Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Vitamin B-2 25 mg Ingredients & Drug Interactions

by Nature's Blend

Vitamin B-2 25 mg label
See full label image
Tablet Or Pill Category: Vitamin
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Vitamin B-2 25 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Vitamin B-2 25 mg is a dietary supplement by Nature's Blend with 1 active ingredient. Its ingredients are commonly taken for riboflavin deficiency, migraine prevention, general energy and metabolism support.Based on those ingredients, 20 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Riboflavin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Vitamin B-2 25 mg by Nature's Blend

Ask about any prescription or over-the-counter medication and we check it for interactions with Vitamin B-2 25 mg by Nature's Blend — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Vitamin B-2 25 mg by Nature's Blend

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 24, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Nature's Blend Vitamin B-2 contains one active ingredient: riboflavin, a B vitamin at 25 mg per tablet. The inactive ingredients are sorbitol, modified cellulose, calcium phosphate, croscamellose sodium, silica, magnesium stearate, triacetin, polydextrose, and carnauba wax — these serve as binders, fillers, and capsule coating to hold the tablet together and aid absorption.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Riboflavin product and its label doesn't state a use — see Riboflavin's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

We hold no effectiveness ratings for riboflavin in our data, so we can't tell you what the evidence shows it does. If you're considering this supplement for a specific reason — energy, migraines, or another purpose — your doctor or pharmacist can fill in whether the research supports that use.

The evidence, ingredient by ingredient Riboflavin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Riboflavin is generally well tolerated at normal doses. The most common side effects are nausea and bright yellow urine, both tied to how much you take.

Rarely, diarrhea or increased urination have been reported at high doses. Riboflavin is considered safe and needed during pregnancy and breastfeeding at recommended amounts, but if you're thinking about a higher-dose supplement while pregnant or nursing, check with your provider first.

Side effects, ingredient by ingredient Riboflavin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Riboflavin.
  • The most serious interaction on file is rated Moderate.
  • For scale: 20 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take a tetracycline antibiotic (such as doxycycline, tetracycline, or minocycline), check with your doctor or pharmacist before starting this supplement — riboflavin may reduce how well the antibiotic works.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This B-2 supplement is straightforward and generally well tolerated at this dose. The main thing to watch for is if you take a tetracycline antibiotic — you'll want to talk with your doctor or pharmacist about whether spacing doses apart or using a different antibiotic makes sense for you.

Otherwise, chat with your provider about whether you need a B-2 supplement and at what dose.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Vitamin B-2 25 mg, straight from the product label.

Brand Nature's Blend
Barcode (UPC) 079854200256
Net contents 100 Tablet(s)
Market status On market
Date entered into DSLD Nov 22, 2022
DSLD ID 274732
Product type Vitamin
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Vitamin B-2 25 mg by Nature's Blend, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
100
UPC/BARCODE
079854200256
IngredientAmount% DV
Riboflavin25 mg1923%

Other ingredients: Sorbitol, Modified Cellulose, Calcium Phosphate, Croscamellose Sodium, Silica, Magnesium Stearate, Triacetin, Polydextrose, Carnauba wax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

Store in a cool, dry place.

Precautions

Keep out of the reach of children.

Double safety sealed for your protection. Do not use if either seal is broken or missing.

Formulation

Preservative & gluten free. No starch, artificial colors, artificial flavors, wheat, yeast, or corn added.

This product is manufactured under strict quality control guidelines; therefore, purity and label potency are guaranteed. Made in USA & American Owned

May help in the release of energy to the body and maintain a normal nervous system.

General Statements

Questions/Comments Call 1-800-682-9862

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one tablet daily, preferably with a meal or as directed by your healthcare professional.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Vitamin B-2 25 mg by Nature's Blend label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Vitamin B-2 25 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Vitamin B-2 25 mg by Nature's Blend

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container100 Amounts shown are per serving.

Riboflavin

Interacts with
20 drugs
25 mg per serving Form: Vitamin B2

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally...

Riboflavin monograph & interactions

Other (inactive) ingredients: Sorbitol, Modified Cellulose, Calcium Phosphate, Croscamellose Sodium, Silica, Magnesium Stearate, Triacetin, Polydextrose, Carnauba wax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Vitamin B-2 25 mg by Nature's Blend Drug Interactions

Want to check YOUR meds against Vitamin B-2 25 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
20Drugs
20 Moderate

Ingredients driving the most interactions

Riboflavin 20

Individual Drug Interactions

The ingredients in Vitamin B-2 25 mg interact with 20 drugs. Click any drug to see the details.

1 of the 1 ingredient in Vitamin B-2 25 mg interact with drugs. Each result below shows which ingredient is responsible. Riboflavin

Each ingredient & the kinds of drugs it affects

For each ingredient in Vitamin B-2 25 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Riboflavin1 drug type · 20 drugs

Tetracycline Antibiotics

Theoretically, taking riboflavin with tetracycline antibiotics may decrease the potency of these antibiotics.
In vitro research suggests that riboflavin may inhibit the potency of tetracycline antibiotics. It is not clear if this effect is clinically significant, as this interaction has not been reported in humans.

Likelihood Possible Evidence D
Riboflavin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Vitamin B-2 25 mg, from the product label.

Nature's Blend

See all Nature's Blend products
Name
National Vitamin Company
City
Casa Grande
State
AZ
ZipCode
85122
Phone Number
1-800-682-9862
Web Address
www.nationalvitamin.com
Pharmacist Counseling Corner

Vitamin B-2 25 mg by Nature's Blend: Common Questions

Does Vitamin B-2 25 mg by Nature's Blend interact with any medications?
Yes. Based on its ingredients, Vitamin B-2 25 mg has a known interaction with 20 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Vitamin B-2 25 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this turn my urine yellow?
Yes, bright yellow urine is a known side effect of riboflavin, especially at higher doses. It's harmless — the excess vitamin is simply being excreted in your urine. At 25 mg per dose, you may or may not notice it, depending on how much you take overall.
Is it safe to take if I'm pregnant or breastfeeding?
Riboflavin at recommended doses is considered safe during pregnancy and breastfeeding — in fact, it's needed at those times. If you're thinking about a higher-dose supplement, check with your provider first to make sure it's right for your situation.
Can I take this every day?
Riboflavin is very safe because your body excretes what it doesn't need in the urine, so daily use at recommended amounts is fine. If you're considering megadoses, talk with your doctor or pharmacist first.
What does riboflavin actually do?
We don't have effectiveness ratings in our data for riboflavin, so we can't tell you what the research says it does. Your doctor or pharmacist can discuss what B-2 is used for and whether you need it.
Will this cause nausea?
Nausea is dose-related with riboflavin — the higher the dose, the greater the risk. At 25 mg per tablet, it's unlikely, but it depends on your total intake and how your body responds.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Vitamin B-2 25 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Vitamin B-2 25 mg label
Go deeper

The Full Monographs Behind Vitamin B-2 25 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Riboflavin

Interacts with 20 drugs

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally very safe at typical doses, and the stro...

Read the full Riboflavin monograph →
Sources

Sources & How We Checked

Vitamin B-2 25 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Riboflavin 5 references
  1. Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. Neurology 1998;50:466-70. PubMed
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Leeson LJ, Weidenheimer JF. Stability of tetracycline and riboflavin. J Pharm Sci. 1969;58(3):355-7. PubMed
  4. MacLennan, S. C., Wade, F. M., Forrest, K. M., Ratanayake, P. D., Fagan, E., and Antony, J. High-dose riboflavin for migraine prophylaxis in children: a double-blind, randomized, placebo-controlled trial. J Child Neurol. 2008;23(11):1300-1304.
  5. Dietary reference intakes (DRIs): estimated average requirements. Food and Nutrition Board, Institute of Medicine, National Academics. https://www.nal.usda.gov/sites/default/files/fnic_uploads//recommended_intakes_individuals.pdf Accessed July 24, 2017.

See these in context on the Riboflavin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team