Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Tribulus 1,000 mg Ingredients & Drug Interactions

by NOW Sports

Tribulus 1,000 mg label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tribulus 1,000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Tribulus 1,000 mg is a dietary supplement by NOW Sports with 1 active ingredient. Its ingredients are commonly taken for low libido and sexual function, athletic performance and muscle building, testosterone support.Based on those ingredients, 259 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Tribulus terrestris standardized extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Tribulus 1,000 mg by NOW Sports

Ask about any prescription or over-the-counter medication and we check it for interactions with Tribulus 1,000 mg by NOW Sports — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Tribulus 1,000 mg by NOW Sports

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: tribulus terrestris standardized extract at 1,000 mg per tablet. Tribulus is a plant extract used traditionally to support sexual function and athletic performance.

The tablet also includes standard inactive ingredients—microcrystalline cellulose (a bulking agent), stearic acid and silicon dioxide (processing aids), and a vegetarian coating.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: enhance vitality and support sexual function.
  • We looked for evidence on: Erectile dysfunction (ED), Male infertility, Sexual dysfunction, Premature ejaculation, Libido, Testosterone support — and 1 related terms.
  • The strongest evidence on file: Tribulus is rated "Possibly Effective" for Sexual dysfunction (Natural Medicines).
  • Also on file: Tribulus is rated "Insufficient Reliable Evidence To Rate" for Erectile dysfunction (ED), Premature ejaculation, Male infertility.

Tribulus shows possibly effective evidence for sexual dysfunction based on our data. For athletic performance, the evidence leans toward possibly ineffective.

For benign prostatic hyperplasia (enlarged prostate), we don't hold enough reliable evidence to rate it either way. If you're considering this supplement for one of those purposes, talk with your doctor or pharmacist about what the research actually supports for your situation.

The evidence, ingredient by ingredient Tribulus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Tribulus is often well tolerated in short-term use by healthy adults, but quality and long-term safety data are limited. Gastrointestinal side effects—abdominal pain, cramping, nausea, vomiting, diarrhea, or constipation—have been reported, though in one study the rates matched placebo.

Rare serious effects including liver and kidney injury, seizures, and painful erection have been reported. The safety data advises against use during pregnancy because it may affect hormones, and against breastfeeding due to lack of reliable safety information.

Side effects, ingredient by ingredient Tribulus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Tribulus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 259 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking NOW Sports Tribulus, check with your pharmacist if you're on any blood pressure medications (antihypertensives)—tribulus can lower blood pressure further. Also check if you take diabetes medication (antidiabetes drugs) or lithium, since tribulus can lower blood sugar and may increase lithium levels.

These are moderate-severity interactions that may need dose adjustments or closer monitoring.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Tribulus may help with sexual dysfunction, but it's not proven for athletic performance and the long-term safety picture isn't clear. If you take blood pressure pills, diabetes medication, or lithium, you'll want to check this with your pharmacist first—tribulus could lower your blood pressure or blood sugar or raise lithium levels.

Talk with your pharmacist about whether it's right for you and how to monitor if you proceed.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tribulus 1,000 mg, straight from the product label.

Brand NOW Sports
Barcode (UPC) 733739021717
Net contents 90 Tablet(s)
Market status On market
Date entered into DSLD Feb 25, 2021
DSLD ID 245447
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Kosher, Adult Male (18-50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tribulus 1,000 mg by NOW Sports, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
733739021717
IngredientAmount% DV
Tribulus terrestris standardized extract1 Gram(s)--

Other ingredients: Microcrystalline Cellulose, Stearic Acid, Vegetarian Coating, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Usage: Take 1 tablet daily with a meal.

Formula

Tribulus terrestris has been used for centuries in ancient Greece, India and Africa to enhance vitality and virility. Recent research indicates that Tribulus can support the body’s free radical defense systems and preliminary studies suggest that Tribulus may help to promote healthy endocrine function and male reproductive health.

Triangle K

This double strength product has twice the tribulus (1,000 mg per tablet) as in our regular strength product (500 mg per capsule).

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Caution: For adults only.

Consult physician if pregnant/nursing, taking medication, or have a medical condition.

Keep out of reach of children.

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Formulation

Natural color variation may occur in this product.

Standardized Extract

Double Strength

V Vegan

Non-GMO

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients.

Storage

Store in a cool, dry, dark place after opening.

Seals/Symbols

GMP Quality Assured

Triangle K

FDA Statement of Identity

A Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tribulus 1,000 mg by NOW Sports label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tribulus 1,000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tribulus 1,000 mg by NOW Sports

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Tribulus terrestris standardized extract

Interacts with
259 drugs
1 Gram(s) per serving Form: Saponins

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims...

Tribulus terrestris standardized extract monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Stearic Acid, Vegetarian Coating, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tribulus 1,000 mg by NOW Sports Drug Interactions

Want to check YOUR meds against Tribulus 1,000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
259Drugs
259 Moderate

Ingredients driving the most interactions

Tribulus terrestris standardized extract 259

Individual Drug Interactions

The ingredients in Tribulus 1,000 mg interact with 259 drugs. Click any drug to see the details.

1 of the 1 ingredient in Tribulus 1,000 mg interact with drugs. Each result below shows which ingredient is responsible. Tribulus terrestris standardized extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Tribulus 1,000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Tribulus terrestris standardized extract3 drug types · 259 drugs

Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.

Likelihood Possible Evidence D
Lithium

Theoretically, tribulus might increase the levels and clinical effects of lithium.
Tribulus is thought to have diuretic properties. Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Tribulus terrestris standardized extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tribulus 1,000 mg, from the product label.

NOW Sports

See all NOW Sports products
Name
NOW FOODS
Street Address
395 S. Glen Ellyn Rd.
City
Bloomingdale
State
IL
ZipCode
60108
Web Address
nowsportsproducts.com
Pharmacist Counseling Corner

Tribulus 1,000 mg by NOW Sports: Common Questions

Does Tribulus 1,000 mg by NOW Sports interact with any medications?
Yes. Based on its ingredients, Tribulus 1,000 mg has a known interaction with 259 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tribulus 1,000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take tribulus if I'm pregnant or breastfeeding?
No. The safety data advises against tribulus during pregnancy because it may affect hormones and safety isn't established. You should also avoid it while breastfeeding due to lack of reliable safety information. Talk with your doctor if you're pregnant or nursing and considering any supplement.
Does tribulus actually improve sexual function?
The evidence says possibly effective for sexual dysfunction, which means there's some promising research but it's not proven. Results vary between people, so it may help some and not others. Your pharmacist can discuss whether it's worth trying for your situation.
What side effects should I watch for?
Most people tolerate it well short-term, but some experience stomach upset—abdominal pain, cramping, nausea, vomiting, diarrhea, or constipation. Rare serious effects like liver or kidney injury and seizures have been reported. Stop and call your doctor if you notice unusual symptoms, especially stomach pain, weakness, or changes in urination.
Is tribulus safe for long-term use?
The data on long-term safety is limited. We know it's generally well tolerated short-term in healthy adults, but we don't have enough research on what happens if you take it for months or years. If you want to use it regularly, check in with your pharmacist.
Will tribulus help my athletic performance?
The evidence leans toward possibly ineffective for athletic performance, so it's not a supported use. If you're looking to boost your workout results, talk with your doctor or trainer about options with better evidence.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Tribulus 1,000 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tribulus 1,000 mg label
Go deeper

The Full Monographs Behind Tribulus 1,000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tribulus

Interacts with 259 drugs

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims is weak and inconsistent. It is general...

Read the full Tribulus monograph →
Sources

Sources & How We Checked

Tribulus 1,000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tribulus 10 references
  1. Sharifi AM, Darabi R, Akbarloo N. Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity. Life Sci 2003;73:2963-71. PubMed
  2. Walker D, Bird A, Flora T, O'Sullivan B. Some effects of feeding Tribulus terrestris, Ipomoea lonchophylla and the seed of Abelmoschus ficulneus on fetal development and the outcome of pregnancy in sheep. Reprod Fertil Dev 1992;4:135-44. PubMed
  3. Al-Ali M, Wahbi S, Twaij H, Al-Badr A. Tribulus terrestris: preliminary study of its diuretic and contractile effects and comparison with Zea mays. J Ethnopharmacol 2003;85:257-60. PubMed
  4. Tabakova, P., Dimitrov, M., Ognyanov, K., and et al. Clinical study of Tribestan in females with endocrine sterility. Documentation for Registration (unpublished) 1999.
  5. Akhtari E, Raisi F, Keshavarz M, et al. Tribulus terrestris for treatment of sexual dysfunction in women: randomized double-blind placebo-controlled study. Daru 2014;22:40. PubMed
  6. Ryan M, Lazar I, Nadasdy GM, et al. Acute kidney injury and hyperbilirubinemia in a young male after ingestion of Tribulus terrestris. Clin Nephrol 2015;83(3):177-83. PubMed
  7. Postigo S, Lima SM, Yamada SS, et al. Assessment of the effects of Tribulus terrestris on sexual function of menopausal women. Rev Bras Ginecol Obstet 2016;38(3):140-6. PubMed
  8. Talasaz AH, Abbasi MR, Abkhiz S, Dashti-Khavidaki S. Tribulus terrestris-induced severe nephrotoxicity in a young healthy male. Nephrol Dial Tranplant 2010;25(11):3792-3. PubMed
  9. Samani NB, Jokar A, Soveid M, Heydari M, Mosavat SH. Efficacy of the hydroalcoholic extract of Tribulus terrestris on the serum glucose and lipid profile of women with diabetes mellitus: a double-blind randomized placebo-controlled clinical trial. J Evid
  10. Siddiqui MA, Itrat M, Mobeen A, Khan MI. Efficacy of khar-i-khasak (Tribulus terrestris Linn.) in prehypertension: a randomized, double-blind, placebo-controlled trial. J Complement Integr Med. 2021.

See these in context on the Tribulus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team