Major interaction on record — check this product against your medications before combining. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Sytrinol Ingredients & Drug Interactions

by Nature's Way

Sytrinol label
See full label image
Softgel Capsule Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Sytrinol against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Sytrinol is a dietary supplement by Nature's Way with 2 active ingredients. Its ingredients are commonly taken for vitamin c source, digestive upset, stress and relaxation (aromatherapy).Based on those ingredients, 246 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Citrus sinensis L extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Sytrinol by Nature's Way

Ask about any prescription or over-the-counter medication and we check it for interactions with Sytrinol by Nature's Way — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Sytrinol by Nature's Way

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Sytrinol” is listed as a grouped ingredient — the label gives one combined amount (150 mg) without saying how much of each component you get.

Sytrinol is a blend of two active ingredients: Sytrinol itself (a proprietary combination) and citrus sinensis L extract, which comes from sweet orange. The product is delivered in a softgel capsule along with inactive ingredients including extra virgin olive oil, gelatin, glycerin, purified water, annatto extract, natural orange flavor, soy lecithin, and yellow beeswax.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Sweet Orange's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Cholesterol Control.
  • We looked for evidence on: Hypercholesterolemia, Dyslipidemia, Cardiovascular health, Blood lipid management.
  • The closest evidence on file: Sweet Orange is rated "Insufficient Reliable Evidence To Rate" for Hypercholesterolemia (Natural Medicines).

The evidence for sweet orange extract in this product isn't established in the data we hold. The supplement has been studied for pre-procedural anxiety, asthma, prostate cancer, common cold, constipation, and depression, but none of these has sufficient reliable evidence to rate whether it actually works.

The evidence, ingredient by ingredient Sweet Orange

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sweet orange fruit and juice are generally well tolerated as food for most people. However, concentrated supplements and extracts haven't been studied as thoroughly as whole fruit, so use caution with this product.

There have been reports of intestinal cramping in children after consuming large amounts of sweet orange peel. For pregnancy and breastfeeding, the safety data rates sweet orange as likely safe, but talk with your doctor or pharmacist about whether this particular product is right for you during those times.

Side effects, ingredient by ingredient Sweet Orange

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Sweet Orange.
  • The most serious interaction on file is rated Major.
  • For scale: 246 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Sytrinol, double-check with your doctor or pharmacist if you take pravastatin (a Major interaction — levels can nearly double), ivermectin, celiprolol, or any OATP substrates (all Major). Also flag any P-glycoprotein substrates, fexofenadine (allergy medicine), or quinolone antibiotics (Moderate severity).

Sweet orange can significantly reduce how well some of these work, or raise the level of others to unsafe amounts.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

Sytrinol's sweet orange extract can significantly alter how your body absorbs or processes many prescription medications — including cholesterol drugs, blood pressure medicines, allergy treatments, and antibiotics. If you take any regular medications, check them against the interaction tool on this page before starting.

Talk with your doctor or pharmacist about whether this product makes sense for you, especially if you're on pravastatin or any of the other medications mentioned.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 23, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sytrinol, straight from the product label.

Brand Nature's Way
Barcode (UPC) 033674155714
Net contents 120 Softgel(s)
Market status On market
Date entered into DSLD Dec 23, 2015
DSLD ID 54775
Product type Botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sytrinol by Nature's Way, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
UPC/BARCODE
033674155714
IngredientAmount% DV
Sytrinol150 mg--
Citrus sinensis L extract0 NP--
Elaeis guineensis extract0 NP--

Other ingredients: extra virgin Olive Oil, Gelatin, Glycerin, purified Water, Annatto extract, natural Orange flavor, Soy Lecithin, yellow Beeswax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Patented Complex

Cholesterol Control

What is Cholesterol? Cholesterol is a waxy, fat-like substance needed for certain body functions. ~ Did you know? The liver produces up to 75% of the body’s cholesterol. Food in the daily diet is another source of cholesterol. Healthy Cholesterol Levels Total cholesterol levels in the blood should be less than 200 mg/dL. The two primary types of cholesterol are: 1) HDL cholesterol, which is “good” because it helps remove cholesterol from the blood. Levels above 40 mg/dL are healthy. 2) LDL cholesterol, which is “bad”. Levels below 100 mg/dL are optimal for cardiovascular health.

Cholesterol Control Helps maintain healthy levels already within the normal range

Recommendation: Take 1 softgel twice daily, or as recommended by a healthcare professional.

Formula

Sytrinol is a unique blend of bioflavonoids (polymethoxylated flavones) and tocotrienols extracted from citrus and palm fruits.

Contains soy.

Brand IP Statement(s)

Sytrinol supports healthy cholesterol levels already within the normal range.*

Sytrinol is a registered trademark of InterHealth N.I. Sytrinol branded blend of citrus and palm fruit extracts (U.S. Patens 6,987,125 and 7,683,095).

2015

FDA Disclaimer Statement

This statement has not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Sytrinol Healthy Heart

FDA Statement of Identity

Dietary Supplement

General

LBN15571.A02 B712060A C8087

Precautions

Caution: Do not use this product if you are pregnant, nursing or trying to conceive. If you are taking any medications, consult a healthcare professional before use.

Contains soy.

Keep out of reach of children.

Safety sealed with printed outer shrinkwrap and inner seal. Do not use if either is broken or missing.

Formulation

Gluten free. No yeast, milk, lactose, wheat, sugar, corn, artificial flavors or preservatives.

Storage

Store in a cool, dry place. Keep bottle tightly closed.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Sytrinol by Nature's Way label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Sytrinol label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Sytrinol by Nature's Way

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sytrinol

150 mg per serving

Other (inactive) ingredients: Extra virgin Olive Oil, Gelatin, Glycerin, Purified Water, Annatto extract, Natural Orange flavor, Soy Lecithin, Yellow Beeswax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sytrinol by Nature's Way Drug Interactions

Want to check YOUR meds against Sytrinol?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
246Drugs
48 Major 198 Moderate

Ingredients driving the most interactions

Citrus sinensis L extract 246

Individual Drug Interactions

The ingredients in Sytrinol interact with 246 drugs. Click any drug to see the details.

1 of the 2 ingredients in Sytrinol interact with drugs. Each result below shows which ingredient is responsible. Citrus sinensis L extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Sytrinol with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Citrus sinensis L extract7 drug types · 246 drugs

Celiprolol (Celicard)

Consuming sweet orange with celiprolol can decrease oral absorption of celiprolol.
A pharmacokinetic study in healthy volunteers shows that celiprolol levels, after a single dose of 100 mg, are decreased by up to 90% in people who drink sweet orange juice 200 mL three times daily. It's not known if lower consumption of sweet orange juice will have the same effect. Theoretically, this occurs due to short-term inhibition of organic anion transporting polypeptide (OATP). Recommend separating drug administration and consumption of sweet orange by at least 4 hours.

Likelihood Likely Evidence B
Ivermectin (Stromectol, Others)

Consuming sweet orange juice with ivermectin can decrease the oral absorption of ivermectin.
A pharmacokinetic study in healthy volunteers shows that taking ivermectin orally with sweet orange juice 750 mL over 4 hours reduces the bioavailability of ivermectin. This effect does not seem to be related to effects on P-glycoprotein. The effect on ivermectin is more pronounced in males compared to females.

Likelihood Likely Evidence B
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Consuming sweet orange juice can decrease oral absorption of OATP substrates. Separate administration by at least 4 hours.
Clinical research shows that consuming sweet orange juice inhibits OATP, which reduces bioavailability of oral drugs that are substrates of OATP. For example, sweet orange juice decreases bioavailability of fexofenadine, a substrate of OATP, by about 72% and of celiprolol, another OATP substrate, by up to 90%. Since sweet orange juice seems to affect OATP for a short time, recommend separating drug administration and consumption of sweet orange juice by at least 4 hours.

Likelihood Likely Evidence B
Pravastatin (Pravachol)

Consuming sweet orange juice with pravastatin can increase the absorption of pravastatin.
A small pharmacokinetic study in healthy volunteers shows that consuming sweet orange juice 800 mL over 3 hours, including before, during, and after taking pravastatin 10 mg, increases pravastatin levels by about 149%, without affecting pravastatin elimination. Theoretically this effect might be due to modulation of organic anion transporting polypeptides (OATPs) by sweet orange juice. Sweet orange juice does not seem to affect simvastatin levels, but it is not known if sweet orange affects any of the other statins.

Likelihood Likely Evidence B
Fexofenadine (Allegra)

Consuming sweet orange juice with fexofenadine can decrease oral absorption of fexofenadine.
Clinical research shows that coadministration of sweet orange juice 1200 mL decreases bioavailability of fexofenadine by about 72%. In an animal model, sweet orange juice decreased bioavailability of fexofenadine by 31%. Fexofenadine manufacturer data indicates that concomitant administration of sweet orange juice and fexofenadine results in larger wheal and flare sizes in research models. This suggests that sweet orange reduces the clinical response to fexofenadine. Theoretically, this occurs due to short-term inhibition of organic anion transporting polypeptide (OATP). Recommend separating drug administration and consumption of sweet orange by at least 4 hours.

Likelihood Likely Evidence B
P-Glycoprotein Substrates

Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Animal and in vitro research suggest that orange juice extract inhibits drug efflux by P-gp, increasing absorption and levels of P-gp substrates. In contrast, pharmacokinetic research in humans shows that drinking large amounts of sweet orange juice decreases absorption and levels of the P-gp substrate celiprolol. This suggests that orange juice actually induces drug efflux by P-gp or affects drug levels by another mechanism such as inhibiting the gut drug transporter called organic anion transporting polypeptide (OATP). Until more is known, sweet orange juice should be used cautiously in people taking P-gp substrates.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium-fortified sweet orange juice might reduce quinolone absorption.
Calcium binds to quinolones in the gut. Theoretically, the calcium in certain fortified orange juices can also bind to quinolone antibiotics and reduce their absorption and levels.

Likelihood Possible Evidence D
Citrus sinensis L extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Sytrinol, from the product label.

Nature's Way

See all Nature's Way products
Phone Number
1-800-962-8873
Web Address
naturesway.com
Pharmacist Counseling Corner

Sytrinol by Nature's Way: Common Questions

Does Sytrinol by Nature's Way interact with any medications?
Yes. Based on its ingredients, Sytrinol has a known interaction with 246 medications, including 48 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sytrinol contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Sytrinol while I'm pregnant or breastfeeding?
Sweet orange is rated as likely safe during pregnancy and breastfeeding based on the safety data we hold. That said, this product hasn't been widely studied in these situations, so talk with your doctor or pharmacist to confirm it's right for your specific pregnancy or nursing plan.
What does Sytrinol actually do?
Sytrinol contains sweet orange extract and has been studied for uses including anxiety before procedures, asthma, prostate cancer, common cold, constipation, and depression. However, there isn't enough reliable evidence in our data to say whether it actually works for any of these.
Are there any side effects I should know about?
Sweet orange is generally well tolerated, though there have been reports of intestinal cramping in children after consuming large amounts of sweet orange peel. Concentrated supplements haven't been studied as much as the whole fruit, so use caution with this product.
Why does sweet orange interact with so many medications?
Sweet orange affects several different transport systems in your gut and liver that control how drugs are absorbed and broken down. Depending on the drug, it can either block absorption (making the medicine less effective) or increase it (potentially causing too much to get into your bloodstream).
What's Sytrinol and what does it do in this product?
Sytrinol is a proprietary blend — the exact mix of ingredients in it is part of the product formulation. It's one of the two active ingredients here, along with sweet orange extract, though the evidence for its effectiveness isn't established in the data we hold.
Is there anything else in this product I should know about?
We couldn't check the second active ingredient, Elaeis guineensis extract (a palm oil derivative), because we hold no interaction data for it. If you're concerned about it, ask your pharmacist or doctor.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Sytrinol is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sytrinol label
Go deeper

The Full Monographs Behind Sytrinol’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sweet Orange

Interacts with 246 drugs

Sweet orange is a common citrus fruit that is a good source of vitamin C, fiber, and antioxidants, and is enjoyed as a food worldwide. Its peel and essential oil are used in aromatherapy and...

Read the full Sweet Orange monograph →
Sources

Sources & How We Checked

Sytrinol's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 17 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sweet Orange 17 references
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. FDA, CFSAN. FDA-approved potassium health claim notification for potassium containing foods. 2000. Available at: www.cfsan.fda.gov/~dms/hclm-k.html.
  3. Kurowska EM, Spence JD, Jordan J, et al. HDL-cholesterol-raising effect of orange juice in subjects with hypercholesterolemia. Am J Clin Nutr 2000;72:1095-100. PubMed
  4. Murry JJ, Healy MD. Drug-mineral interactions: a new responsibility for the hospital dietician. J Am Diet Assoc 1991;91:66-73.
  5. Bailey DG, Dresser GK, Munoz C, et al. Reduction of fexofenadine bioavailability by fruit juices. Clin Pharmacol Ther 2001;69:P21.
  6. Pletz MW, Petzold P, Allen A, et al. Effect of calcium carbonate on bioavailability of orally administered gemifloxacin. Antimicrob Agents Chemother 2003;47:2158-60.. PubMed
  7. Lilja JJ, Juntti-Patinen L, Neuvonen PJ. Orange juice substantially reduces the bioavailability of the beta-adrenergic-blocking agent celiprolol. Clin Pharmacol Ther 2004;75:184-90.
  8. Tian R, Koyabu N, Takanaga H, et al. Effects of grapefruit juice and orange juice on the intestinal efflux of P-glycoprotein substrates. Pharm Res 2002;19:802-9. PubMed
  9. Vanapalli SR, Chen Y, Ellingrod VL, et al. Orange juice decreases the oral bioavailability of ivermectin in health volunteers. Clin Pharmacol Ther 2003;73 (Abstract PDII-A-10):P94.
  10. Huang SM, Lesko LJ. Drug-drug, drug-dietary supplement, and drug-citrus fruit and other food interactions: what have we learned? J Clin Pharmacol 2004;44:559-69. PubMed
  11. Koitabashi Y, Kumai T, Matsumoto N, et al. Orange juice increased the bioavailability of pravastatin, 3-hydroxy-3-methylglutaryl CoA reductase inhibitor, in rats and healthy human subjects. Life Sci 2006;78:2852-9. PubMed
  12. Takanaga H, Ohnishi A, Yamada S, et al. Polymethoxylated flavones in orange juice are inhibitors of P-glycoprotein but not cytochrome P450 3A4. J Pharmacol Exp Ther 2000;293:230-6. DOI
  13. Greenblatt DJ. Analysis of drug interactions involving fruit beverages and organic anion-transporting polypeptides. J Clin Pharmacol 2009;49:1403-7. PubMed
  14. Bailey DG. Fruit juice inhibition of uptake transport: a new type of food-drug interaction. Br J Clin Pharmacol 2010;70:645-55. PubMed
  15. Kamath AV, Yao M, Zhang Y, Chong S. Effect of fruit juices on the oral bioavailability of fexofenadine in rats. J Pharm Sci 2005;94:233-9. PubMed
  16. Kays MB, Overholser BR, Mueller BA, et al. Effects of sevelamer hydrochloride and calcium acetate on the oral bioavailability of ciprofloxacin. Am J Kidney Dis. 2003;42(6):1253-9. PubMed
  17. Neuhofel, A. L., Wilton, J. H., Victory, J. M., Hejmanowsk, L. G., and Amsden, G. W. Lack of bioequivalence of ciprofloxacin when administered with calcium-fortified orange juice: a new twist on an old interaction. J Clin Pharmacol. 2002;42(4):461-466. DOI

See these in context on the Sweet Orange monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team