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Dietary supplement

TruBiotics Ingredients & Drug Interactions

by Bayer One A Day

TruBiotics label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking TruBiotics against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

TruBiotics is a dietary supplement by Bayer One A Day with 2 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus LA-5. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against TruBiotics by Bayer One A Day

Ask about any prescription or over-the-counter medication and we check it for interactions with TruBiotics by Bayer One A Day — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of TruBiotics by Bayer One A Day

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

TruBiotics contains 2 active ingredients: Lactobacillus acidophilus LA-5 and Bifidobacterium animalis BB-12, both live probiotics designed to support digestive and gut health. The product also contains inactive ingredients including anhydrous sugar, skim milk powder, and hydroxypropyl methylcellulose, which serve as binders and stabilizers in the capsule.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive and immune health support.
  • We looked for evidence on: Antibiotic-associated diarrhea, Bacterial vaginosis, Clostridioides difficile infection, Colic, Constipation, Inflammatory bowel disease (IBD) — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis, Irritable bowel syndrome (IBS).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Constipation, Inflammatory bowel disease (IBD), Lactose intolerance, Necrotizing enterocolitis (NEC).

Lactobacillus acidophilus is possibly effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis based on the evidence we hold. It's rated possibly ineffective for atopic disease (allergic or skin conditions).

For acute respiratory distress syndrome, there isn't enough reliable evidence to rate it. We don't have effectiveness data on file for Bifidobacterium animalis BB-12 in this product.

The evidence, ingredient by ingredient Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. However, since it contains live microorganisms, there's a theoretical risk of infection in certain patients — your healthcare provider should know your full medical history before you start.

Oral side effects are uncommon but can include stomach discomfort, abdominal pain, gas, bloating, diarrhea, and burping when combined with other probiotics. In rare cases, a rash or itching has been reported, though it's unclear whether L. acidophilus was the cause.

We don't have specific pregnancy or breastfeeding data on file for either ingredient, so talk with your doctor or pharmacist about use during those times.

Side effects, ingredient by ingredient Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotic drugs, check the timing with your pharmacist before you start TruBiotics — antibiotics can reduce the probiotic's effectiveness if taken at the same time. That's the only medication interaction we have data on for this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

TruBiotics is a two-strain probiotic that may help with digestive issues like IBS and antibiotic-related diarrhea. The main thing to watch: if you're taking antibiotics, time your doses apart so the medication doesn't kill the live bacteria.

Talk to your pharmacist or doctor before starting, especially if you have a compromised immune system or are pregnant or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about TruBiotics, straight from the product label.

Brand Bayer One A Day
Barcode (UPC) 016500556060
Net contents 45 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jun 25, 2018
DSLD ID 178450
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for TruBiotics by Bayer One A Day, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
016500556060
IngredientAmount% DV
Proprietary Blend0 NP--
Lactobacillus acidophilus LA-50 NP--
Bifidobacterium animalis BB-120 NP--

Other ingredients: Anhydrous Sugar, Skim Milk powder, Hydroxypropyl Methylcellulose, Less than 2% of:

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Daily Probiotic Supplement

General Statements

Do more for your overall health and wellness TruBiotics supports your digestive and immune health

Questions or comments? 1-800-353-3343 (Mon-Fri 9AM-5PM EST) Made in Denmark

2 billion live cultures of 2 probiotic strains Backed by One A Day 70 years nutrition & health expertise

Naturally helps support digestive & immune health: Helps replenish good bacteria impacted by lifestyle factors including diet, stress and travel Supports the 70% of your immune system found in the digestive tract Helps support a healthy metabolism By supporting carbohydrate metabolism

Why should I take probiotics? Taking probiotics everyday can help maintain the natural balance of good bacteria in your digestive tract. They are a great way to support digestive health and immune health.

The probiotic strains in TruBiotics are proven to survive the GI tract. The strains work in both the small and large intestines to help support digestive health.

The TruBiotics Promise: Made with highest product and quality standards

Supports your health every day Digestive health Immune health

Brand IP Statement(s)

Bayer, the Bayer Cross, TruBiotics, TruBiotics design, TruPreserve, and One A Day are trademarks of Bayer. BB-12 and LA-5 are registered trademarks of Chr Hansen.

With TruPreserve, a canister designed to safeguard the live and active probiotics From the makers of One A Day, nutritional experts in multivitamins

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General

C6322

Suggested/Recommended/Usage/Directions

Directions: Adults - Take one capsule daily with a meal.

Formula

Contains: Milk.

Why should I take TruBiotics? It has Bifidobacterium animalis (BB-12) and Lactobacillus acidophilus (LA-5), a proprietary blend of two probiotic strains that is one of the most researched combinations of probiotics.

Does not contain animal-based gelatin; contains milk.

Precautions

Contains: Milk.

If you are pregnant or breast-feeding, ask a health professional before use.

Do not exceed recommended intake

Keep out of reach of children

Do not use if break-away tab is broken or missing.

Storage

Store at room temperature. Avoid excessive heat. Replace cap after use.

Formulation

Does not contain animal-based gelatin; contains milk. Does not contain gluten or soy

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

TruBiotics by Bayer One A Day label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

TruBiotics label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in TruBiotics by Bayer One A Day

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

0 NP per serving

Other (inactive) ingredients: Anhydrous Sugar, Skim Milk powder, Hydroxypropyl Methylcellulose, Less than 2% of:. These complete the product’s ingredient list but are not active constituents.

Interaction report

TruBiotics by Bayer One A Day Drug Interactions

Want to check YOUR meds against TruBiotics?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus LA-5 182

Individual Drug Interactions

The ingredients in TruBiotics interact with 182 drugs. Click any drug to see the details.

1 of the 2 ingredients in TruBiotics interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus LA-5

Each ingredient & the kinds of drugs it affects

For each ingredient in TruBiotics with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus LA-51 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus LA-5 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for TruBiotics, from the product label.

Bayer One A Day

See all Bayer One A Day products
Name
Bayer HealthCare LLC
City
Whippany
State
NJ
ZipCode
07981
Phone Number
1-800-353-3343
Pharmacist Counseling Corner

TruBiotics by Bayer One A Day: Common Questions

Does TruBiotics by Bayer One A Day interact with any medications?
Yes. Based on its ingredients, TruBiotics has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
TruBiotics contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this with antibiotics?
You can take both, but not at the exact same time. Antibiotics can kill the live bacteria in TruBiotics, making it less effective. Ask your pharmacist how far apart to space them — usually a few hours is enough.
Will TruBiotics help my IBS?
Lactobacillus acidophilus is possibly effective for IBS symptoms based on our data, though results vary from person to person. It's worth trying, but give it a few weeks and let your doctor know if you don't notice a change.
Are there any side effects?
Stomach discomfort, gas, bloating, and diarrhea are uncommon but possible, especially when you first start or if you take it with other probiotics. A rash or itching has been rarely reported. Most people have no issues at all.
Is this safe if I have a weak immune system?
Because this product contains live microorganisms, there's a theoretical risk in people with severely compromised immunity. Check with your doctor before starting, especially if you've had serious infections or have conditions affecting your immune system.
Can I take this while pregnant or breastfeeding?
We don't have specific safety data on file for either ingredient during pregnancy or breastfeeding. Talk with your doctor or pharmacist — they can weigh the benefits for your situation and give you personalized advice.
What's the difference between the two strains in here?
TruBiotics contains Lactobacillus acidophilus LA-5, which has solid evidence for gut health, and Bifidobacterium animalis BB-12. We don't have detailed effectiveness data on the BB-12 strain alone in our records, but the two are meant to work together to support digestive balance.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if TruBiotics is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

TruBiotics label
Go deeper

The Full Monographs Behind TruBiotics’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

TruBiotics's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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