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Dietary supplement

Vitamin B-2 25 mg Ingredients & Drug Interactions

by Nature's Blend

Vitamin B-2 25 mg label
See full label image
Tablet Or Pill Category: Vitamin
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Vitamin B-2 25 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Vitamin B-2 25 mg is a dietary supplement by Nature's Blend with 1 active ingredient. Its ingredients are commonly taken for riboflavin deficiency, migraine prevention, general energy and metabolism support.Based on those ingredients, 20 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Riboflavin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Vitamin B-2 25 mg by Nature's Blend

Ask about any prescription or over-the-counter medication and we check it for interactions with Vitamin B-2 25 mg by Nature's Blend — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Vitamin B-2 25 mg by Nature's Blend

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: riboflavin (vitamin B-2) at 25 mg per tablet. Riboflavin is a B vitamin that plays a role in energy production and cell function in your body.

The tablet also contains several inactive ingredients — sorbitol, modified cellulose, calcium phosphate, croscamellose sodium, silica, magnesium stearate, triacetin, polydextrose, and carnauba wax — which are fillers, binders, and coating materials.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Riboflavin product and its label doesn't state a use — see Riboflavin's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The product facts provided do not include effectiveness ratings for riboflavin, so we don't have established evidence on file for what this dose may or may not do. If you're considering this supplement for a specific reason, talk with your pharmacist about what the research shows for your particular interest.

The evidence, ingredient by ingredient Riboflavin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Riboflavin is considered very safe, and any excess your body doesn't use is removed through your urine. At recommended doses, it's generally safe during pregnancy and breastfeeding — in fact, your body needs it at those times — but check with your provider before taking high-dose supplements.

When taken by mouth, riboflavin is generally well tolerated. The most common side effects are dose-related nausea and a bright yellow discoloration of urine, particularly at higher doses.

Diarrhea has been reported rarely. In one clinical study, one person out of 28 reported both diarrhea and increased urination after starting a much higher dose (400 mg daily).

At 25 mg, side effects are unlikely.

Side effects, ingredient by ingredient Riboflavin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Riboflavin.
  • The most serious interaction on file is rated Moderate.
  • For scale: 20 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take tetracycline antibiotics (like doxycycline, minocycline, or tetracycline itself), check with your pharmacist before starting this product — riboflavin may reduce how well these antibiotics work. Use the medication checker below to confirm your exact drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Vitamin B-2 by Nature's Blend is a straightforward, well-tolerated B vitamin supplement. If you're on a tetracycline antibiotic, mention this supplement to your pharmacist before starting it — they can advise whether spacing or adjusting your routine makes sense.

Otherwise, it's a safe addition for most people.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Vitamin B-2 25 mg, straight from the product label.

Brand Nature's Blend
Barcode (UPC) 079854200256
Net contents 100 Tablet(s)
Market status On market
Date entered into DSLD Nov 22, 2022
DSLD ID 274732
Product type Vitamin
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Vitamin B-2 25 mg by Nature's Blend, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
100
UPC/BARCODE
079854200256
IngredientAmount% DV
Riboflavin25 mg1923%

Other ingredients: Sorbitol, Modified Cellulose, Calcium Phosphate, Croscamellose Sodium, Silica, Magnesium Stearate, Triacetin, Polydextrose, Carnauba wax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

Store in a cool, dry place.

Precautions

Keep out of the reach of children.

Double safety sealed for your protection. Do not use if either seal is broken or missing.

Formulation

Preservative & gluten free. No starch, artificial colors, artificial flavors, wheat, yeast, or corn added.

This product is manufactured under strict quality control guidelines; therefore, purity and label potency are guaranteed. Made in USA & American Owned

May help in the release of energy to the body and maintain a normal nervous system.

General Statements

Questions/Comments Call 1-800-682-9862

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one tablet daily, preferably with a meal or as directed by your healthcare professional.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Vitamin B-2 25 mg by Nature's Blend label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Vitamin B-2 25 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Vitamin B-2 25 mg by Nature's Blend

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container100 Amounts shown are per serving.

Riboflavin

Interacts with
20 drugs
25 mg per serving Form: Vitamin B2

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally...

Riboflavin monograph & interactions

Other (inactive) ingredients: Sorbitol, Modified Cellulose, Calcium Phosphate, Croscamellose Sodium, Silica, Magnesium Stearate, Triacetin, Polydextrose, Carnauba wax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Vitamin B-2 25 mg by Nature's Blend Drug Interactions

Want to check YOUR meds against Vitamin B-2 25 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
20Drugs
20 Moderate

Ingredients driving the most interactions

Riboflavin 20

Individual Drug Interactions

The ingredients in Vitamin B-2 25 mg interact with 20 drugs. Click any drug to see the details.

1 of the 1 ingredient in Vitamin B-2 25 mg interact with drugs. Each result below shows which ingredient is responsible. Riboflavin

Each ingredient & the kinds of drugs it affects

For each ingredient in Vitamin B-2 25 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Riboflavin1 drug type · 20 drugs

Tetracycline Antibiotics

Theoretically, taking riboflavin with tetracycline antibiotics may decrease the potency of these antibiotics.
In vitro research suggests that riboflavin may inhibit the potency of tetracycline antibiotics. It is not clear if this effect is clinically significant, as this interaction has not been reported in humans.

Likelihood Possible Evidence D
Riboflavin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Vitamin B-2 25 mg, from the product label.

Nature's Blend

See all Nature's Blend products
Name
National Vitamin Company
City
Casa Grande
State
AZ
ZipCode
85122
Phone Number
1-800-682-9862
Web Address
www.nationalvitamin.com
Pharmacist Counseling Corner

Vitamin B-2 25 mg by Nature's Blend: Common Questions

Does Vitamin B-2 25 mg by Nature's Blend interact with any medications?
Yes. Based on its ingredients, Vitamin B-2 25 mg has a known interaction with 20 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Vitamin B-2 25 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this turn my urine yellow?
Possibly. At 25 mg per day, side effects are unlikely, but riboflavin can cause bright yellow urine — especially at higher doses. It's harmless; it just means your body is excreting the excess vitamin.
Is riboflavin safe during pregnancy?
Yes, at recommended amounts. Your body actually needs riboflavin when you're pregnant. If you're thinking about taking a high-dose supplement, check with your provider first.
Can I take this while breastfeeding?
Yes, at recommended doses. Riboflavin is needed during breastfeeding. If you want to take more than the typical amount, ask your provider.
What is riboflavin for?
Riboflavin is a B vitamin that helps your body produce energy and supports cell function. It's found naturally in many foods, but some people take a supplement to ensure they're getting enough.
Will this cause nausea?
At 25 mg, nausea is unlikely. Nausea from riboflavin is dose-related, meaning it's more common at much higher doses. If you do experience it, it's usually mild.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Vitamin B-2 25 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Vitamin B-2 25 mg label
Go deeper

The Full Monographs Behind Vitamin B-2 25 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Riboflavin

Interacts with 20 drugs

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally very safe at typical doses, and the stro...

Read the full Riboflavin monograph →
Sources

Sources & How We Checked

Vitamin B-2 25 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Riboflavin 5 references
  1. Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. Neurology 1998;50:466-70. PubMed
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Leeson LJ, Weidenheimer JF. Stability of tetracycline and riboflavin. J Pharm Sci. 1969;58(3):355-7. PubMed
  4. MacLennan, S. C., Wade, F. M., Forrest, K. M., Ratanayake, P. D., Fagan, E., and Antony, J. High-dose riboflavin for migraine prophylaxis in children: a double-blind, randomized, placebo-controlled trial. J Child Neurol. 2008;23(11):1300-1304.
  5. Dietary reference intakes (DRIs): estimated average requirements. Food and Nutrition Board, Institute of Medicine, National Academics. https://www.nal.usda.gov/sites/default/files/fnic_uploads//recommended_intakes_individuals.pdf Accessed July 24, 2017.

See these in context on the Riboflavin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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