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Dietary supplement

Sulforaphane 400 mcg Ingredients & Drug Interactions

by Swanson

Sulforaphane 400 mcg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Sulforaphane 400 mcg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Sulforaphane 400 mcg is a dietary supplement by Swanson with 1 active ingredient. Its ingredients are commonly taken for antioxidant support, general cellular health, detoxification support.Based on those ingredients, 722 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sulforaphane. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Sulforaphane 400 mcg by Swanson

Ask about any prescription or over-the-counter medication and we check it for interactions with Sulforaphane 400 mcg by Swanson — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Sulforaphane 400 mcg by Swanson

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This supplement contains one active ingredient: sulforaphane, a compound derived from broccoli and other cruciferous vegetables. It's the compound many people associate with the potential health benefits of eating broccoli and related plants.

The other ingredients listed — rice flour and hypromellose — are inactive ingredients that make up the capsule structure and help the supplement hold together.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: enhances liver detoxification and antioxidant defense.
  • We looked for evidence on: Liver disease, oxidative stress, cellular health, detoxification.
  • The closest evidence on file: Sulforaphane is rated "Insufficient Reliable Evidence To Rate" for Liver disease (Natural Medicines).

The evidence for sulforaphane is mixed and limited. It's rated possibly effective for prostate cancer based on available studies.

For Helicobacter pylori (a bacteria linked to stomach ulcers), it's rated possibly ineffective. For allergic rhinitis (hay fever), asthma, and cancer in general, there isn't enough reliable evidence yet to say whether it works.

More research is needed in most areas.

The evidence, ingredient by ingredient Sulforaphane

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sulforaphane from food is considered safe, but concentrated supplements like this one are less studied for long-term use, so caution is warranted if you're taking it regularly. In clinical trials, the most common side effects were bowel discomfort, heartburn, stomach upset, and vomiting.

A small number of trial participants also reported headache, insomnia, and irritability. In one study of young males with autism, patients taking sulforaphane gained an average of 4 pounds over 18 weeks compared to placebo.

There are also two reported cases of seizure in males with autism after starting sulforaphane; one patient experienced a seizure after 3 weeks of use. For pregnancy, concentrated sulforaphane supplements have not been proven safe, so the safety data advises against them — stick to dietary amounts from food instead.

While breastfeeding, there isn't enough information on supplement-level doses, so talk with your doctor or pharmacist about whether dietary amounts or a supplement is right for you.

Side effects, ingredient by ingredient Sulforaphane

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Sulforaphane.
  • The most serious interaction on file is rated Moderate.
  • For scale: 723 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check any CYP3A4 substrates (Moderate severity) — a broad group that includes statins, blood pressure medications, immunosuppressants, and others. Also double-check CYP1A2 substrates and CYP2E1 substrates, both Moderate severity.

Use the search tool on this page with your exact medication names.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Sulforaphane is a broccoli compound with possibly effective evidence for prostate cancer, though evidence for other conditions is limited or absent. The main caution is its interaction with common medications that rely on liver enzymes to be cleared — 712 individual medications are affected at Moderate severity.

If you take any prescription drug, check it against our interaction tool first. Avoid concentrated supplements in pregnancy; discuss supplement use while breastfeeding with your pharmacist.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sulforaphane 400 mcg, straight from the product label.

Brand Swanson
Barcode (UPC) 087614060484
Net contents 60 Veggie Cap(s)
Market status On market
Date entered into DSLD Jun 24, 2019
DSLD ID 203679
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sulforaphane 400 mcg by Swanson, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veggie Capsule(s)
Maximum serving Sizes:
1 Veggie Capsule(s)
UPC/BARCODE
087614060484
IngredientAmount% DV
Sulforaphane400 mcg--

Other ingredients: Rice Flour, Hypromellose, May contain one or both of the following

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Enhances the liver's detoxification capacity Supports the body's defenses against oxidative stress and cell damage Science-Backed Quality Since 1969

Warning: For adults only.

Antioxidant and detox support 400 mcg per capsule Green foods formula

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take one veggie capsule per day with water.

Brand IP Statement(s)

BroccoPhane is a registered trademark of Cyvex Nutrition, Inc., d/b/a Nutegrity. BroccoPhane Broccoli sprout powder

Precautions

Consult your physician before using this or any product if you are pregnant or nursing, taking medication or if you have a medical condition.

Keep out of reach of children.

Do not use if seal is broken.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

Sulforaphane from Broccoli sprout extract

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Sulforaphane 400 mcg by Swanson label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Sulforaphane 400 mcg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Sulforaphane 400 mcg by Swanson

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Veggie Capsule(s) Dosage formCapsule Amounts shown are per serving.

Sulforaphane

Interacts with
722 drugs
400 mcg per serving Form: BroccoPhane 20:1 Broccoli sprout concentrate

Sulforaphane is a natural compound found in broccoli and other cruciferous vegetables that has shown promising antioxidant and anti-inflammatory effec...

Sulforaphane monograph & interactions

Other (inactive) ingredients: Rice Flour, Hypromellose, May contain one or both of the following. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sulforaphane 400 mcg by Swanson Drug Interactions

Want to check YOUR meds against Sulforaphane 400 mcg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
722Drugs
722 Moderate

Ingredients driving the most interactions

Sulforaphane 722

Individual Drug Interactions

The ingredients in Sulforaphane 400 mcg interact with 722 drugs. Click any drug to see the details.

1 of the 1 ingredient in Sulforaphane 400 mcg interact with drugs. Each result below shows which ingredient is responsible. Sulforaphane

Each ingredient & the kinds of drugs it affects

For each ingredient in Sulforaphane 400 mcg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Sulforaphane3 drug types · 722 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, sulforaphane might alter the levels and clinical effects of CYP1A2 substrates.
Animal and in vitro research shows that sulforaphane inhibits CYP1A2 enzyme activity. However, its precursor glucoraphanin also appears to increase the expression of the CYP1A2 enzyme, which could lead to increased metabolism of CYP1A2 substrates. These effects have not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, sulforaphane might increase the levels and effects of CYP2E1 substrates.
In vitro evidence shows that sulforaphane inhibits CYP2E1 enzymes. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, sulforaphane might increase the levels and effects of CYP3A4 substrates.
Animal and in vitro research shows that sulforaphane inhibits CYP3A4 enzyme activity and downregulates its expression. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Sulforaphane full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Sulforaphane 400 mcg, from the product label.

Swanson

See all Swanson products
Name
Swanson Health Products
City
Fargo
State
ND
ZipCode
58104
Phone Number
1-800-437-4148
Web Address
swanson.com
Pharmacist Counseling Corner

Sulforaphane 400 mcg by Swanson: Common Questions

Does Sulforaphane 400 mcg by Swanson interact with any medications?
Yes. Based on its ingredients, Sulforaphane 400 mcg has a known interaction with 722 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sulforaphane 400 mcg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is sulforaphane, and where does it come from?
Sulforaphane is a natural compound found in broccoli and other cruciferous vegetables. This supplement provides a concentrated dose of it in capsule form.
Does sulforaphane actually work for prostate cancer or other conditions?
It's rated possibly effective for prostate cancer based on current evidence. For hay fever, asthma, and cancer in general, there isn't enough reliable evidence yet to say whether it works. The evidence is still developing.
What side effects should I watch for?
The most common ones are bowel discomfort, heartburn, stomach upset, and vomiting. Some people have reported headache, insomnia, or irritability. There are also rare reports of seizure in males with autism. Weight gain has been observed in one study.
Is it safe to take while pregnant or breastfeeding?
Concentrated supplements haven't been proven safe in pregnancy, so avoid them and get your sulforaphane from food instead. While breastfeeding, there's not enough data on supplement doses, so talk with your pharmacist about what's right for you.
How does sulforaphane interact with medications?
It affects how your liver breaks down certain drugs by interfering with three major enzyme systems. This can raise the levels of some medications in your body. Because 712 medications are potentially affected, check your exact drugs with our interaction tool before you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sulforaphane 400 mcg label
Go deeper

The Full Monographs Behind Sulforaphane 400 mcg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sulforaphane

Interacts with 722 drugs

Sulforaphane is a natural compound found in broccoli and other cruciferous vegetables that has shown promising antioxidant and anti-inflammatory effects in lab studies, but strong human evid...

Read the full Sulforaphane monograph →
Sources

Sources & How We Checked

Sulforaphane 400 mcg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sulforaphane 16 references
  1. Park EJ, Pezzuto JM. Botanicals in cancer chemoprevention. Cancer Metastasis Rev 2002;21:231-55. PubMed
  2. Barcelo S, Mace K, Pfeifer AM, Chipman JK. Production of DNA strand breaks by N-nitrosodimethylamine and 2-amino-3-methylimidazo[4,5-f]quinoline in THLE cells expressing human CYP isoenzymes and inhibition by sulforaphane. Mutat Res 1998;402:111-20. PubMed
  3. Cipolla BG, Mandron E, Lefort JM, et al. Effect of sulforaphane in men with biochemical recurrence after radical prostatectomy. Cancer Prev Res (Phila). 2015;8(8):712-9. PubMed
  4. Fahey JW, Wade KL, Wehage SL, et al. Stabilized sulforaphane for clinical use: Phytochemical delivery efficiency. Mol Nutr Food Res. 2017 Apr;61(4). PubMed
  5. Alumkal JJ, Slottke R, Schwartzman J, et al. A phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer. Invest New Drugs. 2015;33(2):480-9. PubMed
  6. Heber D, Li Z, Garcia-Lloret M, et al. Sulforaphane-rich broccoli sprout extract attenuates nasal allergic response to diesel exhaust particles. Food Funct. 2014;5(1):35-41. PubMed
  7. Singh K, Connors SL, Macklin EA, et al. Sulforaphane treatment of autism spectrum disorder (ASD). Proc Natl Acad Sci U S A. 2014;111(43):15550-5. PubMed
  8. Wise RA, Holbrook JT, Criner G, et al. Lack of effect of oral sulforaphane administration on Nrf2 expression in COPD: A randomized, double-blind, placebo controlled trial. PLoS One. 2016;11(11):e0163716. PubMed
  9. Bent S, Lawton B, Warren T, et al. Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli. Mol Autism. 2018;9:35. PubMed
  10. Momtazmanesh S, Amirimoghaddam-Yazdi Z, Moghaddam HS, Mohammadi MR, Akhondzadeh S. Sulforaphane as an adjunctive treatment for irritability in children with autism spectrum disorder: A randomized, double-blind, placebo-controlled clinical trial. Psychiatr PubMed
  11. Fimognari C, Lenzi M, Hrelia P. Interaction of the isothiocyanate sulforaphane with drug disposition and metabolism: pharmacological and toxicological implications. Curr Drug Metab. 2008;9(7):668-78. PubMed
  12. Chinnappan SM, George A, Evans M, Anthony J. Efficacy of Labisia pumila and Eurycoma longifolia standardised extracts on hot flushes, quality of life, hormone and lipid profile of peri-menopausal and menopausal women: a randomised, placebo-controlled stud
  13. Mahéo K, Morel F, Langouët S, et al. Inhibition of cytochromes P-450 and induction of glutathione S-transferases by sulforaphane in primary human and rat hepatocytes. Cancer Res. 1997;57(17):3649-52.
  14. Yoxall V, Kentish P, Coldham N, Kuhnert N, Sauer MJ, Ioannides C. Modulation of hepatic cytochromes P450 and phase II enzymes by dietary doses of sulforaphane in rats: Implications for its chemopreventive activity. Int J Cancer. 2005;117(3):356-62. PubMed
  15. Zimmerman AW, Singh K, Connors SL, et al. Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder. Mol Autism 2021;12(1):38.
  16. Yusin J, Wang V, Henning SM, et al. The effect of broccoli sprout extract on seasonal grass pollen-induced allergic rhinitis. Nutrients 2021;13(4):1337. PubMed

See these in context on the Sulforaphane monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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