Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Super CLA Blend Ingredients & Drug Interactions

by Life Extension

Super CLA Blend label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Super CLA Blend against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Super CLA Blend is a dietary supplement by Life Extension with 2 active ingredients. Its ingredients are commonly taken for heart and cholesterol health, blood pressure support, source of healthy fats and minerals.Based on those ingredients, 528 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sesame seed Lignan extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Super CLA Blend by Life Extension

Ask about any prescription or over-the-counter medication and we check it for interactions with Super CLA Blend by Life Extension — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Super CLA Blend by Life Extension

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Super CLA Blend contains two ingredients. The active component is sesame seed lignan extract, which comes from sesame seeds.

The product also contains Super CLA Blend, which we don't have detailed information on. The softgel capsule also includes several inactive ingredients — gelatin, glycerin, silica, purified water, carob, sunflower lecithin, and rosemary extract — which help hold the capsule together and preserve the formula.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Sesame's overall clinical evidence instead.

Moderate

Some clinical evidence supports Sesame for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Hypertension — rated "Possibly Effective" (Natural Medicines).

Sesame seed lignan extract is rated possibly effective for high blood pressure (hypertension). For cough, the evidence suggests it's possibly ineffective.

For other uses listed — nonalcoholic fatty liver disease, HIV/AIDS-related wasting, Alzheimer disease, and anemia of chronic disease — the evidence isn't established enough to rate. We don't have effectiveness information for the Super CLA Blend ingredient itself.

The evidence, ingredient by ingredient Sesame

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sesame is a major allergen. Multiple allergic reactions to sesame have been documented — ranging from skin reactions like swelling, rash, and itching to respiratory and other symptoms.

Up to 0.5% of the U.S. population reports a sesame allergy, and 0.23% have an IgE-mediated allergic reaction (the immune type). One person in a trial experienced diarrhea.

Food amounts are generally well tolerated, but concentrated supplements are less studied. Pregnant and breastfeeding individuals should check with their doctor — safety data for concentrated sesame supplements in pregnancy and lactation is limited.

Side effects, ingredient by ingredient Sesame

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Sesame.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 528 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications before starting Super CLA Blend, especially if you take blood pressure pills (antihypertensive drugs), diabetes medications, or drugs broken down by the CYP2C9 enzyme in your liver. Tamoxifen users and anyone on P-glycoprotein substrate drugs should also check.

All of these have documented interactions with sesame seed lignan extract.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

If you have high blood pressure and want to explore sesame's effects, this could be worth discussing with your pharmacist — but only if you don't take blood pressure or diabetes medications, or tamoxifen. If you do take any of those, or if you have a sesame allergy or suspect one, skip this product and talk to your pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 21, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Super CLA Blend, straight from the product label.

Brand Life Extension
Barcode (UPC) 737870818120
Net contents 120 Softgel(s)
Market status On market
Date entered into DSLD May 21, 2025
DSLD ID 328717
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Super CLA Blend by Life Extension, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Softgel(s)
Maximum serving Sizes:
3 Softgel(s)
Servings per container
40
UPC/BARCODE
737870818120
IngredientAmount% DV
Calories30 Calorie(s)--
Total Fat3 Gram(s)4%
Sesame seed Lignan extract20 mg--
Super CLA Blend3000 mg--

Other ingredients: Gelatin, Glycerin, Silica, Water, Purified, Carob, Sunflower Lecithin, Rosemary Extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Scan for product info

Precautions

Read the entire label and follow the directions carefully prior to use.

Warnings: Keep out of reach of children.

Do not exceed recommended dose. Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Suggested/Recommended/Usage/Directions

Directions: Take three (3) softgels daily with meals. Can be taken in divided doses or all at once.

This supplement should be taken in conjunction with a healthy diet and regular exercise program. Results may vary.

Storage

Store tightly closed in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Gluten free Non GMO Le certified

Helps maintain optimum weight

Seals/Symbols

Non GMO Le certified

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Super CLA Blend by Life Extension label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Super CLA Blend label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Super CLA Blend by Life Extension

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Softgel(s) Dosage formSoftgel Capsule Servings per container40 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sesame seed Lignan extract

Interacts with
528 drugs
20 mg per serving

Sesame is a nutritious seed and oil widely used in cooking and traditional medicine, and it provides healthy fats, fiber, and antioxidant compounds ca...

Sesame seed Lignan extract monograph & interactions

Super CLA Blend

3000 mg per serving Form: Conjugated Linoleic Acid

Other (inactive) ingredients: Gelatin, Glycerin, Silica, Water, Purified, Carob, Sunflower Lecithin, Rosemary Extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

Super CLA Blend by Life Extension Drug Interactions

Want to check YOUR meds against Super CLA Blend?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
528Drugs
343 Moderate 185 Minor

Ingredients driving the most interactions

Sesame seed Lignan extract 528

Individual Drug Interactions

The ingredients in Super CLA Blend interact with 528 drugs. Click any drug to see the details.

1 of the 2 ingredients in Super CLA Blend interact with drugs. Each result below shows which ingredient is responsible. Sesame seed Lignan extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Super CLA Blend with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Sesame seed Lignan extract5 drug types · 528 drugs

Antidiabetes Drugs

Taking sesame oil with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical studies show that sesame oil can decrease plasma glucose and glycated hemoglobin (HbA1c) levels. Some clinical research in patients taking glibenclamide shows that using sesame oil or a blend of sesame oil and rice bran oil in place of other oil for cooking reduces plasma glucose more than glibenclamide alone. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Antihypertensive Drugs

Taking sesame oil with antihypertensive drugs might increase the risk of hypotension.
Clinical research shows that replacing other cooking oil with sesame oil can lower systolic blood pressure (SBP) and diastolic blood pressure (DBP) in patients with or without hypertension. There is also some evidence that sesame oil has additive effects in patients also taking atenolol, nifedipine, and/or hydrochlorothiazide. In patients using nifedipine, using a blend of sesame oil and rice bran oil for cooking reduces both SBP and DBP more than nifedipine alone.

Likelihood Probable Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, sesame might increase the levels and clinical effects of CYP2C9 substrates.
In vitro, sesame inhibits CYP2C9. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, sesame might interfere with tamoxifen.
In animal research, sesame seed reduces the tumor-inhibitory effect of tamoxifen by reducing apoptosis and increasing proliferation. This interaction has not been reported in humans.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, sesame might alter the transport of P-glycoprotein substrates.
In vitro research suggests that sesamin, a constituent of sesame, can inhibit the multi-drug transporter protein, P-glycoprotein. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Sesame seed Lignan extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Super CLA Blend, from the product label.

Life Extension

See all Life Extension products
Name
Quality Supplements and Vitamins, Inc.
City
Ft. Lauderdale
State
FL
ZipCode
33309
Phone Number
1-866-280-2852
Web Address
LifeExtension.com
Pharmacist Counseling Corner

Super CLA Blend by Life Extension: Common Questions

Does Super CLA Blend by Life Extension interact with any medications?
Yes. Based on its ingredients, Super CLA Blend has a known interaction with 528 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Super CLA Blend contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Do I need to worry about sesame allergies with this product?
Yes — sesame is a major allergen, and allergic reactions range from rashes and swelling to breathing problems. Up to 0.5% of Americans report a sesame allergy. If you have a known sesame allergy or suspect one, avoid this product.
Will this help my high blood pressure?
Sesame seed lignan extract is rated possibly effective for hypertension, so there's some evidence it may help. But if you're already taking blood pressure medication, sesame can lower your pressure too much, which is dangerous — talk to your pharmacist before combining them.
Is it safe to take this while pregnant or breastfeeding?
The safety data for concentrated sesame supplements during pregnancy and breastfeeding is limited. Check with your doctor or pharmacist for personalized advice before taking this product.
What's the difference between the two ingredients in this product?
One is sesame seed lignan extract, which we have detailed information on. The other is Super CLA Blend — we don't hold interaction or effectiveness data for that ingredient on its own.
Are there any fillers or other ingredients I should know about?
The softgel capsule contains gelatin, glycerin, silica, purified water, carob, sunflower lecithin, and rosemary extract — these are inactive ingredients that help preserve and structure the supplement.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Super CLA Blend is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Super CLA Blend label
Go deeper

The Full Monographs Behind Super CLA Blend’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sesame

Interacts with 528 drugs

Sesame is a nutritious seed and oil widely used in cooking and traditional medicine, and it provides healthy fats, fiber, and antioxidant compounds called lignans. Some early research sugges...

Read the full Sesame monograph →
Sources

Sources & How We Checked

Super CLA Blend's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 53 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sesame 53 references
  1. von Moltke LL, Weemhoff JL, Bedir E, et al. Inhibition of human cytochromes P450 by components of Ginkgo biloba. J Pharm Pharmacol 2004;56:1039-44.
  2. Sankar, D., Sambandam, G., Ramakrishna, Rao M., and Pugalendi, K. V. Modulation of blood pressure, lipid profiles and redox status in hypertensive patients taking different edible oils. Clin Chim Acta 2005;355(1-2):97-104. PubMed
  3. Sankar, D., Rao, M. R., Sambandam, G., and Pugalendi, K. V. A pilot study of open label sesame oil in hypertensive diabetics. J Med Food 2006;9(3):408-412. PubMed
  4. Sankar, D., Rao, M. R., Sambandam, G., and Pugalendi, K. V. Effect of sesame oil on diuretics or Beta-blockers in the modulation of blood pressure, anthropometry, lipid profile, and redox status. Yale J Biol.Med. 2006;79(1):19-26.
  5. Sacco, S. M., Chen, J., Power, K. A., Ward, W. E., and Thompson, L. U. Lignan-rich sesame seed negates the tumor-inhibitory effect of tamoxifen but maintains bone health in a postmenopausal athymic mouse model with estrogen-responsive breast tumors. Menop PubMed
  6. Sacco, S. M., Power, K. A., Chen, J., Ward, W. E., and Thompson, L. U. Interaction of sesame seed and tamoxifen on tumor growth and bone health in athymic mice. Exp Biol Med (Maywood) 2007;232(6):754-761.
  7. Hsiao, E. S., Lin, L. J., Li, F. Y., Wang, M. M., Liao, M. Y., and Tzen, J. T. Gene families encoding isoforms of two major sesame seed storage proteins, 11S globulin and 2S albumin. J Agric Food Chem 2006;54(25):9544-9550. PubMed
  8. Ramesh, B., Saravanan, R., and Pugalendi, K. V. Influence of sesame oil on blood glucose, lipid peroxidation, and antioxidant status in streptozotocin diabetic rats. J Med Food 2005;8(3):377-381. PubMed
  9. Panizzolo, C., Tura, M., and Barbato, A. Anaphylaxis to sesame paste. Eur Ann Allergy Clin Immunol 2005;37(1):34-35.
  10. Leduc, V., Moneret-Vautrin, D. A., Tzen, J. T., Morisset, M., Guerin, L., and Kanny, G. Identification of oleosins as major allergens in sesame seed allergic patients. Allergy 2006;61(3):349-356. PubMed
  11. Agne, P. S., Bidat, E., Agne, P. S., Rance, F., and Paty, E. Sesame seed allergy in children. Eur Ann Allergy Clin Immunol 2004;36(8):300-305.
  12. Dalal, I., Binson, I., Levine, A., Somekh, E., Ballin, A., and Reifen, R. The pattern of sesame sensitivity among infants and children. Pediatr Allergy Immunol 2003;14(4):312-316. PubMed
  13. Moneret-Vautrin, D. A., Kanny, G., and Lagrange, A. [Occupational asthma caused by organic substances]. Rev Med Interne 1994;15 Suppl 2:216s-225s.
  14. Keskinen, H., Ostman, P., Vaheri, E., Tarvainen, K., Grenquist-Norden, B., Karppinen, O., and Nordman, H. A case of occupational asthma, rhinitis and urticaria due to sesame seed. Clin Exp Allergy 1991;21(5):623-624. PubMed
  15. Alday, E., Curiel, G., Lopez-Gil, M. J., Carreno, D., and Moneo, I. Occupational hypersensitivity to sesame seeds. Allergy 1996;51(1):69-70. DOI
  16. Kubo, Y., Nonaka, S., and Yoshida, H. Contact sensitivity to unsaponifiable substances in sesame oil. Contact Dermatitis 1986;15(4):215-217. PubMed
  17. Steurich, F. [Allergy to sesame seeds]. Pneumologie 1989;43(12):710-714.
  18. Morisset, M., Moneret-Vautrin, D. A., Kanny, G., Guenard, L., Beaudouin, E., Flabbee, J., and Hatahet, R. Thresholds of clinical reactivity to milk, egg, peanut and sesame in immunoglobulin E-dependent allergies: evaluation by double-blind or single-blind
  19. Tsai, H. J., Kumar, R., Pongracic, J., Liu, X., Story, R., Yu, Y., Caruso, D., Costello, J., Schroeder, A., Fang, Y., Demirtas, H., Meyer, K. E., O'Gorman, M. R., and Wang, X. Familial aggregation of food allergy and sensitization to food allergens: a fam
  20. James, C., Williams-Akita, A., Rao, Y. A., Chiarmonte, L. T., and Scheider, A. T. Sesame seed anaphylaxis. N Y State J Med 1991;91(10):457-458.
  21. Chiu, J. T. and Haydik, I. B. Sesame seed oil anaphylaxis. J Allergy Clin Immunol 1991;88(3 Pt 1):414-415. PubMed
  22. Asero, R., Mistrello, G., Roncarolo, D., Antoniotti, P. L., and Falagiani, P. A case of sesame seed-induced anaphylaxis. Allergy 1999;54(5):526-527.
  23. Pajno, G. B., Passalacqua, G., Magazzu, G., Barberio, G., Vita, D., and Canonica, G. W. Anaphylaxis to sesame. Allergy 2000;55(2):199-201. PubMed
  24. Neering, H., Vitanyi, B. E., Malten, K. E., van Ketel, W. G., and van Dijk, E. Allergens in sesame oil contact dermatitis. Acta Derm Venereol 1975;55(1):31-34. DOI
  25. Caminiti, L., Vita, D., Passalacqua, G., Arrigo, T., Barberi, S., Lombardo, F., and Pajno, G. B. Tahini, a little known sesame-containing food, as an unexpected cause of severe allergic reaction. J Investig Allergol Clin Immunol 2006;16(5):308-310.
  26. Phan, T. G., Strasser, S. I., Koorey, D., McCaughan, G. W., Rimmer, J., Dunckley, H., Goddard, L., and Adelstein, S. Passive transfer of nut allergy after liver transplantation. Arch Intern Med 2003;163(2):237-239. PubMed
  27. Oiso, N., Yamadori, Y., Higashimori, N., Kawara, S., and Kawada, A. Allergic contact dermatitis caused by sesame oil in a topical Chinese medicine, shi-un-ko. Contact Dermatitis 2008;58(2):109.
  28. VAN Dijk, E., Dijk, E., Neering, H., and Vitanyi, B. E. Contact hypersensitivity to sesame oil in patients with leg ulcers and eczema. Acta Derm Venereol 1973;53(2):133-135. DOI
  29. Beyer, K., Bardina, L., Grishina, G., and Sampson, H. A. Identification of sesame seed allergens by 2-dimensional proteomics and Edman sequencing: seed storage proteins as common food allergens. J Allergy Clin Immunol 2002;110(1):154-159. PubMed
  30. Koopman, M., Richter, C., Parren, R. J., and Janssen, M. Bodybuilding, sesame oil and vasculitis. Rheumatology (Oxford) 2005;44(9):1135. PubMed
  31. Kagi, M. K. and Wuthrich, B. Falafel burger anaphylaxis due to sesame seed allergy. Ann Allergy 1993;71(2):127-129.
  32. Hayakawa, R., Matsunaga, K., Suzuki, M., Hosokawa, K., Arima, Y., Shin, C. S., and Yoshida, M. Is sesamol present in sesame oil? Contact Dermatitis 1987;17(3):133-135.
  33. Malish, D., Glovsky, M. M., Hoffman, D. R., Ghekiere, L., and Hawkins, J. M. Anaphylaxis after sesame seed ingestion. J Allergy Clin Immunol 1981;67(1):35-38. PubMed
  34. Fremont, S., Zitouni, N., Kanny, G., Veneri, V., Metche, M., Moneret-Vautrin, D. A., and Nicolas, J. P. Allergenicity of some isoforms of white sesame proteins. Clin Exp Allergy 2002;32(8):1211-1215. PubMed
  35. Pastorello, E. A., Varin, E., Farioli, L., Pravettoni, V., Ortolani, C., Trambaioli, C., Fortunato, D., Giuffrida, M. G., Rivolta, F., Robino, A., Calamari, A. M., Lacava, L., and Conti, A. The major allergen of sesame seeds (Sesamum indicum) is a 2S albu
  36. Wolff, N., Cogan, U., Admon, A., Dalal, I., Katz, Y., Hodos, N., Karin, N., and Yannai, S. Allergy to sesame in humans is associated primarily with IgE antibody to a 14 kDa 2S albumin precursor. Food Chem Toxicol 2003;41(8):1165-1174. PubMed
  37. Wolff, N., Yannai, S., Karin, N., Levy, Y., Reifen, R., Dalal, I., and Cogan, U. Identification and characterization of linear B-cell epitopes of beta-globulin, a major allergen of sesame seeds. J Allergy Clin Immunol 2004;114(5):1151-1158.
  38. Navuluri, L., Parvataneni, S., Hassan, H., Birmingham, N. P., Kelly, C., and Gangur, V. Allergic and anaphylactic response to sesame seeds in mice: identification of Ses i 3 and basic subunit of 11s globulins as allergens. Int Arch Allergy Immunol 2006;14 PubMed
  39. Beyer, K., Grishina, G., Bardina, L., and Sampson, H. A. Identification of 2 new sesame seed allergens: Ses i 6 and Ses i 7. J Allergy Clin Immunol 2007;119(6):1554-1556. PubMed
  40. Moreno, F. J., Rubio, L. A., Olano, A., and Clemente, A. Uptake of 2S albumin allergens, Ber e 1 and Ses i 1, across human intestinal epithelial Caco-2 cell monolayers. J Agric Food Chem 2006;54(22):8631-8639. PubMed
  41. Moreno, F. J., Maldonado, B. M., Wellner, N., and Mills, E. N. Thermostability and in vitro digestibility of a purified major allergen 2S albumin (Ses i 1) from white sesame seeds (Sesamum indicum L.). Biochim Biophys Acta 2005;1752(2):142-153. PubMed
  42. Okura, T., Ibe, M., Umegaki, K., Shinozuka, K., and Yamada, S. Effects of dietary ingredients on function and expression of P-glycoprotein in human intestinal epithelial cells. Biol Pharm Bull 2010;33(2):255-259. PubMed
  43. Nabekura, T., Yamaki, T., Ueno, K., and Kitagawa, S. Inhibition of P-glycoprotein and multidrug resistance protein 1 by dietary phytochemicals. Cancer Chemother Pharmacol 2008;62(5):867-873. PubMed
  44. Devarajan S, Chatterjee B, Urata H, et al. A blend of sesame and rice bran oils lowers hyperglycemia and improves the lipids. Am J Med. 2016;129(7):731-9. PubMed
  45. Khosravi-Boroujeni H, Nikbakht E, Natanelov E, Khalesi S. Can sesame consumption improve blood pressure? A systematic review and meta-analysis of controlled trials. J Sci Food Agric. 2017;97(10):3087-3094. PubMed
  46. Devarajan S, Singh R, Chatterjee B, Zhang B, Ali A. A blend of sesame oil and rice bran oil lowers blood pressure and improves the lipid profile in mild-to-moderate hypertensive patients. J Clin Lipidol. 2016;10(2):339-49. PubMed
  47. Warren CM, Chadha AS, Sicherer SH. Prevalence and severity of sesame allergy in the United States. JAMA Netw Open. 2019;2(8):e199144. PubMed
  48. Sillcox C, Gabrielli S, Clarke AE, et al. Sesame-induced anaphylaxis in pediatric patients from the cross-Canada anaphylaxis registry. Ann Allergy Asthma Immunol 2022;129(3):342-346. PubMed
  49. Yargholi A, Najafi MH, Zareian MA, Hawkins J, Shirbeigi L, Ayati MH. The effects of sesame consumption on glycemic control in adults: A systematic review and meta-analysis of randomized clinical trial. Evid Based Complement Alternat Med 2021;2021:2873534. PubMed
  50. Sohouli MH, Haghshenas N, Hernández-Ruiz Á, Shidfar F. Consumption of sesame seeds and sesame products has favorable effects on blood glucose levels but not on insulin resistance: A systematic review and meta-analysis of controlled clinical trials. Phytot PubMed
  51. Atefi M, Entezari MH, Vahedi H, Hassanzadeh A. The effects of sesame oil on metabolic biomarkers: a systematic review and meta-analysis of clinical trials. J Diabetes Metab Disord 2022;21(1):1065-1080. PubMed
  52. Khani B, Bidgoli SR, Moattar F, Hassani H. Effect of sesame on sperm quality of infertile men. J Res Med Sci. 2013;18(3):184-7.
  53. Huang H, Zhou G, Pu R, Cui Y, Liao D. Clinical evidence of dietary supplementation with sesame on cardiovascular risk factors: An updated meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr. 2022;62(20):5592-5602. PubMed

See these in context on the Sesame monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team