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Dietary supplement

Vitamin B2 100 mg Ingredients & Drug Interactions

by Spring Valley

Vitamin B2 100 mg label
See full label image
Tablet Or Pill Category: Vitamin
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Vitamin B2 100 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Vitamin B2 100 mg is a dietary supplement by Spring Valley with 1 active ingredient. Its ingredients are commonly taken for riboflavin deficiency, migraine prevention, general energy and metabolism support.Based on those ingredients, 20 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Riboflavin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Vitamin B2 100 mg by Spring Valley

Ask about any prescription or over-the-counter medication and we check it for interactions with Vitamin B2 100 mg by Spring Valley — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Vitamin B2 100 mg by Spring Valley

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 24, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: riboflavin (also called vitamin B2), a water-soluble B vitamin. The tablet also includes several inactive ingredients—dicalcium phosphate, microcrystalline cellulose, croscarmellose sodium, stearic acid, hypromellose, magnesium stearate, silicon dioxide, and polyethylene glycol—which are fillers and binders that help hold the tablet together.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Riboflavin's overall clinical evidence instead.

Strong

Strong clinical evidence supports Riboflavin for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Ariboflavinosis — rated "Effective" (Natural Medicines).
  • On file: Migraine headache — rated "Possibly Effective" (Natural Medicines).
  • On file: Hyperhomocysteinemia — rated "Possibly Effective" (Natural Medicines).

We don't have effectiveness ratings on file for riboflavin for any specific health purpose in this product. If you're taking this to support energy, eye health, or another particular need, talk with your doctor or pharmacist about whether the evidence supports that use.

The evidence, ingredient by ingredient Riboflavin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Riboflavin is generally well tolerated and considered very safe; your body excretes excess amounts in the urine, which may turn bright yellow at higher doses. The most common side effects are mild dose-related nausea and that urine discoloration.

Rarely, some people report diarrhea. Riboflavin is needed during pregnancy and while breastfeeding, and it's generally safe at recommended amounts.

If you're pregnant, nursing, or want to take a high-dose supplement, check with your provider first to make sure it's right for you.

Side effects, ingredient by ingredient Riboflavin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Riboflavin.
  • The most serious interaction on file is rated Moderate.
  • For scale: 20 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take a tetracycline antibiotic (used for infections, acne, or other conditions), confirm with your doctor or pharmacist before adding this supplement. The riboflavin in it may reduce how well the antibiotic works, though this hasn't been confirmed in patients.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Vitamin B2 is a safe, well-tolerated B vitamin useful for people whose diet may be low in riboflavin. The main thing to know is that it may affect tetracycline antibiotics, so check with your doctor or pharmacist if you take one of those before starting this supplement.

For any concerns about whether this fits your personal health picture, talk it over with your own healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Vitamin B2 100 mg, straight from the product label.

Brand Spring Valley
Barcode (UPC) 681131087339
Net contents 100 Tablet(s)
Market status On market
Date entered into DSLD Jan 25, 2018
DSLD ID 83025
Product type Vitamin
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Vitamin B2 100 mg by Spring Valley, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
681131087339
IngredientAmount% DV
Riboflavin100 mg5882%

Other ingredients: Dicalcium Phosphate, Riboflavin, Microcrystalline Cellulose, Croscarmellose Sodium, Stearic Acid, Hypromellose, Magnesium Stearate, Silicon Dioxide, Polyethylene Glycol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Vitamin B2 100 mg Riboflavin

General Statements

Energy metabolism

Riboflavin (Vitamin B2) is essential for energy metabolism and may also contribute to skin health and maintenance of normal vision.

164152

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Do not use if printed seal under cap is broken or missing.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Vitamin B2 100 mg by Spring Valley label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Vitamin B2 100 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Vitamin B2 100 mg by Spring Valley

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Riboflavin

Interacts with
20 drugs
100 mg per serving Form: Vitamin B2

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally...

Riboflavin monograph & interactions

Other (inactive) ingredients: Dicalcium Phosphate, Riboflavin, Microcrystalline Cellulose, Croscarmellose Sodium, Stearic Acid, Hypromellose, Magnesium Stearate, Silicon Dioxide, Polyethylene Glycol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Vitamin B2 100 mg by Spring Valley Drug Interactions

Want to check YOUR meds against Vitamin B2 100 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
20Drugs
20 Moderate

Ingredients driving the most interactions

Riboflavin 20

Individual Drug Interactions

The ingredients in Vitamin B2 100 mg interact with 20 drugs. Click any drug to see the details.

1 of the 1 ingredient in Vitamin B2 100 mg interact with drugs. Each result below shows which ingredient is responsible. Riboflavin

Each ingredient & the kinds of drugs it affects

For each ingredient in Vitamin B2 100 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Riboflavin1 drug type · 20 drugs

Tetracycline Antibiotics

Theoretically, taking riboflavin with tetracycline antibiotics may decrease the potency of these antibiotics.
In vitro research suggests that riboflavin may inhibit the potency of tetracycline antibiotics. It is not clear if this effect is clinically significant, as this interaction has not been reported in humans.

Likelihood Possible Evidence D
Riboflavin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Vitamin B2 100 mg, from the product label.

Spring Valley

See all Spring Valley products
Name
Wal-Mart
Pharmacist Counseling Corner

Vitamin B2 100 mg by Spring Valley: Common Questions

Does Vitamin B2 100 mg by Spring Valley interact with any medications?
Yes. Based on its ingredients, Vitamin B2 100 mg has a known interaction with 20 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Vitamin B2 100 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this turn my urine yellow?
Yes, riboflavin is known for turning urine bright yellow, especially at higher doses. This is normal and harmless—it's just excess riboflavin leaving your body.
Is it okay to take this while pregnant or breastfeeding?
Riboflavin is actually needed during pregnancy and breastfeeding and is generally safe at recommended amounts. If you're pregnant, nursing, or want to take a higher dose, talk with your provider first to make sure it's appropriate for you.
What are the side effects?
Riboflavin is very well tolerated. The most common side effect at higher doses is mild nausea. Rarely, people report diarrhea. The bright yellow urine is expected and harmless.
Why would I take a vitamin B2 supplement?
Riboflavin (B2) is an essential nutrient found in foods like eggs, almonds, and mushrooms. You might supplement if your diet is low in these foods or if you have a specific reason your doctor recommends it, though we don't have specific effectiveness data on file for this product.
Can I take this with my antibiotics?
It depends on which antibiotic. If you take a tetracycline antibiotic (like doxycycline or tetracycline), check with your doctor or pharmacist first—this supplement may reduce its effectiveness. Other antibiotics should be fine, but always confirm with your healthcare provider.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Vitamin B2 100 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Vitamin B2 100 mg label
Go deeper

The Full Monographs Behind Vitamin B2 100 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Riboflavin

Interacts with 20 drugs

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally very safe at typical doses, and the stro...

Read the full Riboflavin monograph →
Sources

Sources & How We Checked

Vitamin B2 100 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Riboflavin 5 references
  1. Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. Neurology 1998;50:466-70. PubMed
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Leeson LJ, Weidenheimer JF. Stability of tetracycline and riboflavin. J Pharm Sci. 1969;58(3):355-7. PubMed
  4. MacLennan, S. C., Wade, F. M., Forrest, K. M., Ratanayake, P. D., Fagan, E., and Antony, J. High-dose riboflavin for migraine prophylaxis in children: a double-blind, randomized, placebo-controlled trial. J Child Neurol. 2008;23(11):1300-1304.
  5. Dietary reference intakes (DRIs): estimated average requirements. Food and Nutrition Board, Institute of Medicine, National Academics. https://www.nal.usda.gov/sites/default/files/fnic_uploads//recommended_intakes_individuals.pdf Accessed July 24, 2017.

See these in context on the Riboflavin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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