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Dietary supplement

Tangerine Ingredients & Drug Interactions

by doTERRA

Tangerine label
See full label image
Liquid Category: Botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tangerine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Tangerine is a dietary supplement by doTERRA with 1 active ingredient. Its ingredients are commonly taken for source of vitamin c, digestive support, aromatherapy and relaxation.Based on those ingredients, 643 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Tangerine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Tangerine by doTERRA

Ask about any prescription or over-the-counter medication and we check it for interactions with Tangerine by doTERRA — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Tangerine by doTERRA

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: tangerine (Citrus reticulata), delivered in liquid form. Tangerine is a citrus fruit whose peel and juice contain compounds like tangeretin and limonene.

The product has no inactive ingredients listed.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Tangerine product and its label doesn't state a use — see Tangerine's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The data we hold rates tangerine for cancer prevention as having insufficient reliable evidence to rate. In other words, we don't yet have enough quality research to tell you whether it works for that purpose.

If you're considering this supplement for a specific health goal, talk it over with your doctor or pharmacist—they can help you weigh what the current evidence shows.

The evidence, ingredient by ingredient Tangerine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Tangerine fruit is generally well tolerated when you eat it as food. However, the safety data notes that concentrated extracts and essential oils should be used with caution and only under medical advice, since safety studies on supplements and oils are more limited than for the whole fruit.

A small number of cases report contact dermatitis (skin redness or irritation) from tangerine essential oil in fragrances and topical products. Very few adverse effects from medicinal use have been reported, though a thorough safety evaluation hasn't been completed.

Pregnancy and lactation safety data is not on file for this ingredient—talk with your doctor or pharmacist if you're pregnant or nursing and want to use this product.

Side effects, ingredient by ingredient Tangerine

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Tangerine.
  • The most serious interaction on file is rated Minor.
  • For scale: 644 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking doTERRA Tangerine, double-check with your pharmacist or doctor if you take any medications that depend on the CYP3A4 enzyme to break them down—this includes sedatives like midazolam (Versed), many heart medications, immunosuppressants, statins, and a very wide range of other drugs. The interaction is documented as Minor severity based on human studies, but the sheer number of drugs affected makes it worth confirming your specific medications first.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

doTERRA Tangerine is a straightforward single-ingredient supplement made from tangerine fruit in liquid form. It's generally well tolerated as food, but concentrated supplements and oils warrant caution.

Because tangerine may affect how your liver processes a very large number of medications through the CYP3A4 pathway, check your exact medications with your doctor or pharmacist before starting—especially if you take sedatives, heart drugs, or immunosuppressants.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 28, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tangerine, straight from the product label.

Brand doTERRA
Net contents 5 mL; 0.16 fl. Oz.
Market status On market
Date entered into DSLD May 28, 2019
DSLD ID 202864
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tangerine by doTERRA, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Drop(s)
Maximum serving Sizes:
1 Drop(s)
Servings per container
85
IngredientAmount% DV
Tangerine60 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

For aromatic or topical use. Diffuse aromatically or, to apply topically, dilute with a carrier oil to minimize skin sensitivity.

For internal use dilute one drop in 4 fl. oz. of liquid.

Precautions

Caution: Possible skin sensitivity.

Keep away from children.

Consult your doctor if pregnant or in treatment.

Avoid eyes, inner ears, and sensitive areas. Avoid UV rays for 12 hours after applying product.

General

v5 41660001

Formula

Citrus reticulata

FDA Statement of Identity

Essential Oil Supplement

Brand IP Statement(s)

CPTG Certified Pure Therapeutic Grade

General Statements

Peel back for more information.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tangerine by doTERRA label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tangerine label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tangerine by doTERRA

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Drop(s) Dosage formLiquid Servings per container85 Amounts shown are per serving.

Tangerine

Interacts with
643 drugs
60 mg per serving

Tangerine is a sweet citrus fruit that is a good source of vitamin C and other nutrients, and is widely enjoyed as food. While the peel and essential...

Tangerine monograph & interactions
Interaction report

Tangerine by doTERRA Drug Interactions

Want to check YOUR meds against Tangerine?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
643Drugs
643 Minor

Ingredients driving the most interactions

Tangerine 643

Individual Drug Interactions

The ingredients in Tangerine interact with 643 drugs. Click any drug to see the details.

1 of the 1 ingredient in Tangerine interact with drugs. Each result below shows which ingredient is responsible. Tangerine

Each ingredient & the kinds of drugs it affects

For each ingredient in Tangerine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Tangerine2 drug types · 643 drugs

Cytochrome P450 3A4 (Cyp3A4) Substrates

In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4). This suggests that tangeretin may stimulate CYP3A4 activity. However, in humans, drinking tangerine juice 200 mL slightly delayed the absorption, but did not affect the metabolism, of midazolam, a CYP3A4 substrate. Theoretically, tangerine juice might increase CYP3A4 activity and decrease levels of drugs metabolized by this enzyme. However, this effect is unlikely.
Some drugs metabolized by CYP3A4 include amitriptyline (Elavil), amiodarone (Cordarone), citalopram (Celexa), felodipine (Plendil), lansoprazole (Prevacid), ondansetron (Zofran), prednisone (Deltasone, Orasone), sertraline (Zoloft), sibutramine (Meridia), and many others.

Likelihood Unlikely Evidence B
Midazolam (Versed)

In vitro, tangeretin, a constituent of tangerine, appears to increase the metabolism of midazolam in human liver microsomes by up to 52%. However, in humans, drinking tangerine juice 200 mL slightly delayed the absorption, but did not affect the metabolism, of midazolam. Theoretically, tangerine juice might increase the metabolism and reduce the effects of midazolam. However, this effect is unlikely.

Likelihood Unlikely Evidence B
Tangerine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tangerine, from the product label.

doTERRA

See all doTERRA products
Name
doTERRA Intl, LLC
Street Address
389 South 1300 West
City
Pleasant Grove
State
UT
ZipCode
84062
Pharmacist Counseling Corner

Tangerine by doTERRA: Common Questions

Does Tangerine by doTERRA interact with any medications?
Yes. Based on its ingredients, Tangerine has a known interaction with 643 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tangerine contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is tangerine essential oil the same as this liquid supplement?
The product facts don't specify whether this is pure juice, an extract, or an essential oil. Since concentrated extracts and essential oils warrant medical caution, ask the manufacturer or your pharmacist exactly what's in the bottle before use.
Can I take this if I'm pregnant or breastfeeding?
Pregnancy and lactation safety data isn't on file for tangerine supplements. Eating tangerine fruit as food is fine, but talk with your doctor or pharmacist before taking a concentrated supplement while pregnant or nursing—they can give you personalized advice based on your situation.
Will tangerine affect my sedative medication?
In laboratory tests, tangerine appeared to speed up how your liver breaks down midazolam (a sedative), but human studies using 200 mL of juice showed only a slight delay in absorption, not a reduction in effectiveness. Still, tangerine may affect how your body processes a very large number of medications through the same liver enzyme, so check with your pharmacist before combining them.
What does this supplement actually do?
We have data rating tangerine for cancer prevention, but the evidence is insufficient to say whether it works for that purpose. If you're using it for a specific health reason, your doctor or pharmacist can discuss what the current research actually shows.
Are there side effects from taking tangerine supplements?
Very few side effects from medicinal use have been reported, though a complete safety review hasn't been done. Topically, tangerine essential oil has caused contact dermatitis in some people. If you notice skin irritation or other unusual symptoms, stop and talk with your pharmacist or doctor.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tangerine label
Go deeper

The Full Monographs Behind Tangerine’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tangerine

Interacts with 643 drugs

Tangerine is a sweet citrus fruit that is a good source of vitamin C and other nutrients, and is widely enjoyed as food. While the peel and essential oil are used in traditional medicine and...

Read the full Tangerine monograph →
Sources

Sources & How We Checked

Tangerine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tangerine 3 references
  1. Yuan, J. M., Wang, X. L., Xiang, Y. B., Gao, Y. T., Ross, R. K., and Yu, M. C. Preserved foods in relation to risk of nasopharyngeal carcinoma in Shanghai, China. Int J Cancer 2000;85(3):358-363. DOI
  2. Backman, J. T., Maenpaa, J., Belle, D. J., Wrighton, S. A., Kivisto, K. T., and Neuvonen, P. J. Lack of correlation between in vitro and in vivo studies on the effects of tangeretin and tangerine juice on midazolam hydroxylation. Clin Pharmacol Ther 2000; PubMed
  3. Vilaplana, J. and Romaguera, C. Contact dermatitis from the essential oil of tangerine in fragrance. Contact Dermatitis 2002;46(2):108. PubMed

See these in context on the Tangerine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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