Interactions on record — worth a quick check against your medications. Based on 2 of 7 ingredients. Check your meds →
Dietary supplement

Total Care Soothe Probiotic 15 Billion CFU Ingredients & Drug Interactions

by Probulin

Total Care Soothe Probiotic 15 Billion CFU label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Total Care Soothe Probiotic 15 Billion CFU against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Total Care Soothe Probiotic 15 Billion CFU is a dietary supplement by Probulin with 7 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 1,283 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Ginfort, Sodium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Total Care Soothe Probiotic 15 Billion CFU by Probulin

Ask about any prescription or over-the-counter medication and we check it for interactions with Total Care Soothe Probiotic 15 Billion CFU by Probulin — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Total Care Soothe Probiotic 15 Billion CFU by Probulin

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 4 of its 20 active ingredients.
  • “Total Other Probiotics” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Lactobacillus Blend + Lactobacillus Fermentation Blend” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Bifidobacteria Blend + Bifidobacteria Fermentation Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

Total Care Soothe Probiotic 15 Billion CFU contains 20 ingredients, including multiple probiotic strains (live beneficial bacteria), inulin, and sodium. The probiotic strains are the active components — they include Bifidobacterium and Lactobacillus species, which are commonly used to support digestive health.

Inulin is a prebiotic fiber that helps feed your good bacteria. Sodium is included as a mineral.

The product also contains several inactive ingredients like cellulose, rice extract, and mineral salts that serve as fillers and capsule components.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive support with probiotics and ginger.
  • We looked for evidence on: Antibiotic-associated diarrhea, Constipation, Diarrhea, Dyspepsia, Clostridioides difficile infection, irritable bowel syndrome — and 3 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Ginger is rated "Possibly Effective" for Pregnancy-induced nausea and vomiting.

The evidence for probiotics as a group in this product is mixed and varies by strain. Lactobacillus acidophilus shows possibly effective evidence for irritable bowel syndrome (IBS), antibiotic-associated diarrhea, and bacterial vaginosis.

Bifidobacterium bifidum is possibly effective for IBS and respiratory tract infections. Inulin has possibly effective evidence for obesity, constipation, and diabetes.

Most other claimed uses in this product — such as cognitive decline, anxiety, allergic rhinitis, and asthma — carry insufficient evidence ratings, meaning we don't have enough reliable data to say whether they work. Talk with your pharmacist about whether this product matches what you're hoping it will do.

The evidence, ingredient by ingredient Sodium Ginger

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 8 of the 8 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 8 of 8.
  • General safety write-ups exist for 8 of 8.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The probiotics in this product are generally well tolerated in healthy people, though rare cases of serious infection (bacteremia) have occurred in critically ill or severely immunocompromised patients. If you're seriously ill or have a weakened immune system, check with your doctor first.

Inulin commonly causes gas, bloating, and digestive cramping, especially at higher doses — these side effects are usually mild and temporary. Sodium at high levels is linked to high blood pressure and heart strain; the amounts in a normal diet are fine, but avoid sodium supplements or very high intake without medical advice.

Pregnancy and lactation data are limited for most ingredients; inulin is likely safe, and the Bifidobacterium strains are possibly safe, but talk with your doctor or pharmacist for personalized guidance.

Side effects, ingredient by ingredient Sodium Ginger

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 7 of the 8 matched ingredients can interact with medications — Lactobacillus Acidophilus, Ginger, Inulin, Sodium, Bifidobacterium Bifidum, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 1,284 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check these medications before starting: antibiotic drugs (the probiotics' effectiveness may be reduced if taken at the same time — space them apart), blood pressure medications (sodium may reduce their effectiveness), and diabetes drugs (inulin may theoretically increase low blood sugar risk). If you take lithium, corticosteroids, or blood thinners, or if you're on didanosine or tolvaptan, mention this product to your pharmacist because of sodium content.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic may be worth considering if you have IBS, antibiotic-related diarrhea, or constipation, though the evidence is stronger for some strains than others. If you take blood pressure medications, diabetes drugs, or antibiotics, check your exact medications with the tool on this page before starting.

People who are seriously ill or immunocompromised should talk to their doctor first. A pharmacist can help you time it right — especially with antibiotics — and watch for gas or bloating as you adjust.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 9 of 20 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Total Care Soothe Probiotic 15 Billion CFU, straight from the product label.

Brand Probulin
Barcode (UPC) 810072962508
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2023
DSLD ID 299947
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Halal, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Total Care Soothe Probiotic 15 Billion CFU by Probulin, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
4 Capsule(s)
Servings per container
30
UPC/BARCODE
810072962508
IngredientAmount% DV
Sodium10 mg1%
Inulin55 mg--
Total Other Probiotics0 NP--
Lactobacillus Blend + Lactobacillus Fermentation Blend0 NP--
Bifidobacteria Blend + Bifidobacteria Fermentation Blend0 NP--
Postbiotic + Prebiotic Blend0 NP--
Total Care Soothe Probiotic Blend250 mg--
Bifidobacterium animalis lactis0 NP--
Bifidobacterium longum infantis MAK22B04I0 NP--
Bifidobacterium longum MAK34B12L0 NP--
Minor Bifidobacterium Strains0 NP--
Bifidobacterium bifidum MAK53B66B0 NP--
Lactobacillus acidophilus0 NP--
Lactobacillus fermentum MAK20L13F0 NP--
Lactobacillus reuteri MAK02L14R0 NP--
Lactobacillus rhamnosus MAK79L08R0 NP--
Minor Lactobacillus Strains0 NP--
Lactobacillus brevis MAK11L82B0 NP--
Lactobacillus bulgaricus MAK55L88B0 NP--
Lactobacillus helveticus MAK18L62H0 NP--
Pediococcus acidilactici MAK92P26A0 NP--
Pediococcus pentosaceus MAK99P15P0 NP--
Propionibacterium freudenreichii MAK10P23F0 NP--
Streptococcus thermophilus MAK34S24T0 NP--
Maktabolite Postbiotic0 NP--
Ginfort100 mg--
Menthol, Powder40 mg--

Other ingredients: Complex Marine Polysaccharides, Cellulose, Cellulose, Rice extract, Tricalcium Phosphate, Sodium Chloride, Potassium Chloride

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Probulin goes the extra mile to ensure your probiotics are alive when you: Buy them Take them Digest them

Formulated by: J. Mitchell Jason Mitchell, N.D., founder and CEO Board-certified Naturopathic Doctor Specializing in Research & Development

Doctor formulated

Formula

Probulin Soothe contains 15 probiotic strains, plus peppermint menthol and ginfort concentrated ginger extract for optimal digestive support. For additional support, an advanced usage of four capsules over four weeks can provide the scientifically-studied level of Ginfort concentrated ginger extract

Fermented fruit & vegetable blend Total Care Soothe Probiotic + prebiotic & postbiotic

Contains concentrated ginger extract & soothing peppermint 15 prebiotic strains

Pre Pro Post Prebiotic Food for the probiotic bacteria. Probiotic 15 billion cfu of probiotics, including 4 billion cfu derived from fermented fruits & vegetables at time of manufacturing - 2 year real-time stability in process. Postbiotic Postbiotics are unique compounds produced by probiotic bacteria. They support a healthy digestive microbiome.

Crescent H (Halal)

Brand IP Statement(s)

The Next Generation of Probiotics

Ginfort is a registered trademark of Olene Life Sciences Private Limited, Dolcas, LLC is the exclusive licensee of Ginfort.

Storage

No refrigeration required

FDA Statement of Identity

Dietary Supplement

Formulation

Broad-Spectrum digestive support

No GMOs No gluten No wheat No magnesium stearate No dairy No soy No: GMO's, wheat, gluten, dairy, eggs, magnesium stearate, soy, artificial flavors, artificial colors, artificial sweeteners or shellfish.

Our scientifically-validated MAKTrek 3-D system includes a unique seaweed barrier to protect against stomach acid, prebiotic fiber for food, and electrolytes for hydration.

MAKTrek 3-D for increased probiotic survival

Suggested/Recommended/Usage/Directions

1 capsule for the standard daily serving 4 capsules offers the scientifically-studied level of Ginfort, which has been shown to support reduction of occasional digestive upset and may improve upper abdominal bloating, when used over 4 weeks.

Directions: For a standard daily serving, adults take 1 capsule daily with food. Four capsules offers the scientifically-studied level of Ginfort ginger extract. As a reminder, always discuss the supplements and medications you take with your health care provider.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Caution: Pregnant or nursing mothers, children under 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Caution: Pregnant or nursing mothers, children under 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Do not use if seal is broken.

Keep out of the reach of children.

As a reminder, always discuss the supplements and medications you take with your health care provider.

Seals/Symbols

Crescent H (Halal)

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Total Care Soothe Probiotic 15 Billion CFU by Probulin label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Total Care Soothe Probiotic 15 Billion CFU label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Total Care Soothe Probiotic 15 Billion CFU by Probulin

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sodium

Interacts with
205 drugs
10 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Total Care Soothe Probiotic Blend

250 mg per serving
  • › Total Other Probiotics
  • › Lactobacillus Blend + Lactobacillus Fermentation Blend
  • › Bifidobacteria Blend + Bifidobacteria Fermentation Blend
  • › Postbiotic + Prebiotic Blend

Ginfort

Interacts with
1,007 drugs
100 mg per serving Form: Ginger Extract

Ginger is a widely used culinary spice with a long history in traditional medicine, and it has the strongest evidence for helping with nausea and vomi...

Ginfort monograph & interactions

Menthol, Powder

40 mg per serving Form: Peppermint Leaf Oil

Other (inactive) ingredients: Complex Marine Polysaccharides, Cellulose, Cellulose, Rice extract, Tricalcium Phosphate, Sodium Chloride, Potassium Chloride. These complete the product’s ingredient list but are not active constituents.

Interaction report

Total Care Soothe Probiotic 15 Billion CFU by Probulin Drug Interactions

Want to check YOUR meds against Total Care Soothe Probiotic 15 Billion CFU?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,283Drugs
1,170 Moderate 113 Minor

Ingredients driving the most interactions

Ginfort 1,007
Sodium 205

Individual Drug Interactions

The ingredients in Total Care Soothe Probiotic 15 Billion CFU interact with 1,283 drugs. Click any drug to see the details.

2 of the 7 ingredients in Total Care Soothe Probiotic 15 Billion CFU interact with drugs. Each result below shows which ingredient is responsible. Ginfort Sodium

Each ingredient & the kinds of drugs it affects

For each ingredient in Total Care Soothe Probiotic 15 Billion CFU with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Ginfort14 drug types · 1,007 drugs

Anticoagulant/Antiplatelet Drugs

Ginger may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs. However, research is conflicting.
Laboratory research suggests that ginger inhibits thromboxane synthetase and decreases platelet aggregation. However, this has not been demonstrated unequivocally in humans, with mixed results from clinical trials. Theoretically, excessive amounts of ginger might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, taking ginger with antidiabetes drugs might increase the risk of hypoglycemia.
Animal and human research suggests that ginger might increase insulin levels and/or decrease blood glucose levels.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Ginger might increase or decrease the levels of CYP3A4 substrates.
In vitro research and some case reports suggest that ginger inhibits CYP3A4 activity. Three case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking ginger and cancer medications that are CYP3A4 substrates (imatinib, dabrafenib, and crizotinib). However, the causality of this interaction is unclear due to the presence of multiple interacting drugs and routes of administration.
Conversely, other in vitro research suggests that ginger induces CYP3A4 activity, leading to reduced levels of CYP3A4 substrates. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Losartan (Cozaar)

Theoretically, ginger might increase levels of losartan and the risk of hypotension.
In animal research, ginger increased the levels and hypotensive effects of a single dose of losartan. It is not clear if ginger alters the concentration or effects of losartan when taken continuously. Additionally, this interaction has not been shown in humans.

Likelihood Possible Evidence D
Nifedipine (Procardia)

Ginger may have antiplatelet effects and increase the risk of bleeding if used with nifedipine.
Clinical research shows that combined treatment with ginger 1 gram plus nifedipine 10 mg significantly inhibits platelet aggregation when compared to nifedipine or ginger alone.

Likelihood Possible Evidence B
P-Glycoprotein Substrates

Ginger might increase the absorption and blood levels of P-glycoprotein (P-gp) substrates.
In vitro research and case reports suggest that ginger inhibits drug efflux by P-gp, potentially increasing absorption and serum levels of P-gp substrates. Two case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking ginger and cancer medications that are P-gp substrates (trametinib, crizotinib). However, the causality of this interaction is unclear due to the presence of multiple interacting drugs and routes of administration.

Likelihood Possible Evidence D
Phenprocoumon (Marcoumar, Others)

Ginger might increase the risk of bleeding with phenprocoumon.
Phenprocoumon, a warfarin-related anticoagulant, might increase the international normalized ratio (INR) when taken with ginger. There is one case report of a 76-year-old woman with a stable INR on phenprocoumon that increased to greater than 10 when she began consuming dried ginger and ginger tea.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Ginger might increase the risk of bleeding with warfarin.
Laboratory research suggests that ginger might inhibit thromboxane synthetase and decrease platelet aggregation. In one case report, ginger increased the INR when taken with phenprocoumon, which has similar pharmacological effects as warfarin. In another case report, ginger increased the INR when taken with a combination of warfarin, hydrochlorothiazide, and acetaminophen. A longitudinal analysis suggests that taking ginger increases the risk of bleeding in patients taking warfarin for at least 4 months. However, research in healthy people suggests that ginger has no effect on INR, or the pharmacokinetics or pharmacodynamics of warfarin. Until more is known, monitor INRs closely in patients taking large amounts of ginger.

Likelihood Possible Evidence B
Calcium Channel Blockers

Theoretically, taking ginger with calcium channel blockers might increase the risk of hypotension.
Some animal and in vitro research suggests that ginger has hypotensive and calcium channel-blocking effects. Another animal study shows that concomitant administration of ginger and the calcium channel blocker amlodipine leads to greater reductions in blood pressure when compared with amlodipine alone.

Likelihood Unlikely Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, when taken prior to cyclosporine, ginger might decrease cyclosporine levels.
In an animal model, ginger juice taken 2 hours prior to cyclosporine administration reduced the maximum concentration and area under the curve of cyclosporine by 51% and 40%, respectively. This effect was not observed when ginger juice and cyclosporine were administered at the same time.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ginger might increase the levels of CYP1A2 substrates.
In vitro research shows that ginger inhibits CYP1A2 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, ginger might increase the levels of CYP2B6 substrates.
In vitro research shows that ginger inhibits CYP2B6 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, ginger might increase the levels of CYP2C9 substrates.
In vitro research shows that ginger inhibits CYP2C9 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Metronidazole (Flagyl)

Theoretically, ginger might increase levels of metronidazole.
In an animal model, ginger increased the absorption and plasma half-life of metronidazole. In addition, the elimination rate and clearance of metronidazole was significantly reduced.

Likelihood Possible Evidence D
Ginfort full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Total Care Soothe Probiotic 15 Billion CFU, from the product label.

Probulin

See all Probulin products
Name
Probulin
Street Address
3820 NW 14th Street, Suite A & B
City
Topeka
State
KS
ZipCode
66618
Phone Number
1-888-697-8770
Web Address
www.probulin.com
Pharmacist Counseling Corner

Total Care Soothe Probiotic 15 Billion CFU by Probulin: Common Questions

Does Total Care Soothe Probiotic 15 Billion CFU by Probulin interact with any medications?
Yes. Based on its ingredients, Total Care Soothe Probiotic 15 Billion CFU has a known interaction with 1,283 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Total Care Soothe Probiotic 15 Billion CFU contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this probiotic work if I'm taking an antibiotic?
Not if you take them together. The antibiotic will kill the live probiotic bacteria. Space them out — take your antibiotic dose, wait a few hours, then take this probiotic. Your pharmacist can suggest a good timing schedule for your specific medications.
What causes the gas and bloating I might get from this?
Inulin, the prebiotic fiber in this product, feeds your good bacteria but often causes bloating, gas, and cramping as it does. These side effects are usually mild and tend to ease after a few days as your body adjusts. Starting with a lower dose can help.
Is it safe to take while pregnant or breastfeeding?
Inulin is likely safe in pregnancy and lactation. The Bifidobacterium strains are possibly safe, though data are limited. Sodium carries mixed safety ratings. Talk with your doctor or pharmacist for personalized advice — they know your full health picture.
Does this product actually help with IBS?
Lactobacillus acidophilus and Bifidobacterium bifidum both have possibly effective evidence for IBS, which means some research supports a benefit. Results vary from person to person, and it's not a guarantee. Give it time and track how you feel, and talk with your doctor if symptoms don't improve.
Why is there sodium in a probiotic supplement?
Sodium is included as a mineral and helps with the product's formulation. The amount is small, but if you're watching your sodium intake because of blood pressure or heart issues, mention this product to your pharmacist or doctor.
Can I take this every day?
Yes, probiotics like this are designed for daily use. The active ingredients and inactive fillers are generally well tolerated when used regularly, though watch for ongoing gas or bloating. If side effects don't ease up or get worse, check in with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Total Care Soothe Probiotic 15 Billion CFU is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Total Care Soothe Probiotic 15 Billion CFU label
Go deeper

The Full Monographs Behind Total Care Soothe Probiotic 15 Billion CFU’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Ginger

Interacts with 1,007 drugs

Ginger is a widely used culinary spice with a long history in traditional medicine, and it has the strongest evidence for helping with nausea and vomiting, including from motion sickness, pr...

Read the full Ginger monograph →
Sources

Sources & How We Checked

Total Care Soothe Probiotic 15 Billion CFU's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 185 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sodium 38 references
  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
  2. Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
  3. Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
  4. Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
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Inulin 17 references
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Bifidobacterium Longum 21 references
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Bifidobacterium Bifidum 7 references
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Lactobacillus Acidophilus 15 references
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Lactobacillus Helveticus 2 references
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Streptococcus Thermophilus 21 references
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See these in context on the Streptococcus Thermophilus monograph →

Ginger 64 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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