Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Super 6 Mushroom Complex Ingredients & Drug Interactions

by Nature's Truth

Super 6 Mushroom Complex label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Super 6 Mushroom Complex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Super 6 Mushroom Complex is a dietary supplement by Nature's Truth with 6 active ingredients. Its ingredients are commonly taken for memory and cognitive support, nerve health, mood and anxiety.Based on those ingredients, 662 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Reishi Mushroom Fruiting Body Extract, Lion's Mane Mushroom, Chaga Mushroom. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Super 6 Mushroom Complex by Nature's Truth

Ask about any prescription or over-the-counter medication and we check it for interactions with Super 6 Mushroom Complex by Nature's Truth — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Super 6 Mushroom Complex by Nature's Truth

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • “Maitake” is listed as a grouped ingredient — the label gives one combined amount (100 mg) without saying how much of each component you get.
  • “Shiitake” is listed as a grouped ingredient — the label gives one combined amount (100 mg) without saying how much of each component you get.

Super 6 Mushroom Complex contains 6 active mushroom ingredients: lion's mane mushroom, maitake (also listed as a separate maitake mushroom extract), shiitake (listed both as whole mushroom and as shiitake mushroom extract), reishi mushroom fruiting body extract, chaga mushroom, and cordyceps mushroom. Each brings its own compounds—polysaccharides, beta-glucans, and other bioactive molecules—that the formula is intended to deliver.

The inactive ingredients are rice powder, gelatin capsule material, magnesium stearate, and silica.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Immune support and general wellness.
  • We looked for evidence on: Common cold, Influenza, Hypercholesterolemia, Hyperlipidemia, Hypertension, Diabetes — and 4 related terms.
  • The closest evidence on file: Reishi Mushroom is rated "Possibly Ineffective" for Hyperlipidemia (Natural Medicines).
  • Also on file: Maitake Mushroom is rated "Insufficient Reliable Evidence To Rate" for Chronic fatigue syndrome (CFS), Diabetes, Chemotherapy-related fatigue, Hyperlipidemia, and more.
  • Also on file: Cordyceps is rated "Insufficient Reliable Evidence To Rate" for Fatigue.

The evidence on these mushrooms is incomplete. For lion's mane, we hold insufficient evidence to rate its effects on cognitive function, cognitive impairment, anxiety, Alzheimer's disease, athletic performance, and cancer.

Reishi shows possibly ineffective evidence for cholesterol (hyperlipidemia), though we lack reliable data for Alzheimer's disease, athletic performance, and altitude sickness. Maitake, chaga, cordyceps, and shiitake similarly carry insufficient evidence for the conditions we've reviewed—ranging from allergies and cancer to athletic performance and fatigue.

In short, what these mushrooms are marketed for isn't well established in the data we hold.

The evidence, ingredient by ingredient Lion's Mane Mushroom Maitake Mushroom Shiitake Mushroom Reishi Mushroom Chaga Cordyceps

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lion's mane, reishi, maitake, chaga, and cordyceps are generally well tolerated as foods and short-term supplements, though long-term human safety is not well studied. Common side effects are gastrointestinal—nausea, stomach upset, diarrhea, and discomfort.

Shiitake cooked as a food is generally well tolerated; raw shiitake can cause a distinctive rash called shiitake dermatitis, and handling raw mushrooms can trigger allergic skin reactions or respiratory symptoms in sensitive people. Chaga contains high amounts of oxalate; excessive consumption has been linked to kidney problems in rare cases.

One case of liver inflammation (cholestatic hepatitis) was reported with a cordyceps product, though causation is unclear. Do not use any of these ingredients during pregnancy or while breastfeeding—there isn't enough safety data.

Side effects, ingredient by ingredient Lion's Mane Mushroom Maitake Mushroom Shiitake Mushroom Reishi Mushroom Chaga Cordyceps

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 6 of the 6 matched ingredients can interact with medications — Maitake Mushroom, Cordyceps, Shiitake Mushroom, Reishi Mushroom, Chaga, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 662 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your pharmacist if you take blood-thinning drugs (anticoagulants or antiplatelet agents, including warfarin, aspirin, or clopidogrel)—Moderate risk of increased bleeding. Similarly, check if you take blood sugar medications (Moderate risk of low blood sugar), blood pressure medications (Moderate risk of low blood pressure), or immune-suppressing drugs like cyclosporine or tacrolimus (Moderate risk of reduced effectiveness).

If you take drugs metabolized by the liver enzyme CYP2D6, shiitake mushroom may lower their levels.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you're taking blood thinners, blood pressure medicines, blood sugar medications, or immune-suppressing drugs, you need to check your specific medications before using this product. Talk to your pharmacist or doctor first.

Healthy people without these medications who want to try mushroom supplements should know the long-term safety data are thin, and the evidence for what they're marketed to do isn't solid.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Super 6 Mushroom Complex, straight from the product label.

Brand Nature's Truth
Barcode (UPC) 840093112248
Net contents 60 Quick Release Capsule(s)
Market status On market
Date entered into DSLD Mar 22, 2024
DSLD ID 306821
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Super 6 Mushroom Complex by Nature's Truth, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Quick Release Capsule(s)
Maximum serving Sizes:
1 Quick Release Capsule(s)
Servings per container
60
UPC/BARCODE
840093112248
IngredientAmount% DV
Lion's Mane Mushroom50 mg--
Maitake100 mg--
Shiitake100 mg--
Reishi Mushroom Fruiting Body Extract100 mg--
Maitake Mushroom Extract25 mg--
Chaga Mushroom50 mg--
Shiitake mushroom extract25 mg--
Cordyceps Mushroom50 mg--

Other ingredients: Rice, Powder, Gelatin, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

100% Quality Satisfaction guarantee

Formula

Vitamins Maitake, Reishi, Shiitake, Lion's Mane, Cordyceps, & Chaga

Full Spectrum Blend

Formulation

Gluten Free Non GMO

No gluten, wheat, yeast, milk, lactose, soy, artificial color, artificial flavor, artificial sweetener, preservatives.

Our Non-GMO Pledge Visit our website

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: For adults, take one (1) quick release capsule daily, preferably with a meal.

Precautions

Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

If any adverse reactions occur, immediately stop using this product and consult your doctor. If seal under cap is damaged or missing, do not use.

Keep out of reach of children.

Storage

Store in a cool, dry place.

Brand IP Statement(s)

Copyright 2021 Nature's Truth LLC

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Super 6 Mushroom Complex by Nature's Truth label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Super 6 Mushroom Complex label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Super 6 Mushroom Complex by Nature's Truth

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Quick Release Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lion's Mane Mushroom

Interacts with
327 drugs
50 mg per serving Form: Hericium erinaceus

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and...

Lion's Mane Mushroom monograph & interactions

Maitake

Interacts with
260 drugs
100 mg per serving

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and bl...

Maitake monograph & interactions

Shiitake

Interacts with
312 drugs
100 mg per serving

Shiitake is a popular edible mushroom that is nutritious and safe to eat as food for most people. Some of its extracts (like lentinan and AHCC) have b...

Shiitake monograph & interactions

Reishi Mushroom Fruiting Body Extract

Interacts with
375 drugs
100 mg per serving Form: Ganoderma lucidum Fruiting Body Extract

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits...

Reishi Mushroom Fruiting Body Extract monograph & interactions

Chaga Mushroom

Interacts with
327 drugs
50 mg per serving Form: Inonotus obliquus

Chaga is a fungus that grows mostly on birch trees and is used as a tea or supplement, mainly for immune and antioxidant support. Human evidence for i...

Chaga Mushroom monograph & interactions

Cordyceps Mushroom

Interacts with
249 drugs
50 mg per serving Form: Cordyceps sinensis

Cordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited an...

Cordyceps Mushroom monograph & interactions

Other (inactive) ingredients: Rice, Powder, Gelatin, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Super 6 Mushroom Complex by Nature's Truth Drug Interactions

Want to check YOUR meds against Super 6 Mushroom Complex?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
662Drugs
654 Moderate 8 Minor

Ingredients driving the most interactions

Reishi Mushroom Fruiting Body Extract 375
Lion's Mane Mushroom 327
Chaga Mushroom 327
Shiitake 312
Maitake 260

Individual Drug Interactions

The ingredients in Super 6 Mushroom Complex interact with 662 drugs. Click any drug to see the details.

6 of the 6 ingredients in Super 6 Mushroom Complex interact with drugs. Each result below shows which ingredient is responsible. Reishi Mushroom Fruiting Body Extract Lion's Mane Mushroom Chaga Mushroom Shiitake Maitake Cordyceps Mushroom

Each ingredient & the kinds of drugs it affects

For each ingredient in Super 6 Mushroom Complex with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Reishi Mushroom Fruiting Body Extract3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.

Likelihood Possible Evidence D
Reishi Mushroom Fruiting Body Extract full monograph & interactions

Lion's Mane Mushroom3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
Lion's Mane Mushroom full monograph & interactions

Chaga Mushroom3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, chaga may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that chaga extract can inhibit platelet aggregation. This effect has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking chaga with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that chaga might decrease blood glucose levels and increase insulin levels. This has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, chaga might interfere with immunosuppressive therapy.
In vitro research suggests that certain constituents of chaga stimulate immune function. This has not been reported in humans.

Likelihood Possible Evidence D
Chaga Mushroom full monograph & interactions

Shiitake2 drug types · 312 drugs

Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
In vitro studies suggest that the shiitake mushroom extract AHCC might induce the CYP2D6 enzyme. This effect has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking shiitake mushroom might decrease the effects of immunosuppressive therapy.
In vitro evidence suggests that shiitake mushroom extracts stimulate immune function.

Likelihood Possible Evidence D
Shiitake full monograph & interactions

Maitake3 drug types · 260 drugs

Antidiabetes Drugs

Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking maitake mushroom polysaccharide (MMP) can lower blood glucose levels in patients with types 2 diabetes.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that maitake mushroom can lower blood pressure.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that maitake mushroom may increase the anticoagulant effects of warfarin.
In a case report, a patient previously stabilized on warfarin developed an elevated international normalized ratio (INR) of 5.1 after taking maitake mushroom (Grifron-Pro Maitake D-Fraction) 1 drop/kg daily in three divided doses for one week. The elevated INR resolved after holding warfarin for two days, then reducing the dose by 11%. It is thought that the beta-glucan constituent of maitake mushroom might cause warfarin dissociation from proteins, resulting in increased free warfarin levels and increased warfarin effects.

Likelihood Possible Evidence D
Maitake full monograph & interactions

Cordyceps Mushroom3 drug types · 249 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro and animal research suggests that cordyceps extract inhibits platelet aggregation and function. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Animal and in vitro research suggests that cordyceps stimulates the immune system. However, limited clinical research suggests that taking cordyceps may lower the necessary therapeutic dose of the immunosuppressant cyclosporine, which suggests that cordyceps may have an immunosuppressive effect.

Likelihood Possible Evidence B
Testosterone

Theoretically, concurrent use of cordyceps and testosterone might have additive effects.
Animal research suggests that cordyceps can increase testosterone levels. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
Cordyceps Mushroom full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Super 6 Mushroom Complex, from the product label.

Nature's Truth

See all Nature's Truth products
Name
Nature's Truth LLC
City
Ronkonkoma
State
NY
ZipCode
11779
Phone Number
1-844-544-1030
Web Address
naturestruthproducts.com
Pharmacist Counseling Corner

Super 6 Mushroom Complex by Nature's Truth: Common Questions

Does Super 6 Mushroom Complex by Nature's Truth interact with any medications?
Yes. Based on its ingredients, Super 6 Mushroom Complex has a known interaction with 662 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Super 6 Mushroom Complex contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or nursing?
No, the safety data for all six mushroom ingredients advise against use during pregnancy and while breastfeeding. There isn't enough information to know if they're safe for your baby. Talk with your OB or midwife before taking any new supplement while pregnant or nursing.
What side effects should I watch for?
The most common are stomach-related: nausea, diarrhea, bloating, and abdominal discomfort. Dizziness, dry mouth, and rash can occur. With raw shiitake (not in this product), a distinctive whiplash-like rash called shiitake dermatitis is possible. If you develop persistent stomach upset or any allergic symptoms like rash or difficulty breathing, stop and contact your pharmacist or doctor.
Does this actually work for what it claims?
Honestly, we don't have solid evidence yet. For most of the conditions these mushrooms are marketed for—memory, focus, energy, athletic performance—the data either isn't established or is insufficient. That doesn't mean it's ineffective, just that we need better human research.
Is this a whole-food mushroom product or an extract?
It's a mix. Some ingredients are whole mushroom powders (lion's mane and the separate maitake and shiitake listings), while others are concentrated extracts (reishi mushroom fruiting body extract, maitake mushroom extract, and shiitake mushroom extract). Extracts are more concentrated and may carry different interaction risks than whole foods.
Can I take this long-term?
The safety data we have are mostly short-term. Long-term human safety hasn't been well studied for any of these mushrooms, so there's genuine uncertainty about regular use over months or years. If you want to take it long-term, discuss a plan with your pharmacist.
What are the inactive ingredients?
The capsule contains rice powder, gelatin, magnesium stearate (a processing aid), and silica. If you're allergic to any of these or follow a vegetarian or vegan diet, note that the capsule is gelatin (animal-derived).

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Super 6 Mushroom Complex is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Super 6 Mushroom Complex label
Go deeper

The Full Monographs Behind Super 6 Mushroom Complex’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph → Herb & supplement monograph

Maitake Mushroom

Interacts with 260 drugs

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and blood pressure effects. The human evidence...

Read the full Maitake Mushroom monograph → Herb & supplement monograph

Shiitake Mushroom

Interacts with 312 drugs

Shiitake is a popular edible mushroom that is nutritious and safe to eat as food for most people. Some of its extracts (like lentinan and AHCC) have been studied as immune support, mainly al...

Read the full Shiitake Mushroom monograph → Herb & supplement monograph

Reishi Mushroom

Interacts with 375 drugs

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should...

Read the full Reishi Mushroom monograph → Herb & supplement monograph

Chaga

Interacts with 327 drugs

Chaga is a fungus that grows mostly on birch trees and is used as a tea or supplement, mainly for immune and antioxidant support. Human evidence for its benefits is very limited, and it may...

Read the full Chaga monograph → Herb & supplement monograph

Cordyceps

Interacts with 249 drugs

Cordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited and mostly low quality, so its benefits ar...

Read the full Cordyceps monograph →
Sources

Sources & How We Checked

Super 6 Mushroom Complex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 121 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lion's Mane Mushroom 6 references
  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
  2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
  3. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
  4. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

See these in context on the Lion's Mane Mushroom monograph →

Maitake Mushroom 8 references
  1. Kabir Y, Kimura S. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol (Tokyo) 1989;35:91-4. PubMed
  2. Kabir Y, Yamaguchi M, Kimura S. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo) 1987;33:341-6. PubMed
  3. Konno S, Tortorelis DG, Fullerton SA, et al. A possible hypoglycaemic effect of maitake mushroom on Type 2 diabetic patients. Diabet Med 2001;18:1010. PubMed
  4. Chen JT, Tominaga K, Sato Y, et al. Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate. J Altern Compl
  5. Hanselin MR, Vande Griend JP, Linnebur SA. INR elevation with maitake extract in combination with warfarin. Ann Pharmacother 2010;44:223-4. PubMed
  6. Talpur, N. A., Echard, B. W., Fan, A. Y., Jaffari, O., Bagchi, D., and Preuss, H. G. Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains. Mol.Cell Biochem. 2002;237(1-2):129-136. PubMed
  7. Deng, G., Lin, H., Seidman, A., Fornier, M., D'Andrea, G., Wesa, K., Yeung, S., Cunningham-Rundles, S., Vickers, A. J., and Cassileth, B. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: i
  8. Wesa KM, Cunningham-Rundles S, Klimek VM, et al. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunol Immunother 2015;64(2):237-47. PubMed

See these in context on the Maitake Mushroom monograph →

Shiitake Mushroom 67 references
  1. Hitosugi M, Kitamura O, Takatsu A, Yoshino Y. Autopsy case of duodenal obstruction from impacted mushroom. J Gastroenterol 1998;33:562-5. PubMed
  2. Hanada K, Hashimoto I. Flagellate mushroom (Shiitake) dermatitis and photosensitivity. Dermatol 1998;197:255-7. PubMed
  3. Levy AM, Kita H, Phillips SF, et al. Eosinophilia and gastrointestinal symptoms after ingestion of shiitake mushrooms. J Allergy Clin Immunol 1998;101:613-20. PubMed
  4. Murakami M, Kawabe K, Hosoi Y, et al. Decreased pulmonary perfusion in hypersensitivity pneumonitis caused by Shiitake mushroom spores. J Intern Med 1997;241:85-8. PubMed
  5. Matsui S, Nakazawa T, Umegae Y, Mori M. Hypersensitivity pneumonitis induced by Shiitake mushroom spores. Intern Med 1992;31:1204-6.
  6. Nakamura T. Shiitake (Lentinus edodes) dermatitis. Contact Dermatitis 1992;27:65-70.
  7. Ueda A, Obama K, Aoyama K, et al. Allergic contact dermatitis in shiitake (Lentinus edodes (Berk) Sing) growers. Contact Dermatitis 1992;26:228-33.
  8. Burikhanov, R. B., Wakame, K., Igarashi, Y., Wang, S., and Matsuzaki, S. Suppressive effect of active hexose correlated compound (AHCC) on thymic apoptosis induced by dexamethasone in the rat. Endocr.Regul. 2000;34(4):181-188.
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Chaga 9 references
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Cordyceps 14 references
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