Interactions on record — worth a quick check against your medications. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

Super Carnosine 500 mg Ingredients & Drug Interactions

by Life Extension

Super Carnosine 500 mg label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Super Carnosine 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Super Carnosine 500 mg is a dietary supplement by Life Extension with 4 active ingredients. Its ingredients are commonly taken for preventing or treating thiamine deficiency, beriberi, wernicke-korsakoff syndrome (alcohol-related).Based on those ingredients, 89 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Carnosine, Thiamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Super Carnosine 500 mg by Life Extension

Ask about any prescription or over-the-counter medication and we check it for interactions with Super Carnosine 500 mg by Life Extension — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Super Carnosine 500 mg by Life Extension

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 4 active ingredients. Thiamine is a B vitamin that your body needs to process energy and maintain nerve function.

L-Carnosine is a compound made from amino acids. Benfotiamine is a fat-soluble form of thiamine designed for better absorption.

Luteolin is a plant compound. The capsule itself is made from vegetable cellulose, and the formula also contains rice flour, ascorbyl palmitate, silica, and hydroxypropyl methylcellulose as inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Protects muscle cell membranes.
  • We looked for evidence on: Athletic performance, muscle strength, muscle endurance, exercise recovery.
  • The closest evidence on file: Carnosine is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).

The evidence is strongest for thiamine alone — it's effective for thiamine deficiency and Wernicke-Korsakoff syndrome (a serious brain condition from severe B1 lack). Thiamine is possibly effective for period pain (dysmenorrhea).

Benfotiamine is possibly effective for diabetic neuropathy (nerve damage from diabetes). For the other uses listed — L-Carnosine and benfotiamine in age-related mental decline, Alzheimer disease, athletic performance, and cataracts — the evidence isn't established enough to rate, or it suggests the ingredient doesn't work for that condition.

The data we hold doesn't establish effectiveness for the other uses claimed on the label.

The evidence, ingredient by ingredient Thiamine Carnosine Benfotiamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Thiamine is generally very safe by mouth in normal amounts. L-Carnosine has been generally well tolerated in short-term studies, but long-term safety data are limited; some people report decreased appetite, dry mouth, minor weight changes, foot or joint pain, and rarely pneumonia.

Benfotiamine is generally well tolerated in studies, though long-term safety isn't fully known. In one clinical trial of 98 people taking benfotiamine 300–600 mg daily for 6 weeks, a small number reported allergic skin reactions and slight stomach discomfort, at rates no higher than placebo.

Thiamine is needed in pregnancy and while breastfeeding — use only at recommended amounts under your doctor's guidance. For L-Carnosine and benfotiamine, there isn't enough safety information in pregnancy or while breastfeeding; talk with your doctor before use if you're pregnant or nursing.

Safety data for luteolin while pregnant or breastfeeding isn't on file.

Side effects, ingredient by ingredient Thiamine Carnosine Benfotiamine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Thiamine, Carnosine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 89 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, double-check with your pharmacist if you take antidiabetes drugs (blood sugar medications) — carnosine may theoretically increase low blood sugar risk. Also mention if you take trimethoprim, an antibiotic that may raise thiamine levels.

No other drug interactions are documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product may be worth considering if you're deficient in thiamine or looking to support your nerves, though the evidence for most other uses is limited or mixed. If you take diabetes medications or the antibiotic trimethoprim, check with your pharmacist before starting — carnosine may lower blood sugar, and trimethoprim can raise thiamine levels.

Talk to your pharmacist about how this fits with your medications and health needs.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Super Carnosine 500 mg, straight from the product label.

Brand Life Extension
Barcode (UPC) 737870168799
Net contents 90 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD May 22, 2016
DSLD ID 59813
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Super Carnosine 500 mg by Life Extension, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
UPC/BARCODE
737870168799
IngredientAmount% DV
Thiamine50 mg333%
L-Carnosine500 mg--
Benfotiamine50 mg--
Luteolin4 mg--

Other ingredients: Vegetable Cellulose, Rice Flour, Ascorbyl Palmitate, Silica, Hydroxypropyl Methylcellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Scan for product info

Protects Muscle Cell Membranes

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Suggested/Recommended/Usage/Directions

Read the entire label and follow the directions carefully prior to use. DIRECTIONS: Take one (1) capsule two to three times daily with or without food, or as recommended by a healthcare practitioner.

Storage

Store tightly closed in a cool, dry place.

Precautions

WARNINGS: - KEEP OUT OF REACH OF CHILDREN.

- DO NOT EXCEED RECOMMENDED DOSE. - Do not purchase if outer seal is broken or damaged.

- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

General

Q01687E

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Super Carnosine 500 mg by Life Extension label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Super Carnosine 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Super Carnosine 500 mg by Life Extension

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Thiamine

Interacts with
3 drugs
50 mg per serving Form: Thiamine Hydrochloride, Vitamin B1

Thiamine (vitamin B1) is an essential nutrient your body needs to turn food into energy and to keep your nerves and heart healthy. Most people get eno...

Thiamine monograph & interactions

L-Carnosine

Interacts with
86 drugs
500 mg per serving

Carnosine is a naturally occurring dipeptide (made of beta-alanine and histidine) that acts as an antioxidant and buffer in muscle and brain. It is so...

L-Carnosine monograph & interactions

Benfotiamine

No known
interactions
50 mg per serving

Benfotiamine is a man-made, fat-soluble form of vitamin B1 (thiamine) that the body may absorb more easily than regular thiamine. It is mostly studied...

Benfotiamine monograph & interactions

Luteolin

4 mg per serving Form: Orange extract

Other (inactive) ingredients: Vegetable Cellulose, Rice Flour, Ascorbyl Palmitate, Silica, Hydroxypropyl Methylcellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Super Carnosine 500 mg by Life Extension Drug Interactions

Want to check YOUR meds against Super Carnosine 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
89Drugs
86 Moderate 3 Minor

Ingredients driving the most interactions

L-Carnosine 86
Thiamine 3

Individual Drug Interactions

The ingredients in Super Carnosine 500 mg interact with 89 drugs. Click any drug to see the details.

2 of the 4 ingredients in Super Carnosine 500 mg interact with drugs. Each result below shows which ingredient is responsible. L-Carnosine Thiamine

Each ingredient & the kinds of drugs it affects

For each ingredient in Super Carnosine 500 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Carnosine1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking carnosine with antidiabetes drugs might increase the risk of hypoglycemia.
Some, but not all, preliminary clinical research shows that carnosine might reduce fasting blood glucose levels.

Likelihood Possible Evidence D
L-Carnosine full monograph & interactions

Thiamine1 drug type · 3 drugs

Trimethoprim (Proloprim)

Trimethoprim might increase blood levels of thiamine.
In vitro, animal, and clinical research suggest that trimethoprim inhibits intestinal thiamine transporter ThTR-2, hepatic transporter OCT1, and renal transporters OCT2, MATE1, and MATE2, resulting in paradoxically increased thiamine plasma concentrations.

Likelihood Probable Evidence B
Thiamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Super Carnosine 500 mg, from the product label.

Life Extension

See all Life Extension products
Name
Quality Supplements and Vitamins, Inc.
City
Ft. Lauderdale
State
FL
ZipCode
33309
Phone Number
1-866-280-2852
Web Address
LifeExtension.com
Pharmacist Counseling Corner

Super Carnosine 500 mg by Life Extension: Common Questions

Does Super Carnosine 500 mg by Life Extension interact with any medications?
Yes. Based on its ingredients, Super Carnosine 500 mg has a known interaction with 89 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Super Carnosine 500 mg contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this product safe if I'm pregnant or breastfeeding?
Thiamine is needed during pregnancy and breastfeeding, so use it at your doctor's recommended dose. L-Carnosine and benfotiamine don't have enough safety data in pregnancy or while nursing — talk with your doctor before using them in these situations. We don't have safety information on file for luteolin during pregnancy or breastfeeding.
What does L-Carnosine do in this product?
L-Carnosine is an amino acid compound. The evidence we hold shows it doesn't appear to help with autism spectrum disorder, and we don't have enough data to rate whether it helps with age-related mental decline, Alzheimer disease, athletic performance, or cataracts.
Does benfotiamine work differently than regular thiamine?
Yes — benfotiamine is a fat-soluble form of thiamine designed for better absorption. It's possibly effective for diabetic neuropathy (nerve pain from diabetes), whereas regular thiamine is effective for thiamine deficiency and Wernicke-Korsakoff syndrome.
What side effects might I see from this product?
Thiamine rarely causes allergic reactions. L-Carnosine may cause decreased appetite, dry mouth, minor weight changes, foot or joint pain, or rarely pneumonia. Benfotiamine may cause allergic skin reactions or slight stomach discomfort, though these occurred in small numbers in one trial.
Can I take this with my diabetes medication?
That's a key question to ask your pharmacist. Carnosine in this product may theoretically lower blood sugar levels, so your diabetes medications might work too well if you combine them — raising the risk of low blood sugar.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Super Carnosine 500 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Super Carnosine 500 mg label
Go deeper

The Full Monographs Behind Super Carnosine 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Thiamine

Interacts with 3 drugs

Thiamine (vitamin B1) is an essential nutrient your body needs to turn food into energy and to keep your nerves and heart healthy. Most people get enough from food, but supplements are clear...

Read the full Thiamine monograph → Herb & supplement monograph

Carnosine

Interacts with 86 drugs

Carnosine is a naturally occurring dipeptide (made of beta-alanine and histidine) that acts as an antioxidant and buffer in muscle and brain. It is sold as an anti-aging and performance supp...

Read the full Carnosine monograph → Herb & supplement monograph

Benfotiamine

Benfotiamine is a man-made, fat-soluble form of vitamin B1 (thiamine) that the body may absorb more easily than regular thiamine. It is mostly studied for diabetic nerve problems, but the ev...

Read the full Benfotiamine monograph →
Sources

Sources & How We Checked

Super Carnosine 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 13 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Thiamine 7 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  4. Rogovik, A. L., Vohra, S., and Goldman, R. D. Safety considerations and potential interactions of vitamins: should vitamins be considered drugs? Ann.Pharmacother. 2010;44(2):311-324. PubMed
  5. Arruti N, Bernedo N, Audicana MT, Villarreal O, Uriel O, Muñoz D. Systemic allergic dermatitis caused by thiamine after iontophoresis. Contact Dermatitis. 2013 Dec;69(6):375-6. PubMed
  6. Thiamine hydrochloride injection package insert. Lake Zurich, IL: Fresenius Kabi, LLC; September 2019.
  7. Vora B, Wen A, Yee SW, et al. The Effect of Trimethoprim on Thiamine Absorption: A Transporter-Mediated Drug-Nutrient Interaction. Clin Pharmacol Ther 2023;114(2):381-392.

See these in context on the Thiamine monograph →

Carnosine 5 references
  1. Chengappa KN, Turkin SR, DeSanti S, et al. A preliminary, randomized, double-blind, placebo-controlled trial of L-carnosine to improve cognition in schizophrenia. Schizophr Res 2012;142(1-3):145-52. PubMed
  2. Karkabounas S, Papadopoulos N, Anastasiadou C, et al. Effects of a-lipoic Acid, carnosine, and thiamine supplementation in obese patients with type 2 diabetes mellitus: A randomized, double-blind study. J Med Food. 2018;21(12):1197-1203.
  3. Peng W, Mao P, Liu L, et al. Effect of carnosine supplementation on lipid profile, fasting blood glucose, HbA1C and insulin resistance: a systematic review and meta-analysis of long-term randomized controlled trials. Complement Ther Med 2020;48:102241. PubMed
  4. Siriwattanasit N, Satirapoj B, Supasyndh O. Effect of oral carnosine supplementation on urinary TGF-ß in diabetic nephropathy: a randomized controlled trial. BMC Nephrol 2021;22(1):236. PubMed
  5. Sureshkumar K, Durairaj M, Srinivasan K, et al. Effect of L-Carnosine in Patients with Age-Related Diseases: A Systematic Review and Meta-Analysis. Front Biosci (Landmark Ed) 2023;28(1):18. PubMed

See these in context on the Carnosine monograph →

Benfotiamine 1 reference
  1. Stracke H, Gaus W, Achenbach U, Federlin K, Bretzel RG. Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study. Exp Clin Endocrinol Diabetes 2008;116(10):600-5. PubMed

See these in context on the Benfotiamine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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