Interactions on record — worth a quick check against your medications. Based on 4 of 5 ingredients. Check your meds →
Dietary supplement

Ultra Nox Ingredients & Drug Interactions

by GNC AMP Advanced Muscle Performance

Ultra Nox label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ultra Nox against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Ultra Nox is a dietary supplement by GNC AMP Advanced Muscle Performance with 5 active ingredients. Its ingredients are commonly taken for treating or preventing b12 deficiency, pernicious anemia, low energy and fatigue.Based on those ingredients, 1,048 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Oxyjun Terminalia arjuna bark extract, Agmatine Sulfate, L-Citrulline. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Ultra Nox by GNC AMP Advanced Muscle Performance

Ask about any prescription or over-the-counter medication and we check it for interactions with Ultra Nox by GNC AMP Advanced Muscle Performance — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Ultra Nox by GNC AMP Advanced Muscle Performance

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Ultra Nox contains five active ingredients. Vitamin B12 supports energy and nerve health.

L-citrulline is an amino acid that may help athletic performance by boosting blood flow. Agmatine sulfate is a compound derived from the amino acid arginine, included for possible effects on exercise capacity.

Nitrosigine is a compound we have no interaction data on file for. Terminalia arjuna bark extract comes from a traditional Ayurvedic plant and is added for cardiovascular support.

The product also contains inactive ingredients — microcrystalline cellulose, croscarmellose sodium, and several others — which serve as fillers, binders, and coating materials to hold the tablet together and protect it.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Support workout performance, pumps and endurance.
  • We looked for evidence on: Athletic performance, Physical performance, Fatigue, Muscle strength, Erectile dysfunction (ED), Cardiovascular disease (CVD) — and 4 related terms.
  • The strongest evidence on file: L-citrulline is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Vitamin B12 is rated "Possibly Ineffective" for Physical performance.
  • Also on file: Terminalia is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Hypertension.

The evidence here is mixed and mostly limited. Vitamin B12 is effective for treating B12 deficiency and certain neurological conditions, and it's considered likely effective for cyanide poisoning.

L-citrulline is possibly effective for athletic performance but possibly ineffective for muscle loss (sarcopenia). For agmatine, terminalia arjuna, and several other uses listed — including heart failure, diabetes, hypertension, and others — the evidence we hold isn't strong enough to rate either way.

If any of these are your main reason for choosing this product, talk with us about what the research actually supports for your goal.

The evidence, ingredient by ingredient Vitamin B12 L-citrulline Agmatine Terminalia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B12 is generally very well tolerated with no established upper limit — your body excretes excess. It's considered safe during pregnancy and breastfeeding at recommended doses.

L-citrulline and agmatine are generally well tolerated short-term in healthy adults, though long-term safety hasn't been fully studied. The most common side effects with L-citrulline and agmatine are gastrointestinal — heartburn, stomach upset, diarrhea, nausea — and a small number of people reported cough with L-citrulline.

Rare allergic reactions to B12 (rash, itching) have been reported, and in one case, oral B12 caused contact dermatitis in someone with a cobalt allergy. During pregnancy, L-citrulline and agmatine safety data is insufficient, so the recommendation is to avoid them.

Terminalia arjuna also lacks enough safety data in pregnancy and breastfeeding — avoid supplemental use in both. There isn't enough data on file for B12 pregnancy and breastfeeding safety — discuss your situation with your doctor or pharmacist.

Side effects, ingredient by ingredient Vitamin B12 L-citrulline Agmatine Terminalia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Terminalia, Vitamin B12, L-citrulline, Agmatine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 1,049 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist if you take blood thinners or antiplatelet drugs (like warfarin, aspirin, clopidogrel) — Terminalia arjuna may increase bleeding risk (Moderate). Also double-check blood pressure medications, diabetes drugs, medications processed through your liver's CYP2D6, CYP2C9, or CYP3A4 pathways, omeprazole (Prilosec), chlorzoxazone (Parafon Forte), and metformin (Glucophage) — this product has documented interactions with all of them (mostly Moderate severity, one Minor).

No interactions are documented for Nitrosigine because we hold no data for it.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Ultra Nox is a multi-ingredient performance supplement best suited for healthy adults looking to support athletic performance and muscle work. Because it interacts with a very large number of medications — especially blood thinners, blood pressure drugs, diabetes medications, and drugs your liver breaks down — you absolutely must check your exact prescriptions with the tool on this page before you start.

If you're pregnant, breastfeeding, or taking any regular medications, talk with your pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ultra Nox, straight from the product label.

Brand GNC AMP Advanced Muscle Performance
Net contents 120 Tablet(s)
Market status On market
Date entered into DSLD Jun 24, 2020
DSLD ID 224622
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ultra Nox by GNC AMP Advanced Muscle Performance, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Tablet(s)
Maximum serving Sizes:
4 Tablet(s)
Servings per container
30
IngredientAmount% DV
Vitamin B122.4 mcg100%
L-Citrulline1.5 Gram(s)--
Agmatine Sulfate250 mg--
Nitrosigine1.5 Gram(s)--
Oxyjun Terminalia arjuna bark extract400 mg--

Other ingredients: Microcrystalline Cellulose, Croscarmellose Sodium, Hydroxypropylcellulose, Silica, Hydroxypropyl Methylcellulose, Polydextrose, Magnesium Stearate, Mica, Titanium Dioxide, Stearic Acid, Talc, Medium Chain Triglycerides, FD&C Blue #2 Lake, FD&C Red #40 Lake, Ethylcellulose, Triacetin, Diacetylated Monoglycerides, Oleic Acid, Polyethylene Glycol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Maximize your workout Train harder with this fully-dosed, concentrated formula to support pumps, endurance and energy production.

GNC AMP Ultra NOX delivers the stim-free fuel needed to achieve superior performance, without the jitters.

Superior muscle pumps GNC AMP Ultra NOX is scientifically formulated to maximize N.O. production and blood vessel tone.

Enhanced with clinically studied Oxyjun to support cardiovascular performance, GNC AMP Ultra NOX is designed with non-stimulant, superior fatigue-fighting fuel to drive your workout.

Usage benefits For non-stim pre-workout support Fuels performance, pumps & endurance

Maximizes N.O production & amplifies muscle pumps so you can train harder

If it's on our boxes, then it's in our bottles. Full dosing, full transparency and no proprietary blends.

Clinically proven to support endurance & performance Amplify muscle pumps Challenge your physical working capacity challenge your fatigue threshold Maximize N.O. production Stim-free performance support for intense muscle pumps Maximize N.O. production & blood vessel tone Supports endurance & performance

No sugar, no artificial flavors, no preservatives, sodium free, no wheat, gluten free, no soy, no dairy.

Conforms to USP <2091> for weight.

Formula

This advanced formula targets the mechanisms that amplify muscle pumps and features Nitrosigine, citrulline and agmatine. Fight fatigue Enhanced with clinically studied Oxyjun to support cardiovascular performance, GNC AMP Ultra NOX is designed with non-stimulant, superior fatigue-fighting fuel to drive your workout.

1.5 g Nitrosigine 1.5 g Citrulline 250 mg Agmatine 400 mg Oxyjun

Suggested/Recommended/Usage/Directions

Stack with your existing pre-workout

Directions: As a dietary supplement, take four tablets daily with 8 fl. oz. of water 30-45 minutes prior to exercise. On non-training days, take first thing in the morning with water. See usage benefits for additional suggestions and information.

General Statements

If it's on our boxes, then it's in our bottles.

Clinically studied ingredients backed by real science. Get superior performance and pumps.

Our quality commitment to you Since 1935, our mission as the industry leader has been to provide you with the highest-quality nutritional supplements. We continue to stand behind this mission. If you're not 100% satisfied with your purchase, return the unused portion of the product with your receipt within 30 days and we'll either refund your money or find a replacement product that is right for you.

FDA Statement of Identity

Dietary Supplement

Precautions

Warning: Use only as directed.Do not exceed recommended daily intake.

Consult your physician prior to using this product if you are pregnant, nursing, taking medication, under 18 years of age or have a medical condition.

Consult your physician prior to using this product if you are pregnant, nursing, taking medication, under 18 years of age or have a medical condition.

Discontinue use two weeks prior to surgery.

Keep out of reach of children.

Storage

Store in a cool, dry place.

Brand IP Statement(s)

Nitrosigine, including the Nitrosigine logo, is a registered trademark of Nutrition 21, LLC. Nitrosigine is patent protected. Oxyjun is a registered trademark of and developed by Enovate Biolife.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ultra Nox by GNC AMP Advanced Muscle Performance label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ultra Nox label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ultra Nox by GNC AMP Advanced Muscle Performance

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size4 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B12

Interacts with
20 drugs
2.4 mcg per serving Form: Cyanocobalamin

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

L-Citrulline

Interacts with
178 drugs
1.5 Gram(s) per serving

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. I...

L-Citrulline monograph & interactions

Agmatine Sulfate

Interacts with
258 drugs
250 mg per serving

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most...

Agmatine Sulfate monograph & interactions

Nitrosigine

1.5 Gram(s) per serving

Oxyjun Terminalia arjuna bark extract

Interacts with
933 drugs
400 mg per serving Form: Polyphenols

Terminalia is a group of traditional Ayurvedic tree species (most notably Terminalia arjuna) used for heart, digestive, and general wellness purposes....

Oxyjun Terminalia arjuna bark extract monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Croscarmellose Sodium, Hydroxypropylcellulose, Silica, Hydroxypropyl Methylcellulose, Polydextrose, Magnesium Stearate, Mica, Titanium Dioxide, Stearic Acid, Talc, Medium Chain Triglycerides, FD&C Blue #2 Lake, FD&C Red #40 Lake, Ethylcellulose, Triacetin, Diacetylated Monoglycerides, Oleic Acid, Polyethylene Glycol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ultra Nox by GNC AMP Advanced Muscle Performance Drug Interactions

Want to check YOUR meds against Ultra Nox?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,048Drugs
1,048 Moderate

Ingredients driving the most interactions

Oxyjun Terminalia arjuna bark extract 933
Agmatine Sulfate 258
L-Citrulline 178
Vitamin B12 20

Individual Drug Interactions

The ingredients in Ultra Nox interact with 1,048 drugs. Click any drug to see the details.

4 of the 5 ingredients in Ultra Nox interact with drugs. Each result below shows which ingredient is responsible. Oxyjun Terminalia arjuna bark extract Agmatine Sulfate L-Citrulline Vitamin B12

Each ingredient & the kinds of drugs it affects

For each ingredient in Ultra Nox with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Oxyjun Terminalia arjuna bark extract7 drug types · 933 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of Terminalia arjuna with anticoagulant or antiplatelet drugs may increase the risk of bleeding in some patients.
In vitro, Terminalia arjuna bark extract inhibits platelet aggregation, decreases platelet activation, and shows antithrombotic properties.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of Terminalia bellirica or Terminalia chebula with antidiabetes drugs could affect blood sugar control and increase the risk of hypoglycemia.
Animal and in vitro research shows that Terminalia bellirica and Terminalia chebula fruit and seed extract have hypoglycemic effects.

Likelihood Possible Evidence D
Chlorzoxazone (Parafon Forte, Paraflex)

Theoretically, use of Terminalia chebula may increase the risk of adverse effects from chlorzoxazone.
Animal research shows that enteral administration of Terminalia chebula for 15 days prior to administration of chlorzoxazone increases blood levels of chlorzoxazone and decreases chlorzoxazone clearance. It is speculated that Terminalia chebula reduces the metabolism of chlorzoxazone by inhibiting cytochrome P450 2E1.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2C9 substrates.
In vitro research shows that Terminalia arjuna extract inhibits CYP2C9 enzymes and reduces CYP2C9 substrate metabolism.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.
In vitro research shows that Terminalia arjuna extract inhibits CYP2D6 enzymes and reduces CYP2D6 substrate metabolism.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that Terminalia arjuna extract inhibits CYP3A4 enzymes and reduces CYP3A4 substrate metabolism.

Likelihood Possible Evidence D
Omeprazole (Prilosec)

Theoretically, use of Terminalia chebula may increase the risk of adverse effects from omeprazole.
Animal research shows that enteral administration of Terminalia chebula for 15 days prior to administration of omeprazole increases blood levels of omeprazole and decreases omeprazole clearance. It is speculated that Terminalia chebula reduces the metabolism of omeprazole by inhibiting cytochrome P450 2C19.

Likelihood Possible Evidence D
Oxyjun Terminalia arjuna bark extract full monograph & interactions

Agmatine Sulfate2 drug types · 258 drugs

Antidiabetes Drugs

Theoretically, agmatine might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research suggest that agmatine has mild hypoglycemic effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that agmatine can modestly decrease heart rate and blood pressure.

Likelihood Possible Evidence D
Agmatine Sulfate full monograph & interactions

L-Citrulline2 drug types · 178 drugs

Antihypertensive Drugs

Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.

Likelihood Possible Evidence B
Phosphodiesterase-5 Inhibitors

Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
L-Citrulline full monograph & interactions

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Ultra Nox, from the product label.

GNC AMP Advanced Muscle Performance

See all GNC AMP Advanced Muscle Performance products
Name
General Nutrition Corporation
City
Pittsburgh
State
PA
ZipCode
15222
Phone Number
1-888-462-2548
Web Address
gnc.com
Pharmacist Counseling Corner

Ultra Nox by GNC AMP Advanced Muscle Performance: Common Questions

Does Ultra Nox by GNC AMP Advanced Muscle Performance interact with any medications?
Yes. Based on its ingredients, Ultra Nox has a known interaction with 1,048 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ultra Nox contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I'm pregnant or breastfeeding?
L-citrulline, agmatine, and Terminalia arjuna all lack enough safety data — the recommendation is to avoid them during pregnancy and breastfeeding. Vitamin B12 safety data isn't on file here either, so talk with your doctor or pharmacist about whether this product is right for you right now.
What does L-citrulline do in this product?
L-citrulline is an amino acid that gets converted in your body to another amino acid, which helps relax blood vessels and boost blood flow. That's why it's included for athletic performance — it may help oxygen and nutrients reach your muscles better during exercise.
What are the most common side effects?
Most people tolerate this well, but the most common side effects are gastrointestinal — heartburn, stomach discomfort, diarrhea, and nausea. These tend to be mild and sometimes fade after a few days, though a small number of people stopped use because of them.
Does this actually work for muscle performance?
L-citrulline is possibly effective for athletic performance according to the evidence we hold — that's the strongest claim we can make. The other ingredients have insufficient evidence or haven't been well-studied for performance in humans, so results may vary.
Can I take this with my blood pressure medication?
You need to check first. L-citrulline and agmatine can theoretically lower blood pressure further, which might cause dizziness or fainting. Run your specific blood pressure drug through the interaction checker on this page, or ask your pharmacist.
What's Terminalia arjuna in here for?
It's a traditional plant extract included for possible cardiovascular benefits. The evidence isn't established enough in our data to say whether it works for heart health, but it does have a moderate number of documented drug interactions — especially with blood thinners and drugs your liver processes.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Ultra Nox is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ultra Nox label
Go deeper

The Full Monographs Behind Ultra Nox’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph → Herb & supplement monograph

L-citrulline

Interacts with 178 drugs

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. It is popular for exercise performance an...

Read the full L-citrulline monograph → Herb & supplement monograph

Agmatine

Interacts with 258 drugs

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most of its claimed benefits is limited and...

Read the full Agmatine monograph → Herb & supplement monograph

Terminalia

Interacts with 933 drugs

Terminalia is a group of traditional Ayurvedic tree species (most notably Terminalia arjuna) used for heart, digestive, and general wellness purposes. Some small studies suggest possible ben...

Read the full Terminalia monograph →
Sources

Sources & How We Checked

Ultra Nox's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 50 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B12 30 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  2. Hartman TJ, Woodson K, Stolzenberg-Solomon R, et al. Association of the B-vitamins pyridoxal 5'-phosphate (B6), B12, and folate with lung cancer risk in older men. Am J Epidemiol 2001;153:688-94.. DOI
  3. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  4. Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81. PubMed
  5. Collin, S. M., Metcalfe, C., Refsum, H., Lewis, S. J., Zuccolo, L., Smith, G. D., Chen, L., Harris, R., Davis, M., Marsden, G., Johnston, C., Lane, J. A., Ebbing, M., Bonaa, K. H., Nygard, O., Ueland, P. M., Grau, M. V., Baron, J. A., Donovan, J. L., Nea
  6. Geissbuhler, P., Mermillod, B., and Rapin, C. H. Elevated serum vitamin B12 levels associated with CRP as a predictive factor of mortality in palliative care cancer patients: a prospective study over five years. J.Pain Symptom.Manage. 2000;20(2):93-103. PubMed
  7. Salles, N., Herrmann, F., Sakbani, K., Rapin, C. H., and Sieber, C. High vitamin B12 level: a strong predictor of mortality in elderly inpatients. J Am Geriatr.Soc 2005;53(5):917-918.
  8. Looker, H. C., Fagot-Campagna, A., Gunter, E. W., Pfeiffer, C. M., Sievers, M. L., Bennett, P. H., Nelson, R. G., Hanson, R. L., and Knowler, W. C. Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes. Diabetes Metab Res R
  9. Uhl, W., Nolting, A., Golor, G., Rost, K. L., and Kovar, A. Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study. Clin Toxicol (Phila) 2006;44 Suppl 1:17-28. PubMed
  10. Borron, S. W., Baud, F. J., Barriot, P., Imbert, M., and Bismuth, C. Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. Ann Emerg.Med 2007;49(6):794-801, 801. PubMed
  11. Borron, S. W., Baud, F. J., Megarbane, B., and Bismuth, C. Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation. Am J Emerg.Med 2007;25(5):551-558. PubMed
  12. Lewis, J. G. Gout, Steatorrhoea, and Megaloblastic Anaemia. Ann Rheum.Dis 1962;21(3):284-286. PubMed
  13. Tal, S., Shavit, Y., Stern, F., and Malnick, S. Association between vitamin B12 levels and mortality in hospitalized older adults. J Am Geriatr.Soc 2010;58(3):523-526. PubMed
  14. Baztan, J. J., Gavidia, J. J., Gomez-Pavon, J., Esteve, A., and Ruiperez, I. High vitamin B12 levels and in-hospital mortality. J Am Geriatr.Soc 2010;58(11):2237-2238. PubMed
  15. Omboni, E., Checchini, M., and Longoni, F. [Hypopotassemia and megaloblastic anemia. Presentation of a case]. Minerva Med 8-31-1987;78(16):1255-1257.
  16. Aalfs As, Scholvinck LH, Horvath B. Acneiform eruption in a 5-year old due to vitamin B12 supplementation. Eur J Dermatol 2013;23(5):726-7. PubMed
  17. Balta I, Ozuguz P. Vitamin B12-induced acneiform eruption. Cutan Ocul Toxicol 2014;33(2):94-5. PubMed
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Agmatine 3 references
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Terminalia 9 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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