Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Ultimate K2 Ingredients & Drug Interactions

by Pure TheraPro Rx

Ultimate K2 label
See full label image
Liquid Category: Vitamin
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ultimate K2 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Ultimate K2 is a dietary supplement by Pure TheraPro Rx with 1 active ingredient. Its ingredients are commonly taken for supporting normal blood clotting, bone health, heart and vascular health.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Vitamin K2. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Ultimate K2 by Pure TheraPro Rx

Ask about any prescription or over-the-counter medication and we check it for interactions with Ultimate K2 by Pure TheraPro Rx — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Ultimate K2 by Pure TheraPro Rx

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • “Vitamin K2” is listed as a grouped ingredient — the label gives one combined amount (680 mcg) without saying how much of each component you get.

Ultimate K2 contains two active ingredients: menatetrenone and MenaQ7, both forms of vitamin K2. These are designed to support your body's vitamin K-dependent clotting factors and bone metabolism.

The product also includes medium chain triglycerides, an inactive ingredient that helps with absorption.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Supports bone, brain and cardiovascular health.
  • We looked for evidence on: Osteoporosis, Cardiovascular disease (CVD), Cognitive impairment, Stroke, Hemorrhagic disease, Vitamin K-dependent clotting factors deficiency (VKCFD) — and 4 related terms.
  • The strongest evidence on file: Vitamin K is rated "Effective" for Hemorrhagic disease (Natural Medicines).
  • Also on file: Vitamin K is rated "Effective" for Warfarin anticoagulation, Vitamin K-dependent clotting factors deficiency (VKCFD).
  • Also on file: Vitamin K is rated "Possibly Effective" for Osteoporosis.

The vitamin K2 in this product is rated effective for supporting clotting factors and treating conditions like vitamin K-dependent clotting factors deficiency and hemorrhagic disease. It's also rated possibly effective for osteoporosis.

Effectiveness data for other uses isn't in the product information we hold.

The evidence, ingredient by ingredient Vitamin K

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin K2 taken by mouth is generally well tolerated. The most common side effects are mild gastrointestinal ones: nausea, diarrhea, and stomach upset affect a small number of people who take it.

The data does note that normal dietary amounts are fine, but you should check with your doctor before taking supplements — especially if you're on warfarin or other medications. During pregnancy and lactation, vitamin K2 is rated likely safe.

If you're pregnant, planning to become pregnant, or breastfeeding and have specific questions, talk with your pharmacist or doctor.

Side effects, ingredient by ingredient Vitamin K

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin K.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications against warfarin (Coumadin) before starting. Vitamin K2 in this product can reduce warfarin's effectiveness.

Altogether, these interactions span 2 individual medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

If you're not on warfarin or other blood thinners, this product may be worth considering for clotting factor support or bone health. If you do take warfarin, do not start this without your doctor's approval — the interaction is serious.

Run your medications through the checker on this page before you begin.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ultimate K2, straight from the product label.

Brand Pure TheraPro Rx
Barcode (UPC) X003E06JFT
Net contents 0.5 Fluid Ounce(s); 15 mL
Market status On market
Date entered into DSLD Jan 24, 2024
DSLD ID 305968
Product type Vitamin
Supplement form Liquid
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ultimate K2 by Pure TheraPro Rx, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
5 Drop(s)
Maximum serving Sizes:
5 Drop(s)
Servings per container
90
UPC/BARCODE
X003E06JFT
IngredientAmount% DV
Vitamin K2680 mcg--
Menatetrenone500 mcg--
MenaQ7180 mcg--

Other ingredients: Medium Chain Triglycerides

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

90 day supply

0.5 fl oz (15 mL) drops

Please retain box for reference

Drops MK-4 MK-7 1 100 36 2 200 72 3 300 108 4 400 144 5 500 180 # of Drops = Units in mcg New Please recycle

Formulation

Full spectrum Supports bone, brain & cardiovascular health

Vegan

Non-GMO Soy + gluten free

Concentrated formula

Formulated to exclude: Fillers, gluten, wheat, soy, corn, yeast, animal or dairy products, shellfish, fish, peanuts, egg, ingredients derived from genetically modified organisms (GMO's), artificial preservatives, sweeteners or colors.

Formulated, tested & packaged in the USA

FDA Statement of Identity

Professional Dietary Supplement

Formula

Why you need both MK-4 & MK-7 The two forms are distributed differently and activate different proteins in the body - both are equally essential for good health. MenaQ7 Vitamin K2 and MK-7 A patented form of natural MK-7 derived from chickpea fermentation

Brand IP Statement(s)

MenaQ7 Vitamin K2 and MK-7 A patented form of natural MK-7 derived from chickpea fermentation MenaQ7 MK-7 is a registered trademark of NattoPharma ASA, Norway. Patents granted and pending. Geraniol MK-4 CO2 extracted from Geranium flowers. Bioidentical all-trans form MK-4 supports muscle & cardiovascular function as well as mood, skin & hormonal health. Organic MCT Oil Vitamin K2 is fat soluble and must be taken with a lipid to properly absorb, so we utilize pure medium-chain triglyceride oil from organically grown coconuts as a carrier for maximum bioavailability and efficacy.

Copyright 2023 Pure TheraPro Rx

Precautions

Contains: Tree nut (coconut)

Warning: Individuals taking medication, children and pregnant or lactating women should consult their healthcare practitioner prior to use.

Warning: Individuals taking medication, children and pregnant or lactating women should consult their healthcare practitioner prior to use.

Do not use if tamper seal is damaged.

Keep out of reach of children.

Suggested/Recommended/Usage/Directions

Directions: Shake gently before use. Take up to five (5) drops daily or as directed by a healthcare practitioner. For best results, place drop(s) directly on or under your tongue. Drops may also be placed into juice or water. Consume with meals containing healthy fats.

Storage

Storage: Keep tightly closed. Refrigerate for optimal freshness. May be kept in a cool, dry place away from direct sunlight.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

GMP Certified Good Manufacturing Practice

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ultimate K2 by Pure TheraPro Rx label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ultimate K2 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ultimate K2 by Pure TheraPro Rx

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size5 Drop(s) Dosage formLiquid Servings per container90 Amounts shown are per serving.

Vitamin K2

Interacts with
2 drugs
680 mcg per serving

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but suppl...

Vitamin K2 monograph & interactions

Other (inactive) ingredients: Medium Chain Triglycerides. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ultimate K2 by Pure TheraPro Rx Drug Interactions

Want to check YOUR meds against Ultimate K2?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2Drugs
2 Major

Ingredients driving the most interactions

Vitamin K2 2

Individual Drug Interactions

The ingredients in Ultimate K2 interact with 2 drugs. Click any drug to see the details.

1 of the 1 ingredient in Ultimate K2 interact with drugs. Each result below shows which ingredient is responsible. Vitamin K2

Each ingredient & the kinds of drugs it affects

For each ingredient in Ultimate K2 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin K21 drug type · 2 drugs

Warfarin (Coumadin)

Vitamin K can antagonize and reverse the therapeutic effects of warfarin.
Vitamin K antagonizes the effects of warfarin. Excessive vitamin K intake, either from supplements or from changes in the diet, can reduce the anticoagulant effect of warfarin.

Likelihood Likely Evidence C
Vitamin K2 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Ultimate K2, from the product label.

Pure TheraPro Rx

See all Pure TheraPro Rx products
Name
Pure TheraPro Rx
Street Address
8781 Sheridan Blvd #6080
City
Westminster
State
CO
ZipCode
80003
Phone Number
888-655-4648
Web Address
Purethera.com
Pharmacist Counseling Corner

Ultimate K2 by Pure TheraPro Rx: Common Questions

Does Ultimate K2 by Pure TheraPro Rx interact with any medications?
Yes. Based on its ingredients, Ultimate K2 has a known interaction with 2 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ultimate K2 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this interact with my blood thinner?
If you take warfarin (Coumadin), yes — vitamin K2 can lower how well it works. Check with your doctor or pharmacist before starting. Use the medication checker on this page with your exact prescription name to be sure.
What are the most common side effects?
Taken by mouth, vitamin K2 is generally well tolerated. Some people experience mild gastrointestinal upset — nausea, diarrhea, or stomach discomfort — but it's not common.
Is this safe to take while pregnant or breastfeeding?
Vitamin K2 is rated likely safe during pregnancy and lactation. If you have specific health concerns or take other medications, talk with your pharmacist or doctor for personalized advice.
What does vitamin K2 do?
The vitamin K2 in this product is designed to support your body's clotting factors and bone metabolism. It's effective for correcting vitamin K deficiency and is possibly effective for bone health.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ultimate K2 label
Go deeper

The Full Monographs Behind Ultimate K2’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin K

Interacts with 2 drugs

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but supplements are sometimes used for deficiency...

Read the full Vitamin K monograph →
Sources

Sources & How We Checked

Ultimate K2's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin K 11 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  3. Crowther MA, Ageno W, Garcia D, et al. Oral vitamin K versus placebo to correct excessive anticoagulation in patients receiving warfarin: a randomized trial. Ann Intern Med. 2009;150(5):293-300. PubMed
  4. Dietary vitamin K guidance: an effective strategy for stable control of oral anticoagulation? Nutr Rev. 2010;68(3):178-81. PubMed
  5. Kim JS, Nafziger AN, Gaedigk A, et al. Effects of oral vitamin K on S- and R-warfarin pharmacokinetics and pharmacodynamics: enhanced safety of warfarin as a CYP2C9 probe. J Clin Pharmacol. 2001 Jul;41(7):715-22. PubMed
  6. Riegert-Johnson, D. L. and Volcheck, G. W. The incidence of anaphylaxis following intravenous phytonadione (vitamin K1): a 5-year retrospective review. Ann.Allergy Asthma Immunol. 2002;89(4):400-406. PubMed
  7. Dezee, K. J., Shimeall, W. T., Douglas, K. M., Shumway, N. M., and O'malley, P. G. Treatment of excessive anticoagulation with phytonadione (vitamin K): a meta-analysis. Arch.Intern.Med. 2-27-2006;166(4):391-397. DOI
  8. Dentali, F., Ageno, W., and Crowther, M. Treatment of coumarin-associated coagulopathy: a systematic review and proposed treatment algorithms. J.Thromb.Haemost. 2006;4(9):1853-1863. PubMed
  9. Caluwé R, Vandecasteele S, Van Vlem B, Vermeer C, De Vriese AS. Vitamin K2 supplementation in haemodialysis patients: a randomized dose-finding study. Nephrol Dial Transplant. 2014;29(7):1385-90.
  10. Huang ZB, Wan SL, Lu YJ, Ning L, Liu C, Fan SW. Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials. Osteoporos Int. 2015;26(3):1175-86. PubMed
  11. Hunnali CR, Devi U, Kitchanan S, Sethuraman G. Three Different Regimens for Vitamin K Birth Prophylaxis in Infants Born Preterm: A Randomized Clinical Trial. J Pediatr 2023;255:98-104. PubMed

See these in context on the Vitamin K monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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