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Dietary supplement

Ultra Lutein 20 mg Ingredients & Drug Interactions

by NaturesPlus

Ultra Lutein 20 mg label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ultra Lutein 20 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Ultra Lutein 20 mg is a dietary supplement by NaturesPlus with 2 active ingredients. Its ingredients are commonly taken for eye health, age-related macular degeneration, cataract prevention.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are FloraGLO. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Ultra Lutein 20 mg by NaturesPlus

Ask about any prescription or over-the-counter medication and we check it for interactions with Ultra Lutein 20 mg by NaturesPlus — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Ultra Lutein 20 mg by NaturesPlus

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 24, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This softgel delivers two carotenoids: lutein (supplied as FloraGLO) and zeaxanthin. Both are yellow pigments naturally found in the eye and are believed to filter harmful light and protect eye tissue from oxidative stress.

The product contains 2 active ingredients and relies on gelatin, soybean oil, glycerin, beeswax, lecithin, and natural color as inactive ingredients to form the softgel capsule.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: eye support and antioxidant protection.
  • We looked for evidence on: Age-related macular degeneration (AMD), Asthenopia (eye strain), Cataracts, Central serous retinopathy, Choroideremia, Diabetic retinopathy — and 4 related terms.
  • The strongest evidence on file: Lutein is rated "Possibly Effective" for Age-related macular degeneration (AMD) (Natural Medicines).
  • Also on file: Lutein is rated "Possibly Effective" for Cataracts.
  • Also on file: Zeaxanthin is rated "Possibly Effective" for Age-related macular degeneration (AMD).

Lutein is possibly effective for age-related macular degeneration (AMD) and cataracts, two common eye conditions tied to aging. For other conditions we hold data on—retinitis pigmentosa, necrotizing enterocolitis, retinopathy of prematurity, and bronchopulmonary dysplasia—the evidence suggests lutein is ineffective or the research is too sparse to rate it.

Zeaxanthin is also possibly effective for AMD. For age-related cognitive decline, Alzheimer disease, asthma, breast cancer, and bronchopulmonary dysplasia, the evidence we hold is insufficient to rate whether it works.

The strongest case for either ingredient is supporting eye health in older adults.

The evidence, ingredient by ingredient Lutein Zeaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lutein is generally well tolerated at doses up to 20 mg daily—the exact amount in this product—with no adverse effects reported in trials. Both lutein and zeaxanthin are rated likely safe in pregnancy and lactation, though the caution notes that supplement safety at higher-than-food doses hasn't been thoroughly studied in pregnant or breastfeeding people, so it's wise to discuss this product with your doctor or pharmacist if you're in either situation.

Otherwise, these ingredients are considered safe for most adults at typical supplement levels when you're not taking blood sugar medications.

Side effects, ingredient by ingredient Lutein Zeaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Zeaxanthin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

The main medication class to double-check is antidiabetes drugs (blood sugar medications of any kind—insulin, metformin, sulfonylureas, and others). Zeaxanthin may lower blood sugar, and combining it with a drug that already does so could increase your risk of low blood sugar.

No other medication interactions are documented for the lutein in this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Ultra Lutein 20 mg is a straightforward eye-support supplement for anyone concerned about macular degeneration or cataracts as they age. If you take any blood sugar medication, talk with your doctor or pharmacist before starting it, because zeaxanthin may theoretically increase the risk of low blood sugar.

Pregnant or breastfeeding? Same conversation is worth having, even though the ingredient is rated likely safe.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ultra Lutein 20 mg, straight from the product label.

Brand NaturesPlus
Barcode (UPC) 097467492653
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Oct 24, 2023
DSLD ID 298631
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ultra Lutein 20 mg by NaturesPlus, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
60
UPC/BARCODE
097467492653
IngredientAmount% DV
FloraGLO20 mg--
FloraGLO860 mcg--

Other ingredients: Gelatin, Soybean Oil, Glycerin, Water, Purified, Beeswax, Lecithin, Natural Color

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Ultra Lutein features FloraGLO brand lutein, an active carotenoid from the marigold flower. Ultra Lutein contains a full 20 mg lutein, a level shown by scientific studies to effectively promote antioxidant protection of the eyes. Ultra Lutein provides 860 mcg zeaxanthin to synergistically enhance antioxidant support.

Ultra Lutein 20 mg with 860 mcg zeaxanthin

Formulation

Free from artificial colors and artificial preservatives.

Gluten free

Eye support

Storage

Keep tightly closed in a cool, dry place.

Precautions

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: One softgel daily.

Brand IP Statement(s)

FloraGLO is a trademark of Kermin Industries, Inc.

Copyright Natural Organics

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ultra Lutein 20 mg by NaturesPlus label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ultra Lutein 20 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ultra Lutein 20 mg by NaturesPlus

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

FloraGLO

No known
interactions
20 mg per serving Form: Lutein

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help...

FloraGLO monograph & interactions

FloraGLO

Interacts with
86 drugs
860 mcg per serving Form: Zeaxanthin

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The stron...

FloraGLO monograph & interactions

Other (inactive) ingredients: Gelatin, Soybean Oil, Glycerin, Water, Purified, Beeswax, Lecithin, Natural Color. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ultra Lutein 20 mg by NaturesPlus Drug Interactions

Want to check YOUR meds against Ultra Lutein 20 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

FloraGLO 86

Individual Drug Interactions

The ingredients in Ultra Lutein 20 mg interact with 86 drugs. Click any drug to see the details.

1 of the 2 ingredients in Ultra Lutein 20 mg interact with drugs. Each result below shows which ingredient is responsible. FloraGLO

Each ingredient & the kinds of drugs it affects

For each ingredient in Ultra Lutein 20 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

FloraGLO1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.
In an animal diabetic model, zeaxanthin has hypoglycemic effects. However, population research has found that increasing intake of dietary zeaxanthin plus lutein does not decrease the risk of developing type 2 diabetes.

Likelihood Possible Evidence D
FloraGLO full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Ultra Lutein 20 mg, from the product label.

NaturesPlus

See all NaturesPlus products
Name
NaturesPlus Div. of Natural Organics, Inc.
Street Address
548 Broadhollow Rd.
City
Melville
State
NY
ZipCode
11747
Web Address
www.naturesplus.com
Pharmacist Counseling Corner

Ultra Lutein 20 mg by NaturesPlus: Common Questions

Does Ultra Lutein 20 mg by NaturesPlus interact with any medications?
Yes. Based on its ingredients, Ultra Lutein 20 mg has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ultra Lutein 20 mg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does lutein actually prevent or slow macular degeneration?
Lutein is possibly effective for age-related macular degeneration, meaning there's promising evidence but it's not yet conclusive. The research suggests it may help, but it's not a guaranteed preventive or treatment. Talk with your eye doctor about whether it fits your situation.
Is this safe if I'm pregnant or breastfeeding?
Both lutein and zeaxanthin are rated likely safe in pregnancy and lactation. However, the safety data on supplement doses—rather than food sources—isn't as thorough, so check with your doctor or pharmacist before adding this product if you're pregnant or nursing.
What's the difference between lutein and zeaxanthin?
They're both yellow carotenoids found in leafy greens and the macula of your eye, and they work similarly to filter harmful light and protect eye tissue. Zeaxanthin is slightly different in structure, but for the purposes of this product, they're partner nutrients doing the same job.
Will 20 mg of lutein daily cause side effects?
No, studies show that lutein at doses up to 20 mg daily is generally well tolerated with no reported adverse effects. This product's dose sits right at that safe threshold.
Can I take this if I'm on diabetes medication?
Zeaxanthin may theoretically lower blood sugar, which could increase the risk of low blood sugar if you're already on a blood sugar medication. Don't start this product without checking with your doctor or pharmacist first so they can help you decide if it's right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Ultra Lutein 20 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ultra Lutein 20 mg label
Go deeper

The Full Monographs Behind Ultra Lutein 20 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lutein

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help slow progression of age-related macular...

Read the full Lutein monograph → Herb & supplement monograph

Zeaxanthin

Interacts with 86 drugs

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The strongest evidence relates to slowing progres...

Read the full Zeaxanthin monograph →
Sources

Sources & How We Checked

Ultra Lutein 20 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lutein 2 references
  1. Brown L, Rimm EB, Seddon JM, et al. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr 1999;70:517-24. PubMed
  2. Chasan-Taber L, Willett WC, Seddon JM, et al. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr 1999;70:509-16. PubMed

See these in context on the Lutein monograph →

Zeaxanthin 4 references
  1. Montonen J, Knekt P, Jarvinen R, Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 2004;27:362-6. PubMed
  2. Leermakers ET, Darweesh SK, Baena CP, et al. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Am J Clin Nutr 2016;103(2):481-94. PubMed
  3. Kou L, Du M, Zhang C, Dai Z, Li X, Zhang B. The Hypoglycemic, Hypolipidemic, and Anti-Diabetic Nephritic Activities of Zeaxanthin in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Appl Biochem Biotechnol 2017;182(3):944-955. PubMed
  4. Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. Milk and Plasma Lutein and Zeaxanthin Concentrations in Chinese Breast-Feeding Mother-Infant Dyads With Healthy Maternal Fruit and Vegetable Intake. J Am Coll Nutr 2019;38(2):179-184. PubMed

See these in context on the Zeaxanthin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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