Interactions on record — worth a quick check against your medications. Based on 3 of 6 ingredients. Check your meds →
Dietary supplement

TrimSynergy Probiotic 20 Billion CFU Ingredients & Drug Interactions

by Probulin

TrimSynergy Probiotic 20 Billion CFU label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking TrimSynergy Probiotic 20 Billion CFU against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

TrimSynergy Probiotic 20 Billion CFU is a dietary supplement by Probulin with 6 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 1,502 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sensoril, Sodium, Inulin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against TrimSynergy Probiotic 20 Billion CFU by Probulin

Ask about any prescription or over-the-counter medication and we check it for interactions with TrimSynergy Probiotic 20 Billion CFU by Probulin — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of TrimSynergy Probiotic 20 Billion CFU by Probulin

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 4 of its 15 active ingredients.
  • “Lactobacillus Blend” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Bifidobacteria Blend” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “TrimSynergy Probiotic Blend” is a proprietary blend — the label gives one combined amount (200 mg) without saying how much of each component you get.

TrimSynergy Probiotic contains 15 ingredients, including several live probiotic bacteria strains (Lactobacillus salivarius, L. plantarum, L. acidophilus, L. bulgaricus, L. helveticus, L. brevis, L. rhamnosus, L. fermentum, Bifidobacterium lactis, B. longum, and B. bifidum), plus inulin (a type of dietary fiber), ashwagandha extract (Sensoril), sodium, and IGOB 131. The inactive ingredients are brown seaweed, cellulose, rice maltodextrin, tricalcium phosphate, sodium chloride, and potassium chloride.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports digestive health, weight management and energy.
  • We looked for evidence on: Antibiotic-associated diarrhea, Anxiety, Athletic performance, Constipation, Diarrhea, Fatigue — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Ashwagandha is rated "Possibly Effective" for Anxiety, Generalized anxiety disorder (GAD), Stress.
  • Also on file: Inulin is rated "Possibly Effective" for Constipation.

The probiotic bacteria strains in this product have been studied for a range of digestive and immune purposes. L. acidophilus is possibly effective for irritable bowel syndrome (IBS), antibiotic-associated diarrhea, bacterial vaginosis, and Helicobacter pylori infection.

B. bifidum is possibly effective for IBS and respiratory tract infections. Inulin is possibly effective for obesity, constipation, and diabetes.

Ashwagandha (Sensoril) is possibly effective for insomnia, anxiety, stress, and generalized anxiety disorder. However, most of the bacteria and ashwagandha carry ratings of insufficient evidence for several conditions.

The data we hold does not establish effectiveness for the product as a whole or for claims beyond what's listed here.

The evidence, ingredient by ingredient Sodium Inulin Ashwagandha

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L. acidophilus and the other live probiotic bacteria are generally well tolerated in healthy adults and children, though gastrointestinal side effects like bloating, flatulence, abdominal discomfort, and diarrhea can occur, especially when first starting. Rare but serious concerns include the risk of pathogenic infection in severely ill or immunocompromised patients; a small number of cases of bacteremia and sepsis have been reported with these organisms in critical patients.

Inulin is well tolerated at typical food amounts but commonly causes bloating, flatulence, and gastrointestinal cramps, especially at doses above 30 grams. Ashwagandha is generally well tolerated short-term in healthy adults, though nausea, diarrhea, and gastrointestinal upset can occur; rare cases of liver damage and intracranial bleeding have been reported.

Sodium is essential in small amounts but excess intake is linked to high blood pressure and heart strain. The product should not be used during pregnancy, as ashwagandha carries traditional concerns for miscarriage, and there is insufficient information to recommend it while breastfeeding.

Side effects, ingredient by ingredient Sodium Inulin Ashwagandha

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 7 of the 7 matched ingredients can interact with medications — Lactobacillus Acidophilus, Ashwagandha, Inulin, Sodium, Bifidobacterium Bifidum, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 1,503 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check these medication types with the search tool on this page: blood pressure medications (antihypertensive drugs), lithium, corticosteroids, sedatives and benzodiazepines, diabetes medications, blood thinners and other sodium-containing drugs, thyroid hormone, immunosuppressants, antibiotics, and medications processed by your liver's CYP1A2 enzyme. Sodium, ashwagandha, and several of the probiotic bacteria all carry interactions—the most serious are with lithium and blood pressure control.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic may help with digestive issues like IBS or antibiotic-associated diarrhea if you tolerate live bacteria well. However, if you take blood pressure medications, lithium, diabetes medications, benzodiazepines, sedatives, corticosteroids, immunosuppressants, thyroid hormone, or antibiotics, check your exact medications with the tool below before starting—the sodium and ashwagandha content carry meaningful risks.

Pregnant or breastfeeding? Talk to your doctor or pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 15 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about TrimSynergy Probiotic 20 Billion CFU, straight from the product label.

Brand Probulin
Barcode (UPC) 855757003701
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2023
DSLD ID 299948
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Halal, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for TrimSynergy Probiotic 20 Billion CFU by Probulin, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
855757003701
IngredientAmount% DV
Sodium11 mg1%
Lactobacillus salivarius0 NP--
Lactobacillus plantarum0 NP--
Lactobacillus acidophilus0 NP--
Lactobacillus bulgaricus0 NP--
Inulin50 mg--
Lactobacillus helveticus0 NP--
Lactobacillus brevis0 NP--
Lactobacillus rhamnosus0 NP--
Sensoril125 mg--
Lactobacillus Blend0 NP--
Lactobacillus fermentum0 NP--
Bifidobacteria Blend0 NP--
Bifidobacteria lactis0 NP--
Bifidobacteria longum0 NP--
Bifidobacteria bifidum0 NP--
TrimSynergy Probiotic Blend200 mg--
IGOB 131150 mg--

Other ingredients: Brown Seaweed, Cellulose, Rice Maltodextrin, Tricalcium Phosphate, Sodium Chloride, Potassium Chloride

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Probulin TrimSynergy Probiotic is a unique combination of clinically researched herbal extracts for weight management (African Mango Seed Extract) and energy (Ashwagandha). Partnered with key probiotic strains TrimSynergy: Features: 20 Billion cfu per day 11 Probiotic strains Shelf stable African Mango Extract (Irvingia gabonensis, IGOB 131) and Sensoril (Ashwagandha extract)

20 Billion cfu per day

Includes African Mango Seed Extract

Halal

Formulation

Benefits: Supports digestive health Supports digestive balance Supports weight management Supports energy levels Supports emotional well-being

Non-GMO

Helps support energy levels

All Probulin products include the patent pending MAKTrek 3-D delivery system, to ensure that the beneficial probiotic bacteria have better survival in the body. Lifestyle challenges such as diet, normal aging, overuse of alcohol consumption, and much more may all contribute to digestive imbalance of essential beneficial bacteria such as bifidobacteria. Taking a daily probiotic is an important part of your routine.

No: GMO's, wheat, gluten, milk, dairy, eggs, magnesium stearate, soy, artificial flavors, artificial colors, artificial sweeteners or shellfish.

No GMOs No Gluten No Wheat No Dairy No Magnesium Stearate No Soy

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Probulin The Next Generation Probiotic

MAKTrek 3-D "Seaweed Submarine" All Probulin products include the patent pending MAKTrek 3-D delivery system, to ensure that the beneficial probiotic bacteria have better survival in the body.

Probulin The Next Generation of Probiotics

Sensoril is a trademark of Natreon, Inc. and protected under US Patent 6,713,092. IGOB 131 is a trademark of Gateway Health Alliance, Inc. and is protected under US Patent 7,537,790.

FDA Statement of Identity

Dietary Supplement

General Statements

Probulin is formulated by: J. Mitchell Jason Mitchell, N.D. In Collaboration with: Dr. Challa Dr. Shekhar Challa Authror of Probiotics for Dummies

at Best Buy date as long as recommended storage conditions are maintained.

Suggested/Recommended/Usage/Directions

Directions: Adults take one (1) capsule twice daily (2 capsules per day) approximately 30 minutes prior to meal time. As a reminder, discuss the supplements and medications that you take with your health care providers.

Precautions

Caution: Do not exceed recommended dose.

Pregnant or nursing mothers, children under 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Pregnant or nursing mothers, children under 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Do not accept if seal is broken.

Keep out of the reach of children.

Storage

Refrigeration is not required but may extend shelf life. Store in a cool, dry place at 72 degrees F (22 degrees C) or below.

Seals/Symbols

Halal

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

TrimSynergy Probiotic 20 Billion CFU by Probulin label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

TrimSynergy Probiotic 20 Billion CFU label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in TrimSynergy Probiotic 20 Billion CFU by Probulin

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sodium

Interacts with
205 drugs
11 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Inulin

Interacts with
86 drugs
50 mg per serving

Inulin is a type of plant fiber (a prebiotic) found naturally in foods like chicory root, onions, and garlic, and it is widely added to supplements an...

Inulin monograph & interactions

TrimSynergy Probiotic Blend

200 mg per serving
  • › Sensoril
  • › Lactobacillus Blend
  • › Bifidobacteria Blend
  • › IGOB 131

Other (inactive) ingredients: Brown Seaweed, Cellulose, Rice Maltodextrin, Tricalcium Phosphate, Sodium Chloride, Potassium Chloride. These complete the product’s ingredient list but are not active constituents.

Interaction report

TrimSynergy Probiotic 20 Billion CFU by Probulin Drug Interactions

Want to check YOUR meds against TrimSynergy Probiotic 20 Billion CFU?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,502Drugs
1,067 Moderate 435 Minor

Ingredients driving the most interactions

Sensoril 1,372
Sodium 205
Inulin 86

Individual Drug Interactions

The ingredients in TrimSynergy Probiotic 20 Billion CFU interact with 1,502 drugs. Click any drug to see the details.

3 of the 6 ingredients in TrimSynergy Probiotic 20 Billion CFU interact with drugs. Each result below shows which ingredient is responsible. Sensoril Sodium Inulin

Each ingredient & the kinds of drugs it affects

For each ingredient in TrimSynergy Probiotic 20 Billion CFU with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sensoril10 drug types · 1,372 drugs

Antidiabetes Drugs

Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.

Likelihood Possible Evidence D
Benzodiazepines

Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.

Likelihood Possible Evidence D
Thyroid Hormone

Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Serotonergic Drugs

Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]

Likelihood Possible Evidence C
Sensoril full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Inulin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, inulin might increase the risk of hypoglycemia with antidiabetes drugs.
Some clinical research shows that inulin improves glycemic control in patients with diabetes; however, it is unclear if it has hypoglycemic effects.

Likelihood Unlikely Evidence D
Inulin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for TrimSynergy Probiotic 20 Billion CFU, from the product label.

Probulin

See all Probulin products
Name
Probulin
Street Address
3820 NW 14th Street, Suite A & B
City
Topeka
State
KS
ZipCode
66618
Phone Number
1-888-697-8770
Web Address
www.probulin.com
Pharmacist Counseling Corner

TrimSynergy Probiotic 20 Billion CFU by Probulin: Common Questions

Does TrimSynergy Probiotic 20 Billion CFU by Probulin interact with any medications?
Yes. Based on its ingredients, TrimSynergy Probiotic 20 Billion CFU has a known interaction with 1,502 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
TrimSynergy Probiotic 20 Billion CFU contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this probiotic help my IBS?
L. acidophilus and B. bifidum are both possibly effective for IBS, so they may help—but results vary by person. You'll want to give it time and watch for bloating or gas when you first start, since probiotics can trigger that. If you don't see improvement or if side effects are bad, tell your pharmacist.
Can I take this with my antibiotics?
No, not at the same time. The antibiotics will kill the live bacteria in the probiotic. Separate them by a few hours if you can—take your antibiotic, wait, then take the probiotic. Ask your pharmacist for the best timing for your specific medications.
What's the sodium content, and should I be worried?
The product contains sodium (and sodium chloride in the inactive ingredients), and the sodium monograph shows interactions with blood pressure medications, lithium, and several other drugs. If you have high blood pressure, take lithium, or have been told to limit sodium, check with your pharmacist before starting.
Is it safe to take this if I'm pregnant or breastfeeding?
The ashwagandha in this product carries traditional concerns about miscarriage during pregnancy, so it should be avoided. There isn't enough safety data to recommend it while breastfeeding either. Talk to your doctor or pharmacist about whether this is right for you.
What side effects should I expect?
The most common are bloating, flatulence, abdominal discomfort, and diarrhea—these usually come from the probiotics and inulin, especially when you first start. Ashwagandha can cause nausea, diarrhea, or drowsiness in some people. These effects are usually mild and go away, but if they're bothersome or don't improve, let your pharmacist know.
Does this work for weight loss?
Inulin (one of the ingredients) is possibly effective for obesity, but that doesn't mean this probiotic will help you lose weight on its own. It's not established as a weight-loss product in our data. Talk to your healthcare provider about realistic expectations.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if TrimSynergy Probiotic 20 Billion CFU is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

TrimSynergy Probiotic 20 Billion CFU label
Go deeper

The Full Monographs Behind TrimSynergy Probiotic 20 Billion CFU’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Inulin

Interacts with 86 drugs

Inulin is a type of plant fiber (a prebiotic) found naturally in foods like chicory root, onions, and garlic, and it is widely added to supplements and processed foods. It may help with regu...

Read the full Inulin monograph → Herb & supplement monograph

Ashwagandha

Interacts with 1,372 drugs

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evidence is still limited. It is generally w...

Read the full Ashwagandha monograph →
Sources

Sources & How We Checked

TrimSynergy Probiotic 20 Billion CFU's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 132 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sodium 38 references
  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
  2. Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
  3. Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
  4. Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
  5. Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
  6. Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
  7. Boudville N, Ward S, Benaroia M, House AA. Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease. Am J Hypertens 2005;18(10):1300-5. PubMed
  8. Bennett WM. Drug interactions and consequences of sodium restriction. Am J Clin Nutr 1997;65(2 Suppl):678S-681S. PubMed
  9. Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med 1994;97(4):383-9. PubMed
  10. Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/openbook.php?record_id=10925. DOI
  11. D'Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr 2012;31(4):489-98. PubMed
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Lactobacillus Acidophilus 15 references
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Inulin 17 references
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Lactobacillus Helveticus 2 references
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  2. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed

See these in context on the Lactobacillus Helveticus monograph →

Ashwagandha 32 references
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  20. Suryawanshi G, Abdallah M, Thomson M, Desai N, Chauhan A, Lim N. Ashwagandha-Associated Acute Liver Failure Requiring Liver Transplantation. Am J Ther 2023;30(1):e80-e83. PubMed
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  23. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
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  30. Hayashi M, Hamada H, Azuma SI, Hayashi K. Painless Thyroiditis by Withania somnifera (Ashwagandha). Cureus 2024;16(3):e55352. PubMed
  31. Vazirani S, Kothari A, Fujimoto J, Gomez M. Supplements Are Not a Synonym for Safe: Suspected Liver Injury From Ashwagandha. Fed Pract 2023;40(9):315-319. PubMed
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Bifidobacterium Longum 21 references
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  2. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  3. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  4. Rautava S, Kainonen E, Salminen S, Isolauri E. Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant. J Allergy Clin Immunol. 2012;130(6):1355-60. PubMed
  5. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
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  7. Pellonperä O, Mokkala K, Houttu N, et al. Efficacy of fish oil and/or probiotic intervention on the incidence of gestational diabetes mellitus in an at-risk group of overweight and obese women: A randomized, placebo-controlled, double-blind clinical trial PubMed
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  10. Enomoto T, Sowa M, Nishimori K, et al. Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota. Allergol Int 2014;63(4):575-85. PubMed
  11. US Food and Drug Administration (FDA). Dear Healthcare Provider Letter: Warning Regarding Use of Probiotics in Preterm Infants. September 2023. Available at: https://www.fda.gov/media/172606/download?attachment. Accessed November 1, 2023.
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  13. Sabaté JM, Iglicki F. Effect of Bifidobacterium longum 35624 on disease severity and quality of life in patients with irritable bowel syndrome. World J Gastroenterol 2022;28(7):732-744.
  14. Malaguarnera M, Greco F, Barone G, Gargante MP, Malaguarnera M, Toscano MA. Bifidobacterium longum with fructo-oligosaccharide (FOS) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. Dig Dis Sci 2007;52(11) PubMed
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  16. Tamaki H, Nakase H, Inoue S, et al. Efficacy of probiotic treatment with Bifidobacterium longum 536 for induction of remission in active ulcerative colitis: A randomized, double-blinded, placebo-controlled multicenter trial. Dig Endosc 2016;28(1):67-74.
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  18. Esaiassen E, Cavanagh P, Hjerde E, Simonsen GS, Støen R, Klingenberg C. Bifidobacterium longum subspecies infantis bacteremia in 3 extremely preterm infants receiving probiotics. Emerg Infect Dis 2016;22(9):1664-6.
  19. Tena D, Losa C, Medina MJ, Sáez-Nieto JA. Peritonitis caused by Bifidobacterium longum: case report and literature review. Anaerobe 2014;27:27-30. PubMed
  20. Sangkanjanavanich S, Pradubpongsa P, Mitthamsiri W, Sangasapaviliya A, Boonpiyathad T. Bifidobacterium infantis 35624 efficacy in patients with uncontrolled asthma: A randomized placebo-controlled trial. Ann Allergy Asthma Immunol 2022;129(6):790-792. PubMed
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See these in context on the Bifidobacterium Longum monograph →

Bifidobacterium Bifidum 7 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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