Tribulus 500 mg Ingredients & Drug Interactions
by NOW Sports
What is this page for?
First and foremost: checking Tribulus 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Tribulus 500 mg is a dietary supplement by NOW Sports with 1 active ingredient. Its ingredients are commonly taken for low libido and sexual function, athletic performance and muscle building, testosterone support.Based on those ingredients, 259 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Tribulus terrestris Aerial Parts, Fruit Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Tribulus 500 mg by NOW Sports
Ask about any prescription or over-the-counter medication and we check it for interactions with Tribulus 500 mg by NOW Sports — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Tribulus 500 mg by NOW Sports
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: Tribulus terrestris Aerial Parts, Fruit Extract at 500 mg per capsule. Tribulus is a plant extract traditionally used for sexual function and athletic performance.
The capsule also contains inactive ingredients — hypromellose, rice flour, silicon dioxide, and magnesium stearate — which are fillers, binders, and capsule material.
Does it work?
Moderate evidence
Tribulus shows possibly effective evidence for sexual dysfunction, suggesting it may help in this area, though the evidence isn't definitive. For athletic performance, the evidence points to possibly ineffective — meaning it's unlikely to deliver what people hope for in that regard.
For benign prostatic hyperplasia (enlarged prostate), we don't have reliable evidence to rate it one way or the other.
How safe is it?
Well-documented data
Tribulus is generally well tolerated short-term in healthy adults, but long-term safety data and product quality information are limited. The most common side effects are gastrointestinal — abdominal pain, cramping, nausea, vomiting, diarrhea, or constipation — though in one study these rates were similar to placebo.
Rare serious effects including liver and kidney injury, seizures, and prolonged painful erection have been reported. Do not use tribulus during pregnancy — the safety data advises against it because it may affect hormones.
Avoid it while breastfeeding as well, since we don't have reliable safety information for nursing infants.
Meds to double-check
Moderate interaction found
Before you take this product, double-check your medications with your pharmacist or our search tool. The main concerns are blood pressure medications (risk of pressure dropping too low), diabetes drugs (risk of low blood sugar), and lithium (risk of elevated levels).
These are Moderate-severity interactions and deserve a quick conversation.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Tribulus may be worth considering if you're interested in sexual function support and have no blood pressure or diabetes medications, and you're not pregnant or nursing. If you take antihypertensives, diabetes drugs, or lithium, you need to check with your pharmacist first — the interaction risks are real.
Talk to us before starting, especially if you're on any regular medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Tribulus 500 mg, straight from the product label.
| Brand | NOW Sports |
|---|---|
| Barcode (UPC) | 733739021700 |
| Net contents | 100 Veg Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Aug 22, 2024 |
| DSLD ID | 314506 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Kosher, Adult Male (18-50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Tribulus 500 mg by NOW Sports, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Tribulus terrestris Aerial Parts, Fruit Extract | 500 mg | -- |
Other ingredients: Hypromellose, Rice Flour, Silicon Dioxide, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Usage: Take 1 capsule 1 to 3 times daily with food.
Formula
Tribulus terrestris has been used for centuries in ancient Greece, India and Africa to enhance vitality and virility. Recent research indicates that Tribulus can support the body’s free radical defense systems and preliminary studies suggest that Tribulus may help to promote healthy endocrine function and male reproductive health.
Men's health
Tribulus 500 MG Standardized Extract
Triangle K (Kosher)
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Precautions
Caution: For adults only.
Consult physician if pregnant/nursing, taking medication, or have a medical condition.
Keep out of reach of children.
Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish, shellfish, tree nut or sesame ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.
Seals/Symbols
GMP Quality Assured
Triangle K (Kosher)
Formulation
Vitality
Non-GMO
V Vegan
Made and quality tested in the USA with globally sourced ingredients.
Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish, shellfish, tree nut or sesame ingredients.
Natural color variation may occur in this product.
FDA Statement of Identity
A Dietary Supplement
Storage
Store in a cool, dry, dark place after opening.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Tribulus 500 mg by NOW Sports label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Tribulus 500 mg by NOW Sports
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Veg Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.
Tribulus terrestris Aerial Parts, Fruit Extract
Interacts with259 drugs
Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims...
Tribulus terrestris Aerial Parts, Fruit Extract monograph & interactionsOther (inactive) ingredients: Hypromellose, Rice Flour, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Tribulus 500 mg by NOW Sports Drug Interactions
HelloPharmacist Interaction Report
Tribulus 500 mg by NOW Sports has documented interactions with three medication categories.
The most serious concern is with blood pressure medications (antihypertensives) — tribulus can lower blood pressure on its own, and combining it with these drugs raises your risk of blood pressure dropping too low (hypotension). This is a Moderate-severity interaction.
Read the full breakdown — every affected drug type, severity by severity
Tribulus also carries Moderate interactions with diabetes medications and with lithium. If you take diabetes drugs, tribulus may lower your blood sugar further, raising the risk of low blood sugar (hypoglycemia).
With lithium, tribulus's diuretic properties may reduce how your kidneys clear the drug, potentially raising lithium levels in your bloodstream — your dose might need adjusting.
Altogether, these interactions span 259 individual medications. Before you start this product, use the medication checker below to run through your current prescriptions — especially if you take anything for blood pressure, blood sugar, or mood.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Tribulus 500 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Tribulus 500 mg interact with 259 drugs. Click any drug to see the details.
1 of the 1 ingredient in Tribulus 500 mg interact with drugs. Each result below shows which ingredient is responsible. Tribulus terrestris Aerial Parts, Fruit Extract
AcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Tribulus 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Tribulus Terrestris Aerial Parts, Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Tribulus Terrestris Aerial Parts, Fruit Extract + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Tribulus 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Tribulus Terrestris Aerial Parts, Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Read the full Tribulus Terrestris Aerial Parts, Fruit Extract + Acebutolol interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Tribulus 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Tribulus Terrestris Aerial Parts, Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Read the full Tribulus Terrestris Aerial Parts, Fruit Extract + Acetazolamide interactionAcetohexamideDymelor
How Acetohexamide interacts with Tribulus 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Tribulus Terrestris Aerial Parts, Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Tribulus Terrestris Aerial Parts, Fruit Extract + Acetohexamide interactionAlbiglutideTanzeum
How Albiglutide interacts with Tribulus 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Tribulus Terrestris Aerial Parts, Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Tribulus Terrestris Aerial Parts, Fruit Extract + Albiglutide interactionAliskirenTekturna
How Aliskiren interacts with Tribulus 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Tribulus Terrestris Aerial Parts, Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Read the full Tribulus Terrestris Aerial Parts, Fruit Extract + Aliskiren interactionAlogliptinNesina
How Alogliptin interacts with Tribulus 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Tribulus Terrestris Aerial Parts, Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Tribulus Terrestris Aerial Parts, Fruit Extract + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Tribulus 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Tribulus Terrestris Aerial Parts, Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Tribulus Terrestris Aerial Parts, Fruit Extract + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Tribulus 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Tribulus Terrestris Aerial Parts, Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Tribulus Terrestris Aerial Parts, Fruit Extract + Alogliptin, Pioglitazone interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Tribulus 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Tribulus Terrestris Aerial Parts, Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Read the full Tribulus Terrestris Aerial Parts, Fruit Extract + Ambrisentan interactionAmilorideAmilamont, Midamor
How Amiloride interacts with Tribulus 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Tribulus Terrestris Aerial Parts, Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Read the full Tribulus Terrestris Aerial Parts, Fruit Extract + Amiloride interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Tribulus 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Tribulus Terrestris Aerial Parts, Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Read the full Tribulus Terrestris Aerial Parts, Fruit Extract + Amiloride, Hydrochlorothiazide interactionAmlodipineNorliqva
How Amlodipine interacts with Tribulus 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Tribulus Terrestris Aerial Parts, Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Read the full Tribulus Terrestris Aerial Parts, Fruit Extract + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with Tribulus 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Tribulus Terrestris Aerial Parts, Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Read the full Tribulus Terrestris Aerial Parts, Fruit Extract + Amlodipine Benzoate interactionAmlodipine BesilateIstin
How Amlodipine Besilate interacts with Tribulus 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Tribulus Terrestris Aerial Parts, Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Read the full Tribulus Terrestris Aerial Parts, Fruit Extract + Amlodipine Besilate interactionAmlodipine BesylateNorvasc
How Amlodipine Besylate interacts with Tribulus 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Tribulus Terrestris Aerial Parts, Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Read the full Tribulus Terrestris Aerial Parts, Fruit Extract + Amlodipine Besylate interactionAmlodipine Besylate, BenazeprilLotrel
How Amlodipine Besylate, Benazepril interacts with Tribulus 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Tribulus Terrestris Aerial Parts, Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Read the full Tribulus Terrestris Aerial Parts, Fruit Extract + Amlodipine Besylate, Benazepril interactionAmlodipine, CelecoxibConsensi
How Amlodipine, Celecoxib interacts with Tribulus 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Tribulus Terrestris Aerial Parts, Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Read the full Tribulus Terrestris Aerial Parts, Fruit Extract + Amlodipine, Celecoxib interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with Tribulus 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Tribulus Terrestris Aerial Parts, Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Read the full Tribulus Terrestris Aerial Parts, Fruit Extract + Ammonium Chloride interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Tribulus 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Tribulus Terrestris Aerial Parts, Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Tribulus Terrestris Aerial Parts, Fruit Extract + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionAprocitentanTryvio
How Aprocitentan interacts with Tribulus 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Tribulus Terrestris Aerial Parts, Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Read the full Tribulus Terrestris Aerial Parts, Fruit Extract + Aprocitentan interactionAtenololAtenix, Tenormin
How Atenolol interacts with Tribulus 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Tribulus Terrestris Aerial Parts, Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Read the full Tribulus Terrestris Aerial Parts, Fruit Extract + Atenolol interactionAtenolol, ChlortalidoneAtenixCo, Tenoret 50, Totaretic
How Atenolol, Chlortalidone interacts with Tribulus 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Tribulus Terrestris Aerial Parts, Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Read the full Tribulus Terrestris Aerial Parts, Fruit Extract + Atenolol, Chlortalidone interactionAtenolol, ChlorthalidoneTenoretic
How Atenolol, Chlorthalidone interacts with Tribulus 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Tribulus Terrestris Aerial Parts, Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Read the full Tribulus Terrestris Aerial Parts, Fruit Extract + Atenolol, Chlorthalidone interactionAzilsartanEdarbi
How Azilsartan interacts with Tribulus 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Tribulus Terrestris Aerial Parts, Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Read the full Tribulus Terrestris Aerial Parts, Fruit Extract + Azilsartan interactionAzilsartan, ChlorthalidoneEdarbyclor
How Azilsartan, Chlorthalidone interacts with Tribulus 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Tribulus Terrestris Aerial Parts, Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Read the full Tribulus Terrestris Aerial Parts, Fruit Extract + Azilsartan, Chlorthalidone interactionBenazeprilLotensin
How Benazepril interacts with Tribulus 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Tribulus Terrestris Aerial Parts, Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Read the full Tribulus Terrestris Aerial Parts, Fruit Extract + Benazepril interactionBenazepril, HydrochlorothiazideLotensin HCT
How Benazepril, Hydrochlorothiazide interacts with Tribulus 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Tribulus Terrestris Aerial Parts, Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Read the full Tribulus Terrestris Aerial Parts, Fruit Extract + Benazepril, Hydrochlorothiazide interactionBendroflumethiazideAprinox, Naturetin, Neo-NaClex
How Bendroflumethiazide interacts with Tribulus 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Tribulus Terrestris Aerial Parts, Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Read the full Tribulus Terrestris Aerial Parts, Fruit Extract + Bendroflumethiazide interactionBendroflumethiazide, NadololCorzide
How Bendroflumethiazide, Nadolol interacts with Tribulus 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Tribulus Terrestris Aerial Parts, Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Read the full Tribulus Terrestris Aerial Parts, Fruit Extract + Bendroflumethiazide, Nadolol interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Tribulus 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Tribulus terrestris Aerial Parts, Fruit Extract
Antidiabetes Drugs
Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications.
Antihypertensive Drugs
Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.
Lithium
Theoretically, tribulus might increase the levels and clinical effects of lithium.
Tribulus is thought to have diuretic properties. Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.
Brand information
Manufacturer and brand details for Tribulus 500 mg, from the product label.
NOW Sports
See all NOW Sports products- Name
- NOW FOODS
- Street Address
- 395 S. Glen Ellyn Rd.
- City
- Bloomingdale
- State
- IL
- ZipCode
- 60108
- Web Address
- nowsportsproducts.com
Tribulus 500 mg by NOW Sports: Common Questions
Does Tribulus 500 mg by NOW Sports interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take Tribulus if I'm pregnant or breastfeeding?
What are the side effects?
Does tribulus actually improve athletic performance?
How much data do we have on long-term use?
Does this product have any fillers or inactive ingredients?
What is tribulus used for?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Tribulus 500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Tribulus 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Tribulus 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 10 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Tribulus 10 references
- Sharifi AM, Darabi R, Akbarloo N. Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity. Life Sci 2003;73:2963-71. PubMed
- Walker D, Bird A, Flora T, O'Sullivan B. Some effects of feeding Tribulus terrestris, Ipomoea lonchophylla and the seed of Abelmoschus ficulneus on fetal development and the outcome of pregnancy in sheep. Reprod Fertil Dev 1992;4:135-44. PubMed
- Al-Ali M, Wahbi S, Twaij H, Al-Badr A. Tribulus terrestris: preliminary study of its diuretic and contractile effects and comparison with Zea mays. J Ethnopharmacol 2003;85:257-60. PubMed
- Tabakova, P., Dimitrov, M., Ognyanov, K., and et al. Clinical study of Tribestan in females with endocrine sterility. Documentation for Registration (unpublished) 1999.
- Akhtari E, Raisi F, Keshavarz M, et al. Tribulus terrestris for treatment of sexual dysfunction in women: randomized double-blind placebo-controlled study. Daru 2014;22:40. PubMed
- Ryan M, Lazar I, Nadasdy GM, et al. Acute kidney injury and hyperbilirubinemia in a young male after ingestion of Tribulus terrestris. Clin Nephrol 2015;83(3):177-83. PubMed
- Postigo S, Lima SM, Yamada SS, et al. Assessment of the effects of Tribulus terrestris on sexual function of menopausal women. Rev Bras Ginecol Obstet 2016;38(3):140-6. PubMed
- Talasaz AH, Abbasi MR, Abkhiz S, Dashti-Khavidaki S. Tribulus terrestris-induced severe nephrotoxicity in a young healthy male. Nephrol Dial Tranplant 2010;25(11):3792-3. PubMed
- Samani NB, Jokar A, Soveid M, Heydari M, Mosavat SH. Efficacy of the hydroalcoholic extract of Tribulus terrestris on the serum glucose and lipid profile of women with diabetes mellitus: a double-blind randomized placebo-controlled clinical trial. J Evid
- Siddiqui MA, Itrat M, Mobeen A, Khan MI. Efficacy of khar-i-khasak (Tribulus terrestris Linn.) in prehypertension: a randomized, double-blind, placebo-controlled trial. J Complement Integr Med. 2021.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC