Interactions on record — worth a quick check against your medications. Based on 2 of 5 ingredients. Check your meds →
Dietary supplement

Tru-Sorb Megacor Ingredients & Drug Interactions

by Physician's Signature

Tru-Sorb Megacor label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tru-Sorb Megacor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Tru-Sorb Megacor is a dietary supplement by Physician's Signature with 5 active ingredients. Its ingredients are commonly taken for bone health and osteoporosis, correcting vitamin d deficiency, immune system support.Based on those ingredients, 743 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin D, Astaxanthin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Tru-Sorb Megacor by Physician's Signature

Ask about any prescription or over-the-counter medication and we check it for interactions with Tru-Sorb Megacor by Physician's Signature — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Tru-Sorb Megacor by Physician's Signature

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 6 of its 7 active ingredients.
  • “OmegaChoice TG Omega-3 Essential Fatty Acids” is listed as a grouped ingredient — the label gives one combined amount (840 mg) without saying how much of each component you get.

Tru-Sorb Megacor contains 7 active ingredients. Vitamin D is included to support bone health and calcium metabolism — it's effective for conditions like rickets, osteomalacia (soft bones), and renal bone disease.

The product also delivers eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), two omega-3 fatty acids from fish, plus astaxanthin, a plant-derived antioxidant. The remaining actives are monounsaturated fat, polyunsaturated fat, and a proprietary omega-3 blend (OmegaChoice TG).

The softgel is made with gelatin, glycerin, fish oil concentrate, and other inactive ingredients that help the supplement dissolve and absorb.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Optimal absorption of omega-3 fish oil and nutrients.
  • We looked for evidence on: Cardiovascular disease (CVD), Hyperlipidemia, Exercise-induced muscle damage, Exercise-induced muscle soreness, Athletic performance, Aging skin — and 4 related terms.
  • The closest evidence on file: Vitamin D is rated "Possibly Ineffective" for Cardiovascular disease (CVD) (Natural Medicines).
  • Also on file: Vitamin D is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Hyperlipidemia, Exercise-induced muscle damage.
  • Also on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Aging skin, Athletic performance, Exercise-induced muscle soreness.

Vitamin D in this product is effective for rickets, osteomalacia, renal osteodystrophy, hypoparathyroidism, and familial hypophosphatemia — these are established uses. For astaxanthin, the evidence we hold is insufficient to rate whether it helps with age-related cognitive decline, macular degeneration, aging skin, Alzheimer disease, athletic performance, or carpal tunnel syndrome.

The omega-3 fatty acids in the product are not rated in our data for any specific use.

The evidence, ingredient by ingredient Vitamin D Astaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin D is generally well tolerated at recommended doses, but very high doses taken over time can cause toxicity with symptoms like high blood calcium, kidney problems, and anemia. Rare symptoms of overdose include bone loss in adults and slowed growth in children.

Astaxanthin appears well tolerated in studies, though long-term safety data are limited — the most common side effects reported are abdominal pain, diarrhea, and red-colored stools. For pregnancy, vitamin D at recommended amounts is often used, but check with your doctor first.

Astaxanthin should be avoided during pregnancy and breastfeeding — there isn't enough safety data.

Side effects, ingredient by ingredient Vitamin D Astaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Vitamin D, Astaxanthin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications.
  • For scale: 744 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Tru-Sorb Megacor, double-check if you use heart rhythm medications like verapamil, diltiazem, or digoxin; cholesterol drugs like atorvastatin; thiazide diuretics (water pills); calcipotriene cream for psoriasis; or any medications broken down by your liver (CYP3A4 or CYP2B6 substrates). Vitamin D at high doses is the primary concern — it can raise blood calcium levels and interfere with how these drugs work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product is designed for people looking to support bone health and cardiovascular function with vitamin D and omega-3 fatty acids. If you take heart medications, cholesterol drugs, water pills, or drugs broken down by your liver, you'll want to check your specific medications with our tool before starting.

Talk to your pharmacist or doctor, especially if you're pregnant, breastfeeding, or take any prescription medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tru-Sorb Megacor, straight from the product label.

Brand Physician's Signature
Barcode (UPC) 854755007193
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Sep 22, 2022
DSLD ID 272421
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tru-Sorb Megacor by Physician's Signature, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel Capsule(s)
Maximum serving Sizes:
2 Softgel Capsule(s)
Servings per container
30
UPC/BARCODE
854755007193
IngredientAmount% DV
Calories10 Calorie(s)--
Total Fat1 Gram(s)1%
Saturated Fat0 Gram(s)1%
Trans Fat0 Gram(s)--
Vitamin D50 mcg250%
Eicosapentaenoic Acid80 mg--
Docosahexaenoic Acid480 mg--
Monounsaturated Fat0 Gram(s)--
Total Omega-3 Fatty Acids620 mg--
Polyunsaturated Fat0.5 Gram(s)--
Astaxanthin600 mcg--
OmegaChoice TG Omega-3 Essential Fatty Acids840 mg--

Other ingredients: Fish Oil Concentrate, Gelatin, Glycerin, VESIsorb Microemulsion preconcentrate, Medium Chain Triglyceride, Nonionic Surfactant, Sucrose, Sucrose Fatty Acid Esters, natural Annatto color

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Optimal absorption and bioavailability

1 Tru-Sorb Megacor softgel equals 6 regular fish oil softgels

Formula

Tru-Sorb Megacor utilizes a patented colloidal droplet delivery system for dramatically improved absorption and is formulated with OmegaChoice supercritical CO2 extracted fish oil, AstaReal Astaxanthin, and vitamin D3.

Tru-Sorb uses VESIsorb a patented colloidal droplet delivery system.

Omega 3 with Astaxanthin and vitamin D3

Brand IP Statement(s)

Tru-Sorb uses VESIsorb a patented colloidal droplet delivery system. VESIsorb and CoQSource are registered trademarks of SourceOne Global Partners.

Rawleigh A Friend of the Family Since 1889

Physician's Signature by W.T. Rawleigh

Suggested/Recommended/Usage/Directions

Directions: Take two (2) softgels daily with food or as recommended by your healthcare professional.

Precautions

Caution: Consult your physician prior to using this product if you are pregnant, nursing, or have any pre-existing medical conditions.

Keep out of reach of children

Do not purchase if seal is broken

Contains: Fish (Anchovy).

Storage

Store in a cool, dry place

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tru-Sorb Megacor by Physician's Signature label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tru-Sorb Megacor label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tru-Sorb Megacor by Physician's Signature

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Softgel Capsule(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin D

Interacts with
715 drugs
50 mcg per serving Form: Cholecalciferol, Vitamin D3

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people,...

Vitamin D monograph & interactions

Astaxanthin

Interacts with
671 drugs
600 mcg per serving

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise...

Astaxanthin monograph & interactions

OmegaChoice TG Omega-3 Essential Fatty Acids

840 mg per serving
  • › Eicosapentaenoic Acid
  • › Docosahexaenoic Acid
  • › Total Omega-3 Fatty Acids

Other (inactive) ingredients: Fish Oil Concentrate, Gelatin, Glycerin, VESIsorb Microemulsion preconcentrate, Medium Chain Triglyceride, Nonionic Surfactant, Sucrose, Sucrose Fatty Acid Esters, Natural Annatto color. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tru-Sorb Megacor by Physician's Signature Drug Interactions

Want to check YOUR meds against Tru-Sorb Megacor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
743Drugs
743 Moderate

Ingredients driving the most interactions

Vitamin D 715
Astaxanthin 671

Individual Drug Interactions

The ingredients in Tru-Sorb Megacor interact with 743 drugs. Click any drug to see the details.

2 of the 5 ingredients in Tru-Sorb Megacor interact with drugs. Each result below shows which ingredient is responsible. Vitamin D Astaxanthin

Each ingredient & the kinds of drugs it affects

For each ingredient in Tru-Sorb Megacor with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin D8 drug types · 715 drugs

Aluminum

Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
The protein that transports calcium across the intestinal wall can also bind and transport aluminum. This protein is stimulated by vitamin D, which may therefore increase aluminum absorption. This mechanism may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.

Likelihood Probable Evidence B
Atorvastatin (Lipitor)

Vitamin D might reduce absorption of atorvastatin.
A small, low-quality clinical study shows that taking vitamin D reduces levels of atorvastatin and its active metabolites by up to 55%. However, while atorvastatin levels decreased, total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels did not substantially change. Atorvastatin is metabolized in the gut by CYP3A4 enzymes, and researchers theorized that vitamin D might induce CYP3A4, causing reduced levels of atorvastatin. However, this proposed mechanism was not specifically studied.

Likelihood Probable Evidence B
Calcipotriene (Dovonex)

Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with vitamin D supplements might increase the risk of hypercalcemia.

Likelihood Probable Evidence D
Digoxin (Lanoxin)

Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and digoxin concurrently.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically this could also occur with diltiazem. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and diltiazem concurrently.

Likelihood Probable Evidence B
Thiazide Diuretics

Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Thiazide diuretics decrease urinary calcium excretion, which could lead to hypercalcemia if vitamin D supplements are taken concurrently. This has been reported in people being treated with vitamin D for hypoparathyroidism, and also in elderly people with normal parathyroid function who were taking a thiazide, vitamin D, and calcium-containing antacids daily.

Likelihood Probable Evidence D
Verapamil (Calan, Others)

Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of verapamil in atrial fibrillation. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and verapamil concurrently.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
There is some concern that vitamin D might induce CYP3A4. In vitro research suggests that vitamin D induces CYP3A4 transcription. Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found. A small, low-quality clinical study shows that taking vitamin D reduces levels of the CYP3A4 substrate atorvastatin and its active metabolites by up to 55%; however, the clinical effects of atorvastatin were not reduced. While researchers theorized that vitamin D might induce CYP3A4, this proposed mechanism was not specifically studied.

Likelihood Possible Evidence D
Vitamin D full monograph & interactions

Astaxanthin2 drug types · 671 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Astaxanthin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tru-Sorb Megacor, from the product label.

Physician's Signature

See all Physician's Signature products
Name
Vitamins Direct
City
West Palm Beach
State
FL
ZipCode
33407
Phone Number
866-354-8384
Web Address
www.wtraleigh.com
Pharmacist Counseling Corner

Tru-Sorb Megacor by Physician's Signature: Common Questions

Does Tru-Sorb Megacor by Physician's Signature interact with any medications?
Yes. Based on its ingredients, Tru-Sorb Megacor has a known interaction with 743 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tru-Sorb Megacor contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is it safe to take this if I'm pregnant?
Vitamin D at recommended doses is often used during pregnancy, but you should only take it under your doctor's guidance. Astaxanthin should be avoided — there isn't enough safety data. Talk to your pharmacist or doctor before starting, especially if you're pregnant or planning to be.
What's astaxanthin for?
Astaxanthin is an antioxidant derived from plants. The evidence we hold on whether it helps with age-related cognitive decline, macular degeneration, skin aging, Alzheimer disease, athletic performance, or carpal tunnel syndrome is insufficient to rate it.
Can too much vitamin D in this product hurt me?
Yes — very high doses of vitamin D taken over time can cause toxicity. Symptoms include high blood calcium, kidney problems, anemia, bone loss, and rarely, eye problems and photophobia. Stick to recommended doses and check with your doctor if you're taking other vitamin D sources.
What side effects might I notice?
Vitamin D is well tolerated at recommended doses. Astaxanthin may cause abdominal pain, diarrhea, or red-colored stools in some people — these are the most common side effects reported in studies.
Is this safe while breastfeeding?
Vitamin D at recommended doses is generally considered acceptable — check with your doctor before taking higher amounts. Astaxanthin should be avoided while breastfeeding because there isn't enough safety data.
Does this product have fillers?
Yes. The inactive ingredients include fish oil concentrate, gelatin, glycerin, medium chain triglyceride, surfactants, and other compounds that help the softgel dissolve and absorb.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tru-Sorb Megacor label
Go deeper

The Full Monographs Behind Tru-Sorb Megacor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin D

Interacts with 715 drugs

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people, especially those with low sun exposure,...

Read the full Vitamin D monograph → Herb & supplement monograph

Astaxanthin

Interacts with 671 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph →
Sources

Sources & How We Checked

Tru-Sorb Megacor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 29 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin D 26 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Tatro DS, ed. Drug Interactions Facts. Facts and Comparisons Inc., St. Louis, MO. 1999.
  3. Koutkia P, Chen TC, Holick MF. Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med 2001;345:66-7. PubMed
  4. Bar-Or D, Yoel G. Calcium and calciferol antagonize effect of verapamil in atrial fibrillation. Br Med J 1981;282:1585-6.
  5. Demontis R, Leflon A, Fournier A, et al. 1 alpha(OH) vitamin D3 increases plasma aluminum in hemodialyzed patients taking AI(OH)3. Clin Nephrol 1986;26:146-9.
  6. Crowe M, Wollner L, Griffiths RA. Hypercalcemia following vitamin D and thiazide therapy in the elderly. Practitioner 1984;228:312-3.
  7. Parfitt AM. Thiazide-induced hypercalcemia in vitamin D-treated hypoparathyroidism. Ann Intern Med 1972;77:557-63. PubMed
  8. Thiazide diuretics and the risk of osteoporosis. Pharmacist's Letter/Prescriber's Letter 2003;19(11):191105.
  9. Moon J. The role of vitamin D in toxic metal absorption. J Am Coll Nutr 1994;13:559-64.
  10. Demontis R, Reissi D, Noel C, et al. Indirect clinical evidence that 1alphaOH vitamin D<SUB>3</SUB> increases the intestinal absorption of aluminum. Clin Nephrol 1989;31:123-7.
  11. Adler AJ, Berlyne GM. Duodenal aluminum absorption in the rat: effect of vitamin D. Am J Physiol 1985;249:G209-13. PubMed
  12. Schwartz JB. Effects of vitamin D supplementation in atorvastatin-treated patients: A new drug interaction with an unexpected consequence. Clin Pharmacol Ther 2009;85:198-203. PubMed
  13. Dietary reference intakes for calcium and vitamin D. Institute of Medicine, November 30, 2010. Available at: http://www.iom.edu/~/media/Files/Report%20Files/2010/Dietary-Reference-Intakes-for-Calcium-and-Vitamin-D/Vitamin%20D%20and%20Calcium%202010%20Repo
  14. Cox KA, Dunn MA. Aluminum toxicity alters the regulation of calbindin-D28k protein and mRNA expression in chick intestine. J Nutr 2001;131:2007-13. PubMed
  15. Escribano, J., Balaguer, A., Pagone, F., Feliu, A., and Roque, I. Figuls. Pharmacological interventions for preventing complications in idiopathic hypercalciuria. Cochrane.Database.Syst.Rev. 2009;(1):CD004754. PubMed
  16. Carlton, S., Clopton, D., and Cappuzzo, K. A. Vitamin D deficiency: appropriate replenishment therapies and the effects of vitamin D toxicity. Consult Pharm 2010;25(3):171-177. PubMed
  17. Wang, H., Xia, N., Yang, Y., and Peng, D. Q. Influence of vitamin D supplementation on plasma lipid profiles: a meta-analysis of randomized controlled trials. Lipids Health Dis. 2012;11:42. PubMed
  18. Turner AN, Carr Reese P, Fields KS, Anderson J, Ervin M, Davis JA, Fichorova RN, Roberts MW, Klebanoff MA, Jackson RD. A blinded, randomized controlled trial of high-dose vitamin D supplementation to reduce recurrence of bacterial vaginosis. Am J Obstet G PubMed
  19. Weiner M, Epstein FH. Signs and symptoms of electrolyte disorders. Yale J Biol Med. 1970;43(2):76-109.
  20. Lappe J, Watson P, Travers-Gustafson D, Recker R, Garland C, Gorham E, Baggerly K, McDonnell SL. Effect of Vitamin D and Calcium Supplementation on Cancer Incidence in Older Women: A Randomized Clinical Trial. JAMA. 2017 Mar 28;317(12):1234-1243. PubMed
  21. Roth DE, Leung M, Mesfin E, Qamar H, Watterworth J, Papp E. Vitamin D supplementation during pregnancy: state of the evidence from a systematic review of randomised trials. BMJ. 2017;359:j5237. PubMed
  22. Murai IH, Fernandes AL, Sales LP, et al. Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to severe COVID-19: A randomized clinical trial. JAMA. 2021.
  23. Wang Z, Schuetz EG, Xu Y, Thummel KE. Interplay between vitamin D and the drug metabolizing enzyme CYP3A4. J Steroid Biochem Mol Biol 2013;136:54-8. PubMed
  24. Doyle D, Browne U, Brickley A, Murphy D. Vitamin D-induced hypercalcaemia and acute kidney injury in sarcoidosis. BMJ Case Rep 2023;16(1):e250580. PubMed
  25. Williamson A, Martineau AR, Sheikh A, Jolliffe D, Griffiths CJ. Vitamin D for the management of asthma. Cochrane Database Syst Rev 2023;2(2):CD011511. PubMed
  26. Kinesya E, Santoso D, Gde Arya N, et al. Vitamin D as adjuvant therapy for diabetic foot ulcers: Systematic review and meta-analysis approach. Clin Nutr ESPEN 2023;54:137-143. PubMed

See these in context on the Vitamin D monograph →

Astaxanthin 3 references
  1. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

See these in context on the Astaxanthin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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