Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Sublingual B-12 5000 mcg Ingredients & Drug Interactions

by Vitamin World

Sublingual B-12 5000 mcg label
See full label image
Other (e.g. Tea Bag) Category: Vitamin
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Sublingual B-12 5000 mcg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Sublingual B-12 5000 mcg is a dietary supplement by Vitamin World with 2 active ingredients. Its ingredients are commonly taken for treating or preventing b12 deficiency, pernicious anemia, low energy and fatigue.Based on those ingredients, 20 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Vitamin B12. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Sublingual B-12 5000 mcg by Vitamin World

Ask about any prescription or over-the-counter medication and we check it for interactions with Sublingual B-12 5000 mcg by Vitamin World — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Sublingual B-12 5000 mcg by Vitamin World

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product has 2 active ingredients: Vitamin B12 and Coenzyme B12 (another form of the same vitamin). Both are designed to be absorbed under the tongue, which may help your body use them more quickly.

The tablet also contains inactive ingredients like mannitol, crospovidone, and stearic acid — common fillers and binders that help hold the tablet together.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: B12 supplementation and deficiency support.
  • We looked for evidence on: Vitamin B12 deficiency, Fatigue, Peripheral neuropathy, Chemotherapy-induced peripheral neuropathy, Diabetic neuropathy, Energy support — and 2 related terms.
  • The strongest evidence on file: Vitamin B12 is rated "Effective" for Vitamin B12 deficiency (Natural Medicines).
  • Also on file: Vitamin B12 is rated "Insufficient Reliable Evidence To Rate" for Chemotherapy-induced peripheral neuropathy, Diabetic neuropathy, Fatigue, Peripheral neuropathy.

The B12 in this product is effective for treating vitamin B12 deficiency and Imerslund-Grasbeck disease (a rare inherited condition that affects B12 absorption). It's also likely effective for cyanide poisoning — though that's a medical emergency and not something you'd self-treat with a supplement.

For canker sores and nerve pain after shingles (postherpetic neuralgia), the evidence is possibly effective — meaning some research suggests it may help, but we don't have strong proof yet.

The evidence, ingredient by ingredient Vitamin B12

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

B12 is generally very well tolerated. Your body excretes excess B12 in your urine, so there's no established upper limit — you won't overdose on it.

When taken by mouth, B12 rarely causes problems, though allergic reactions like rash or itching are possible (and may be tied to a cobalt allergy in rare cases). B12 is needed during pregnancy and breastfeeding and is considered safe at normal recommended amounts — follow your provider's guidance on dosing.

Side effects, ingredient by ingredient Vitamin B12

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin B12.
  • The most serious interaction on file is rated Minor.
  • For scale: 20 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take metformin (Glucophage) for diabetes, check with your pharmacist before starting. Metformin can lower B12 levels, which is why your doctor may want to monitor you if you're using both.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

This is a straightforward B12 supplement for anyone with low B12 or those who need extra support — vegetarians, vegans, and older adults often benefit. If you take metformin for diabetes, mention this supplement to your pharmacist first so they can keep an eye on your B12 levels.

It's safe and well tolerated for most people.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sublingual B-12 5000 mcg, straight from the product label.

Brand Vitamin World
Barcode (UPC) 074312714733
Net contents 60 Microlozenge(s)
Market status On market
Date entered into DSLD Jun 24, 2016
DSLD ID 60387
Product type Vitamin
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sublingual B-12 5000 mcg by Vitamin World, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Microlozenge(s)
Maximum serving Sizes:
1 Microlozenge(s)
UPC/BARCODE
074312714733
IngredientAmount% DV
Vitamin B125000 mcg83333%
Coenzyme B12100 mcg--

Other ingredients: Mannitol, Crospovidone, Stearic Acid, natural Cherry flavor, Contains <2% of:

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

Quality Assured

General Statements

At Vitamin World we ensure the quality of all of our premium nutritional products, every step of the way. Strict quality analysis at our world-class facilities guarantees that all Vitamin World products are at the highest standard of potency and purity.

To reorder prod. #1473 www.vitaminworld.com 1-800-228-4533

Supports Energy Metabolism Supports Heart Health

B vitamins play a role in energy metabolism in the body. Vitamin B-12 is essential for normal formation of blood cells and contributes to the health of the nervous system.

Part no. 22-14737

Did you know that absorption of B-12 from the digestive system naturally decreases as we age? This decrease in absorption is usually due to a loss of stomach acid as well as insufficient functioning of stomach enzymes.

Sublingual B-12 is important for heart health, nervous system health and energy metabolism. Heart health: Vitamin B-12 is one of the three major B vitamins, along with B-6 and Folic Acid, that help maintain homocysteine levels already within a normal range by converting homocysteine into the amino acid methionine. Healthy levels of homocysteine are believed to play an important role in heart and cardiovascular health.

Nervous system health: B-12 is essential for maintaining nerve cells, which is important for relaying messages from the brain to all the cells of the body. Taking Sublingual B-12 every day helps keep your nervous system working efficiently.

Energy metabolism: B-12 works in conjunction with important enzymes in the body. By helping to activate these enzymes, the breakdown of important nutrients such as amino acids can occur, which supports energy metabolism.

Formulation

No Artificial Flavor, No Preservatives, No Sugar, No Starch, No Milk, No Lactose, No Soy, No Gluten, No Yeast, No Fish. Sodium Free.

Vegetarian Vitamin Supplement

Precautions

Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Do not use if seal under cap is broken or missing.

Storage

Store at room temperature.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

2016 Vitamin World, Inc.

Nutrition From The Source

General

Product No. 1473 B1471 11E

Formula

B VITAMINS

Our super potency formula maximizes B-12 levels in the digestive system, to help increase overall B-12 absorption.

FDA Statement of Identity

Vegetarian Vitamin Supplement

Suggested/Recommended/Usage/Directions

Directions: For adults, take one (1) microlozenge daily. Place microlozenge under tongue for 30 seconds before swallowing.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Sublingual B-12 5000 mcg by Vitamin World label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Sublingual B-12 5000 mcg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Sublingual B-12 5000 mcg by Vitamin World

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Microlozenge(s) Dosage formOther (e.g. Tea Bag) Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B12

Interacts with
20 drugs
5000 mcg per serving Form: Cyanocobalamin

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Coenzyme B12

Interacts with
20 drugs
100 mcg per serving Form: Dibencozide

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Coenzyme B12 monograph & interactions

Other (inactive) ingredients: Mannitol, Crospovidone, Stearic Acid, Natural Cherry flavor, Contains <2% of:. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sublingual B-12 5000 mcg by Vitamin World Drug Interactions

Want to check YOUR meds against Sublingual B-12 5000 mcg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
20Drugs
20 Minor

Ingredients driving the most interactions

Vitamin B12 20

Individual Drug Interactions

The ingredients in Sublingual B-12 5000 mcg interact with 20 drugs. Click any drug to see the details.

1 of the 2 ingredients in Sublingual B-12 5000 mcg interact with drugs. Each result below shows which ingredient is responsible. Vitamin B12

Each ingredient & the kinds of drugs it affects

For each ingredient in Sublingual B-12 5000 mcg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Sublingual B-12 5000 mcg, from the product label.

Vitamin World

See all Vitamin World products
Name
Vitamin World, Inc.
City
Holbrook
State
NY
ZipCode
11741
Phone Number
1-800-228-4533
Web Address
www.vitaminworld.com
Pharmacist Counseling Corner

Sublingual B-12 5000 mcg by Vitamin World: Common Questions

Does Sublingual B-12 5000 mcg by Vitamin World interact with any medications?
Yes. Based on its ingredients, Sublingual B-12 5000 mcg has a known interaction with 20 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sublingual B-12 5000 mcg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on metformin?
Metformin can reduce B12 levels over time, so let your pharmacist or doctor know you're considering this supplement. They may want to check your B12 level first and monitor it while you're on both. It's not a reason to avoid the supplement — just something to manage together.
Is this safe if I'm pregnant or breastfeeding?
Yes. B12 is needed during pregnancy and breastfeeding and is considered safe at normal recommended amounts. Follow your provider's advice on the right dose for you.
What's the difference between Vitamin B12 and Coenzyme B12?
They're both forms of the same vitamin and have the same effectiveness and safety profile. Coenzyme B12 is sometimes thought to be more bioavailable (easier for your body to use), but both work well for treating B12 deficiency.
Can I take too much B12?
No. Excess B12 is water-soluble, which means your body removes any amount it doesn't need through your urine. There's no established upper limit.
What side effects should I watch for?
B12 taken by mouth is very well tolerated. Allergic reactions like rash or itching are rare but possible — especially if you have a cobalt allergy. Stop and contact your pharmacist if you develop any unusual symptoms.
Will this help my canker sores or nerve pain?
The evidence is possibly effective for both, meaning some research suggests it may help, but we don't have strong proof. Talk to your doctor if you're using it for these — there may be other treatments worth considering first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Sublingual B-12 5000 mcg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sublingual B-12 5000 mcg label
Go deeper

The Full Monographs Behind Sublingual B-12 5000 mcg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph →
Sources

Sources & How We Checked

Sublingual B-12 5000 mcg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 30 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B12 30 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  2. Hartman TJ, Woodson K, Stolzenberg-Solomon R, et al. Association of the B-vitamins pyridoxal 5'-phosphate (B6), B12, and folate with lung cancer risk in older men. Am J Epidemiol 2001;153:688-94.. DOI
  3. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  4. Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81. PubMed
  5. Collin, S. M., Metcalfe, C., Refsum, H., Lewis, S. J., Zuccolo, L., Smith, G. D., Chen, L., Harris, R., Davis, M., Marsden, G., Johnston, C., Lane, J. A., Ebbing, M., Bonaa, K. H., Nygard, O., Ueland, P. M., Grau, M. V., Baron, J. A., Donovan, J. L., Nea
  6. Geissbuhler, P., Mermillod, B., and Rapin, C. H. Elevated serum vitamin B12 levels associated with CRP as a predictive factor of mortality in palliative care cancer patients: a prospective study over five years. J.Pain Symptom.Manage. 2000;20(2):93-103. PubMed
  7. Salles, N., Herrmann, F., Sakbani, K., Rapin, C. H., and Sieber, C. High vitamin B12 level: a strong predictor of mortality in elderly inpatients. J Am Geriatr.Soc 2005;53(5):917-918.
  8. Looker, H. C., Fagot-Campagna, A., Gunter, E. W., Pfeiffer, C. M., Sievers, M. L., Bennett, P. H., Nelson, R. G., Hanson, R. L., and Knowler, W. C. Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes. Diabetes Metab Res R
  9. Uhl, W., Nolting, A., Golor, G., Rost, K. L., and Kovar, A. Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study. Clin Toxicol (Phila) 2006;44 Suppl 1:17-28. PubMed
  10. Borron, S. W., Baud, F. J., Barriot, P., Imbert, M., and Bismuth, C. Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. Ann Emerg.Med 2007;49(6):794-801, 801. PubMed
  11. Borron, S. W., Baud, F. J., Megarbane, B., and Bismuth, C. Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation. Am J Emerg.Med 2007;25(5):551-558. PubMed
  12. Lewis, J. G. Gout, Steatorrhoea, and Megaloblastic Anaemia. Ann Rheum.Dis 1962;21(3):284-286. PubMed
  13. Tal, S., Shavit, Y., Stern, F., and Malnick, S. Association between vitamin B12 levels and mortality in hospitalized older adults. J Am Geriatr.Soc 2010;58(3):523-526. PubMed
  14. Baztan, J. J., Gavidia, J. J., Gomez-Pavon, J., Esteve, A., and Ruiperez, I. High vitamin B12 levels and in-hospital mortality. J Am Geriatr.Soc 2010;58(11):2237-2238. PubMed
  15. Omboni, E., Checchini, M., and Longoni, F. [Hypopotassemia and megaloblastic anemia. Presentation of a case]. Minerva Med 8-31-1987;78(16):1255-1257.
  16. Aalfs As, Scholvinck LH, Horvath B. Acneiform eruption in a 5-year old due to vitamin B12 supplementation. Eur J Dermatol 2013;23(5):726-7. PubMed
  17. Balta I, Ozuguz P. Vitamin B12-induced acneiform eruption. Cutan Ocul Toxicol 2014;33(2):94-5. PubMed
  18. Carman KB, Belgemen T, Yis U. Involuntary movements misdiagnosed as seizure during vitamin B12 treatment. Pediatr Emerg Care 2013;29(11):1223-4. PubMed
  19. Djuric V, Bogic M, Popadic AP, et al. Anaphylactic reaction to hydroxycobalamin with tolerance to cyanocobalamin. Ann Allergy Asthma Immunol 2012;108(3):207-8. PubMed
  20. Kartel O, Gulec M, Demirel F, et al. Vitamin B12 allergy and successful desensitization with cyanocobalamin: A case report. Allergol Immunopath (Madr) 2012;40(5):324-5.
  21. Patiroglu T, Unal E, Yildirim S. Infantile tremor syndrome associated with cobalamin therapy: A case report. Clin Neurol Neurosurg 2013;115(9):1903-5. PubMed
  22. Schulte S, Barkema LW, Kardaun SH. Long-lasting atypical acneiform eruption with prominent comedones induced by hydroxocobalamin (vitamin B12). J Dtsch Dermatol Ges 2014;12(6):502-3.
  23. Zanus C, Alberini E, Costa P, et al. Involuntary movements after correction of vitamin B12 deficiency: A video-case report. Epileptic Disord 2012;14(2):174-80. PubMed
  24. Fanidi A, Carreras-Torres R, Larose TL, et al. Is high vitamin B12 status a cause of lung cancer? Int J Cancer. 2019 Sep 15;145(6):1499-1503. PubMed
  25. Fujita Y, Mizukami T, Maya Y, et al. Vitamin B12 allergy manifesting as lymphomatoid contact dermatitis. Eur J Dermatol. 2020;30(3):304-305. PubMed
  26. Dépret F, Hoffmann C, Daoud L, et al. Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study. Crit Care. 2019;23(1):421. PubMed
  27. Khairan P, Sobue T, Eshak ES, et al. Association of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer: the Japan Public Health Center-based (JPHC) prospective study. BMC Cancer 2021;21(1):982. PubMed
  28. Evans J, Pandya A, Ding Y, Qunibi WY. Hydroxocobalamin-Induced Oxalate Nephropathy in a Patient With Smoke Inhalation. Kidney Int Rep 2021;6(8):2228-2231. PubMed
  29. Lacombe V, Chabrun F, Lacout C, et al. Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer. Sci Rep 2021;11(1):13361. PubMed
  30. Pegalajar-García MD, Cebolla-Verdugo M, Prados-Carmona Á, Llamas-Segura C, Navarro-Triviño FJ. Systemic allergic dermatitis to cobalt present in cyanocobalamin supplementation. Contact Dermatitis 2023;89(3):203-205. PubMed

See these in context on the Vitamin B12 monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team