Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Vitex Pure 400 mg Ingredients & Drug Interactions

by Eu Natural

Vitex Pure 400 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Vitex Pure 400 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Vitex Pure 400 mg is a dietary supplement by Eu Natural with 2 active ingredients. Its ingredients are commonly taken for premenstrual syndrome (pms), irregular or absent menstrual periods, cyclical breast pain (mastalgia).Based on those ingredients, 121 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Chaste Tree. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Vitex Pure 400 mg by Eu Natural

Ask about any prescription or over-the-counter medication and we check it for interactions with Vitex Pure 400 mg by Eu Natural — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Vitex Pure 400 mg by Eu Natural

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Vitex Pure contains 2 active ingredients, both of which are chaste tree (Vitex agnus-castus). The product also includes cellulose and rice extract as inactive ingredients to form and stabilize the capsule.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: promote healthy hormone levels.
  • We looked for evidence on: Amenorrhea, Dysmenorrhea, Fibrocystic breast disease, Hyperprolactinemia, Infertility, Mastalgia — and 4 related terms.
  • The strongest evidence on file: Vitex Agnus-castus is rated "Possibly Effective" for Mastalgia (Natural Medicines).
  • Also on file: Vitex Agnus-castus is rated "Insufficient Reliable Evidence To Rate" for Amenorrhea, Fibrocystic breast disease, Hyperprolactinemia, Menopausal symptoms, and more.

Chaste tree is possibly effective for premenstrual syndrome (PMS) and breast pain (mastalgia). For fractures, the evidence suggests it's likely ineffective.

For aging skin, premenstrual dysphoric disorder (PMDD), and anxiety, we don't have enough reliable evidence in our data to rate whether it works.

The evidence, ingredient by ingredient Vitex Agnus-castus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Chaste tree is generally well tolerated in the short term, though it may affect your hormones — so it's best used with guidance from your doctor or pharmacist. The safety data advises against it during pregnancy and while breastfeeding because of possible hormonal effects and unclear safety with milk.

You may experience diarrhea, fatigue, headache, insomnia, irregular menstruation, nausea, stomach pain, or vomiting. Skin problems like itching, rash, acne, or eczema have also been reported, as have changes in menstrual bleeding.

Side effects, ingredient by ingredient Vitex Agnus-castus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitex Agnus-castus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 121 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist if you're on antipsychotic medications, dopamine agonists (like bromocriptine or levodopa), metoclopramide (Reglan), birth control pills, or estrogen replacement therapy. All of these have documented Moderate-severity interactions with chaste tree.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Chaste tree is worth considering if you're dealing with PMS or breast pain and aren't on dopamine-related medications, birth control, or hormone therapy. If you take any of those medications, talk to your pharmacist before starting — the interactions are real and could affect how your prescriptions work.

Avoid it if you're pregnant or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 18, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Vitex Pure 400 mg, straight from the product label.

Brand Eu Natural
Barcode (UPC) 855244008035
Net contents 60 Vegetarian Capsules
Market status On market
Date entered into DSLD Dec 18, 2021
DSLD ID 258034
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Vitex Pure 400 mg by Eu Natural, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
Servings per container
60
UPC/BARCODE
855244008035
IngredientAmount% DV
Chaste Tree350 mg--
Chaste Tree50 mg--

Other ingredients: Cellulose, Rice extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Plant-powered multi-blends for "Eu" (you)!

Share your story #EuNatural #BeYou

Suggested/Recommended/Usage/Directions

Suggested use 1 capsule once daily with a meal and 8 oz. H20

Formulation

Taken to promote healthy hormone levels, full spectrum Vitex supports your physical and daily wellness.

Zero fillers/binders, artificial ingredients

Zero fillers, zero binders, zero artificial ingredients Gluten, wheat & dairy free

Precautions

Caution: Keep out of reach of children.

If you are pregnant, nursing, or taking any prescription medicine, consult your physician before taking this product.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

CGMP certified Blended in the USA

Formula

Standardized whole extract

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Vitex Pure 400 mg by Eu Natural label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Vitex Pure 400 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Vitex Pure 400 mg by Eu Natural

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Chaste Tree

Interacts with
121 drugs
350 mg per serving

Vitex (chasteberry) is an herbal remedy most often used for PMS and menstrual cycle problems, and the strongest evidence is for easing some PMS sympto...

Chaste Tree monograph & interactions

Chaste Tree

Interacts with
121 drugs
50 mg per serving Form: Agnuside

Vitex (chasteberry) is an herbal remedy most often used for PMS and menstrual cycle problems, and the strongest evidence is for easing some PMS sympto...

Chaste Tree monograph & interactions

Other (inactive) ingredients: Cellulose, Rice extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

Vitex Pure 400 mg by Eu Natural Drug Interactions

Want to check YOUR meds against Vitex Pure 400 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
121Drugs
121 Moderate

Ingredients driving the most interactions

Chaste Tree 121

Individual Drug Interactions

The ingredients in Vitex Pure 400 mg interact with 121 drugs. Click any drug to see the details.

1 of the 2 ingredients in Vitex Pure 400 mg interact with drugs. Each result below shows which ingredient is responsible. Chaste Tree

Each ingredient & the kinds of drugs it affects

For each ingredient in Vitex Pure 400 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Chaste Tree5 drug types · 121 drugs

Antipsychotic Drugs

Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.
Vitex agnus-castus might interfere with the action of dopamine antagonists such as antipsychotic drugs due to its dopamine agonist effects.

Likelihood Possible Evidence D
Contraceptive Drugs

Theoretically, vitex agnus-castus could interfere with oral contraceptives.
Vitex agnus-castus might interfere with the efficacy of oral contraceptives due to possible hormone modulating activity.

Likelihood Possible Evidence B
Dopamine Agonists

Theoretically, vitex agnus-castus could interfere with dopamine agonists.
Vitex agnus-castus might potentiate the actions of dopaminergic agonists due to possible dopaminergic effects.

Likelihood Possible Evidence D
Estrogens

Theoretically, vitex agnus-castus could interfere with the activity of estrogens.
Vitex agnus-castus has hormone modulating activity that can interfere with the efficacy of hormone replacement therapy.

Likelihood Probable Evidence D
Metoclopramide (Reglan)

Theoretically, dopaminergic effects of vitex agnus-castus could interfere with metoclopramide.
Vitex agnus-castus might interfere with the action of dopamine antagonists such as metoclopramide due to its possible dopaminergic effects.

Likelihood Possible Evidence D
Chaste Tree full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Vitex Pure 400 mg, from the product label.

Eu Natural

See all Eu Natural products
Name
Eu Natural Inc
City
Henderson
State
NV
ZipCode
89052
Phone Number
408-256-1387
Web Address
EuNatural.com
Pharmacist Counseling Corner

Vitex Pure 400 mg by Eu Natural: Common Questions

Does Vitex Pure 400 mg by Eu Natural interact with any medications?
Yes. Based on its ingredients, Vitex Pure 400 mg has a known interaction with 121 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Vitex Pure 400 mg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my PMS or painful breasts?
Chaste tree is possibly effective for both premenstrual syndrome and breast pain. That means there's evidence it may help, but results vary person to person. It's worth trying if you're a good fit otherwise, but talk to your doctor about your specific situation.
What side effects should I watch for?
The most common ones are diarrhea, fatigue, headache, insomnia, nausea, and stomach pain. Some people report changes in their menstrual bleeding. Skin irritation, rash, or acne can happen too. If any of these bother you, let your pharmacist know.
Can I take this while I'm on birth control?
No — chaste tree is documented to interfere with oral contraceptives and may reduce how well they work. You need to skip this supplement if you're using birth control, or talk to your doctor about alternatives.
Is it safe during pregnancy?
No. The safety data advises against it during pregnancy because of possible hormonal effects and limited safety information. Don't take it if you're pregnant or planning to become pregnant — talk to your doctor first.
Can I breastfeed while taking this?
No. Chaste tree may affect hormones related to milk production and breastfeeding, and safety isn't clear. Avoid it while breastfeeding and talk to your pharmacist if you want to know when it's safe to start.
What if I'm on an antipsychotic or Parkinson's medication?
You'll want to check with your pharmacist first. Chaste tree can interfere with how these dopamine-related drugs work because of its own dopamine effects. Don't start the supplement without their OK.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Vitex Pure 400 mg label
Go deeper

The Full Monographs Behind Vitex Pure 400 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitex Agnus-castus

Interacts with 121 drugs

Vitex (chasteberry) is an herbal remedy most often used for PMS and menstrual cycle problems, and the strongest evidence is for easing some PMS symptoms. It is generally well tolerated by ma...

Read the full Vitex Agnus-castus monograph →
Sources

Sources & How We Checked

Vitex Pure 400 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 23 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitex Agnus-castus 23 references
  1. Wuttke W. Dopaminergic action of extracts of Agnus Castus. Forschende Komplementarmedizen 1996;3:329-30.
  2. Jarry H, Leonhardt S., Gorkow C, Wuttke W. In vitro prolactin but not LH and FSH release is inhibited by compounds in extracts of Agnus Castus: direct evidence for a dopaminergic principle by the dopamine receptor assay. Exp Clin Endocrinol 1994;102:448- PubMed
  3. Schellenberg R. Treatment for the premenstrual syndrome with agnus castus fruit extract: prospective, randomised, placebo-controlled study. BMJ 2001;322:134-7. PubMed
  4. Lauritzen CH, Reuter HD, Repges R, et al. Treatment of premenstrual tension syndrome with Vitex agnus castus: Controlled-double blind versus pyridoxine. Phytomedicine 1997;4:183-9.
  5. Berger D, Schaffner W, Schrader E, et al. Efficacy of Vitex agnus castus L. extract Ze 440 in patients with premenstrual syndrome (PMS). Arch Gynecol Obstet 2000;264:150-3.
  6. Loch EG, Selle H, Boblitz N. Treatment of premenstrual syndrome with a phytopharmaceutical formulation containing Vitex agnus castus. J Womens Health Gend Based Med 2000;9:315-20. PubMed
  7. Meier B, Berger D, Hoberg E, et al. Pharmacological activities of Vitex agnus-castus extracts in vitro. Phytomedicine 2000;7:373-81. PubMed
  8. Liu J, Burdette JE, Xu H, et al. Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms. J Agric Food Chem 2001;49:2472-9.. PubMed
  9. Wuttke W, Jarry H, Christoffel V, et al. Chaste tree (Vitex agnus-castus)--pharmacology and clinical indications. Phytomedicine 2003;10:348-57. PubMed
  10. Atmaca M, Kumru S, Tezcan E. Fluoxetine versus Vitex agnus castus extract in the treatment of premenstrual dysphoric disorder. Hum Psychopharmacol 2003;18:191-5..
  11. Daniele C, Thompson Coon J, Pittler MH, Ernst E. Vitex agnus castus: a systematic review of adverse events. Drug Saf 2005;28:319-32..
  12. Halaska M, Beles P, Gorkow C, Sieder C. Treatment of cyclical mastalgia with a solution containing a Vitex agnus castus extract: results of a placebo-controlled double-blind study. Breast 1999;8:175-81. PubMed
  13. Prilepskaya VN, Ledina AV, Tagiyeva AV, Revazova FS. Vitex agnus castus: Successful treatment of moderate to severe premenstrual syndrome. Maturitas 2006;55 Suppl 1:S55-63. DOI
  14. Ma, L., Lin, S., Chen, R., and Wang, X. Treatment of moderate to severe premenstrual syndrome with Vitex agnus castus (BNO 1095) in Chinese women. Gynecol.Endocrinol. 2010;26(8):612-616. PubMed
  15. Ma, L., Lin, S., Chen, R., Zhang, Y., Chen, F., and Wang, X. Evaluating therapeutic effect in symptoms of moderate-to-severe premenstrual syndrome with Vitex agnus castus (BNO 1095) in Chinese women. Aust.N.Z.J Obstet.Gynaecol. 2010;50(2):189-193. PubMed
  16. Dinç T, Coskun F. Comparison of fructus agni casti and flurbiprofen in the treatment of cyclic mastalgia in premenopausal women. Ulus Cerrahi Derg. 2014 Mar 1;30(1):34-8 PubMed
  17. Momoeda M, Sasaki H, Tagashira E, Ogishima M, Takano Y, Ochiai K. Efficacy and safety of Vitex agnus-castus extract for treatment of premenstrual syndrome in Japanese patients: a prospective, open-label study. Adv Ther. 2014 Mar;31(3):362-73. PubMed
  18. Yavarikia P, Shahnazi M, Hadavand Mirzaie S, Javadzadeh Y, Lutfi R. Comparing the effect of mefenamic Acid and vitex agnus on intrauterine device induced bleeding. J Caring Sci. 2013 Aug 31;2(3):245-54.
  19. Van Die MD, Burger HC, Teede HG, Bone KM. Vitex agnus castus extracts for female reproductive disorders: a systematic review of clinical trials. Planta Med 2013:79:562-575. PubMed
  20. Ooi SL, Watts S, McClean R, Pak SC. Vitex agnus-castus for the treatment of cyclic mastalgia: A systematic review and meta-analysis. J Womens Health (Larchmt). 2020;29(2):262-278. PubMed
  21. Mollazadeh S, Mirghafourvand M, Abdollahi NG. The effects of Vitex agnus-castus on menstrual bleeding: A systematic review and meta-analysis. J Complement Integr Med. 2019;17(1). pii: /j/jcim.2019.17.issue-1/jcim-2018-0053/jcim-2018-0053.xml.
  22. Najib FS, Poordast T, Mahmudi MS, Shiravani Z, Namazi N, Omrani GR. Does Vitex Agnus-Castus L. Have Deleterious Effect on Fertility and Pregnancy Outcome? An Experimental Study on Rats for Prediction of Its Safety. J Pharmacopuncture 2022;25(2):106-113. PubMed
  23. Somuncu E, Solak IHA. Colonic Obstruction Secondary to Phytobezoar Caused by Vitex Agnus-Castus Seeds: A Case Report. J Coll Physicians Surg Pak 2022;32(8):S115-S117. PubMed

See these in context on the Vitex Agnus-castus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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