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Dietary supplement

Stinging Nettles 500 mg Ingredients & Drug Interactions

by tnvitamins

Stinging Nettles 500 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Stinging Nettles 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Stinging Nettles 500 mg is a dietary supplement by tnvitamins with 1 active ingredient. Its ingredients are commonly taken for enlarged prostate (bph) symptoms, seasonal allergies, joint pain and arthritis.Based on those ingredients, 164 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Stinging Nettles. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Stinging Nettles 500 mg by tnvitamins

Ask about any prescription or over-the-counter medication and we check it for interactions with Stinging Nettles 500 mg by tnvitamins — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Stinging Nettles 500 mg by tnvitamins

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: stinging nettles (500 mg per capsule). The inactive ingredients are gelatin (the capsule), rice powder, and vegetable magnesium stearate (a flow agent).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Stinging Nettle's overall clinical evidence instead.

Moderate

Some clinical evidence supports Stinging Nettle for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Diabetes — rated "Possibly Effective" (Natural Medicines).

Stinging nettles are possibly effective for diabetes, based on clinical research suggesting the herb may help lower blood sugar. For other uses — hay fever, anemia, asthma, benign prostatic hyperplasia (enlarged prostate), and gingivitis (gum inflammation) — the evidence isn't strong enough yet to rate whether it works.

If you're considering this for any of those other conditions, talk with your pharmacist or doctor about what the current evidence says.

The evidence, ingredient by ingredient Stinging Nettle

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Stinging nettles are generally well tolerated by most adults when used as directed, though evidence and quality can vary between products. The most common side effects are constipation and diarrhea when taken by mouth.

Touching the fresh plant (leaves or stalk) can cause itching, rash, and stinging on the skin; in rare cases, mouth or throat contact with the raw plant has caused severe swelling and pain lasting hours. Isolated case reports describe liver damage linked to herbal products containing stinging nettle, though the actual ingredient responsible was unclear.

Stinging nettle should be avoided during pregnancy because there isn't enough safety data, and traditional use raises concerns about effects on the uterus. Safety during breastfeeding hasn't been established either, so avoid it until you've talked with your doctor.

Side effects, ingredient by ingredient Stinging Nettle

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Stinging Nettle.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 164 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take stinging nettles, check with your pharmacist if you use blood thinners like warfarin, diabetes medications, water pills (diuretics), or lithium. These combinations carry Moderate-severity interactions that may change how your drugs work or require dose adjustments.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Stinging nettles may be worth considering if you're interested in blood sugar support, but they're not right for everyone. If you take a blood thinner, diabetes medication, diuretic, or lithium, you need to check with your pharmacist first — these combinations need careful watching.

Pregnant and breastfeeding women should skip this product.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Stinging Nettles 500 mg, straight from the product label.

Brand tnvitamins
Barcode (UPC) 095234264601
Net contents 100 Capsule(s)
Market status On market
Date entered into DSLD Apr 23, 2020
DSLD ID 217876
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Stinging Nettles 500 mg by tnvitamins, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
50
UPC/BARCODE
095234264601
IngredientAmount% DV
Stinging Nettles1000 mg--

Other ingredients: Gelatin, Rice powder, Vegetable Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Natural herbs

Free of: Wheat, yeast, milk, lactose, soy, artificial color, artificial flavor, artificial sweetener, preservatives. Non GMO.

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Directions: For adults, take two (2) capsules daily, preferably with a meal, or as directed by a healthcare professional.

Precautions

Caution: Pregnant or lactating women should consult a doctor before use.

If you are under medical supervision, please consult a doctor before use. Discontinue use and consult a doctor if any adverse reactions occur.

Keep out of reach of children.

Storage

Store in a cool, dry place.

General Statements

Reorder tnvitamins.com 800-645-4446

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Stinging Nettles 500 mg by tnvitamins label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Stinging Nettles 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Stinging Nettles 500 mg by tnvitamins

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.

Stinging Nettles

Interacts with
164 drugs
1000 mg per serving

Stinging nettle is a common plant used as food and in traditional medicine, most often for prostate symptoms, allergies, and joint pain. The evidence...

Stinging Nettles monograph & interactions

Other (inactive) ingredients: Gelatin, Rice powder, Vegetable Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Stinging Nettles 500 mg by tnvitamins Drug Interactions

Want to check YOUR meds against Stinging Nettles 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
164Drugs
164 Moderate

Ingredients driving the most interactions

Stinging Nettles 164

Individual Drug Interactions

The ingredients in Stinging Nettles 500 mg interact with 164 drugs. Click any drug to see the details.

1 of the 1 ingredient in Stinging Nettles 500 mg interact with drugs. Each result below shows which ingredient is responsible. Stinging Nettles

Each ingredient & the kinds of drugs it affects

For each ingredient in Stinging Nettles 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Stinging Nettles4 drug types · 164 drugs

Antidiabetes Drugs

Theoretically, stinging nettle might have additive effects with antidiabetes drugs.
Clinical research shows that stinging nettle might decrease blood glucose levels in patients with diabetes.

Likelihood Possible Evidence B
Diuretic Drugs

Theoretically, combining stinging nettle with diuretic drugs may have additive effects.
Animal research suggests that the above ground parts and roots of stinging nettle may have a diuretic effect.

Likelihood Possible Evidence D
Lithium

Theoretically, stinging nettle might reduce excretion and increase levels of lithium.
Animal research suggests that stinging nettle has diuretic and natriuretic properties, which could alter the excretion of lithium. The dose of lithium might need to be decreased.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is some concern that stinging nettle might decrease the effects of anticoagulant drugs such as warfarin.
Stinging nettle contains a significant amount of vitamin K. When taken in large quantities, this might interfere with the activity of warfarin.

Likelihood Possible Evidence D
Stinging Nettles full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Stinging Nettles 500 mg, from the product label.

tnvitamins

See all tnvitamins products
Name
TOTAL NUTRITION, INC.
City
FARMINGDALE
State
NY
ZipCode
11735
Phone Number
800-645-4446
Web Address
tnvitamins.com
Pharmacist Counseling Corner

Stinging Nettles 500 mg by tnvitamins: Common Questions

Does Stinging Nettles 500 mg by tnvitamins interact with any medications?
Yes. Based on its ingredients, Stinging Nettles 500 mg has a known interaction with 164 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Stinging Nettles 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take stinging nettles if I'm pregnant or breastfeeding?
No. During pregnancy, there isn't enough safety data, and traditional concerns about effects on the uterus mean you should avoid it. Safety during breastfeeding hasn't been established either. Talk with your doctor before considering it in either situation.
What are the side effects I might experience?
When taken by mouth, the most common side effects are constipation and diarrhea. If you touch the fresh plant, you may get itching, rash, and stinging on your skin. Very rarely, contact with the raw plant in the mouth or throat has caused severe swelling and pain lasting several hours.
Does stinging nettle actually lower blood sugar?
Clinical research suggests stinging nettle might help decrease blood glucose levels in people with diabetes, so it's rated possibly effective for that use. The evidence for other conditions it's marketed for — hay fever, anemia, asthma, and prostate health — isn't established yet.
Why is stinging nettle a concern if I take warfarin?
Stinging nettle contains a lot of vitamin K. When you take large amounts, vitamin K can interfere with how warfarin works and reduce its ability to prevent clots. Your doctor may need to adjust your warfarin dose if you start taking this supplement.
What happens if I combine stinging nettle with a water pill?
Both stinging nettle and diuretics increase fluid loss from your body. Taking them together might cause extra dehydration or electrolyte imbalances. Your doctor should know you're taking both so they can monitor you.
Is it safe to take stinging nettle long-term?
Stinging nettles are generally well tolerated for most adults when used as directed, but evidence and quality vary by product. We don't hold long-term safety data, so if you're planning to take it regularly, ask your pharmacist or doctor whether it's right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Stinging Nettles 500 mg label
Go deeper

The Full Monographs Behind Stinging Nettles 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Stinging Nettle

Interacts with 164 drugs

Stinging nettle is a common plant used as food and in traditional medicine, most often for prostate symptoms, allergies, and joint pain. The evidence is mixed and mostly preliminary, so it i...

Read the full Stinging Nettle monograph →
Sources

Sources & How We Checked

Stinging Nettles 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 23 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Stinging Nettle 23 references
  1. Monographs on the medicinal uses of plant drugs. Exeter, UK: European Scientific Co-op Phytother, 1997.
  2. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  3. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  4. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
  5. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  6. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  7. Mittman P. Randomized, double-blind study of freeze-dried Urtica dioica in the treatment of allergic rhinitis. Planta Med 1990;56:44-7.
  8. Vontobel HP, Herzog R, Rutishauser G, Kres H. [Results of a double-blind study on the effectiveness of ERU (extractum radicis Urticae) capsules in conservative treatment of benign prostatic hyperplasia]. (Abstract). Urologe A 1985;24:49-51.
  9. Randall C, Randall H, Dobbs F, et al. Randomized controlled trial of nettle sting for treatment of base-of-thumb pain. J R Soc Med 2000;93:305-9. PubMed
  10. Caliskaner Z, Karaayvaz M, Ozturk S. Misuse of a herb: stinging nettle (Urtica urens) induced severe tongue oedema. Complement Ther Med 2004;12:57-8. PubMed
  11. Krzeski, T., Kazon, M., Borkowski, A., Witeska, A., and Kuczera, J. Combined extracts of Urtica dioica and Pygeum africanum in the treatment of benign prostatic hyperplasia: double-blind comparison of two doses. Clin Ther 1993;15(6):1011-1020.
  12. Randall, C., Meethan, K., Randall, H., and Dobbs, F. Nettle sting of Urtica dioica for joint pain--an exploratory study of this complementary therapy. Complement Ther Med 1999;7(3):126-131. PubMed
  13. Tahri, A., Yamani, S., Legssyer, A., Aziz, M., Mekhfi, H., Bnouham, M., and Ziyyat, A. Acute diuretic, natriuretic and hypotensive effects of a continuous perfusion of aqueous extract of Urtica dioica in the rat. J Ethnopharmacol 2000;73(1-2):95-100. PubMed
  14. Sahin, M., Yilmaz, H., Gursoy, A., Demirel, A. N., Tutuncu, N. B., and Guvener, N. D. Gynaecomastia in a man and hyperoestrogenism in a woman due to ingestion of nettle (Urtica dioica). N.Z.Med.J. 2007;120(1265):U2803.
  15. Randall, C., Dickens, A., White, A., Sanders, H., Fox, M., and Campbell, J. Nettle sting for chronic knee pain: a randomised controlled pilot study. Complement Ther.Med. 2008;16(2):66-72. PubMed
  16. Rayburn, K., Fleischbein, E., Song, J., Allen, B., Kundert, M., Leiter, C., and Bush, T. Stinging nettle cream for osteoarthritis. Altern.Ther.Health Med. 2009;15(4):60-61.
  17. Oliver, F., Amon, E. U., Breathnach, A., Francis, D. M., Sarathchandra, P., Black, A. K., and Greaves, M. W. Contact urticaria due to the common stinging nettle (Urtica dioica)-- histological, ultrastructural and pharmacological studies. Clin Exp Dermato PubMed
  18. Kulze, A. and Greaves, M. Contact urticaria caused by stinging nettles. Br.J Dermatol. 1988;119(2):269-270. PubMed
  19. Patten G. Medicinal plant review: Urtica. Aust J Med Herbalism 1993;5(1):5-13.
  20. Maor D, Little M. Skin contact with a stinging tree requiring intensive care unit admission. Contact Dermatitis. 2017 Nov;77(5):335-37. PubMed
  21. Easton L, Vaid S, Nagel AK, Venci JV, Fortuna RJ. Stinging Nettle (Urtica dioica): An Unusual Case of Galactorrhea. Am J Case Rep 2021;22:e933999. PubMed
  22. Niazi B, Ahmed K, Ahmed M, Ali S, Song K, Elias S. Drug-Induced Liver Injury from Herbal Liver Detoxification Tea. Case Rep Gastroenterol 2022;16(3):612-617. PubMed
  23. Nnamani I, Tolu-Akinnawo O, Dufera RR, Akintunde A, Maliakkal B. Tinospora cordifolia (Guduchi/Giloy)-Induced Liver Injury: A Case Review. Cureus 2023;15(5):e39793. PubMed

See these in context on the Stinging Nettle monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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