Vitamin B-6 50 mg Ingredients & Drug Interactions
by Nature Made
What is this page for?
First and foremost: checking Vitamin B-6 50 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Vitamin B-6 50 mg is a dietary supplement by Nature Made with 1 active ingredient. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 210 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin B6. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Vitamin B-6 50 mg by Nature Made
Ask about any prescription or over-the-counter medication and we check it for interactions with Vitamin B-6 50 mg by Nature Made — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Vitamin B-6 50 mg by Nature Made
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: vitamin B6 (also called pyridoxine). It's a water-soluble B vitamin your body needs for nerve function, immune health, and protein metabolism.
The tablet also contains inactive ingredients — fillers and binders like calcium phosphate, cellulose gel, and magnesium stearate — that help hold it together.
Does it work?
Strong evidence
Vitamin B6 is effective for sideroblastic anemia (a type of anemia where your bone marrow can't make red blood cells properly) and for vitamin B6 deficiency itself. It's also effective for pyridoxine-dependent epilepsy (a rare seizure disorder).
The evidence is likely effective for high homocysteine levels (hyperhomocysteinemia), a blood marker linked to heart risk. For pregnancy-related nausea and vomiting, the evidence is possibly effective — it may help, but we don't have as much proof yet.
How safe is it?
Well-documented data
Vitamin B6 at this dose (50 mg) is well tolerated in most people. At doses under 100 mg daily, side effects like nausea, headache, or loss of appetite are mild and uncommon.
The main caution is with high doses taken over time — doses above 1000 mg daily or cumulative doses of 1000 grams or more can damage nerves (sensory neuropathy), causing tingling or numbness, though nerve damage can rarely occur at lower doses too. During pregnancy, vitamin B6 is likely safe, though one rating marks it as possibly unsafe — talk with your doctor about what's right for you.
It's likely safe during breastfeeding.
Meds to double-check
Moderate interaction found
Before taking this product, double-check with your doctor or pharmacist if you take blood pressure medications (antihypertensive drugs), amiodarone for heart rhythm, phenobarbital or phenytoin for seizures, or levodopa for Parkinson's disease — all have documented interactions with vitamin B6 at this dose or higher.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Vitamin B6 50 mg is a straightforward supplement for correcting deficiency or supporting conditions like sideroblastic anemia or high homocysteine. If you take blood pressure medication, a heart rhythm drug, or seizure medication, check with your doctor or pharmacist before starting this — the interactions are real and worth reviewing together.
For everyone else, it's generally well tolerated at this dose.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2012.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Vitamin B-6 50 mg, straight from the product label.
| Brand | Nature Made |
|---|---|
| Barcode (UPC) | 031604012847 |
| Net contents | 100 Premium Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Jun 25, 2012 |
| DSLD ID | 8851 |
| Product type | Vitamin |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Vitamin B-6 50 mg by Nature Made, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Vitamin B6 | 50 mg | 2500% |
Other ingredients: Dibasic Calcium Phosphate, Pyridoxine Hydrochloride, Cellulose Gel, Croscarmellose Sodium, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General
List No. 1284 L31AA Cat. 440 5A002
General Statements
Recommended By Pharmacists
ENTER CODE WELLNESS REWARDS CODE VISIT OUR WEBSITE & EARN FREE VITAMINS www.NatureMade.com - 1-800-276-2878
ESSENTIAL FOR PROTEIN AND AMINO ACID METABOLISM - Vitamin B-6 plays a role in converting food into energy. It is also essential in red blood cell formation.
USP has tested and verified ingredients, potency and manufacturing process. USP sets official standards for dietary supplements. See: www.usp-dsvp.org . Valid only for U.S. and Puerto Rico residents. Lot.: Exp.:
Supplement
Seals/Symbols
DIETARY SUPPLEMENT USP VERIFIED(TM)
Formulation
No Artificial Colors - No Artificial Flavors - No Preservatives No Chemical Solvents, Yeast, Starch or Gluten
Suggested/Recommended/Usage/Directions
SUGGESTED USE: Take one tablet daily with a meal.
Storage
Keep bottle tightly closed.
Precautions
Store in a cool, dry place, out of reach of children.
Do not use if imprinted seal under cap is broken or missing.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Vitamin B-6 50 mg by Nature Made label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Vitamin B-6 50 mg by Nature Made
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.
Vitamin B6
Interacts with210 drugs
Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...
Vitamin B6 monograph & interactionsOther (inactive) ingredients: Dibasic Calcium Phosphate, Pyridoxine Hydrochloride, Cellulose Gel, Croscarmellose Sodium, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Vitamin B-6 50 mg by Nature Made Drug Interactions
HelloPharmacist Interaction Report
Nature Made Vitamin B-6 50 mg interacts with several medication types through its single active ingredient, vitamin B6.
The most serious interaction is with antihypertensive drugs (blood pressure medications), where vitamin B6 may add to their effects and lower your blood pressure further.
Read the full breakdown — every affected drug type, severity by severity
Vitamin B6 also interacts moderately with amiodarone (a heart rhythm medication), where it may worsen sun sensitivity; with phenobarbital and phenytoin (seizure medications), where high doses may reduce how well these drugs work by speeding up how your body breaks them down. There's a minor interaction with levodopa (a Parkinson's medication), but this doesn't happen if you're also taking carbidopa, which is usually combined with levodopa anyway.
Additionally, vitamin B6 has no known interactions with other medication types we could check. Run your exact medications through the search tool on this page to see if any of yours are affected.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Vitamin B-6 50 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Vitamin B-6 50 mg interact with 210 drugs. Click any drug to see the details.
1 of the 1 ingredient in Vitamin B-6 50 mg interact with drugs. Each result below shows which ingredient is responsible. Vitamin B6
Belladonna, Ergotamine Tartrate, Phenobarbital
How Belladonna, Ergotamine Tartrate, Phenobarbital interacts with Vitamin B-6 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Phenobarbital (luminal) Moderate
Interaction Summary
High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Read the full Vitamin B6 + Belladonna, Ergotamine Tartrate, Phenobarbital interactionBelladonna, Ergotamine, PhenobarbitalBellergal-S
How Belladonna, Ergotamine, Phenobarbital interacts with Vitamin B-6 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Phenobarbital (luminal) Moderate
Interaction Summary
High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Read the full Vitamin B6 + Belladonna, Ergotamine, Phenobarbital interactionBelladonna, PhenobarbitalBellophen, Susano
How Belladonna, Phenobarbital interacts with Vitamin B-6 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Phenobarbital (luminal) Moderate
Interaction Summary
High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Read the full Vitamin B6 + Belladonna, Phenobarbital interactionBellafoline, PhenobarbitalBelladenal, Belladenal-S
How Bellafoline, Phenobarbital interacts with Vitamin B-6 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Phenobarbital (luminal) Moderate
Interaction Summary
High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Read the full Vitamin B6 + Bellafoline, Phenobarbital interactionBenazeprilLotensin
How Benazepril interacts with Vitamin B-6 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Benazepril interactionBenazepril, HydrochlorothiazideLotensin HCT
How Benazepril, Hydrochlorothiazide interacts with Vitamin B-6 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Benazepril, Hydrochlorothiazide interactionBendroflumethiazideAprinox, Naturetin, Neo-NaClex
How Bendroflumethiazide interacts with Vitamin B-6 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Bendroflumethiazide interactionBendroflumethiazide, NadololCorzide
How Bendroflumethiazide, Nadolol interacts with Vitamin B-6 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Bendroflumethiazide, Nadolol interactionBendroflumethiazide, Rauwolfia SerpentinaRauzide
How Bendroflumethiazide, Rauwolfia Serpentina interacts with Vitamin B-6 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Bendroflumethiazide, Rauwolfia Serpentina interactionBenzthiazideExna
How Benzthiazide interacts with Vitamin B-6 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Benzthiazide interactionBetaxololBetoptic, Kerlone
How Betaxolol interacts with Vitamin B-6 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Betaxolol interactionBisoprololZebeta
How Bisoprolol interacts with Vitamin B-6 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Bisoprolol interactionBisoprolol, HydrochlorothiazideZiac
How Bisoprolol, Hydrochlorothiazide interacts with Vitamin B-6 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Bisoprolol, Hydrochlorothiazide interactionBosentanTracleer
How Bosentan interacts with Vitamin B-6 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Bosentan interactionBumetanideBurinex
How Bumetanide interacts with Vitamin B-6 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Bumetanide interactionBumetanide (iv)Bumex
How Bumetanide (iv) interacts with Vitamin B-6 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Bumetanide (iv) interactionBumetanide (oral)Bumex
How Bumetanide (oral) interacts with Vitamin B-6 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Bumetanide (oral) interactionButabarbital, Phenobarbital, SecobarbitalS.B.P.
How Butabarbital, Phenobarbital, Secobarbital interacts with Vitamin B-6 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Phenobarbital (luminal) Moderate
Interaction Summary
High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Read the full Vitamin B6 + Butabarbital, Phenobarbital, Secobarbital interactionButalbital, Phenobarbital, SecobarbitalTribarb
How Butalbital, Phenobarbital, Secobarbital interacts with Vitamin B-6 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Phenobarbital (luminal) Moderate
Interaction Summary
High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Read the full Vitamin B6 + Butalbital, Phenobarbital, Secobarbital interactionCamphor, Hyoscyamine, Passif, Phenobarbital, Scopolamine, ValerianNevrotose #3
How Camphor, Hyoscyamine, Passif, Phenobarbital, Scopolamine, Valerian interacts with Vitamin B-6 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Phenobarbital (luminal) Moderate
Interaction Summary
High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Read the full Vitamin B6 + Camphor, Hyoscyamine, Passif, Phenobarbital, Scopolamine, Valerian interactionCandesartan CilexetilAmias, Atacand
How Candesartan Cilexetil interacts with Vitamin B-6 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Candesartan Cilexetil interactionCandesartan Cilexetil, HydrochlorothiazideAtacand HCT
How Candesartan Cilexetil, Hydrochlorothiazide interacts with Vitamin B-6 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Candesartan Cilexetil, Hydrochlorothiazide interactionCaptoprilAcepril, Capoten
How Captopril interacts with Vitamin B-6 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Captopril interactionCaptopril, HydrochlorothiazideAcezide, Capozide
How Captopril, Hydrochlorothiazide interacts with Vitamin B-6 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Captopril, Hydrochlorothiazide interactionCarteololCartrol, Ocupress
How Carteolol interacts with Vitamin B-6 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Carteolol interactionCarvedilolCoreg, Coreg CR
How Carvedilol interacts with Vitamin B-6 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Carvedilol interactionCeliprololCelicard
How Celiprolol interacts with Vitamin B-6 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Celiprolol interactionChlorothiazideDiuril
How Chlorothiazide interacts with Vitamin B-6 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Chlorothiazide interactionChlorothiazide, MethyldopaAldochlor, Aldoclor 150, Aldoclor 250
How Chlorothiazide, Methyldopa interacts with Vitamin B-6 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Chlorothiazide, Methyldopa interactionChlorothiazide, ReserpineDiupres
How Chlorothiazide, Reserpine interacts with Vitamin B-6 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Chlorothiazide, Reserpine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Vitamin B-6 50 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Vitamin B6
Amiodarone (Cordarone)
Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.
Antihypertensive Drugs
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.
Phenobarbital (Luminal)
High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.
Phenytoin (Dilantin)
High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.
Levodopa
Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.
Brand information
Manufacturer and brand details for Vitamin B-6 50 mg, from the product label.
Nature Made
See all Nature Made products- Name
- Nature Made Nutritional Products
- City
- Mission Hills
- State
- CA
- ZipCode
- 91346-9606
- Phone Number
- 1-800-276-2878
- Web Address
- www.NatureMade.com
Vitamin B-6 50 mg by Nature Made: Common Questions
Does Vitamin B-6 50 mg by Nature Made interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm pregnant?
What side effects might I get?
Is this dose too high?
Will this actually help with my nausea?
Can I breastfeed while taking this?
What is vitamin B6 actually used for?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Vitamin B-6 50 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Vitamin B-6 50 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Vitamin B-6 50 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 32 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Vitamin B6 32 references
- Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
- Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
- Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
- South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
- Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
- Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
- Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
- Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
- Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
- Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
- Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
- Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
- Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
- Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI
- Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
- Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
- Hatzitolios, A., Iliadis, F., Katsiki, N., and Baltatzi, M. Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review. Clin Exp.Hypertens. 2008;30(7):628-639. PubMed
- Vasdev, S., Ford, C. A., Parai, S., Longerich, L., and Gadag, V. Dietary vitamin B6 supplementation attenuates hypertension in spontaneously hypertensive rats. Mol.Cell Biochem. 1999;200(1-2):155-162.
- de, Vogel S., Dindore, V., van, Engeland M., Goldbohm, R. A., van den Brandt, P. A., and Weijenberg, M. P. Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer. J Nutr 2008;138(12):2372-2378. PubMed
- Hagen, I., Nesheim, B. I., and Tuntland, T. No effect of vitamin B-6 against premenstrual tension. A controlled clinical study. Acta Obstet.Gynecol.Scand. 1985;64(8):667-670. PubMed
- Aybak, M., Sermet, A., Ayyildiz, M. O., and Karakilcik, A. Z. Effect of oral pyridoxine hydrochloride supplementation on arterial blood pressure in patients with essential hypertension. Arzneimittelforschung. 1995;45(12):1271-1273.
- Lal, K. J., Dakshinamurti, K., and Thliveris, J. The effect of vitamin B6 on the systolic blood pressure of rats in various animal models of hypertension. J Hypertens. 1996;14(3):355-363. PubMed
- Lauritzen CH, Reuter HD, Repges R, Bohnert K, and Schmidt U. Treatment of premenstrual tension syndrome with Vitex agnus castus. Controlled, double-blind study versus pyridoxine. Phytomed 1997;4(3):183-189. PubMed
- Fonseca VA, Lavery LA, Thethi TK, et al. Metanx in type 2 diabetes with peripheral neuropathy: A randomized trial. Am J Med 2013;126(2):141-9. PubMed
- Hankey GJ, Eikelboom JW, Yi Q, et al. Treatment with B vitamins and incidence of cancer in patients with previous stroke or transient ischemic attack: Results of a randomized placebo-controlled trial. Stroke 2012;43(6):1572-7. PubMed
- Hoyer-Kuhn H, Kohbrok S, Volland R, Franklin J, Hero B, Beck BB, Hoppe B. Vitamin B6 in primary hyperoxaluria I: first prospective trial after 40 years of practice. Clin J Am Soc Nephrol. 2014 Mar;9(3):468-77. PubMed
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