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Naturally & Artificially Flavored

Manufactured in a U.S. cGMP Facility

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

HydroMax is a registered trademark of Glanbia plc.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Stars 'N Pipes 'Merican Made by 'Merica Labz label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Stars 'N Pipes 'Merican Made label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Stars 'N Pipes 'Merican Made by 'Merica Labz

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size20.1 Gram(s) Dosage formPowder Servings per container20 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Citrulline

Interacts with
178 drugs
6000 mg per serving

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. I...

L-Citrulline monograph & interactions

Betaine Anhydrous

No known
interactions
5000 mg per serving

Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and a...

Betaine Anhydrous monograph & interactions

HydroMax

5000 mg per serving Form: Glycerol

Other (inactive) ingredients: Silica, Citric Acid, Malic Acid, Sucralose, Natural and Artificial flavoring. These complete the product’s ingredient list but are not active constituents.

Interaction report

Stars 'N Pipes 'Merican Made by 'Merica Labz Drug Interactions

Want to check YOUR meds against Stars 'N Pipes 'Merican Made?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
178Drugs
178 Moderate

Ingredients driving the most interactions

L-Citrulline 178

Individual Drug Interactions

The ingredients in Stars 'N Pipes 'Merican Made interact with 178 drugs. Click any drug to see the details.

1 of the 3 ingredients in Stars 'N Pipes 'Merican Made interact with drugs. Each result below shows which ingredient is responsible. L-Citrulline

Each ingredient & the kinds of drugs it affects

For each ingredient in Stars 'N Pipes 'Merican Made with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Citrulline2 drug types · 178 drugs

Antihypertensive Drugs

Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.

Likelihood Possible Evidence B
Phosphodiesterase-5 Inhibitors

Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
L-Citrulline full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Stars 'N Pipes 'Merican Made, from the product label.

'Merica Labz

Name
'Merica Labz, LLC.
City
Virginia
Web Address
www.MericaLabz.com
Pharmacist Counseling Corner

Stars 'N Pipes 'Merican Made by 'Merica Labz: Common Questions

Does Stars 'N Pipes 'Merican Made by 'Merica Labz interact with any medications?
Yes. Based on its ingredients, Stars 'N Pipes 'Merican Made has a known interaction with 178 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Stars 'N Pipes 'Merican Made contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does L-citrulline actually improve athletic performance?
The data shows L-citrulline is possibly effective for athletic performance, which means there's some evidence it may help, but the case isn't definitive. Your results will depend on your training, diet, and individual response.
What are the most common side effects I might feel?
L-citrulline most often causes gastrointestinal discomfort and heartburn. Betaine anhydrous may cause body odor, diarrhea, nausea, vomiting, or GI distress. Stop taking it if these bother you and talk to us.
Can I take this while I'm pregnant or breastfeeding?
No. There isn't enough safety data for L-citrulline in pregnancy, so the data advises against it. For breastfeeding, safety is unknown and should be avoided. Talk with your doctor before using any supplement during pregnancy or nursing.
What does betaine anhydrous do?
Betaine anhydrous is effective for a rare genetic condition called homocystinuria and possibly effective for lowering high homocysteine levels in your blood — a compound linked to heart health. It's also used in sports supplements to support hydration and performance.
Is this safe to take long-term?
L-citrulline is generally well tolerated, but long-term safety hasn't been fully studied. Betaine anhydrous is generally well tolerated at studied doses, but you should check with your healthcare provider before long-term use to be sure it's right for you.
Will this raise my cholesterol?
Elevated cholesterol levels have been reported with betaine anhydrous use. If you have cholesterol concerns, mention this product to your doctor before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Stars 'N Pipes 'Merican Made label
Go deeper

The Full Monographs Behind Stars 'N Pipes 'Merican Made’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

L-citrulline

Interacts with 178 drugs

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. It is popular for exercise performance an...

Read the full L-citrulline monograph → Herb & supplement monograph

Betaine Anhydrous

Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and as a prescription medicine for a rare gen...

Read the full Betaine Anhydrous monograph →
Sources

Sources & How We Checked

Stars 'N Pipes 'Merican Made's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 19 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

L-citrulline 8 references
  1. Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
  2. Schwedhelm E, Maas R, Freese R, et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol 2008;65:51-9. PubMed
  3. Romero MJ, Platt DH, Caldwell RB, Caldwell RW. Therapeutic use of citrulline in cardiovascular disease. Cardiovasc Drug Rev 2006;24:275-90. PubMed
  4. Balderas-Munoz K, Castillo-Martínez L, Orea-Tejeda A, et al. Improvement of ventricular function in systolic heart failure patients with oral L-citrulline supplementation. Cardiol J 2012;19:612-7. PubMed
  5. Sharif Kashani B, Tahmaseb Pour P, Malekmohammad M, et al. Oral l-citrulline malate in patients with idiopathic pulmonary arterial hypertension and Eisenmenger Syndrome: a clinical trial. J Cardiol 2014;64:231-5. PubMed
  6. Pérez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res 2010;24:1215-22. PubMed
  7. Mirenayat MS, Moradi S, Mohammadi H, Rouhani MH. Effect of L-citrulline supplementation on blood pressure: a systematic review and meta-analysis of clinical trials. Curr Hypertens Rep. 2018;20(11):98. PubMed
  8. Xu Z, Liu C, Liu S, Zhou Z. Comparison of efficacy and safety of daily oral L-arginine and PDE5Is alone or combination in treating erectile dysfunction: A systematic review and meta-analysis of randomised controlled trials. Andrologia. 2021:e14007. PubMed

See these in context on the L-citrulline monograph →

Betaine Anhydrous 11 references
  1. Cystadane (betaine anhydrous for oral solution) Package insert. Orphan Medical, Inc. Minnetonka, MN. November 2005.
  2. Abdelmalek MF, Angulo P, Jorgensen RA, et al. Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study. Am J Gastroenterol 2001;96:2711-7.. PubMed
  3. Schwab U, Torronen A, Toppinen L, et al. Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects. Am J Clin Nutr 2002;76:961-7. PubMed
  4. McGregor DO, Dellow WJ, Robson RA, et al. Betaine supplementation decreases post-methionine hyperhomocysteinemia in chronic renal failure. Kidney Int 2002;61:1040-6. PubMed
  5. Olthof MR, van Vliet T, Verhoef P, et al. Effect of homocysteine-lowering nutrients on blood lipids: results from four randomised, placebo-controlled studies in healthy humans. PloS Med 2005;2:e135. PubMed
  6. Knopman, D. and Patterson, M. An open-label, 24-week pilot study of the methyl donor betaine in Alzheimer disease patients. Alzheimer Dis.Assoc.Disord. 2001;15(3):162-165. PubMed
  7. Moat, S. J., Madhavan, A., Taylor, S. Y., Payne, N., Allen, R. H., Stabler, S. P., Goodfellow, J., McDowell, I. F., Lewis, M. J., and Lang, D. High- but not low-dose folic acid improves endothelial function in coronary artery disease. Eur J Clin Invest 2 PubMed
  8. Abdelmalek, M. F., Sanderson, S. O., Angulo, P., Soldevila-Pico, C., Liu, C., Peter, J., Keach, J., Cave, M., Chen, T., McClain, C. J., and Lindor, K. D. Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial. Hepa PubMed
  9. Ashtary-Larky D, Bagheri R, Ghanavati M, et al. Effects of betaine supplementation on cardiovascular markers: a systematic review and meta-analysis. Crit Rev Food Sci Nutr. 2021 Mar 25:1-18. PubMed
  10. Zawieja EE, Zawieja B, Chmurzynska A. Betaine supplementation moderately increases total cholesterol levels: a systematic review and meta-analysis. J Diet Suppl. 2021;18(1):105-117. PubMed
  11. Imbard A, Toumazi A, Magréault S, et al. Efficacy and pharmacokinetics of betaine in CBS and cblC deficiencies: a cross-over randomized controlled trial. Orphanet J Rare Dis 2022;17(1):417. PubMed

See these in context on the Betaine Anhydrous monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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