SuperYou Ingredients & Drug Interactions
by Moon Juice
What is this page for?
First and foremost: checking SuperYou against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
SuperYou is a dietary supplement by Moon Juice with 4 active ingredients. Its ingredients are commonly taken for women's reproductive health, promoting breast milk supply, digestive complaints.Based on those ingredients, 1,484 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Ashwagandha (Withania somnifera) root and leaf extract, Rhodiola (Rhodiola rosea) root extract, Organic Amla (Phyllanthus emblica) fruit extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against SuperYou by Moon Juice
Ask about any prescription or over-the-counter medication and we check it for interactions with SuperYou by Moon Juice — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of SuperYou by Moon Juice
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
SuperYou contains four active herbal extracts. Shatavari (Asparagus racemosus) root extract is included for its traditional uses, though evidence for specific benefits remains insufficient.
Ashwagandha (Withania somnifera) root and leaf extract is added for its possibly-effective support of anxiety, stress, and insomnia. Amla (Phyllanthus emblica), also called Indian gooseberry fruit extract, is possibly effective for reflux (GERD) and cholesterol levels.
Rhodiola (Rhodiola rosea) root extract rounds out the blend, though its effectiveness for specific conditions isn't yet established in the data we hold. The capsule also contains inactive ingredients—rice flour, organic rice, medium chain triglycerides, organic rice bran extract, organic gum arabic, organic sunflower oil, and the capsule itself—which serve as fillers, carriers, and binding agents.
Does it work?
Moderate evidence
Ashwagandha shows the strongest evidence here: it's possibly effective for anxiety, stress, and insomnia. Amla is possibly effective for acid reflux (GERD) and high cholesterol.
For the other conditions listed—Shatavari for tuberculosis, muscle strength, sexual desire, and bronchitis; Rhodiola for altitude sickness, anxiety, arrhythmia, athletic performance, and bladder cancer—the evidence we hold is insufficient to rate their effectiveness.
How safe is it?
Well-documented data
Ashwagandha is the ingredient with the most documented safety concerns. It's traditionally thought to risk miscarriage, so avoid it during pregnancy; there's not enough safety data to use it while breastfeeding.
When taken orally, it's generally well tolerated short-term, but serious rare adverse effects include acute hepatitis and liver failure. Gastrointestinal upset, nausea, vomiting, and diarrhea may occur, though they're uncommon at typical doses.
Drowsiness has also been reported. Shatavari and Amla are generally well tolerated as foods, but supplement safety is less studied at higher doses.
Shatavari is traditionally used to support milk supply but lacks reliable safety data; if you're breastfeeding, use only under professional guidance. Shatavari should be avoided during pregnancy.
Amla should be avoided during pregnancy and breastfeeding due to insufficient data. Rhodiola is generally well tolerated short-term, but long-term safety isn't well studied; avoid it during pregnancy and breastfeeding.
Adverse effects reported with Rhodiola include dizziness and changes in saliva production.
Meds to double-check
Moderate interaction found
Before taking SuperYou, double-check with your own doctor or pharmacist if you take blood pressure medications (antihypertensives), blood thinners or antiplatelet drugs including aspirin and clopidogrel, sedatives or benzodiazepines, diabetes medications, thyroid hormones, immunosuppressants, diuretics, or any drug that stresses the liver. Ashwagandha and Rhodiola also interact with certain enzyme pathways in the liver that affect how many drugs are processed, so any chronic prescription is worth confirming.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
SuperYou may appeal to those interested in herbal support for stress, anxiety, or sleep, since Ashwagandha is possibly effective for these. However, because of its significant interactions with blood pressure medications, blood thinners, diabetes drugs, sedatives, liver-damaging drugs, and thyroid medications, anyone taking prescription drugs should clear this product with their own doctor or pharmacist before starting.
It's not recommended during pregnancy or breastfeeding. If you have liver disease or take any chronic medications, this is especially important to discuss.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about SuperYou, straight from the product label.
| Brand | Moon Juice |
|---|---|
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | May 22, 2020 |
| DSLD ID | 220573 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for SuperYou by Moon Juice, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Shatavari (Asparagus racemosus) root extract | 450 mg | -- |
| organic Ashwagandha (Withania somnifera) root and leaf extract | 250 mg | -- |
| Organic Amla (Phyllanthus emblica) fruit extract | 150 mg | -- |
| Rhodiola (Rhodiola rosea) root extract | 150 mg | -- |
Other ingredients: Rice Flour, Capsule, organic Rice, Medium Chain Triglycerides, organic Rice Bran extract, organic Gum Arabic, organic Sunflower Oil
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Daily stress management Clinically shown to reduce the effects of stress and improve mood, focus & energy
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
SuperYou by Moon Juice label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in SuperYou by Moon Juice
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Shatavari (Asparagus racemosus) root extract
Interacts with76 drugs
Asparagus racemosus, often called shatavari, is an Ayurvedic herb traditionally used to support women's health, digestion, and overall vitality. Human...
Shatavari (Asparagus racemosus) root extract monograph & interactionsOrganic Ashwagandha (Withania somnifera) root and leaf extract
Interacts with1,372 drugs
Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evid...
Organic Ashwagandha (Withania somnifera) root and leaf extract monograph & interactionsOrganic Amla (Phyllanthus emblica) fruit extract
Interacts with208 drugs
Indian gooseberry (amla) is a vitamin C-rich fruit used in Ayurvedic medicine for many purposes, from antioxidant support to cholesterol and digestion...
Organic Amla (Phyllanthus emblica) fruit extract monograph & interactionsRhodiola (Rhodiola rosea) root extract
Interacts with1,271 drugs
Rhodiola is an herb traditionally used to fight fatigue and help the body cope with stress. Some small studies suggest it may modestly reduce fatigue...
Rhodiola (Rhodiola rosea) root extract monograph & interactionsOther (inactive) ingredients: Rice Flour, Capsule, Organic Rice, Medium Chain Triglycerides, Organic Rice Bran extract, Organic Gum Arabic, Organic Sunflower Oil. These complete the product’s ingredient list but are not active constituents.
SuperYou by Moon Juice Drug Interactions
HelloPharmacist Interaction Report
SuperYou by Moon Juice contains four active ingredients—Shatavari, Ashwagandha, Amla, and Rhodiola—that together interact with a significant number of medications.
The most serious concern is Ashwagandha's interaction with hepatotoxic drugs (Moderate severity), where the ingredient has been linked to cases of acute hepatitis, liver failure, and in rare instances, death from liver damage.
Read the full breakdown — every affected drug type, severity by severity
Ashwagandha poses Moderate-severity interactions with CNS depressants (sedatives, anxiolytics, barbiturates), benzodiazepines, antihypertensive drugs (blood pressure medications), immunosuppressants, antidiabetes drugs, and thyroid hormones. Shatavari may increase diuresis and electrolyte loss with diuretic drugs, and could theoretically reduce lithium excretion and raise its blood levels (both Moderate).
Amla can increase bleeding risk with anticoagulants (blood thinners), antiplatelet drugs, aspirin, and clopidogrel, and may lower blood sugar with antidiabetes medications (all Moderate).
Rhodiola interacts with antihypertensive drugs, immunosuppressants, and antidiabetes drugs (all Moderate), and may increase levels of certain blood pressure and heart medications, including losartan. It also affects drugs processed by the liver through CYP2C9, CYP1A2, and CYP3A4 pathways.
Ashwagandha carries a Minor interaction with CYP1A2 substrates; Rhodiola has Minor interactions with CYP1A2 and CYP3A4 substrates.
Altogether, these interactions span 1,485 individual medications. Before taking SuperYou, check your exact medications with the tool on this page or discuss this product with your own doctor or pharmacist.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against SuperYou?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in SuperYou interact with 1,484 drugs. Click any drug to see the details.
4 of the 4 ingredients in SuperYou interact with drugs. Each result below shows which ingredient is responsible. organic Ashwagandha (Withania somnifera) root and leaf extract Rhodiola (Rhodiola rosea) root extract Organic Amla (Phyllanthus emblica) fruit extract Shatavari (Asparagus racemosus) root extract
Dasiglucagon HydrochlorideZegalogue
How Dasiglucagon Hydrochloride interacts with SuperYou — through 3 ingredients. Tap an ingredient for the detail:
Organic Amla (phyllanthus Emblica) Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking Indian gooseberry with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Organic Amla (phyllanthus Emblica) Fruit Extract + Dasiglucagon Hydrochloride interactionOrganic Ashwagandha (withania Somnifera) Root And Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Organic Ashwagandha (withania Somnifera) Root And Leaf Extract + Dasiglucagon Hydrochloride interactionRhodiola (rhodiola Rosea) Root ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rhodiola (rhodiola Rosea) Root Extract + Dasiglucagon Hydrochloride interactionDaunorubicin, CytarabineVyxeos
How Daunorubicin, Cytarabine interacts with SuperYou — through 1 ingredient. Tap an ingredient for the detail:
Organic Ashwagandha (withania Somnifera) Root And Leaf ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Organic Ashwagandha (withania Somnifera) Root And Leaf Extract + Daunorubicin, Cytarabine interactionDeferasiroxExjade, Jadenu
How Deferasirox interacts with SuperYou — through 1 ingredient. Tap an ingredient for the detail:
Organic Ashwagandha (withania Somnifera) Root And Leaf ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Organic Ashwagandha (withania Somnifera) Root And Leaf Extract + Deferasirox interactionDefibrotide SodiumDefitelio
How Defibrotide Sodium interacts with SuperYou — through 1 ingredient. Tap an ingredient for the detail:
Organic Amla (phyllanthus Emblica) Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, Indian gooseberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Read the full Organic Amla (phyllanthus Emblica) Fruit Extract + Defibrotide Sodium interactionDeflazacortEmflaza
How Deflazacort interacts with SuperYou — through 2 ingredients. Tap an ingredient for the detail:
Rhodiola (rhodiola Rosea) Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Immunosuppressants Moderate
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
Read the full Rhodiola (rhodiola Rosea) Root Extract + Deflazacort interactionOrganic Ashwagandha (withania Somnifera) Root And Leaf ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Immunosuppressants Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Organic Ashwagandha (withania Somnifera) Root And Leaf Extract + Deflazacort interactionDehydrocholic Acid, Homatropine Methylbromide, PhenobarbitalG.B.S.
How Dehydrocholic Acid, Homatropine Methylbromide, Phenobarbital interacts with SuperYou — through 2 ingredients. Tap an ingredient for the detail:
Organic Ashwagandha (withania Somnifera) Root And Leaf ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Read the full Organic Ashwagandha (withania Somnifera) Root And Leaf Extract + Dehydrocholic Acid, Homatropine Methylbromide, Phenobarbital interactionRhodiola (rhodiola Rosea) Root ExtractCns Depressants Minor
Interaction Summary
Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
Read the full Rhodiola (rhodiola Rosea) Root Extract + Dehydrocholic Acid, Homatropine Methylbromide, Phenobarbital interactionDemeclocyclineDeclomycin
How Demeclocycline interacts with SuperYou — through 2 ingredients. Tap an ingredient for the detail:
Organic Ashwagandha (withania Somnifera) Root And Leaf ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Organic Ashwagandha (withania Somnifera) Root And Leaf Extract + Demeclocycline interactionRhodiola (rhodiola Rosea) Root ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, rhodiola might increase levels of P-glycoprotein substrates.
Read the full Rhodiola (rhodiola Rosea) Root Extract + Demeclocycline interactionDenosumabProlia, XGEVA
How Denosumab interacts with SuperYou — through 2 ingredients. Tap an ingredient for the detail:
Organic Ashwagandha (withania Somnifera) Root And Leaf ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Read the full Organic Ashwagandha (withania Somnifera) Root And Leaf Extract + Denosumab interactionRhodiola (rhodiola Rosea) Root ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, rhodiola use might interfere with immunosuppressive therapy.
Read the full Rhodiola (rhodiola Rosea) Root Extract + Denosumab interactionDeserpidineHarmonyl
How Deserpidine interacts with SuperYou — through 2 ingredients. Tap an ingredient for the detail:
Organic Ashwagandha (withania Somnifera) Root And Leaf ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Read the full Organic Ashwagandha (withania Somnifera) Root And Leaf Extract + Deserpidine interactionRhodiola (rhodiola Rosea) Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.
Read the full Rhodiola (rhodiola Rosea) Root Extract + Deserpidine interactionDeserpidine, HydrochlorothiazideOreticyl, Oreticyl Forte
How Deserpidine, Hydrochlorothiazide interacts with SuperYou — through 3 ingredients. Tap an ingredient for the detail:
Rhodiola (rhodiola Rosea) Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.
Read the full Rhodiola (rhodiola Rosea) Root Extract + Deserpidine, Hydrochlorothiazide interactionShatavari (asparagus Racemosus) Root ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, asparagus racemosus root might increase diuresis and electrolyte loss when used with diuretic drugs.
Read the full Shatavari (asparagus Racemosus) Root Extract + Deserpidine, Hydrochlorothiazide interactionOrganic Ashwagandha (withania Somnifera) Root And Leaf ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Read the full Organic Ashwagandha (withania Somnifera) Root And Leaf Extract + Deserpidine, Hydrochlorothiazide interactionDeserpidine, MethyclothiazideEnduronyl, Enduronyl Forte
How Deserpidine, Methyclothiazide interacts with SuperYou — through 3 ingredients. Tap an ingredient for the detail:
Organic Ashwagandha (withania Somnifera) Root And Leaf ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Read the full Organic Ashwagandha (withania Somnifera) Root And Leaf Extract + Deserpidine, Methyclothiazide interactionRhodiola (rhodiola Rosea) Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.
Read the full Rhodiola (rhodiola Rosea) Root Extract + Deserpidine, Methyclothiazide interactionShatavari (asparagus Racemosus) Root ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, asparagus racemosus root might increase diuresis and electrolyte loss when used with diuretic drugs.
Read the full Shatavari (asparagus Racemosus) Root Extract + Deserpidine, Methyclothiazide interactionDesiccated Thyroid ExtractWesthroid, WP Thyroid
How Desiccated Thyroid Extract interacts with SuperYou — through 1 ingredient. Tap an ingredient for the detail:
Organic Ashwagandha (withania Somnifera) Root And Leaf ExtractThyroid Hormone Moderate
Interaction Summary
Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Read the full Organic Ashwagandha (withania Somnifera) Root And Leaf Extract + Desiccated Thyroid Extract interactionDesiccated Thyroid Extract (prescription Drug)Nature-Throid, Thyrar
How Desiccated Thyroid Extract (prescription Drug) interacts with SuperYou — through 1 ingredient. Tap an ingredient for the detail:
Organic Ashwagandha (withania Somnifera) Root And Leaf ExtractThyroid Hormone Moderate
Interaction Summary
Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Read the full Organic Ashwagandha (withania Somnifera) Root And Leaf Extract + Desiccated Thyroid Extract (prescription Drug) interactionDesipramineDesipramine, Norpramin, Pertofrane
How Desipramine interacts with SuperYou — through 2 ingredients. Tap an ingredient for the detail:
Organic Ashwagandha (withania Somnifera) Root And Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Ashwagandha (withania Somnifera) Root And Leaf Extract + Desipramine interactionRhodiola (rhodiola Rosea) Root ExtractCns Depressants, Antidepressant Drugs +1 Minor
Interaction Summary
Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
Read the full Rhodiola (rhodiola Rosea) Root Extract + Desipramine interactionDesogestrel, Ethinyl EstradiolDesogen, Marvelon, Marvelon 21, Marvelon 28, Mircette, Ortho-Cept +2 more
How Desogestrel, Ethinyl Estradiol interacts with SuperYou — through 2 ingredients. Tap an ingredient for the detail:
Organic Ashwagandha (withania Somnifera) Root And Leaf ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Organic Ashwagandha (withania Somnifera) Root And Leaf Extract + Desogestrel, Ethinyl Estradiol interactionRhodiola (rhodiola Rosea) Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates +2 Moderate
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
Read the full Rhodiola (rhodiola Rosea) Root Extract + Desogestrel, Ethinyl Estradiol interactionDeucravacitinibSotyktu
How Deucravacitinib interacts with SuperYou — through 2 ingredients. Tap an ingredient for the detail:
Organic Ashwagandha (withania Somnifera) Root And Leaf ExtractImmunosuppressants, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Read the full Organic Ashwagandha (withania Somnifera) Root And Leaf Extract + Deucravacitinib interactionRhodiola (rhodiola Rosea) Root ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, rhodiola use might interfere with immunosuppressive therapy.
Read the full Rhodiola (rhodiola Rosea) Root Extract + Deucravacitinib interactionDeutetrabenazineAustedo
How Deutetrabenazine interacts with SuperYou — through 2 ingredients. Tap an ingredient for the detail:
Organic Ashwagandha (withania Somnifera) Root And Leaf ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Read the full Organic Ashwagandha (withania Somnifera) Root And Leaf Extract + Deutetrabenazine interactionRhodiola (rhodiola Rosea) Root ExtractCns Depressants Minor
Interaction Summary
Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
Read the full Rhodiola (rhodiola Rosea) Root Extract + Deutetrabenazine interactionDexamethasoneDecadron, Dexone, Dextenza, Dexycu, Hemady, Hexadrol +1 more
How Dexamethasone interacts with SuperYou — through 2 ingredients. Tap an ingredient for the detail:
Organic Ashwagandha (withania Somnifera) Root And Leaf ExtractImmunosuppressants, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Read the full Organic Ashwagandha (withania Somnifera) Root And Leaf Extract + Dexamethasone interactionRhodiola (rhodiola Rosea) Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Immunosuppressants +1 Moderate
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
Read the full Rhodiola (rhodiola Rosea) Root Extract + Dexamethasone interactionDexmedetomidineIgalmi, Precedex
How Dexmedetomidine interacts with SuperYou — through 2 ingredients. Tap an ingredient for the detail:
Organic Ashwagandha (withania Somnifera) Root And Leaf ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Read the full Organic Ashwagandha (withania Somnifera) Root And Leaf Extract + Dexmedetomidine interactionRhodiola (rhodiola Rosea) Root ExtractCns Depressants Minor
Interaction Summary
Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
Read the full Rhodiola (rhodiola Rosea) Root Extract + Dexmedetomidine interactionDextrothyroxineCholoxin
How Dextrothyroxine interacts with SuperYou — through 1 ingredient. Tap an ingredient for the detail:
Organic Ashwagandha (withania Somnifera) Root And Leaf ExtractThyroid Hormone Moderate
Interaction Summary
Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Read the full Organic Ashwagandha (withania Somnifera) Root And Leaf Extract + Dextrothyroxine interactionDiazepamDiastat AcuDial, Valium, Valium injection, Valtoco
How Diazepam interacts with SuperYou — through 2 ingredients. Tap an ingredient for the detail:
Organic Ashwagandha (withania Somnifera) Root And Leaf ExtractBenzodiazepines, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
Read the full Organic Ashwagandha (withania Somnifera) Root And Leaf Extract + Diazepam interactionRhodiola (rhodiola Rosea) Root ExtractCns Depressants, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
Read the full Rhodiola (rhodiola Rosea) Root Extract + Diazepam interactionDiclofenacZorvolex
How Diclofenac interacts with SuperYou — through 3 ingredients. Tap an ingredient for the detail:
Organic Ashwagandha (withania Somnifera) Root And Leaf ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Organic Ashwagandha (withania Somnifera) Root And Leaf Extract + Diclofenac interactionRhodiola (rhodiola Rosea) Root ExtractCytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP2C9.
Read the full Rhodiola (rhodiola Rosea) Root Extract + Diclofenac interactionOrganic Amla (phyllanthus Emblica) Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, Indian gooseberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Read the full Organic Amla (phyllanthus Emblica) Fruit Extract + Diclofenac interactionDiclofenac PotassiumCambia, Cataflam, Cataflam IR, Voltaren Rapide, Voltarol Rapid
How Diclofenac Potassium interacts with SuperYou — through 3 ingredients. Tap an ingredient for the detail:
Organic Ashwagandha (withania Somnifera) Root And Leaf ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Organic Ashwagandha (withania Somnifera) Root And Leaf Extract + Diclofenac Potassium interactionRhodiola (rhodiola Rosea) Root ExtractCytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP2C9.
Read the full Rhodiola (rhodiola Rosea) Root Extract + Diclofenac Potassium interactionOrganic Amla (phyllanthus Emblica) Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, Indian gooseberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Read the full Organic Amla (phyllanthus Emblica) Fruit Extract + Diclofenac Potassium interactionDiclofenac SodiumAcoflam, Acoflam 75 SR, Acoflam Retard, Defenac, Defenac Retard, Defenac SR +40 more
How Diclofenac Sodium interacts with SuperYou — through 3 ingredients. Tap an ingredient for the detail:
Organic Amla (phyllanthus Emblica) Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, Indian gooseberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Read the full Organic Amla (phyllanthus Emblica) Fruit Extract + Diclofenac Sodium interactionRhodiola (rhodiola Rosea) Root ExtractCytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP2C9.
Read the full Rhodiola (rhodiola Rosea) Root Extract + Diclofenac Sodium interactionOrganic Ashwagandha (withania Somnifera) Root And Leaf ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Organic Ashwagandha (withania Somnifera) Root And Leaf Extract + Diclofenac Sodium interactionDiclofenac Sodium, MisoprostolArthrotec 50, Arthrotec 75
How Diclofenac Sodium, Misoprostol interacts with SuperYou — through 3 ingredients. Tap an ingredient for the detail:
Organic Ashwagandha (withania Somnifera) Root And Leaf ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Organic Ashwagandha (withania Somnifera) Root And Leaf Extract + Diclofenac Sodium, Misoprostol interactionRhodiola (rhodiola Rosea) Root ExtractCytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP2C9.
Read the full Rhodiola (rhodiola Rosea) Root Extract + Diclofenac Sodium, Misoprostol interactionOrganic Amla (phyllanthus Emblica) Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, Indian gooseberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Read the full Organic Amla (phyllanthus Emblica) Fruit Extract + Diclofenac Sodium, Misoprostol interactionDiclofenac EpolamineFlector, Licart
How Diclofenac Epolamine interacts with SuperYou — through 3 ingredients. Tap an ingredient for the detail:
Organic Amla (phyllanthus Emblica) Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, Indian gooseberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Read the full Organic Amla (phyllanthus Emblica) Fruit Extract + Diclofenac Epolamine interactionRhodiola (rhodiola Rosea) Root ExtractCytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP2C9.
Read the full Rhodiola (rhodiola Rosea) Root Extract + Diclofenac Epolamine interactionOrganic Ashwagandha (withania Somnifera) Root And Leaf ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Organic Ashwagandha (withania Somnifera) Root And Leaf Extract + Diclofenac Epolamine interactionDicumarolDicumarol
How Dicumarol interacts with SuperYou — through 1 ingredient. Tap an ingredient for the detail:
Organic Amla (phyllanthus Emblica) Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, Indian gooseberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Read the full Organic Amla (phyllanthus Emblica) Fruit Extract + Dicumarol interactionDicyclomine, PhenobarbitalBentyl w/ Pb
How Dicyclomine, Phenobarbital interacts with SuperYou — through 2 ingredients. Tap an ingredient for the detail:
Organic Ashwagandha (withania Somnifera) Root And Leaf ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Read the full Organic Ashwagandha (withania Somnifera) Root And Leaf Extract + Dicyclomine, Phenobarbital interactionRhodiola (rhodiola Rosea) Root ExtractCns Depressants Minor
Interaction Summary
Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
Read the full Rhodiola (rhodiola Rosea) Root Extract + Dicyclomine, Phenobarbital interactionDiethylstilbestrol, MethyltestosteroneTylosterone
How Diethylstilbestrol, Methyltestosterone interacts with SuperYou — through 1 ingredient. Tap an ingredient for the detail:
Organic Ashwagandha (withania Somnifera) Root And Leaf ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Organic Ashwagandha (withania Somnifera) Root And Leaf Extract + Diethylstilbestrol, Methyltestosterone interactionDigoxinDigitek, Lanoxicaps, Lanoxin
How Digoxin interacts with SuperYou — through 1 ingredient. Tap an ingredient for the detail:
Rhodiola (rhodiola Rosea) Root ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, rhodiola might increase levels of P-glycoprotein substrates.
Read the full Rhodiola (rhodiola Rosea) Root Extract + Digoxin interactionEach ingredient & the kinds of drugs it affects
For each ingredient in SuperYou with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
organic Ashwagandha (Withania somnifera) root and leaf extract
Antidiabetes Drugs
Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.
Antihypertensive Drugs
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Benzodiazepines
Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.
Cns Depressants
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.
Hepatotoxic Drugs
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.
Immunosuppressants
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.
Thyroid Hormone
Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.
Serotonergic Drugs
Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]
Rhodiola (Rhodiola rosea) root extract
Antidiabetes Drugs
Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.
In vitro and animal research shows that rhodiola extract can decrease blood glucose due to alpha-glucosidase activity.
Antihypertensive Drugs
Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.
In vitro and animal research shows that rhodiola extract inhibits angiotensin-converting enzyme (ACE) and might lower blood pressure.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, rhodiola might increase levels of drugs metabolized by CYP2C9.
In vitro research shows that rhodiola inhibits CYP2C9. This effect is highly variable and appears to be dependent on the rhodiola product studied. Also, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.
Immunosuppressants
Theoretically, rhodiola use might interfere with immunosuppressive therapy.
In vitro and animal research show that rhodiola has immunostimulatory effects.
Losartan (Cozaar)
Rhodiola might increase the levels and adverse effects of losartan.
A clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.
P-Glycoprotein Substrates
Theoretically, rhodiola might increase levels of P-glycoprotein substrates.
In vitro research shows that rhodiola inhibits P-glycoprotein. Theoretically, using rhodiola with P-glycoprotein substrates might increase drug levels and potentially increase the risk of adverse effects.
Antidepressant Drugs
Theoretically, rhodiola might increase the risk of adverse effects when taken with antidepressants.
A review of adverse event reports in Poland identified cases of tachyarrhythmias, myalgia, arthralgia, gum pain, restless leg syndrome, swallowing disorders, and changes in consciousness when rhodiola was taken in combination with paroxetine, escitalopram, fluoxetine, sertraline, trazodone, and/or duloxetine.
Cns Depressants
Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
A review of adverse event reports in Poland identified cases of excessive sedation, myoclonus, hypotension, and hallucinations when rhodiola was taken with haloperidol, diazepam, or alprazolam.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that rhodiola inhibits CYP1A2. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of caffeine, a CYP1A2 substrate.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that rhodiola inhibits CYP3A4. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of midazolam, a CYP3A4 substrate.
Organic Amla (Phyllanthus emblica) fruit extract
Anticoagulant/Antiplatelet Drugs
Theoretically, Indian gooseberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Clinical research shows that taking Indian gooseberry 500 mg as a single dose or twice daily for 10 days reduces platelet aggregation by about 24% to 36%, increases bleeding time by about 3.8-5.9 seconds, and increases clotting time by about 9.8-12.7 seconds when compared to baseline. However, taking Indian gooseberry 500 mg along with clopidogrel 75 mg or ecosprin 75 mg, as a single dose or for 10 days, does not significantly reduce platelet aggregation or increase bleeding time or clotting time when compared with clopidogrel 75 mg or ecosprin 75 mg alone. Until more is known, use caution when taking Indian gooseberry in combination with anticoagulant/antiplatelet drugs.
Antidiabetes Drugs
Taking Indian gooseberry with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking Indian gooseberry fruit or fruit extract alone or in conjunction with antidiabetes medications can lower blood glucose levels. Dose adjustments to diabetes medications might be necessary.
Aspirin
Theoretically, Indian gooseberry may increase the risk of bleeding if used with aspirin; however, research is conflicting.
Clinical research shows that taking Indian gooseberry 500 mg as a single dose or twice daily for 10 days reduces platelet aggregation by about 24% to 36%, increases bleeding time by about 3.8-5.9 seconds, and increases clotting time by about 9.8-12.7 seconds when compared to baseline. However, taking a single dose of Indian gooseberry 500 mg along with ecosprin 75 mg, or taking a combination of Indian gooseberry 500 mg twice daily plus ecosprin 75 mg once daily for 10 days, does not significantly reduce platelet aggregation or increase bleeding time or clotting time when compared with ecosprin 75 mg alone.
Clopidogrel (Plavix)
Theoretically, Indian gooseberry may increase the risk of bleeding if used with clopidogrel; however, research is conflicting.
Clinical research shows that taking Indian gooseberry 500 mg as a single dose or twice daily for 10 days reduces platelet aggregation by about 24% to 36%, increases bleeding time by about 3.8-5.9 seconds, and increases clotting time by about 9.8-12.7 seconds when compared to baseline. However, taking a single dose of Indian gooseberry 500 mg along with clopidogrel 75 mg, or taking a combination of Indian gooseberry 500 mg twice daily plus clopidogrel 75 mg once daily for 10 days, does not significantly reduce platelet aggregation or increase bleeding time or clotting time when compared with clopidogrel 75 mg alone.
Shatavari (Asparagus racemosus) root extract
Diuretic Drugs
Theoretically, asparagus racemosus root might increase diuresis and electrolyte loss when used with diuretic drugs.
Animal studies show that asparagus racemosus root has diuretic effects when used in high doses. This effect has not been reported in humans.
Lithium
Theoretically, Asparagus racemosus root could reduce excretion and increase levels of lithium.
Animal research suggests that Asparagus racemosus root has diuretic properties when used in high doses. Therefore, it might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.
Brand information
Manufacturer and brand details for SuperYou, from the product label.
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The Full Monographs Behind SuperYou’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Asparagus Racemosus
Interacts with 76 drugsAsparagus racemosus, often called shatavari, is an Ayurvedic herb traditionally used to support women's health, digestion, and overall vitality. Human evidence for most of these uses is limi...
Read the full Asparagus Racemosus monograph → Herb & supplement monographAshwagandha
Interacts with 1,372 drugsAshwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evidence is still limited. It is generally w...
Read the full Ashwagandha monograph → Herb & supplement monographIndian Gooseberry
Interacts with 208 drugsIndian gooseberry (amla) is a vitamin C-rich fruit used in Ayurvedic medicine for many purposes, from antioxidant support to cholesterol and digestion. Early research is promising for some u...
Read the full Indian Gooseberry monograph → Herb & supplement monographRhodiola
Interacts with 1,271 drugsRhodiola is an herb traditionally used to fight fatigue and help the body cope with stress. Some small studies suggest it may modestly reduce fatigue and improve mood, but the evidence is li...
Read the full Rhodiola monograph →Sources & How We Checked
SuperYou's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 52 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Asparagus Racemosus 1 reference
- Satish Kumar MC, Udupa AL, Sammodavardhana K, Rathnakar UP, Shvetha U, Kodancha GP. Acute toxicity and diuretic studies of the roots of Asparagus racemosus Willd in rats. West Indian Med J. 2010;59(1):3-6.
Ashwagandha 32 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Upton R, ed. Ashwagandha Root (Withania somnifera): Analytical, quality control, and therapuetic monograph. Santa Cruz, CA: American Herbal Pharmacopoeia 2000:1-25.
- Davis L, Kuttan G. Effect of Withania somnifera on cyclophosphamide-induced urotoxicity. Cancer Lett 2000;148:9-17. PubMed
- Davis L, Kuttan G. Suppressive effect of cyclophosphamide-induced toxicity by Withania somnifera extract in mice. J Ethnopharmacol 1998;62:209-14. PubMed
- Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Altern Med Rev 2000;5:334-46. DOI
- Andallu B, Radhika B. Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root. Indian J Exp Biol 2000;38:607-9.
- Kulkarni RR, Patki PS, Jog VP, et al. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. J Ethnopharmacol 1991;33:91-5. PubMed
- Ahumada F, Aspee F, Wikman G, Hancke J. Withania somnifera exract. Its effects on arterial blood pressure in anaesthetized dogs. Phytother Res 1991;5:111-14.
- Panda S, Kar A. Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. J Ethnopharmacol 1999;67:233-39. PubMed
- Panda S, Kar A. Changes in thyroid hormone concentrations after administration of ashwagandha root extract to adult male mice. J Pharm Pharmacol 1998;50:1065-68. PubMed
- Sehgal, V. N., Verma, P., and Bhattacharya, S. N. Fixed-drug eruption caused by ashwagandha (Withania somnifera): a widely used Ayurvedic drug. Skinmed. 2012;10(1):48-49.
- Agnihotri AP, Sontakke SD, Thawani VR, Saoji A, Goswami VS. Effects of Withania somnifera in patients of schizophrenia: a randomized, double blind, placebo controlled pilot trial study. Indian J Pharmacol. 2013;45(4):417-8. PubMed
- Biswal BM, Sulaiman SA, Ismail HC, Zakaria H, Musa KI. Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients. Integr Cancer Ther. 2013;12(4):312-22.
- Sharma AK, Basu I, Singh S. Efficacy and safety of Ashwagandha root extract in subclinical hypothyroid patients: a double-blind, randomized placebo-controlled trial. J Altern Complement Med. 2018 Mar;24(3):243-248. PubMed
- Durg S, Bavage S, Shivaram SB. Withania somnifera (Indian ginseng) in diabetes mellitus: A systematic review and meta-analysis of scientific evidence from experimental research to clinical application. Phytother Res. 2020;34(5):1041-1059.
- Björnsson HK, Björnsson ES, Avula B, et al. Ashwagandha-induced liver injury: A case series from Iceland and the US Drug-Induced Liver Injury Network. Liver Int. 2020;40(4):825-829. PubMed
- Tharakan A, Shukla H, Benny IR, Tharakan M, George L, Koshy S. Immunomodulatory Effect of Withania somnifera (Ashwagandha) Extract-A Randomized, Double-Blind, Placebo Controlled Trial with an Open Label Extension on Healthy Participants. J Clin Med 2021;1 PubMed
- Ireland PJ, Hardy T, Burt AD, Donnelly MC. Drug-induced hepatocellular injury due to herbal supplement ashwagandha. J R Coll Physicians Edinb. 2021;51(4):363-365. PubMed
- Kamal HI, Patel K, Brdak A, Heffernan J, Ahmad N. Ashwagandha as a unique cause of thyrotoxicosis presenting with supraventricular tachycardia. Cureus. 2022 Mar 25;14(3):e23494. PubMed
- Suryawanshi G, Abdallah M, Thomson M, Desai N, Chauhan A, Lim N. Ashwagandha-Associated Acute Liver Failure Requiring Liver Transplantation. Am J Ther 2023;30(1):e80-e83. PubMed
- Pusec CM, Wolsky R, Llerena C, Sura P. A Case of Supplement-Induced Hepatitis. Cureus 2022;14(10):e30433. PubMed
- Ajgaonkar A, Jain M, Debnath K. Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract for Improvement of Sexual Health in Healthy Women: A Prospective, Randomized, Placebo-Controlled Study. Cureus 2022;14(10):e30787. PubMed
- Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
- Lubarska M, Halasinski P, Hryhorowicz S, et al. Liver Dangers of Herbal Products: A Case Report of Ashwagandha-Induced Liver Injury. Int J Environ Res Public Health 2023;20(5):3921. PubMed
- Tóth M, Benedek AE, Longerich T, Seitz HK. Ashwagandha-induced acute liver injury: A case report. Clin Case Rep 2023;11(3):e7078.
- Bokan G, Glamocanin T, Mavija Z, et al. Herb-Induced Liver Injury by Ayurvedic Ashwagandha as Assessed for Causality by the Updated RUCAM: An Emerging Cause. Pharmaceuticals (Basel) 2023;16(8):1129. PubMed
- Patel PA, Sanborn E, Then R, Williams DM. Recurrent Reversible Cerebral Vasoconstriction Syndrome: A Report of Two Cases. Cureus 2023;15(8):e42992. PubMed
- Majeed M, Nagabhushanam K, Murali A, Vishwanathan DT, Mamidala RV, Mundkur L. A Standardized Withania somniferra (Linn.) Root Extract with Piperine Alleviates the Symptoms of Anxiety and Depression by Increasing Serotonin Levels: A Double-Blind, Randomize
- Philips CA, Valsan A, Theruvath AH, et al. Ashwagandha-induced liver injury-A case series from India and literature review. Hepatol Commun 2023;7(10):e0270. PubMed
- Hayashi M, Hamada H, Azuma SI, Hayashi K. Painless Thyroiditis by Withania somnifera (Ashwagandha). Cureus 2024;16(3):e55352. PubMed
- Vazirani S, Kothari A, Fujimoto J, Gomez M. Supplements Are Not a Synonym for Safe: Suspected Liver Injury From Ashwagandha. Fed Pract 2023;40(9):315-319. PubMed
- Patel M, Newell R, Hillier M, Ramalingam R. Herbal remedies as a potential cause of hypoadrenalism. Br J Hosp Med (Lond) 2024;85(6):1-4. PubMed
Indian Gooseberry 6 references
- Sabu, M. C. and Kuttan, R. Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property. J Ethnopharmacol. 2002;81(2):155-160. PubMed
- Fatima N, Pingali U, Muralidhar N. Study of pharmacodynamic interaction of Phyllanthus emblica extract with clopidogrel and ecosprin in patients with type II diabetes mellitus. Phytomedicine. 2014;21(5):579-85. PubMed
- Shanmugarajan D, Girish C, Harivenkatesh N, Chanaveerappa B, Prasanna Lakshmi NC. Antihypertensive and pleiotropic effects of Phyllanthus emblica extract as an add-on therapy in patients with essential hypertension-A randomized double-blind placebo-contro
- Akhtar MS, Ramzan A, Ali A, Ahmad M. Effect of amla fruit (Emblica officinalis Gaertn.) on blood glucose and lipid profile of normal subjects and type 2 diabetic patients. Int J Food Sci Nutr. 2011;62(6):609-16.
- Usharani P, Fatima N, Muralidhar N. Effects of Phyllanthus emblica extract on endothelial dysfunction and biomarkers of oxidative stress in patients with type 2 diabetes mellitus: a randomized, double-blind, controlled study. Diabetes Metab Syndr Obes. 20 PubMed
- Majeed M, Mundkur L, Paulose S, Nagabhushanam K. Novel Emblica officinalis extract containing ß-glucogallin vs. metformin: a randomized, open-label, comparative efficacy study in newly diagnosed type 2 diabetes mellitus patients with dyslipidemia. Food Fu
Rhodiola 13 references
- Kim SH, Hyun SH, Choung SY. Antioxidative effects of Cinnamomi cassiae and Rhodiola rosea extracts in liver of diabetic mice. Biofactors 2006;26:209-19.
- Kwon YI, Jang HD, Shetty K. Evaluation of Rhodiola crenulata and Rhodiola rosea for management of type II diabetes and hypertension. Asia Pac J Clin Nutr 2006;15:425-32.
- Bystritsky A, Kerwin L, Feusner JD. A pilot study of Rhodiola rosea (Rhodax) for generalized anxiety disorder (GAD). J Altern Complement Med 2008;14:175-80.
- Shevtsov VA, Zholus BI, Shervarly VI, et al. A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine 2003;10:95-105. PubMed
- Apostolidis E, Kwon YI, Shetty K. Potential of cranberry-based herbal synergies for diabetes and hypertension management. Asia Pac J Clin Nutr 2006;15:433-41.
- Hellum BH, Tosse A, Hoybakk K, et al. Potent in vitro inhibition of CYP3A4 and P-glycoprotein by Rhodiola rosea. Planta Med 2010;76:331-8.
- Skopriska-Rozewska E, Wojcik R, Siwicki AK, et al. The effect of Rhodiola quadrifida extracts on cellular immunity in mice and rats. Pol J Vet Sci 2008;11:105-11.
- Mishra KP, Chanda S, Shukla K, Ganju L. Adjuvant effect of aqueous extract of Rhodiola imbricate rhizome on the immune responses to tetanus toxoid and ovalbumin in rats. Immunopharmacol Immunotoxicol 2010;32:141-6.
- Li HX, Sze SC, Tong Y, Ng TB. Production of Th1- and Th2-dependent cytokines induced by the Chinese medicine herb, Rhodiola algida, on human peripheral blood monocytes. J Ethnopharmacol 2009;123:257-66. PubMed
- Mishra KP, Ganju L, Chanda S, et al. Aqueous extract of Rhodiola imbricate rhizome stimulates Toll-like receptor 4, granzyme-B and Th1 cytokines in vitro. Immunobiology 2009;214:27-31.
- Thu OK, Nilsen OG, Hellum B. In vitro inhibition of cytochrome P-450 activities and quantification of constituents in a selection of commercial Rhodiola rosea products. Pharm Bio. 2016 Dec;54(12):3249-3256.
- Thu OK, Spigset O, Nilsen OG, Hellum B. Effect of commercial Rhodiola rosea on CYP enzyme activity in humans. Eur J Clin Pharmacol. 2016 Mar;72(3):295-300. PubMed
- Woron J, Siwek M. Unwanted effects of psychotropic drug interactions with medicinal products and diet supplements containing plant extracts. Psychiatr Pol 2018;52(6):983-96. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC