Vitamin D3 125 mcg (5,000 IU) Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Vitamin D3 125 mcg (5,000 IU) against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Vitamin D3 125 mcg (5,000 IU) is a dietary supplement by Life Extension with 1 active ingredient. Its ingredients are commonly taken for bone health and osteoporosis, correcting vitamin d deficiency, immune system support.Based on those ingredients, 715 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin D3. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Vitamin D3 125 mcg (5,000 IU) by Life Extension
Ask about any prescription or over-the-counter medication and we check it for interactions with Vitamin D3 125 mcg (5,000 IU) by Life Extension — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Vitamin D3 125 mcg (5,000 IU) by Life Extension
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: vitamin D3, a form of vitamin D your body produces when sunlight hits your skin and which you also get from fatty fish and fortified foods. The dose here — 5,000 IU (125 mcg) — is above the recommended daily amount for most adults but within prescribed therapeutic ranges for certain bone and mineral disorders.
The softgel also includes inactive ingredients (olive oil, gelatin, medium-chain triglycerides, glycerin, water, and rosemary extract) that help deliver and preserve the vitamin.
Does it work?
Strong evidence
Vitamin D3 is established as effective for treating rickets, osteomalacia (soft bones from vitamin D deficiency), renal bone disease, hypoparathyroidism (low parathyroid hormone), and familial hypophosphatemia (a rare inherited phosphate disorder). For other uses — such as general bone health, immune function, or mood — the evidence we hold does not establish effectiveness.
If you're considering this product for a condition other than those listed, talk with your pharmacist or doctor about what the science actually shows.
How safe is it?
Well-documented data
Vitamin D is generally well tolerated at recommended doses. However, the 5,000 IU in this product exceeds the safe upper limit (4,000 IU daily) set for preventing toxicity in adults; very high doses over time can cause vitamin D toxicity, marked by elevated blood calcium, bone loss, and in children, slowed growth.
Rare serious side effects from excessive doses include kidney damage and anemia. For pregnancy, the safety data shows it is likely safe at recommended amounts, though one rating flags possibly unsafe — use only under your doctor's guidance.
Breastfeeding is rated likely safe at recommended doses; check with your doctor before taking higher amounts.
Meds to double-check
Moderate interaction found
Check your medications against these types before taking this product: thiazide diuretics and other blood pressure or fluid pills, verapamil or diltiazem (calcium channel blockers for heart rhythm and blood pressure), digoxin or other heart rhythm drugs, atorvastatin or other statin cholesterol medications, calcipotriene (psoriasis treatment), and any medications broken down by your liver's CYP3A4 enzyme system. Altogether, these interactions span 705 individual medications.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product is intended for medical treatment of specific bone and mineral disorders under a doctor's supervision, not general supplementation. If you take thiazide diuretics, heart medications (especially verapamil, diltiazem, or digoxin), cholesterol drugs, or calcipotriene, you must check with your pharmacist before starting.
Anyone pregnant, breastfeeding, or with kidney disease should discuss this dose with their doctor first.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Vitamin D3 125 mcg (5,000 IU), straight from the product label.
| Brand | Life Extension |
|---|---|
| Barcode (UPC) | 737870171362 |
| Net contents | 60 Softgel(s) |
| Market status | On market |
| Date entered into DSLD | Aug 23, 2020 |
| DSLD ID | 232274 |
| Product type | Vitamin |
| Supplement form | Softgel Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Vitamin D3 125 mcg (5,000 IU) by Life Extension, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Vitamin D3 | 125 mcg | 625% |
Other ingredients: extra virgin Olive Oil, Gelatin, Medium Chain Triglycerides, Glycerin, purified Water, Rosemary extract
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Read the entire label and follow the directions carefully prior to use. Directions: Take one (1) softgel daily with food, or as recommended by a healthcare practitioner.
1 daily
Precautions
Caution: Individuals consuming more than 2,000 IU/day of vitamin D (from diet and supplements) should periodically obtain a serum 25-hydroxy vitamin D measurement. Do not exceed 10,000 IU per day unless recommended by your doctor. Vitamin D supplementation is not recommended for individuals with high blood calcium levels.
Warnings: Keep out of reach of children.
Do not exceed recommended dose. Do not purchase if outer seal is broken or damaged.
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
To report a serious adverse event or obtain product information, contact 1-866-280-2852.
Formulation
Gluten free
Non GMO LE Certified
Essential for maintaining healthy bone growth and density
Seals/Symbols
Non GMO LE Certified
FDA Statement of Identity
Dietary Supplement
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Storage
Store tightly closed in a cool, dry place.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Vitamin D3 125 mcg (5,000 IU) by Life Extension label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Vitamin D3 125 mcg (5,000 IU) by Life Extension
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.
Vitamin D3
Interacts with715 drugs
Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people,...
Vitamin D3 monograph & interactionsOther (inactive) ingredients: Extra virgin Olive Oil, Gelatin, Medium Chain Triglycerides, Glycerin, Purified Water, Rosemary extract. These complete the product’s ingredient list but are not active constituents.
Vitamin D3 125 mcg (5,000 IU) by Life Extension Drug Interactions
HelloPharmacist Interaction Report
Life Extension Vitamin D3 125 mcg (5,000 IU) does interact with several medication types, and the dose in this product is higher than the safety threshold for certain drug combinations.
The single biggest concern is thiazide diuretics (water pills used for blood pressure and fluid retention): at this dose, vitamin D can theoretically raise your blood calcium level dangerously high, especially if the diuretic is already reducing how much calcium you lose in urine. This is a Moderate-severity interaction.
Read the full breakdown — every affected drug type, severity by severity
Vitamin D at this strength also poses Moderate-severity risks with heart medications — verapamil and diltiazem (used for arrhythmia and blood pressure) can lose effectiveness if vitamin D raises your blood calcium, and digoxin (a heart rhythm drug) carries a serious theoretical risk of fatal arrhythmias from the same mechanism. Calcipotriene, a vitamin D-like topical psoriasis treatment, should not be combined with this supplement for the same reason.
Additionally, vitamin D may reduce how your body absorbs atorvastatin (a cholesterol drug), lower how fast your liver breaks down certain medications (CYP3A4 substrates — a broad category), and theoretically increase absorption of aluminum, though that last risk mainly applies if you have kidney problems.
Aluminum-containing products and this vitamin D dose should be discussed with your pharmacist. Use the medication checker below to verify your exact prescriptions before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Vitamin D3 125 mcg (5,000 IU)?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Vitamin D3 125 mcg (5,000 IU) interact with 715 drugs. Click any drug to see the details.
1 of the 1 ingredient in Vitamin D3 125 mcg (5,000 IU) interact with drugs. Each result below shows which ingredient is responsible. Vitamin D3
Alginic Acid, Aluminum HydroxideRafton
How Alginic Acid, Aluminum Hydroxide interacts with Vitamin D3 125 mcg (5,000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Aluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D3 + Alginic Acid, Aluminum Hydroxide interactionAluminum Acetate, Benzethonium ChlorideBuro-Sol Otic Solution
How Aluminum Acetate, Benzethonium Chloride interacts with Vitamin D3 125 mcg (5,000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Aluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D3 + Aluminum Acetate, Benzethonium Chloride interactionAluminum ChlorideAluminum Chloride, Anhydrol Forte, Driclor, Drysol
How Aluminum Chloride interacts with Vitamin D3 125 mcg (5,000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Aluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D3 + Aluminum Chloride interactionAluminum HydroxideAlu-Cap, Amphojel, Gaviscon
How Aluminum Hydroxide interacts with Vitamin D3 125 mcg (5,000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Aluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D3 + Aluminum Hydroxide interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Vitamin D3 125 mcg (5,000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Aluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D3 + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Vitamin D3 125 mcg (5,000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Aluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D3 + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAluminum Hydroxide, Magnesium Hydroxide (otc Drug)Maalox, Mucogel
How Aluminum Hydroxide, Magnesium Hydroxide (otc Drug) interacts with Vitamin D3 125 mcg (5,000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Aluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D3 + Aluminum Hydroxide, Magnesium Hydroxide (otc Drug) interactionAluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug)Mylanta
How Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug) interacts with Vitamin D3 125 mcg (5,000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Aluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D3 + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug) interactionAluminum, CalciumDomeboro
How Aluminum, Calcium interacts with Vitamin D3 125 mcg (5,000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Aluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D3 + Aluminum, Calcium interactionAluminum, Magnesium (otc Drug)Almagel
How Aluminum, Magnesium (otc Drug) interacts with Vitamin D3 125 mcg (5,000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Aluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D3 + Aluminum, Magnesium (otc Drug) interactionAluminum, Magnesium Hydroxide (otc Drug)Wingel
How Aluminum, Magnesium Hydroxide (otc Drug) interacts with Vitamin D3 125 mcg (5,000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Aluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D3 + Aluminum, Magnesium Hydroxide (otc Drug) interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Vitamin D3 125 mcg (5,000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Amiloride, Hydrochlorothiazide interactionAspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #3
How Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interacts with Vitamin D3 125 mcg (5,000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Aluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D3 + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionAtenolol, ChlortalidoneAtenixCo, Tenoret 50, Totaretic
How Atenolol, Chlortalidone interacts with Vitamin D3 125 mcg (5,000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Atenolol, Chlortalidone interactionAtenolol, ChlorthalidoneTenoretic
How Atenolol, Chlorthalidone interacts with Vitamin D3 125 mcg (5,000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Atenolol, Chlorthalidone interactionAtorvastatinAtorvaliq
How Atorvastatin interacts with Vitamin D3 125 mcg (5,000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates, Atorvastatin (lipitor) Moderate
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Atorvastatin interactionAtorvastatin CalciumLipitor
How Atorvastatin Calcium interacts with Vitamin D3 125 mcg (5,000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Atorvastatin (lipitor), Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Vitamin D might reduce absorption of atorvastatin.
Read the full Vitamin D3 + Atorvastatin Calcium interactionAzilsartan, ChlorthalidoneEdarbyclor
How Azilsartan, Chlorthalidone interacts with Vitamin D3 125 mcg (5,000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Azilsartan, Chlorthalidone interactionBenazepril, HydrochlorothiazideLotensin HCT
How Benazepril, Hydrochlorothiazide interacts with Vitamin D3 125 mcg (5,000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Benazepril, Hydrochlorothiazide interactionBendroflumethiazideAprinox, Naturetin, Neo-NaClex
How Bendroflumethiazide interacts with Vitamin D3 125 mcg (5,000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Bendroflumethiazide interactionBendroflumethiazide, NadololCorzide
How Bendroflumethiazide, Nadolol interacts with Vitamin D3 125 mcg (5,000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Bendroflumethiazide, Nadolol interactionBendroflumethiazide, PotassiumCentyl K, Neo-NaClex-K
How Bendroflumethiazide, Potassium interacts with Vitamin D3 125 mcg (5,000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Bendroflumethiazide, Potassium interactionBendroflumethiazide, Rauwolfia SerpentinaRauzide
How Bendroflumethiazide, Rauwolfia Serpentina interacts with Vitamin D3 125 mcg (5,000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Bendroflumethiazide, Rauwolfia Serpentina interactionBenzthiazideExna
How Benzthiazide interacts with Vitamin D3 125 mcg (5,000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Benzthiazide interactionBetamethasone Dipropionate, CalcipotrieneEnstilar, Wynzora
How Betamethasone Dipropionate, Calcipotriene interacts with Vitamin D3 125 mcg (5,000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Calcipotriene (dovonex) Moderate
Interaction Summary
Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Read the full Vitamin D3 + Betamethasone Dipropionate, Calcipotriene interactionBisoprolol, HydrochlorothiazideZiac
How Bisoprolol, Hydrochlorothiazide interacts with Vitamin D3 125 mcg (5,000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Bisoprolol, Hydrochlorothiazide interactionCalcipotrieneDovonex
How Calcipotriene interacts with Vitamin D3 125 mcg (5,000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Calcipotriene (dovonex) Moderate
Interaction Summary
Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Read the full Vitamin D3 + Calcipotriene interactionCandesartan Cilexetil, HydrochlorothiazideAtacand HCT
How Candesartan Cilexetil, Hydrochlorothiazide interacts with Vitamin D3 125 mcg (5,000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Candesartan Cilexetil, Hydrochlorothiazide interactionCaptopril, HydrochlorothiazideAcezide, Capozide
How Captopril, Hydrochlorothiazide interacts with Vitamin D3 125 mcg (5,000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Captopril, Hydrochlorothiazide interactionChlorothiazideDiuril
How Chlorothiazide interacts with Vitamin D3 125 mcg (5,000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Chlorothiazide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Vitamin D3 125 mcg (5,000 IU) with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Vitamin D3
Aluminum
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
The protein that transports calcium across the intestinal wall can also bind and transport aluminum. This protein is stimulated by vitamin D, which may therefore increase aluminum absorption. This mechanism may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.
Atorvastatin (Lipitor)
Vitamin D might reduce absorption of atorvastatin.
A small, low-quality clinical study shows that taking vitamin D reduces levels of atorvastatin and its active metabolites by up to 55%. However, while atorvastatin levels decreased, total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels did not substantially change. Atorvastatin is metabolized in the gut by CYP3A4 enzymes, and researchers theorized that vitamin D might induce CYP3A4, causing reduced levels of atorvastatin. However, this proposed mechanism was not specifically studied.
Calcipotriene (Dovonex)
Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with vitamin D supplements might increase the risk of hypercalcemia.
Digoxin (Lanoxin)
Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and digoxin concurrently.
Diltiazem (Cardizem, Others)
Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically this could also occur with diltiazem. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and diltiazem concurrently.
Thiazide Diuretics
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Thiazide diuretics decrease urinary calcium excretion, which could lead to hypercalcemia if vitamin D supplements are taken concurrently. This has been reported in people being treated with vitamin D for hypoparathyroidism, and also in elderly people with normal parathyroid function who were taking a thiazide, vitamin D, and calcium-containing antacids daily.
Verapamil (Calan, Others)
Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of verapamil in atrial fibrillation. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and verapamil concurrently.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
There is some concern that vitamin D might induce CYP3A4. In vitro research suggests that vitamin D induces CYP3A4 transcription. Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found. A small, low-quality clinical study shows that taking vitamin D reduces levels of the CYP3A4 substrate atorvastatin and its active metabolites by up to 55%; however, the clinical effects of atorvastatin were not reduced. While researchers theorized that vitamin D might induce CYP3A4, this proposed mechanism was not specifically studied.
Brand information
Manufacturer and brand details for Vitamin D3 125 mcg (5,000 IU), from the product label.
Life Extension
See all Life Extension products- Name
- Quality Supplements and Vitamins, Inc.
- City
- Ft. Lauderdale
- State
- FL
- ZipCode
- 33309
- Phone Number
- 1-866-280-2852
- Web Address
- LifeExtension.com
Vitamin D3 125 mcg (5,000 IU) by Life Extension: Common Questions
Does Vitamin D3 125 mcg (5,000 IU) by Life Extension interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is 5,000 IU of vitamin D safe for daily use?
Can I take this vitamin D if I'm pregnant or breastfeeding?
What are the signs of vitamin D toxicity from taking too much?
Will vitamin D interact with my cholesterol or blood pressure medications?
Is this product just a supplement, or is it medicine?
Can I take this with aluminum-containing antacids?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Vitamin D3 125 mcg (5,000 IU) is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Vitamin D3 125 mcg (5,000 IU)’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Vitamin D3 125 mcg (5,000 IU)'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 26 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Vitamin D 26 references
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Tatro DS, ed. Drug Interactions Facts. Facts and Comparisons Inc., St. Louis, MO. 1999.
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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