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Dietary supplement

Triple-Strength Phosphatidylserine 300 mg Ingredients & Drug Interactions

by Swanson Ultra

Triple-Strength Phosphatidylserine 300 mg label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Triple-Strength Phosphatidylserine 300 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Triple-Strength Phosphatidylserine 300 mg is a dietary supplement by Swanson Ultra with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, age-related cognitive decline, attention and focus (adhd).Based on those ingredients, 219 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Phosphatidylserine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Triple-Strength Phosphatidylserine 300 mg by Swanson Ultra

Ask about any prescription or over-the-counter medication and we check it for interactions with Triple-Strength Phosphatidylserine 300 mg by Swanson Ultra — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Triple-Strength Phosphatidylserine 300 mg by Swanson Ultra

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: phosphatidylserine 300 mg per softgel. Phosphatidylserine is a phospholipid — a compound found naturally in cell membranes — that your body uses in nerve and brain cell function.

The softgel capsule itself is made from gelatin, glycerin, purified water, soy lecithin, medium-chain triglycerides oil, silica, and an antioxidant blend.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Phosphatidylserine's overall clinical evidence instead.

Moderate

Some clinical evidence supports Phosphatidylserine for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Age-related cognitive decline — rated "Possibly Effective" (Natural Medicines).
  • On file: Alzheimer disease — rated "Possibly Effective" (Natural Medicines).

Phosphatidylserine is possibly effective for age-related cognitive decline and Alzheimer disease, according to the evidence we hold. For athletic performance, attention deficit-hyperactivity disorder (ADHD), general cognitive function, and dementia, the evidence is not strong enough to rate it — meaning we don't have reliable data showing it works for these uses.

The evidence, ingredient by ingredient Phosphatidylserine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Phosphatidylserine is generally well tolerated in studies, though long-term safety hasn't been fully established. The most common side effects are flatulence, gastrointestinal upset, headache, insomnia, and nausea.

Headache and insomnia appear more likely at higher doses — insomnia in particular at 600 mg — and gastrointestinal upset can occur at doses of 200–300 mg per day, which is the dose in this product. The safety data advises against use during pregnancy.

Safety while breastfeeding is unknown, so avoidance is recommended. If you are pregnant, breastfeeding, or planning either, talk with your doctor or pharmacist before taking this supplement.

Side effects, ingredient by ingredient Phosphatidylserine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Phosphatidylserine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check your medications against anticholinergic drugs (like antihistamines, certain antidepressants, and medications for urinary symptoms) and cholinergic drugs (like some Alzheimer disease medications or myasthenia gravis treatments). Phosphatidylserine may interfere with anticholinergics or add to the effects of cholinergics.

Confirm with your doctor or pharmacist that it's safe to combine.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This supplement may help with age-related cognitive decline or Alzheimer disease, though the evidence is modest. If you take anticholinergic or cholinergic medications, check with your doctor or pharmacist first — phosphatidylserine could theoretically affect how well they work.

Be ready for potential stomach upset, headache, or insomnia, especially at higher doses. Discuss it with your own healthcare provider to see if it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Triple-Strength Phosphatidylserine 300 mg, straight from the product label.

Brand Swanson Ultra
Barcode (UPC) 087614028057
Net contents 30 Softgel(s)
Market status On market
Date entered into DSLD Jun 25, 2018
DSLD ID 178026
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Triple-Strength Phosphatidylserine 300 mg by Swanson Ultra, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
UPC/BARCODE
087614028057
IngredientAmount% DV
Phosphatidylserine300 mg--

Other ingredients: Gelatin, Glycerin, purified (deionized) Water, Soy Lecithin, Medium-Chain Triglycerides Oil, Silica, Antioxidant Blend

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

The most advanced nutrition technology Softgels

To reorder, call toll free 1-800-437-4148 or visit our website at www.swansonvitamins.com

Brand IP Statement(s)

Dietary Supplement

Sharp-PS is a registered trademark of Enzymotec Ltd. manufactured and protected under U.S. patent #8,324,187.

Formula

Sharp-PS

Seals/Symbols

Guaranteed purity & potency

Precautions

Do not use if seal is broken.

Keep out of reach of children.

Storage

Store in a cool, dry place. Do not refrigerate.

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take one softgel one to three times per day with water.

General

SWU805 Rev 0 01 12 17

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Triple-Strength Phosphatidylserine 300 mg by Swanson Ultra label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Triple-Strength Phosphatidylserine 300 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Triple-Strength Phosphatidylserine 300 mg by Swanson Ultra

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Phosphatidylserine

Interacts with
219 drugs
300 mg per serving Form: MCT Oil, Sharp-PS 28D Soybean Phospholipid, Sunflower Oil

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...

Phosphatidylserine monograph & interactions

Other (inactive) ingredients: Gelatin, Glycerin, Purified (deionized) Water, Soy Lecithin, Medium-Chain Triglycerides Oil, Silica, Antioxidant Blend. These complete the product’s ingredient list but are not active constituents.

Interaction report

Triple-Strength Phosphatidylserine 300 mg by Swanson Ultra Drug Interactions

Want to check YOUR meds against Triple-Strength Phosphatidylserine 300 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
219Drugs
219 Moderate

Ingredients driving the most interactions

Phosphatidylserine 219

Individual Drug Interactions

The ingredients in Triple-Strength Phosphatidylserine 300 mg interact with 219 drugs. Click any drug to see the details.

1 of the 1 ingredient in Triple-Strength Phosphatidylserine 300 mg interact with drugs. Each result below shows which ingredient is responsible. Phosphatidylserine

Each ingredient & the kinds of drugs it affects

For each ingredient in Triple-Strength Phosphatidylserine 300 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Phosphatidylserine2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.

Likelihood Possible Evidence B
Cholinergic Drugs

Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence B
Phosphatidylserine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Triple-Strength Phosphatidylserine 300 mg, from the product label.

Swanson Ultra

See all Swanson Ultra products
Name
Swanson Health Products
Street Address
PO BOX 2803
City
Fargo
State
ND
ZipCode
58108
Phone Number
1-800-437-4148
Web Address
www.swansonvitamins.com
Pharmacist Counseling Corner

Triple-Strength Phosphatidylserine 300 mg by Swanson Ultra: Common Questions

Does Triple-Strength Phosphatidylserine 300 mg by Swanson Ultra interact with any medications?
Yes. Based on its ingredients, Triple-Strength Phosphatidylserine 300 mg has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Triple-Strength Phosphatidylserine 300 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my memory or thinking?
Phosphatidylserine is possibly effective for age-related cognitive decline and Alzheimer disease. For other memory or thinking issues — like ADHD or general cognitive function — the evidence isn't strong enough to say whether it works.
Can I take this if I'm pregnant or breastfeeding?
No — the safety data advises against use during pregnancy, and safety while breastfeeding is unknown. Talk with your doctor or pharmacist before taking it if you are pregnant, breastfeeding, or planning either.
What side effects should I expect?
Most people tolerate it well, but common side effects include flatulence, stomach upset, headache, insomnia, and nausea. Insomnia is more likely at higher doses, and stomach upset can happen at the 300 mg dose in this product.
Does it have any fillers?
The capsule itself contains gelatin, glycerin, purified water, soy lecithin, medium-chain triglycerides oil, silica, and an antioxidant blend — these are the inactive ingredients that make up the softgel.
What is phosphatidylserine, and where does it come from?
Phosphatidylserine is a compound found naturally in cell membranes that plays a role in nerve and brain function. The product facts on file don't specify its source — check the label or contact the manufacturer for that detail.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Triple-Strength Phosphatidylserine 300 mg label
Go deeper

The Full Monographs Behind Triple-Strength Phosphatidylserine 300 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Phosphatidylserine

Interacts with 219 drugs

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinking. Some research suggests possible bene...

Read the full Phosphatidylserine monograph →
Sources

Sources & How We Checked

Triple-Strength Phosphatidylserine 300 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phosphatidylserine 9 references
  1. Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6.
  2. Pepping J. Phosphatidylserine. Am J Health-Syst Pharm 1999;56:2038,2043-4.
  3. Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
  4. Kim HY, Akbar M, Lau A, et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem 2000;275:35215-23.. PubMed
  5. Zanotti A, Valzelli L, Toffano G. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology (Berl) 1989;99:316-21.. PubMed
  6. Schreiber S, Kampf-Sherf O, Gorfine M, et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci 2000;37:302-7.
  7. Pepping, J. Phosphatidylserine. Am J Health Syst.Pharm. 10-15-1999;56(20):2038, 2043-2038, 2044.
  8. Monteverde, A., Gnemmi, P., Rossi, F., Monteverde, A., and Finali, G. C. Selegiline in the treatment of mild to moderate Alzheimer-type dementia. Clin.Ther 1990;12(4):315-322.
  9. Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement Geri PubMed

See these in context on the Phosphatidylserine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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