Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

Stomach Advanced Ingredients & Drug Interactions

by BioAnue

Stomach Advanced label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Stomach Advanced against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Stomach Advanced is a dietary supplement by BioAnue with 3 active ingredients. Its ingredients are commonly taken for low stomach acid (hypochlorhydria), bloating and gas, indigestion.Based on those ingredients, 36 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Betaine Hydrochloride. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Stomach Advanced by BioAnue

Ask about any prescription or over-the-counter medication and we check it for interactions with Stomach Advanced by BioAnue — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Stomach Advanced by BioAnue

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (370 mg) without saying how much of each component you get.

Stomach Advanced has 3 active ingredients. Betaine hydrochloride is a compound that boosts stomach acid — it's used to support digestive function.

Pepsin is a protein-digesting enzyme (protease) your stomach naturally makes to break down food. The third ingredient is a proprietary blend, which means its exact components and amounts are not disclosed on the label; we list them individually where we can identify them.

The capsule itself is made from gelatin.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: stomach digestion and acid support.
  • We looked for evidence on: Dyspepsia, Indigestion, Bloating, Low stomach acid.
  • The closest evidence on file: Betaine Hydrochloride is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia (Natural Medicines).

The evidence on betaine hydrochloride for dyspepsia (indigestion), hypothyroidism, diarrhea, rheumatoid arthritis, food allergies, and hay fever is insufficient — we don't have reliable data showing whether it works for these purposes. Pepsin's effectiveness ratings are also not established in our data.

Because this is a digestive enzyme product with limited evidence behind its specific claims, talk with your pharmacist about what it's meant to do for you and whether the science backs it up.

The evidence, ingredient by ingredient Betaine Hydrochloride Proteolytic Enzymes (proteases)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Betaine hydrochloride can irritate your stomach and is not safe if you have ulcers, gastritis, or true acid reflux — the very conditions someone might think this helps. It may also cause heartburn.

Pepsin is generally well tolerated in most adults, though it can cause digestive upset or allergic reactions in some people; rarely, occupational exposure to pepsin has triggered allergic rhinitis or asthma in sensitive individuals. For pregnancy, the safety data advises against betaine hydrochloride.

Pepsin safety in pregnancy hasn't been established — talk with your doctor or pharmacist. During breastfeeding, betaine hydrochloride should be avoided, and pepsin is not recommended without medical guidance.

Side effects, ingredient by ingredient Betaine Hydrochloride Proteolytic Enzymes (proteases)

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Betaine Hydrochloride.
  • The most serious interaction on file is rated Minor.
  • For scale: 36 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check proton pump inhibitors (PPIs), H2-blockers, and antacids before taking this product — betaine hydrochloride can weaken their effects. All interactions are Minor severity, but they're real enough to matter if you're relying on those medications to control your stomach acid.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

This product is for people looking to support stomach acid and digestive enzyme activity — but the evidence it actually works is limited. If you take any acid-reducing medication (PPIs, H2-blockers, antacids), check your specific drugs on this page before starting.

Anyone with ulcers, gastritis, or acid reflux should skip it. Pregnant or breastfeeding?

Talk to your pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Stomach Advanced, straight from the product label.

Brand BioAnue
Net contents 10 Capsule(s); 370 mg
Market status On market
Date entered into DSLD Nov 25, 2013
DSLD ID 27426
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Stomach Advanced by BioAnue, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
10
IngredientAmount% DV
Betaine Hydrochloride0 Not Present--
Proprietary Blend370 mg--
Pepsin0 Not Present--
Stomach Extract0 Not Present--

Other ingredients: Gelatin Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Your Edge - Your New Beginning

Date Code:

Suggested/Recommended/Usage/Directions

Usage: Consume about 50 to 75% of the meal then take one (1) or more capsules every 10 minutes until a warm sensation occurs, then consume the rest of the meal. At every meal thereafter take the activation dosage after 50 to 75% of the meal has been consumed.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Stomach Advanced by BioAnue label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Stomach Advanced label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Stomach Advanced by BioAnue

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container10 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

370 mg per serving

Other (inactive) ingredients: Gelatin Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Stomach Advanced by BioAnue Drug Interactions

Want to check YOUR meds against Stomach Advanced?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
36Drugs
36 Minor

Ingredients driving the most interactions

Betaine Hydrochloride 36

Individual Drug Interactions

The ingredients in Stomach Advanced interact with 36 drugs. Click any drug to see the details.

1 of the 3 ingredients in Stomach Advanced interact with drugs. Each result below shows which ingredient is responsible. Betaine Hydrochloride

Each ingredient & the kinds of drugs it affects

For each ingredient in Stomach Advanced with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Betaine Hydrochloride3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D
Betaine Hydrochloride full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Stomach Advanced, from the product label.

BioAnue

See all BioAnue products
Name
BioAnue Laboratories Inc.
Street Address
P.O. Box 1056, 123 Wood Tech Dr.
City
Rochelle
State
GA
ZipCode
31079
Pharmacist Counseling Corner

Stomach Advanced by BioAnue: Common Questions

Does Stomach Advanced by BioAnue interact with any medications?
Yes. Based on its ingredients, Stomach Advanced has a known interaction with 36 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Stomach Advanced contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I have acid reflux?
No — betaine hydrochloride is not safe for people with true acid reflux. It increases stomach acid, which is the opposite of what you need. Talk with your pharmacist about what's actually right for your reflux.
Is this safe during pregnancy or breastfeeding?
The data advises against betaine hydrochloride in pregnancy and recommends avoiding it while breastfeeding. Pepsin safety hasn't been fully established in pregnancy, and it's not recommended during breastfeeding without medical advice. Speak with your doctor or pharmacist for personalized guidance.
What's pepsin and why is it in here?
Pepsin is a protein-digesting enzyme your stomach makes naturally to break down food. It's included to support digestion. However, rarely, it can cause allergic reactions or digestive upset in some people.
What does the proprietary blend contain?
The label doesn't say — proprietary blends keep their formula secret. We can't tell you the exact ingredients or amounts, so you won't know precisely what you're getting besides betaine hydrochloride and pepsin.
Does this actually work for indigestion?
The evidence isn't established yet. We don't have reliable data showing betaine hydrochloride works for indigestion or the other conditions this product claims to address, so ask your pharmacist whether it's worth trying for your specific situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Stomach Advanced label
Go deeper

The Full Monographs Behind Stomach Advanced’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Betaine Hydrochloride

Interacts with 36 drugs

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...

Read the full Betaine Hydrochloride monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph →
Sources

Sources & How We Checked

Stomach Advanced's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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