Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Tribulus Pro Ingredients & Drug Interactions

by Universal

Tribulus Pro label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tribulus Pro against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Tribulus Pro is a dietary supplement by Universal with 2 active ingredients. Its ingredients are commonly taken for low libido and sexual function, athletic performance and muscle building, testosterone support.Based on those ingredients, 259 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Tribulus terrestris powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Tribulus Pro by Universal

Ask about any prescription or over-the-counter medication and we check it for interactions with Tribulus Pro by Universal — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Tribulus Pro by Universal

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Proprietary Tribulus Blend” is a proprietary blend — the label gives one combined amount (625 mg) without saying how much of each component you get.

Tribulus Pro contains 2 active ingredients: tribulus terrestris powder and tribulus terrestris extract, both from the same plant source. The product also contains inactive ingredients—gelatin (the capsule), dicalcium phosphate, and magnesium stearate (a binder)—that don't affect how the supplement works.

One ingredient listed is a proprietary tribulus blend, which means the individual components aren't broken out on the label.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Strength, libido, and hormone support.
  • We looked for evidence on: Athletic performance, Erectile dysfunction (ED), Male infertility, Premature ejaculation, Sexual dysfunction, Menopausal symptoms — and 4 related terms.
  • The strongest evidence on file: Tribulus is rated "Possibly Effective" for Sexual dysfunction (Natural Medicines).
  • Also on file: Tribulus is rated "Possibly Ineffective" for Athletic performance.
  • Also on file: Tribulus is rated "Insufficient Reliable Evidence To Rate" for Erectile dysfunction (ED), Menopausal symptoms, Polycystic ovary syndrome (PCOS), Premature ejaculation, and more.

Tribulus terrestris has been studied mainly for sexual function. The evidence suggests it may be possibly effective for sexual dysfunction, though the research is not definitive.

For athletic performance, the evidence points toward it being possibly ineffective. For benign prostatic hyperplasia (enlarged prostate)—a common condition in older men—we don't hold reliable evidence yet to rate it one way or the other.

The evidence, ingredient by ingredient Tribulus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Tribulus is generally well tolerated in the short term for healthy adults, but good long-term safety data are limited. Gastrointestinal side effects like abdominal pain, cramping, nausea, vomiting, diarrhea, and constipation can occur, though one study found these complaints happened at similar rates in people taking tribulus and those on placebo.

Rare serious adverse effects—liver and kidney injury, seizures, and chronic painful erection with impaired sexual function—have been reported. During pregnancy, tribulus safety is not established and it may affect hormones; the data advises against it.

While breastfeeding, there isn't reliable safety information, so it's best avoided. If you're pregnant, planning pregnancy, or breastfeeding, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Tribulus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Tribulus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 259 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you take blood pressure medications, diabetes medications, or lithium. Tribulus may lower blood pressure and blood sugar further and may raise lithium levels—all Moderate concerns that could need a dose adjustment.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Tribulus Pro is marketed mainly for sexual function, where the evidence suggests it may help, and for athletic performance, where it likely doesn't. If you take blood pressure medication, diabetes medication, or lithium, you'll want to check with your doctor or pharmacist before starting—tribulus can affect how these drugs work.

For most other people, it's generally well tolerated short-term, though long-term safety data are sparse.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tribulus Pro, straight from the product label.

Brand Universal
Barcode (UPC) 039442045041
Net contents 110 Capsule(s)
Market status On market
Date entered into DSLD Oct 24, 2022
DSLD ID 275415
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tribulus Pro by Universal, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
110
UPC/BARCODE
039442045041
IngredientAmount% DV
Tribulus terrestris powder0 NP--
Proprietary Tribulus Blend625 mg--
Tribulus Terrestris extract0 NP--

Other ingredients: Gelatin, Dicalcium Phosphate, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

YouTube.com Facebook.com Instagram.com Twitter.com @UniversalUSA Who We Are Founded in 1977, we are a family-run company that has been formulating and manufacturing proven nutritional products for dedicated athletes. Our products are found in over 90 countries around the world. Classic Series Since the 70s, we've been dedicated to making some of the finest nutritional products for world-class bodybuilders. Today, the new Classic Series still represents our steadfast commitment to those individuals seeking to achieve strength and perfection in the gym.

Plant US-#300104580

Classic series 100 Capsules + 10 Free

Formula

Tribulus Pro Tribulus Pro is a natural herbal supplement containing biologically active compounds including saponins, flavonoids, alkaloids, and sterols. Tribulus Pro combines both the powdered whole fruit with a standardized 40% extract for the best of both worlds. The unique formula found in Tribulus Pro can best deliver the physiological benefits that the herb has to offer. Combines powder & extract Extract standardized for 40% saponins Contains saponins, flavonoids & sterols

Professional strength tribulus

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

EAC (Eurasian Union)

Brand IP Statement(s)

Universal Nutrition Universal Starts With U

Formulation

Strength Libido support Hormone support

FDA Statement of Identity

Dietary Supplement

Precautions

Made in a GMP facility on equipment that processes milk, soy, egg, peanuts, tree nuts, fish, shellfish, and wheat.

Warning: Not for use by those under the age of 18.

Consult a physician before using this product.

Do not use if pregnant or nursing.

Do not exceed recommended dose. Do not use this product if you are at risk of or are being treated for high blood pressure, heart, kidney, thyroid or psychiatric disease, anxiety, depression, seizure disorder, stroke or any other medical condition. Discontinue use and consult your healthcare professional if dizziness, sleeplessness, tremors, nervousness, headache or heart palpitations occur. Use of this product may be banned by some athletic associations. Athletes should consult with their sanctioning authority before use. California Residents: Warning: Reproductive harm - www.P65Warnings.ca.gov.

Suggested/Recommended/Usage/Directions

Dosage: As a dietary supplement, take 1 capsule with morning and evening meals.

Storage

Store product in a cool, dry place, away from heat, moisture and sunlight.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tribulus Pro by Universal label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tribulus Pro label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tribulus Pro by Universal

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container110 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Tribulus Blend

625 mg per serving

Other (inactive) ingredients: Gelatin, Dicalcium Phosphate, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tribulus Pro by Universal Drug Interactions

Want to check YOUR meds against Tribulus Pro?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
259Drugs
259 Moderate

Ingredients driving the most interactions

Tribulus terrestris powder 259

Individual Drug Interactions

The ingredients in Tribulus Pro interact with 259 drugs. Click any drug to see the details.

1 of the 2 ingredients in Tribulus Pro interact with drugs. Each result below shows which ingredient is responsible. Tribulus terrestris powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Tribulus Pro with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Tribulus terrestris powder3 drug types · 259 drugs

Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.

Likelihood Possible Evidence D
Lithium

Theoretically, tribulus might increase the levels and clinical effects of lithium.
Tribulus is thought to have diuretic properties. Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Tribulus terrestris powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tribulus Pro, from the product label.

Universal

See all Universal products
Name
Universal Nutrition
City
New Brunswick
State
New Jersey
ZipCode
08901
Phone Number
800-872-0101
Web Address
www.UniversalUSA.com
Pharmacist Counseling Corner

Tribulus Pro by Universal: Common Questions

Does Tribulus Pro by Universal interact with any medications?
Yes. Based on its ingredients, Tribulus Pro has a known interaction with 259 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tribulus Pro contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does tribulus actually improve sexual function?
The evidence suggests it may be possibly effective for sexual dysfunction, but the research isn't conclusive. Some studies show a benefit; others don't. It's worth discussing with your doctor if you're considering it for this reason.
Can I take this if I'm pregnant or breastfeeding?
No. The safety data advise against tribulus during pregnancy because it may affect hormones and safety isn't established. While breastfeeding, there's a lack of reliable safety information, so it's best avoided. Talk with your doctor or pharmacist if you have questions about what's safe during these times.
What side effects might I experience?
Most people tolerate tribulus well, but stomach upset—abdominal pain, cramping, nausea, vomiting, diarrhea, or constipation—can happen. Rare serious effects like liver or kidney injury and seizures have been reported, though they're uncommon. If you develop any unusual symptoms, stop taking it and talk with your doctor or pharmacist right away.
Why is there a 'proprietary blend' on the label?
That means the exact amounts and individual components aren't disclosed by the manufacturer—it's listed as a group. We can't analyze that ingredient separately, but the two other tribulus forms on the label carry the same interaction profile.
Will this help me build muscle or improve athletic performance?
The evidence suggests tribulus is possibly ineffective for athletic performance. If building strength or endurance is your goal, talk with your doctor or trainer about what's backed by solid research.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Tribulus Pro is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tribulus Pro label
Go deeper

The Full Monographs Behind Tribulus Pro’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tribulus

Interacts with 259 drugs

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims is weak and inconsistent. It is general...

Read the full Tribulus monograph →
Sources

Sources & How We Checked

Tribulus Pro's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tribulus 10 references
  1. Sharifi AM, Darabi R, Akbarloo N. Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity. Life Sci 2003;73:2963-71. PubMed
  2. Walker D, Bird A, Flora T, O'Sullivan B. Some effects of feeding Tribulus terrestris, Ipomoea lonchophylla and the seed of Abelmoschus ficulneus on fetal development and the outcome of pregnancy in sheep. Reprod Fertil Dev 1992;4:135-44. PubMed
  3. Al-Ali M, Wahbi S, Twaij H, Al-Badr A. Tribulus terrestris: preliminary study of its diuretic and contractile effects and comparison with Zea mays. J Ethnopharmacol 2003;85:257-60. PubMed
  4. Tabakova, P., Dimitrov, M., Ognyanov, K., and et al. Clinical study of Tribestan in females with endocrine sterility. Documentation for Registration (unpublished) 1999.
  5. Akhtari E, Raisi F, Keshavarz M, et al. Tribulus terrestris for treatment of sexual dysfunction in women: randomized double-blind placebo-controlled study. Daru 2014;22:40. PubMed
  6. Ryan M, Lazar I, Nadasdy GM, et al. Acute kidney injury and hyperbilirubinemia in a young male after ingestion of Tribulus terrestris. Clin Nephrol 2015;83(3):177-83. PubMed
  7. Postigo S, Lima SM, Yamada SS, et al. Assessment of the effects of Tribulus terrestris on sexual function of menopausal women. Rev Bras Ginecol Obstet 2016;38(3):140-6. PubMed
  8. Talasaz AH, Abbasi MR, Abkhiz S, Dashti-Khavidaki S. Tribulus terrestris-induced severe nephrotoxicity in a young healthy male. Nephrol Dial Tranplant 2010;25(11):3792-3. PubMed
  9. Samani NB, Jokar A, Soveid M, Heydari M, Mosavat SH. Efficacy of the hydroalcoholic extract of Tribulus terrestris on the serum glucose and lipid profile of women with diabetes mellitus: a double-blind randomized placebo-controlled clinical trial. J Evid
  10. Siddiqui MA, Itrat M, Mobeen A, Khan MI. Efficacy of khar-i-khasak (Tribulus terrestris Linn.) in prehypertension: a randomized, double-blind, placebo-controlled trial. J Complement Integr Med. 2021.

See these in context on the Tribulus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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