Total Kidney Detox 2 Evening Formula Ingredients & Drug Interactions
by Renew Life
What is this page for?
First and foremost: checking Total Kidney Detox 2 Evening Formula against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Total Kidney Detox 2 Evening Formula is a dietary supplement by Renew Life with 2 active ingredients. Its ingredients are commonly taken for urinary tract infections, urinary discomfort, mild diuretic.Based on those ingredients, 850 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Uva Ursi extract, Potassium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Total Kidney Detox 2 Evening Formula by Renew Life
Ask about any prescription or over-the-counter medication and we check it for interactions with Total Kidney Detox 2 Evening Formula by Renew Life — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Total Kidney Detox 2 Evening Formula by Renew Life
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Total Kidney Detox 2 Evening Formula contains 2 active ingredients. Uva ursi extract is an herbal ingredient traditionally used for urinary tract support.
Potassium is an essential mineral. The product is enclosed in a vegetable capsule.
Does it work?
Leans against
The evidence for uva ursi in urinary tract infections is rated as possibly ineffective. For bronchitis and benign prostatic hyperplasia (enlarged prostate), the data we hold shows insufficient reliable evidence to make a rating.
There are no effectiveness ratings on file for potassium relative to this product's stated purpose.
How safe is it?
Well-documented data
Uva ursi is generally well tolerated at low doses and for short-term use, but can be toxic at high doses or with prolonged use. Common side effects include diarrhea, nausea, stomach upset, and vomiting.
At very high doses (20 grams or more of dried herb), it has caused serious effects like convulsions, delirium, and shortness of breath; doses of 30 grams or more may be fatal. Potassium from food is safe, but supplements require caution — they can cause dangerously high blood levels, especially in people with kidney disease.
Common side effects are abdominal pain, belching, diarrhea, flatulence, nausea, and vomiting. Serious effects from high potassium include irregular heartbeat, low blood pressure, and mental confusion.
Uva ursi safety data in pregnancy and breastfeeding advise against use. Potassium from supplements during pregnancy and breastfeeding should be discussed with your doctor or pharmacist.
Meds to double-check
Moderate interaction found
Before taking Total Kidney Detox 2 Evening Formula, check whether you take lithium (uva ursi may raise levels — Moderate severity), potassium-sparing diuretics, ACE inhibitors, or angiotensin receptor blockers (potassium may accumulate dangerously — Moderate severity). Also flag any CYP2C19 or CYP3A4 substrate drugs, glucuronidated drugs, urinary acidifying agents, or P-glycoprotein substrates you're on — uva ursi may affect how these are metabolized or work.
Your pharmacist can run your medications through the interaction checker on this page.
The bottom line
Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product combines uva ursi and potassium, both with documented medication interactions. If you take any blood pressure medication, a diuretic, or lithium, you need to check with your pharmacist before adding this formula — the interactions could be significant.
Because uva ursi can be toxic at high doses and long-term use, keep any use short-term and talk to your pharmacist about whether this product is right for you and your medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 25, 2014.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Total Kidney Detox 2 Evening Formula, straight from the product label.
| Brand | Renew Life |
|---|---|
| Barcode (UPC) | 631257535689 |
| Net contents | 60 Vegetable Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Nov 25, 2014 |
| DSLD ID | 39277 |
| Product type | Botanical With Nutrients |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Total Kidney Detox 2 Evening Formula by Renew Life, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Uva Ursi extract | 500 mg | -- |
| Potassium | 198 mg | 6% |
Other ingredients: Vegetable Capsule
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Use of Total Kidney Detox(TM): For the first 3 days, take 1 capsule of Total Kidney Detox 1 in the morning with 8 oz. purified water and 1 capsule of Total Kidney Detox 2 with your evening meal and 8 oz. purified water. Increase to 2 capsules each for the remaining 11 days. Rest 2 weeks, repeat at full strength.
Directions: For the first 3 days, take 1 capsule each day with your evening meal and a full glass of water. After 3 days, take 2 capsules each day with your evening meal and a full glass of water. Please read accompanying literature.
General Statements
Total Kidney Detox 2 Evening Formula
For Both Bottles:
Total Kidney Detox: The herbs and potassium in Total Kidney Detox simultaneously support the natural cleansing processes of the kidneys, bladder and urinary tract and promote the normal healthy sterile environment of the urinary tract.*
This is a Non-Laxative Formula
Kidney, Bladder and Urinary Support 30-Day Program Promotes Kidney Detoxification Nourishes Urinary Tract
TKD 2
MADE IN USA
Brenda Watson, C.N.C., Cleanse & Detox Expert For over a decade ReNew Life has been helping millions of people live healthier lives through better digestion and nutrition. Founded by best-selling author and PBS mainstay Brenda Watson after her own battle with poor health, it is now the leading cleansing and digestive care company in America. Brenda’s passion and dedication have been instrumental in developing a complete line of premium herbal cleansing formulas and nutritional supplements for every need.
Call Toll-Free 1-800-830-1800 for Free Product Specialist Support If you have any questions as you begin your cleansing and detoxi¬fication journey, we’d like to know. Simply call for additional information, and you will be connected to a Product Specialist who can help guide you on your way.
Quality and Purity Guaranteed
Manufactured in a GMP facility
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Precautions
WARNING: Do not use this product if you are pregnant or nursing. Consult your physician before using this or any product if you are trying to conceive, taking medication or have a medical condition.
Not for prolonged use. Notice: Discontinue use if adverse effects occur.
KEEP OUT OF REACH OF CHILDREN.
TAMPER EVIDENT: DO NOT USE IF SAFETY SEAL IS BROKEN OR MISSING.
Formulation
Contains no GMOs, yeast, sugar, soy, wheat, corn, gluten, dairy, animal products, binders, fillers or artificial ingredients
Gluten-Free
Storage
Store in a dry place at 59-86(0)F (15-30(0)C).
Brand IP Statement(s)
For Ideal Results, We Recommend: Prior to this Detox Program First Cleanse(TM) (or) CleanseSMART(TM) During this Detox Program FiberSMART(TM) Ultimage Flora 50 Billion(TM) Maintenance After Detox Program FiberSMART(TM) Ultimate Flora 50 Billion(TM) OilSMART(TM)
Formula
Sterilization of Urinary System: Uva Ursi Leaf Alkalization of Urinary System: Potassium
With Uva Ursi, Potassium & Cranberry
Seals/Symbols
RENEW LIFE(R) The Digestive Care Experts
{recycle}
FDA Statement of Identity
Dietary Supplement
General
#15827 020114
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Total Kidney Detox 2 Evening Formula by Renew Life label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Total Kidney Detox 2 Evening Formula by Renew Life
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Uva Ursi extract
Interacts with803 drugs
Uva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial...
Uva Ursi extract monograph & interactionsPotassium
Interacts with62 drugs
Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...
Potassium monograph & interactionsOther (inactive) ingredients: Vegetable Capsule. These complete the product’s ingredient list but are not active constituents.
Total Kidney Detox 2 Evening Formula by Renew Life Drug Interactions
HelloPharmacist Interaction Report
Total Kidney Detox 2 Evening Formula by Renew Life contains two active ingredients, and both carry documented interactions with medications.
Read the full breakdown — every affected drug type, severity by severity
Uva ursi extract is the more complex ingredient here. It may slow how your body metabolizes certain drugs through multiple pathways — specifically CYP2C19 and CYP3A4 substrates, and glucuronidated drugs — all rated Moderate severity.
The most serious concern is lithium: uva ursi's diuretic properties may reduce lithium excretion and raise blood levels, potentially requiring a dose adjustment. Additionally, uva ursi may reduce the effectiveness of urinary acidifying agents by working best in alkaline urine, and it may alter levels of P-glycoprotein substrate drugs (Minor severity).
Potassium, the second ingredient, poses a Moderate-severity risk if you're on potassium-sparing diuretics (water pills that preserve potassium), ACE inhibitors, or angiotensin receptor blockers (ARBs) — common blood pressure medications. These drugs already reduce how much potassium your body excretes, so adding a supplement increases the risk of dangerously high blood potassium levels (hyperkalemia).
Although the in vitro (lab) data on uva ursi's enzyme effects are theoretical and haven't been confirmed in humans, the interactions are documented. Altogether, these interactions span 837 individual medications.
Before you start this product, check your exact prescriptions with the search tool on this page.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Total Kidney Detox 2 Evening Formula?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Total Kidney Detox 2 Evening Formula interact with 850 drugs. Click any drug to see the details.
2 of the 2 ingredients in Total Kidney Detox 2 Evening Formula interact with drugs. Each result below shows which ingredient is responsible. Uva Ursi extract Potassium
Ado-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Total Kidney Detox 2 Evening Formula — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Read the full Uva Ursi Extract + Ado-trastuzumab Emtansine interactionAbemaciclibVerzenio
How Abemaciclib interacts with Total Kidney Detox 2 Evening Formula — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Read the full Uva Ursi Extract + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Total Kidney Detox 2 Evening Formula — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Read the full Uva Ursi Extract + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Total Kidney Detox 2 Evening Formula — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Read the full Uva Ursi Extract + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Total Kidney Detox 2 Evening Formula — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractCytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP2C19 substrates.
Read the full Uva Ursi Extract + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Total Kidney Detox 2 Evening Formula — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractP-glycoprotein Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
Read the full Uva Ursi Extract + Acalabrutinib interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Total Kidney Detox 2 Evening Formula — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractGlucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi Extract + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Total Kidney Detox 2 Evening Formula — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractGlucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Total Kidney Detox 2 Evening Formula — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Total Kidney Detox 2 Evening Formula — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractGlucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Total Kidney Detox 2 Evening Formula — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractGlucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi Extract + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Total Kidney Detox 2 Evening Formula — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi Extract + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Total Kidney Detox 2 Evening Formula — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Glucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Read the full Uva Ursi Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Total Kidney Detox 2 Evening Formula — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractGlucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi Extract + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Total Kidney Detox 2 Evening Formula — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractGlucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Total Kidney Detox 2 Evening Formula — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Total Kidney Detox 2 Evening Formula — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Glucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Read the full Uva Ursi Extract + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Total Kidney Detox 2 Evening Formula — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Total Kidney Detox 2 Evening Formula — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Glucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Read the full Uva Ursi Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Total Kidney Detox 2 Evening Formula — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi Extract + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Total Kidney Detox 2 Evening Formula — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Glucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Read the full Uva Ursi Extract + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Total Kidney Detox 2 Evening Formula — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Total Kidney Detox 2 Evening Formula — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Total Kidney Detox 2 Evening Formula — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Total Kidney Detox 2 Evening Formula — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Glucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Read the full Uva Ursi Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Total Kidney Detox 2 Evening Formula — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Total Kidney Detox 2 Evening Formula — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Glucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Read the full Uva Ursi Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Total Kidney Detox 2 Evening Formula — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi Extract + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Total Kidney Detox 2 Evening Formula — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi Extract + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Total Kidney Detox 2 Evening Formula — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi Extract + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Total Kidney Detox 2 Evening Formula with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Uva Ursi extract
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, uva ursi may decrease the metabolism of CYP2C19 substrates.
In vitro, uva ursi appears to inhibit cytochrome CYP2C19. This effect has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
In vitro, uva ursi appears to inhibit CYP3A4. This effect has not been reported in humans.
Glucuronidated Drugs
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
In vitro, uva ursi extract appears to strongly inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1). However, uva ursi extract does not appear to inhibit UGT1A1 in animal models. This effect has not been reported in humans.
Lithium
Theoretically, uva ursi may increase lithium levels, necessitating a decrease in dose.
Uva ursi may have diuretic properties. Diuretics may increase lithium reabsorption with sodium in the proximal tubule of the kidney. Theoretically, uva ursi might reduce excretion and increase levels of lithium.
Urinary Acidifying Agents
Effects of uva ursi in the urinary tract may be reduced by urinary acidifying agents.
Uva ursi seems to work best in alkaline urine. Theoretically, taking uva ursi with medications known to acidify the urine may decrease any effects of uva ursi on the urinary tract.
P-Glycoprotein Substrates
Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
In vitro, uva ursi appears to inhibit the multi-drug transporter protein, P-glycoprotein. This effect has not been reported in humans.
Potassium
Ace Inhibitors (Aceis)
Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.
Angiotensin Receptor Blockers (Arbs)
Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.
Potassium-Sparing Diuretics
Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.
Brand information
Manufacturer and brand details for Total Kidney Detox 2 Evening Formula, from the product label.
Renew Life
- Web Address
- www.renewlife.com
Total Kidney Detox 2 Evening Formula by Renew Life: Common Questions
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The Full Monographs Behind Total Kidney Detox 2 Evening Formula’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Uva Ursi
Interacts with 803 drugsUva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial effects in the urine. Evidence in people...
Read the full Uva Ursi monograph → Herb & supplement monographPotassium
Interacts with 62 drugsPotassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...
Read the full Potassium monograph →Sources & How We Checked
Total Kidney Detox 2 Evening Formula's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 20 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Uva Ursi 8 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Wang L, Del Priore LV. Bull's-eye maculopathy secondary to herbal toxicity from uva ursi. Am J Ophthalmol 2004;137:1135-7. PubMed
- Beaux, D., Fleurentin, J., and Mortier, F. Effect of extracts of Orthosiphon stamineus Benth, Hieracium pilosella L., Sambucus nigra L. and Arctostaphylos uva-ursi (L.) Spreng. in rats. Phytother.Res 1999;13(3):222-225.
- de Arriba SG, Naser B, Nolte KU. Risk assessment of free hydroquinone derived from Arctostaphylos Uva-ursi folium herbal preparations. Int J Toxicol. 2013;32(6):442-453.
- Park JB, Kim D, Min JS, et al. Identification and characterization of in vitro inhibitors against UDP-glucuronosyltransferase 1A1 in uva-ursi extracts and evaluation of in vivo uva-ursi-drug interactions. Food Chem Toxicol. 2018;120:651-661. PubMed
- Chauhan B, Yu C, Krantis A, et al. In vitro activity of uva-ursi against cytochrome P450 isoenzymes and P-glycoprotein. Can J Physiol Pharmacol. 2007;85(11):1099-107.
Potassium 12 references
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
- Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials. JAMA 1997;277:1624-32. PubMed
- Phillips, C. O., Kashani, A., Ko, D. K., Francis, G., and Krumholz, H. M. Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: a quantitative review of data from ra DOI
- Altieri, P. I., Herrero, C., Suero, R., and Ortiz, A. Bleeding duodenal ulcer in a patient taking slow-releasing potassium tablets. Bol.Asoc.Med P.R. 1977;69(8):276.
- Raf, L. E. Enteric-coated potassium chloride tablets and ulcer of the small intestine. Acta Chir Scand Suppl 1967;(374):1-87.
- Potassium chloride oral solution [package insert]. Allentown, PA: Lehigh Valley Technologies, Inc.; 2014.
- Potassium chloride injection [package insert]. Lake Forest, IL: Hospira Inc.; 2009.
- Patel RB, Tannenbaum S, Viana-Tejedor A, et al. Serum potassium levels, cardiac arrhythmias, and mortality following non-ST-elevation myocardial infarction or unstable angina: insights from MERLIN-TIMI 36. Eur Heart J Acute Cardiovasc Care 2017 Feb;6(1):1 PubMed
- Malta D, Arcand J, Ravindran A, Floras V, Allard JP, Newton GE. Adequate intake of potassium does not cause hyperkalemia in hypertensive individuals taking medications that antagonize the renin angiotensin aldosterone system. Am J Clin Nutr 2016 Oct;104(4 PubMed
- Keskin M, Kaya A, Tatlisu MA, et al. The effect of serum potassium level on in-hospital and long-term mortality in ST elevation myocardial infarction. Int J cardiol. 2016 Oct 15;221:505-10.
- Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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