Major interaction on record — check this product against your medications before combining. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

Weight Management Ingredients & Drug Interactions

by Sanutra Wellness

Weight Management label
See full label image
Other (e.g. Tea Bag) Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Weight Management against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Weight Management is a dietary supplement by Sanutra Wellness with 4 active ingredients. Its ingredients are commonly taken for flavoring and culinary use, digestive complaints like bloating and indigestion, boosting absorption of other supplements.Based on those ingredients, 1,329 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Black Pepper fruit extract, Coleus forskohlii root extract, Garcinia cambogia fruit extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Weight Management by Sanutra Wellness

Ask about any prescription or over-the-counter medication and we check it for interactions with Weight Management by Sanutra Wellness — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Weight Management by Sanutra Wellness

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 4 ingredients, three of which are active. Black Pepper fruit extract supplies piperine, which may support absorption of other compounds.

Garcinia cambogia fruit extract is included for its hydroxycitric acid (HCA) content, thought to influence how your body handles fat and sugar. Coleus forskohlii root extract contains forskolin, which acts on cell signaling.

The remaining ingredient is an inert filler (microcrystalline cellulose and other inactive excipients that help form and stabilize the product).

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: support lean body mass and healthy body composition.
  • We looked for evidence on: Obesity, Athletic performance, Weight loss, Body composition.
  • The closest evidence on file: Black Pepper is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Black Pepper is rated "Insufficient Reliable Evidence To Rate" for Obesity.
  • Also on file: Garcinia is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Obesity.

The evidence we hold doesn't establish that any of these ingredients work for weight management or the other conditions listed. Black Pepper is rated insufficient evidence for hay fever, asthma, athletic performance, headache, depression, and diarrhea.

Garcinia cambogia shows insufficient evidence for athletic performance, fatty liver disease, high cholesterol, and obesity. Coleus forskohlii has insufficient evidence for angina, asthma, cancer, heart failure, eczema, and dry eye.

In short, we don't have reliable data showing these ingredients deliver the results the product name suggests.

The evidence, ingredient by ingredient Black Pepper Garcinia Coleus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Black Pepper is well tolerated in food amounts, though concentrated supplements warrant caution — common mild side effects include a burning aftertaste, indigestion, and reduced taste perception. Rare allergic reactions have been reported.

Garcinia cambogia is generally well tolerated short-term in clinical trials, but rare cases of liver injury, heart inflammation, and mania have been reported, which is why caution is warranted. It should be avoided in pregnancy and while breastfeeding due to insufficient safety data.

Coleus forskohlii is generally well tolerated but may lower blood pressure and isn't well studied long-term — use with care and professional guidance. It should also be avoided in pregnancy and breastfeeding.

Common side effects of Coleus include constipation, diarrhea, nausea, and vomiting.

Side effects, ingredient by ingredient Black Pepper Garcinia Coleus

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Black Pepper, Garcinia, Coleus.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 1,330 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before starting if you take nitrates or calcium channel blockers (Major risk). Also flag for your pharmacist: any blood pressure medication, blood thinners (anticoagulants or antiplatelets), warfarin, heart medications, seizure drugs, antiretrovirals, immunosuppressants, cholesterol drugs, asthma medications, antidepressants or other serotonergic drugs, diabetes medications, or any drug metabolized by the liver enzyme CYP2C9 or CYP3A4 — that last group includes many common medicines.

Altogether, these interactions span 1,308 individual medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

This product mixes three botanicals with real interactions with many common medications, including heart drugs, blood thinners, seizure medications, and diabetes drugs — the stakes are not trivial. If you're on any prescription medication, run it through the interaction checker on this page before you start.

Talk to your pharmacist or doctor first, especially if you take heart medication or blood thinners.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Weight Management, straight from the product label.

Brand Sanutra Wellness
Barcode (UPC) 767382033490
Net contents 90 Caplet(s)
Market status On market
Date entered into DSLD Jan 23, 2015
DSLD ID 41488
Product type Botanical
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Weight Management by Sanutra Wellness, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Caplet(s)
Maximum serving Sizes:
1 Caplet(s)
Servings per container
90
UPC/BARCODE
767382033490
IngredientAmount% DV
Black Pepper fruit extract5 mg--
Garcinia cambogia fruit extract250 mg--
Garcinia cambogia fruit extract167 mg--
Coleus forskohlii root extract125 mg--

Other ingredients: Microcrystalline Cellulose, Polyvinylpyrrolidone, Sodium Starch Glycolate, Magnesium Stearate, Croscarmellose Sodium, Hydroxypropyl Methyl Cellulose, Silicon Dioxide, Propylene Glycol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

This product should be considered supplement to, not substitute for, sensible diet and exercise.

SUPPORT FORMULA

Brand IP Statement(s)

Citrin(R)K, GarCitrin(R) and ForsLean(R) were clinically studied to support lean body mass, healthy body composition and weight reduction. BioPerine(R) improves absorption of the nutrients.

BCitrin(R)K, GarCitrin(R), ForsLean(R) and BioPerine(R) are registered trademarks of Sabinsa Corporation.

Patent Numbers: Citrin(R)K US 5,783,603, US 6,770,782; GarCitrin(R) US 7,063,861, AU773081, NZ518116, EP1254209, JP4205943; ForsLean(R) EP0977564, CA2281562; BioPerine(R) US 5,536,506, US 5,744,151, US 5,972,382, US 6,054,585, EP0810868, JP3953513, CA2247467

Suggested/Recommended/Usage/Directions

Suggested Use: Take one caplet twice a day preferably at mealtimes.

Precautions

Precautions/Warnings: Do not use if bottle seal is missing, torn or damaged.

If you are pregnant, nursing, taking any medication or have a medical condition, consult your healthcare practitioner before taking any dietary supplement.

Keep out of reach of children.

Storage

Store in a cool place.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

CitrinK

BioPerine(R)

GarCitrin

BioPerine(R)

FDA Statement of Identity

Herbal Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Weight Management by Sanutra Wellness label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Weight Management label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Weight Management by Sanutra Wellness

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Caplet(s) Dosage formOther (e.g. Tea Bag) Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Black Pepper fruit extract

Interacts with
1,019 drugs
5 mg per serving

Black pepper is a common kitchen spice that is generally safe in the amounts used in food. Its extract, piperine, is mostly added to supplements to he...

Black Pepper fruit extract monograph & interactions

Garcinia cambogia fruit extract

Interacts with
704 drugs
250 mg per serving Form: Hydroxy Citric Acid

Garcinia is a tropical fruit whose rind contains hydroxycitric acid (HCA), widely marketed for weight loss and appetite control. The scientific eviden...

Garcinia cambogia fruit extract monograph & interactions

Garcinia cambogia fruit extract

Interacts with
704 drugs
167 mg per serving Form: Garcinol, HCA

Garcinia is a tropical fruit whose rind contains hydroxycitric acid (HCA), widely marketed for weight loss and appetite control. The scientific eviden...

Garcinia cambogia fruit extract monograph & interactions

Coleus forskohlii root extract

Interacts with
915 drugs
125 mg per serving Form: Forskolin

Coleus is a plant from the mint family whose root contains a compound called forskolin, often marketed for weight loss, asthma, and heart health. Whil...

Coleus forskohlii root extract monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Polyvinylpyrrolidone, Sodium Starch Glycolate, Magnesium Stearate, Croscarmellose Sodium, Hydroxypropyl Methyl Cellulose, Silicon Dioxide, Propylene Glycol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Weight Management by Sanutra Wellness Drug Interactions

Want to check YOUR meds against Weight Management?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,329Drugs
29 Major 1,288 Moderate 12 Minor

Ingredients driving the most interactions

Black Pepper fruit extract 1,019
Coleus forskohlii root extract 915
Garcinia cambogia fruit extract 704

Individual Drug Interactions

The ingredients in Weight Management interact with 1,329 drugs. Click any drug to see the details.

3 of the 4 ingredients in Weight Management interact with drugs. Each result below shows which ingredient is responsible. Black Pepper fruit extract Coleus forskohlii root extract Garcinia cambogia fruit extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Weight Management with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Black Pepper fruit extract17 drug types · 1,019 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, black pepper might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit platelet aggregation. This has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, black pepper might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that piperine, a constituent of black pepper, can reduce blood glucose levels. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Atorvastatin (Lipitor)

Theoretically, black pepper might increase blood levels of atorvastatin.
Animal research shows that taking piperine, a constituent of black pepper, 35 mg/kg can increase the maximum serum concentration of atorvastatin three-fold. This has not been reported in humans.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, black pepper might increase the effects and side effects of cyclosporine.
In vitro research shows that piperine, a constituent of black pepper, increases the bioavailability of cyclosporine. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP2D6.
In vitro research suggests that some constituents of black pepper inhibit CYP2D6. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
In vitro research and pharmacokinetic simulation data suggest that piperine, a constituent of black pepper, as well as the pepper fruit seem to inhibit CYP3A4. This has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, black pepper might increase blood levels of lithium due to its diuretic effects. The dose of lithium might need to be reduced.
Black pepper is thought to have diuretic properties.

Likelihood Probable Evidence D
Nevirapine (Viramune)

Black pepper might increase blood levels of nevirapine.
Clinical research shows that piperine, a constituent of black pepper, increases the plasma concentration of nevirapine. However, no adverse effects were observed in this study.

Likelihood Probable Evidence D
P-Glycoprotein Substrates

Theoretically, black pepper might increase levels of P-glycoprotein substrates.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit P-glycoprotein.

Likelihood Possible Evidence D
Pentobarbital (Nembutal)

Theoretically, black pepper might increase the sedative effects of pentobarbital.
Animal research shows that piperine, a constituent of black pepper, increases pentobarbital-induced sleeping time.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Black pepper might increase blood levels of phenytoin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption, slow elimination, and increase levels of phenytoin. Taking a single dose of black pepper 1 gram along with phenytoin seems to double the serum concentration of phenytoin. Consuming a soup with black pepper providing piperine 44 mg/200 mL of soup along with phenytoin also seems to increase phenytoin levels when compared with consuming the same soup without black pepper.

Likelihood Possible Evidence B
Propranolol (Inderal)

Black pepper might increase blood levels of propranolol.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of propranolol.

Likelihood Possible Evidence B
Rifampin (Rifadin)

Black pepper might increase blood levels of rifampin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and serum levels of rifampin.

Likelihood Possible Evidence B
Theophylline

Black pepper might increase blood levels of theophylline.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of theophylline.

Likelihood Possible Evidence D
Amoxicillin (Amoxil, Trimox)

Theoretically, black pepper might increase the effects and side effects of amoxicillin.
Animal research shows that taking piperine, a constituent of black pepper, with amoxicillin increases plasma levels of amoxicillin. This has not been reported in humans.

Likelihood Possible Evidence D
Carbamazepine (Tegretol)

Theoretically, black pepper might increase blood levels of carbamazepine, potentially increasing the effects and side effects of carbamazepine.
One clinical study in patients taking carbamazepine 300 mg or 500 mg twice daily shows that taking a single 20 mg dose of purified piperine, a constituent of black pepper, increases carbamazepine levels. Piperine may increase carbamazepine absorption by increasing blood flow to the GI tract, increasing the surface area of the small intestine, or inhibiting cytochrome P450 3A4 (CYP3A4) in the gut wall. Absorption was significantly increased by 7-10 mcg/mL/hour. The time to eliminate carbamazepine was also increased by 4-8 hours. Although carbamazepine levels were increased, this did not appear to increase side effects. In vitro research also shows that piperine can increase carbamazepine levels by 11% in a time-dependent manner.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, black pepper might decrease levels and clinical effects of drugs metabolized by CYP1A2.
In vitro research suggests that black pepper induces CYP1A2. This has not been reported in humans.

Likelihood Possible Evidence D
Black Pepper fruit extract full monograph & interactions

Coleus forskohlii root extract7 drug types · 915 drugs

Calcium Channel Blockers

Theoretically, combining coleus with calcium channel blockers might increase the coronary vasodilatory effects.
Forskolin, a constituent of coleus, and calcium channel blockers both cause coronary vasodilatory effects.

Likelihood Probable Evidence B
Nitrates

Theoretically, combining coleus with nitrates might increase the coronary vasodilatory effects.
Forskolin, a constituent of coleus, and nitrates both cause coronary vasodilatory effects.

Likelihood Probable Evidence B
Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of coleus and anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding.
In vitro and animal research shows that forskolin, a constituent of coleus, can inhibit platelet aggregation and adhesion.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, combining coleus with antihypertensive drugs might cause additive blood pressure lowering effects and increase the risk of hypotension.
Animal research shows that forskolin, a constituent of coleus, may lower blood pressure.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, taking coleus may affect drugs metabolized by CYP2C9 and increase the risk of adverse effects or reduce the effectiveness.
Research on the effect of coleus on CYP2C9 is conflicting. Some animal research shows that coleus extract can induce CYP2C9, while in vitro research shows that coleus can inhibit CYP2C9. Until more is known, advise patients that taking coleus might increase or decrease levels of drugs metabolized by CYP2C9.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, taking coleus might decrease serum levels of drugs metabolized by CYP3A4.
In vitro research shows that coleus can activate the nuclear receptor, pregnane X receptor (PXR), which results in increased expression of CYP3A4. Although the clinical significance of this is not known, use caution when considering concomitant use of coleus and other drugs affected by these enzymes.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, taking coleus may affect the metabolism of warfarin and increase the risk of adverse effects or reduce the effectiveness.
Some animal research shows that coleus extract can induce cytochrome P450 2C9 (CYP2C9), an enzyme that metabolizes warfarin. However, other in vitro research shows that coleus can inhibit CYP2C9. Theoretically, taking coleus with drugs metabolized by CYP2C9 might affect drug levels and the risk of adverse effects. Until more is known, advise patients that taking coleus might increase or decrease levels of warfarin.

Likelihood Possible Evidence D
Coleus forskohlii root extract full monograph & interactions

Garcinia cambogia fruit extract4 drug types · 704 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
HCA inhibits platelet aggregation in vitro. The inhibitory effect seems to be greater in platelets extracted from diabetic subjects than non-diabetic subjects.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.
HCA reduces fasting and postprandial blood glucose levels in animal models, theoretically by delaying glucose absorption. This effect has not been reported in humans.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
There have been reports of acute hepatitis with elevated liver enzymes associated with garcinia, when taken alone or in combination with other ingredients. Case reports collected from the Drug Induced Liver Injury Network suggest this risk may be greater in people who carry the HLA B*35:01 allele.

Likelihood Possible Evidence D
Serotonergic Drugs

Theoretically, combining garcinia with other serotonergic drugs might increase the risk of serotonergic side effects, including serotonin syndrome.
In one report, a patient experienced serotonin syndrome after taking garcinia extract (60% hydroxycitric acid) 1000 mg daily in combination with escitalopram 20 mg, which had been taken for a year. The patient was switched to sertraline 50 mg daily and again experienced serotonin syndrome.

Likelihood Possible Evidence D
Garcinia cambogia fruit extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Weight Management, from the product label.

Sanutra Wellness

See all Sanutra Wellness products
Name
America's Finest, Inc. (AFI)
City
East Windsor
State
NJ
ZipCode
08520
Phone Number
800-350-3305
Web Address
www.afisupplements.com
Pharmacist Counseling Corner

Weight Management by Sanutra Wellness: Common Questions

Does Weight Management by Sanutra Wellness interact with any medications?
Yes. Based on its ingredients, Weight Management has a known interaction with 1,329 medications, including 29 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Weight Management contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or nursing?
The safety data doesn't support it. Garcinia and Coleus both carry a rating of avoid during pregnancy and breastfeeding due to insufficient safety information. Black Pepper has no pregnancy or lactation safety data on file. Talk with your doctor or pharmacist about whether this product is right for you in these situations.
Does this actually help you lose weight?
We don't have reliable evidence in our data that it does. Garcinia cambogia hasn't been proven effective for obesity, and Coleus and Black Pepper don't have solid evidence for weight management either. If weight loss is your goal, talk with your doctor about what's backed by science.
What are the most common side effects?
Black Pepper may cause a burning aftertaste, indigestion, and reduced taste perception. Garcinia can cause diarrhea, stomach discomfort, headache, and nausea. Coleus may cause diarrhea, nausea, vomiting, or constipation. Most of these are mild, but if they persist or worsen, let us know.
Is this safe to use long-term?
Coleus isn't well studied for long-term use, so we recommend professional guidance if you're thinking of taking it regularly. Garcinia is generally tolerated short-term in trials, but rare serious events like liver injury have been reported. Talk with your pharmacist about your timeline and concerns.
Can this interact with my heart medication?
Yes — potentially in serious ways. Coleus can amplify the effects of nitrates and calcium channel blockers (Major risk). Black Pepper can raise levels of some heart and blood pressure drugs. Check your exact medications with the tool on this page right away, and loop in your pharmacist.
What does each ingredient actually do?
Black Pepper supplies piperine to help your body absorb other compounds. Garcinia cambogia contains hydroxycitric acid (HCA), thought to influence how your body processes fat and sugar — though this hasn't been proven in humans. Coleus has forskolin, which affects how cells communicate. None are proven to work for weight loss in our data.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Weight Management is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Weight Management label
Go deeper

The Full Monographs Behind Weight Management’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Black Pepper

Interacts with 1,019 drugs

Black pepper is a common kitchen spice that is generally safe in the amounts used in food. Its extract, piperine, is mostly added to supplements to help the body absorb other ingredients (li...

Read the full Black Pepper monograph → Herb & supplement monograph

Garcinia

Interacts with 704 drugs

Garcinia is a tropical fruit whose rind contains hydroxycitric acid (HCA), widely marketed for weight loss and appetite control. The scientific evidence is weak and mixed, with most studies...

Read the full Garcinia monograph → Herb & supplement monograph

Coleus

Interacts with 915 drugs

Coleus is a plant from the mint family whose root contains a compound called forskolin, often marketed for weight loss, asthma, and heart health. While early lab and small human studies are...

Read the full Coleus monograph →
Sources

Sources & How We Checked

Weight Management's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 89 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Black Pepper 29 references
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Bano G, Amla V, Raina RK, et al. The effect of piperine on pharmacokinetics of phenytoin in healthy volunteers. Planta Med 1987;53:568-9. PubMed
  4. Bano G, et al. Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers. Eur J Clin Pharmacol 1991;41;615-7. PubMed
  5. Cohle SD, Trestrail JD III, Graham MA, et al. Fatal pepper aspiration. Am J Dis Child 1988;142:633-6. PubMed
  6. Bhardwaj RK, Glaeser H, Becquemont L, et al. Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. J Pharmacol Exp Ther 2002;302:645-50. PubMed
  7. Velpandian T, Jasuja R, Bhardwaj RK, et al. Piperine in food: interference in the pharmacokinetics of phenytoin. Eur J Drug Metab Pharmacokinet 2001;26:241-7. PubMed
  8. Pattanaik S, Hota D, Prabhakar S, et al. Pharmacokinetic interaction of a single dose of piperine with steady-state carbamazepine in epilepsy patients. Phytother Res 2009;23:1281-6.
  9. Munakata, M., Kobayashi, K., Niisato-Nezu, J., Tanaka, S., Kakisaka, Y., Ebihara, T., Ebihara, S., Haginoya, K., Tsuchiya, S., and Onuma, A. Olfactory stimulation using black pepper oil facilitates oral feeding in pediatric patients receiving long-term en
  10. Myers, B. M., Smith, J. L., and Graham, D. Y. Effect of red pepper and black pepper on the stomach. Am J Gastroenterol 1987;82(3):211-214.
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Coleus 16 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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