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Dietary supplement

Vitamin D3 Gold 5,000 IU Ingredients & Drug Interactions

by NutriGold

Softgel Capsule Category: Vitamin
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Vitamin D3 Gold 5,000 IU is a dietary supplement by NutriGold with 1 active ingredient. Its ingredients are commonly taken for bone health and osteoporosis, correcting vitamin d deficiency, immune system support.Based on those ingredients, 715 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin D. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Vitamin D3 Gold 5,000 IU by NutriGold

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Vitamin D3 Gold 5,000 IU contains one active ingredient: vitamin D, delivered as 5,000 IU per softgel capsule. The softgels also contain organic extra virgin olive oil and a softgel shell as inactive ingredients.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Supports calcium absorption and bone health.
  • We looked for evidence on: Corticosteroid-induced osteoporosis, Dental caries, Fractures, Hyperparathyroidism-related bone loss, Kidney transplant-related bone loss, Osteomalacia — and 3 related terms.
  • The strongest evidence on file: Vitamin D is rated "Effective" for Osteomalacia (Natural Medicines).
  • Also on file: Vitamin D is rated "Effective" for Renal osteodystrophy, Rickets.
  • Also on file: Vitamin D is rated "Likely Effective" for Corticosteroid-induced osteoporosis.

Vitamin D is established as effective for rickets, renal bone disease (renal osteodystrophy), vitamin D-resistant bone disease (osteomalacia), and familial hypophosphatemia. These are conditions where your body doesn't absorb or process vitamin D properly, or where your bones lose mineral density because of kidney disease or genetic disorders.

At 5,000 IU daily, this dose is higher than typical dietary intake and is used under medical supervision for these specific conditions.

The evidence, ingredient by ingredient Vitamin D

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin D is generally well tolerated at recommended doses, but very high doses over time can cause toxicity — essentially vitamin D poisoning. Symptoms of overdose include high blood calcium (hypercalcemia) with weakness and bone loss, and rarely, eye inflammation and light sensitivity.

The product notes say vitamin D is often used during pregnancy at recommended amounts, but you should use it only under your doctor's guidance if you're pregnant or breastfeeding. Because this is a 5,000 IU dose, which is above the tolerable upper limit of 4,000 IU daily for adults, it should only be taken under medical supervision.

Side effects, ingredient by ingredient Vitamin D

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin D.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications.
  • For scale: 716 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist or doctor if you're on digoxin (heart rhythm medication), thiazide diuretics (water pills), verapamil or diltiazem (heart drugs), atorvastatin (cholesterol medication), calcipotriene (psoriasis cream), aluminum-containing products, or any drug metabolized by your liver's CYP3A4 enzyme. High-dose vitamin D can raise blood calcium and reduce how well several of these drugs work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is prescribed-strength vitamin D, not an over-the-counter supplement — it's meant for people with bone disease, kidney disease, or vitamin D metabolism disorders under doctor supervision. If you have heart rhythm issues, take cholesterol medications, or use thiazide diuretics, talk with your pharmacist before starting.

Run your medications through the checker on this page.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 28, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Vitamin D3 Gold 5,000 IU, straight from the product label.

Brand NutriGold
Barcode (UPC) 859447002159
Net contents 360 Mini Softgel(s)
Market status On market
Date entered into DSLD May 28, 2019
DSLD ID 202552
Product type Vitamin
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Vitamin D3 Gold 5,000 IU by NutriGold, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Mini Softgel(s)
Maximum serving Sizes:
1 Mini Softgel(s)
Servings per container
360
UPC/BARCODE
859447002159
IngredientAmount% DV
Vitamin D5000 IU1250%

Other ingredients: organic extra virgin Olive Oil, Softgel shell

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Bioidentical form of vitamin D as cholecalciferol from lanolin, formulated with organic olive oil for enhanced bioavailability.

Health Benefits: Supports calcium absorption and bone, dental, immune, prostate, and breast health.

Bioavailable form of Vitamin D

Formulation

Verified free of corn, egg, gluten, milk, peanut, shellfish, and soy allergens by an independent lab. No magnesium stearate, stearic acid, dioxides, sulfates, artificial ingredients, or preservatives. Tested and verified non-GMO by an independent lab.

Soy-Free No harmful additives

General Statements

SKU # 215 To learn more about this product, scan QR or visit nutrigold.com/item/215

FDA Statement of Identity

Vitamin Supplement

Seals/Symbols

Gluten-Free

Soy-Free

Non-GMO Verified

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, adults take one (1) mini softgel daily, or as directed by a healthcare professional.

Precautions

Caution: Please consult a healthcare professional before taking this supplement if you are pregnant, breastfeeding, or taking any medications.

Do not exceed the recommended dosage.

Keep out of reach of children.

Storage

Store in original container away from moisture and direct sunlight.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

215-980402

See for yourself

Vitamin D3 Gold 5,000 IU by NutriGold label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Vitamin D3 Gold 5,000 IU by NutriGold

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Mini Softgel(s) Dosage formSoftgel Capsule Servings per container360 Amounts shown are per serving.

Vitamin D

Interacts with
715 drugs
5000 IU per serving Form: D3

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people,...

Vitamin D monograph & interactions

Other (inactive) ingredients: Organic extra virgin Olive Oil, Softgel shell. These complete the product’s ingredient list but are not active constituents.

Interaction report

Vitamin D3 Gold 5,000 IU by NutriGold Drug Interactions

Want to check YOUR meds against Vitamin D3 Gold 5,000 IU?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
715Drugs
80 Moderate 635 Minor

Ingredients driving the most interactions

Vitamin D 715

Each ingredient & the kinds of drugs it affects

For each ingredient in Vitamin D3 Gold 5,000 IU with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin D8 drug types · 715 drugs

Aluminum

Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
The protein that transports calcium across the intestinal wall can also bind and transport aluminum. This protein is stimulated by vitamin D, which may therefore increase aluminum absorption. This mechanism may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.

Likelihood Probable Evidence B
Atorvastatin (Lipitor)

Vitamin D might reduce absorption of atorvastatin.
A small, low-quality clinical study shows that taking vitamin D reduces levels of atorvastatin and its active metabolites by up to 55%. However, while atorvastatin levels decreased, total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels did not substantially change. Atorvastatin is metabolized in the gut by CYP3A4 enzymes, and researchers theorized that vitamin D might induce CYP3A4, causing reduced levels of atorvastatin. However, this proposed mechanism was not specifically studied.

Likelihood Probable Evidence B
Calcipotriene (Dovonex)

Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with vitamin D supplements might increase the risk of hypercalcemia.

Likelihood Probable Evidence D
Digoxin (Lanoxin)

Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and digoxin concurrently.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically this could also occur with diltiazem. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and diltiazem concurrently.

Likelihood Probable Evidence B
Thiazide Diuretics

Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Thiazide diuretics decrease urinary calcium excretion, which could lead to hypercalcemia if vitamin D supplements are taken concurrently. This has been reported in people being treated with vitamin D for hypoparathyroidism, and also in elderly people with normal parathyroid function who were taking a thiazide, vitamin D, and calcium-containing antacids daily.

Likelihood Probable Evidence D
Verapamil (Calan, Others)

Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of verapamil in atrial fibrillation. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and verapamil concurrently.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
There is some concern that vitamin D might induce CYP3A4. In vitro research suggests that vitamin D induces CYP3A4 transcription. Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found. A small, low-quality clinical study shows that taking vitamin D reduces levels of the CYP3A4 substrate atorvastatin and its active metabolites by up to 55%; however, the clinical effects of atorvastatin were not reduced. While researchers theorized that vitamin D might induce CYP3A4, this proposed mechanism was not specifically studied.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Vitamin D3 Gold 5,000 IU, from the product label.

NutriGold

Name
NutriGold Inc.
City
Orem
State
UT
ZipCode
84057
Phone Number
800-476-3542
Web Address
www.nutrigold.com
Pharmacist Counseling Corner

Vitamin D3 Gold 5,000 IU by NutriGold: Common Questions

Does Vitamin D3 Gold 5,000 IU by NutriGold interact with any medications?
Yes. Based on its ingredients, Vitamin D3 Gold 5,000 IU has a known interaction with 715 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Vitamin D3 Gold 5,000 IU contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Vitamin D is often used during pregnancy at recommended amounts, but this is a high dose (5,000 IU daily is above the standard upper limit of 4,000 IU). Use it only under your doctor's guidance if you're pregnant or breastfeeding. There isn't enough data on file to know about breastfeeding safety specifically — talk with your doctor or pharmacist for personalized advice.
What are the side effects?
At normal doses, vitamin D is well tolerated with few side effects. At very high doses over time, you can develop vitamin D toxicity — symptoms include weakness, bone loss from high blood calcium, and rarely eye inflammation or light sensitivity. Because this product is 5,000 IU daily (above the safe upper limit), it should only be taken under medical supervision.
Is this a safe dose to take on my own?
This is a prescription-strength dose — 5,000 IU is above the tolerable upper intake level of 4,000 IU daily for adults. It's meant to be taken only under medical supervision for specific bone or kidney diseases. Don't take this without your doctor's direction.
What is vitamin D used for in this product?
This dose of vitamin D is effective for rickets, vitamin D-resistant bone disease (osteomalacia), kidney-related bone disease (renal osteodystrophy), and familial hypophosphatemia — conditions where your body can't absorb or use vitamin D properly or where kidney disease damages bone.
Are there any fillers or other ingredients besides vitamin D?
The softgel capsules contain organic extra virgin olive oil and a softgel shell as inactive ingredients — no unnecessary fillers are listed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Vitamin D3 Gold 5,000 IU is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Vitamin D3 Gold 5,000 IU label
Go deeper

The Full Monographs Behind Vitamin D3 Gold 5,000 IU’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Vitamin D3 Gold 5,000 IU's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 26 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin D 26 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Tatro DS, ed. Drug Interactions Facts. Facts and Comparisons Inc., St. Louis, MO. 1999.
  3. Koutkia P, Chen TC, Holick MF. Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med 2001;345:66-7. PubMed
  4. Bar-Or D, Yoel G. Calcium and calciferol antagonize effect of verapamil in atrial fibrillation. Br Med J 1981;282:1585-6.
  5. Demontis R, Leflon A, Fournier A, et al. 1 alpha(OH) vitamin D3 increases plasma aluminum in hemodialyzed patients taking AI(OH)3. Clin Nephrol 1986;26:146-9.
  6. Crowe M, Wollner L, Griffiths RA. Hypercalcemia following vitamin D and thiazide therapy in the elderly. Practitioner 1984;228:312-3.
  7. Parfitt AM. Thiazide-induced hypercalcemia in vitamin D-treated hypoparathyroidism. Ann Intern Med 1972;77:557-63. PubMed
  8. Thiazide diuretics and the risk of osteoporosis. Pharmacist's Letter/Prescriber's Letter 2003;19(11):191105.
  9. Moon J. The role of vitamin D in toxic metal absorption. J Am Coll Nutr 1994;13:559-64.
  10. Demontis R, Reissi D, Noel C, et al. Indirect clinical evidence that 1alphaOH vitamin D<SUB>3</SUB> increases the intestinal absorption of aluminum. Clin Nephrol 1989;31:123-7.
  11. Adler AJ, Berlyne GM. Duodenal aluminum absorption in the rat: effect of vitamin D. Am J Physiol 1985;249:G209-13. PubMed
  12. Schwartz JB. Effects of vitamin D supplementation in atorvastatin-treated patients: A new drug interaction with an unexpected consequence. Clin Pharmacol Ther 2009;85:198-203. PubMed
  13. Dietary reference intakes for calcium and vitamin D. Institute of Medicine, November 30, 2010. Available at: http://www.iom.edu/~/media/Files/Report%20Files/2010/Dietary-Reference-Intakes-for-Calcium-and-Vitamin-D/Vitamin%20D%20and%20Calcium%202010%20Repo
  14. Cox KA, Dunn MA. Aluminum toxicity alters the regulation of calbindin-D28k protein and mRNA expression in chick intestine. J Nutr 2001;131:2007-13. PubMed
  15. Escribano, J., Balaguer, A., Pagone, F., Feliu, A., and Roque, I. Figuls. Pharmacological interventions for preventing complications in idiopathic hypercalciuria. Cochrane.Database.Syst.Rev. 2009;(1):CD004754. PubMed
  16. Carlton, S., Clopton, D., and Cappuzzo, K. A. Vitamin D deficiency: appropriate replenishment therapies and the effects of vitamin D toxicity. Consult Pharm 2010;25(3):171-177. PubMed
  17. Wang, H., Xia, N., Yang, Y., and Peng, D. Q. Influence of vitamin D supplementation on plasma lipid profiles: a meta-analysis of randomized controlled trials. Lipids Health Dis. 2012;11:42. PubMed
  18. Turner AN, Carr Reese P, Fields KS, Anderson J, Ervin M, Davis JA, Fichorova RN, Roberts MW, Klebanoff MA, Jackson RD. A blinded, randomized controlled trial of high-dose vitamin D supplementation to reduce recurrence of bacterial vaginosis. Am J Obstet G PubMed
  19. Weiner M, Epstein FH. Signs and symptoms of electrolyte disorders. Yale J Biol Med. 1970;43(2):76-109.
  20. Lappe J, Watson P, Travers-Gustafson D, Recker R, Garland C, Gorham E, Baggerly K, McDonnell SL. Effect of Vitamin D and Calcium Supplementation on Cancer Incidence in Older Women: A Randomized Clinical Trial. JAMA. 2017 Mar 28;317(12):1234-1243. PubMed
  21. Roth DE, Leung M, Mesfin E, Qamar H, Watterworth J, Papp E. Vitamin D supplementation during pregnancy: state of the evidence from a systematic review of randomised trials. BMJ. 2017;359:j5237. PubMed
  22. Murai IH, Fernandes AL, Sales LP, et al. Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to severe COVID-19: A randomized clinical trial. JAMA. 2021.
  23. Wang Z, Schuetz EG, Xu Y, Thummel KE. Interplay between vitamin D and the drug metabolizing enzyme CYP3A4. J Steroid Biochem Mol Biol 2013;136:54-8. PubMed
  24. Doyle D, Browne U, Brickley A, Murphy D. Vitamin D-induced hypercalcaemia and acute kidney injury in sarcoidosis. BMJ Case Rep 2023;16(1):e250580. PubMed
  25. Williamson A, Martineau AR, Sheikh A, Jolliffe D, Griffiths CJ. Vitamin D for the management of asthma. Cochrane Database Syst Rev 2023;2(2):CD011511. PubMed
  26. Kinesya E, Santoso D, Gde Arya N, et al. Vitamin D as adjuvant therapy for diabetic foot ulcers: Systematic review and meta-analysis approach. Clin Nutr ESPEN 2023;54:137-143. PubMed

See these in context on the Vitamin D monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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