Whole and Complete Pomegranate Ingredients & Drug Interactions
by Solgar
What is this page for?
First and foremost: checking Whole and Complete Pomegranate against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Whole and Complete Pomegranate is a dietary supplement by Solgar with 1 active ingredient. Its ingredients are commonly taken for heart and blood vessel health, antioxidant support, high blood pressure.Based on those ingredients, 922 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are standardized Pomegranate whole fruit extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Whole and Complete Pomegranate by Solgar
Ask about any prescription or over-the-counter medication and we check it for interactions with Whole and Complete Pomegranate by Solgar — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Whole and Complete Pomegranate by Solgar
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: a standardized pomegranate whole fruit extract. The extract is delivered in a vegetable capsule made with cellulose, microcrystalline cellulose, vegetable magnesium stearate, and silica — all inactive ingredients that help form and stabilize the capsule.
Does it work?
Moderate evidence
The supplement shows mixed evidence. For high blood pressure (hypertension), pomegranate is rated possibly effective — the research suggests it may help, but the data isn't definitive.
For high cholesterol (hyperlipidemia) and type 2 diabetes (diabetes), the evidence rates it possibly ineffective, meaning it's not shown to be reliably helpful for those goals. For nonalcoholic fatty liver disease (NAFLD), there isn't enough reliable evidence in our data to rate whether it works at all.
How safe is it?
Well-documented data
Pomegranate fruit and juice are generally well tolerated as food. The most common side effects from supplements are mild gastrointestinal ones — diarrhea and flatulence — occurring in a small percentage of people taking extract.
A few users at higher doses also reported nausea, abdominal pain, constipation, or vomiting, though these were uncommon. Because this is a concentrated extract rather than whole fruit, use caution if you have a sensitive stomach.
Avoid pomegranate root, stem, or peel products in large amounts due to limited safety data.
Meds to double-check
Moderate interaction found
Before taking this product, check with your doctor or pharmacist if you take warfarin or other blood thinners, blood pressure medications (antihypertensive drugs or ACE inhibitors), rosuvastatin or other statin cholesterol drugs, or any medication broken down by your liver's CYP2D6 enzyme system. Pomegranate may raise levels of some of these drugs or heighten their effects.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
Pomegranate extract is generally well tolerated and shows promise for blood pressure, but it interacts with blood thinners, blood pressure drugs, and certain cholesterol medications at a Moderate severity level. If you take warfarin, any blood pressure pill, or rosuvastatin, you need to talk with your doctor or pharmacist before starting this supplement.
Even if you don't take those, run your exact medications through the checker on this page.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Whole and Complete Pomegranate, straight from the product label.
| Brand | Solgar |
|---|---|
| Barcode (UPC) | 033984022447 |
| Net contents | 60 Vegetable Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Mar 24, 2020 |
| DSLD ID | 214789 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Whole and Complete Pomegranate by Solgar, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Total Carbohydrates | 1 Gram(s) | 1% |
| standardized Pomegranate whole fruit extract | 800 mg | -- |
Other ingredients: Vegetable Cellulose, Microcrystalline Cellulose, Vegetable Magnesium Stearate, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Solgar's Whole and Complete Pomegranate Vegetable Capsules are free of corn, yeast, wheat, soy, dairy products and gluten and are formulated without the use of artificial preservatives, flavors, or colors.
Suitable for vegetarians
Sugar, salt and starch free
Storage
To assure freshness and potency, store at room temperature 59 degrees-86 degrees F (15 degrees-30 degrees C). Store away from heat, light and moisture.
Formula
Solgar's KOF-K certification #K-1250
Precautions
Do not use if outer bottle seal is missing, torn or damaged in any way.
If you are pregnant, nursing, taking any medication or have a medical condition, please consult your healthcare practitioner before taking any dietary supplement.
Keep out of reach of children.
General Statements
Solgar since 1947
FDA Statement of Identity
Dietary Supplement
Seals/Symbols
K Parve (Kosher)
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement for adults, take two (2) vegetable capsules daily, preferably at mealtime, or as directed by a healthcare practitioner.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Whole and Complete Pomegranate by Solgar label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Whole and Complete Pomegranate by Solgar
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Vegetarian Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Standardized Pomegranate whole fruit extract
Interacts with922 drugs
Pomegranate is a nutrient-rich fruit that is high in antioxidants and is widely enjoyed as food and juice. Early research suggests it may support hear...
Standardized Pomegranate whole fruit extract monograph & interactionsOther (inactive) ingredients: Vegetable Cellulose, Microcrystalline Cellulose, Vegetable Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.
Whole and Complete Pomegranate by Solgar Drug Interactions
HelloPharmacist Interaction Report
Solgar's Whole and Complete Pomegranate contains a standardized pomegranate extract that interacts with several medication types.
The most serious concern is with blood thinners like warfarin (Coumadin) — pomegranate may raise warfarin levels and increase bleeding risk, and stopping it suddenly could lower warfarin levels just as much. The single ingredient here is pomegranate fruit extract, and it affects a range of drugs across multiple categories.
Read the full breakdown — every affected drug type, severity by severity
Mederate interactions are also documented with blood pressure medications (antihypertensive drugs and ACE inhibitors), which together might lower your blood pressure further; with certain cholesterol drugs, especially rosuvastatin (Crestor), where a case of serious muscle breakdown (rhabdomyolysis) was reported in a patient combining the supplement with rosuvastatin and ezetimibe; and with drugs broken down by your liver's CYP2D6 enzyme system, where pomegranate may raise drug levels in ways we don't yet fully understand in real-world use.
Minor interactions are documented with other liver-metabolized drug categories (CYP2C9 and CYP3A4 substrates) and with the anti-seizure medication carbamazepine (Tegretol), though evidence suggests these are unlikely to be clinically important. Altogether, these interactions span 923 individual medications.
If you take any prescription medications — especially blood thinners, blood pressure drugs, or cholesterol drugs — run them through the interaction checker on this page before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Whole and Complete Pomegranate?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Whole and Complete Pomegranate interact with 922 drugs. Click any drug to see the details.
1 of the 1 ingredient in Whole and Complete Pomegranate interact with drugs. Each result below shows which ingredient is responsible. standardized Pomegranate whole fruit extract
VoclosporinLupkynis
How Voclosporin interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Standardized Pomegranate Whole Fruit Extract + Voclosporin interactionVonoprazan, AmoxicillinVoquezna Dual
How Vonoprazan, Amoxicillin interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Standardized Pomegranate Whole Fruit Extract + Vonoprazan, Amoxicillin interactionVonoprazan, Amoxicillin, ClarithromycinVoquezna Triple
How Vonoprazan, Amoxicillin, Clarithromycin interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Standardized Pomegranate Whole Fruit Extract + Vonoprazan, Amoxicillin, Clarithromycin interactionVorapaxarZontivity
How Vorapaxar interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Standardized Pomegranate Whole Fruit Extract + Vorapaxar interactionVoriconazoleVfend
How Voriconazole interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Standardized Pomegranate Whole Fruit Extract + Voriconazole interactionVoxelotorOxbryta
How Voxelotor interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Standardized Pomegranate Whole Fruit Extract + Voxelotor interactionZafirlukastAccolate
How Zafirlukast interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2C9.
Read the full Standardized Pomegranate Whole Fruit Extract + Zafirlukast interactionZaleplonSonata, Starnoc
How Zaleplon interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Standardized Pomegranate Whole Fruit Extract + Zaleplon interactionZanubrutinibBrukinsa
How Zanubrutinib interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Standardized Pomegranate Whole Fruit Extract + Zanubrutinib interactionZileutonZyflo, Zyflo CR
How Zileuton interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Standardized Pomegranate Whole Fruit Extract + Zileuton interactionZiprasidoneGeodon
How Ziprasidone interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Standardized Pomegranate Whole Fruit Extract + Ziprasidone interactionZolpidemAmbien CR, Intermezzo, Sublinox
How Zolpidem interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Standardized Pomegranate Whole Fruit Extract + Zolpidem interactionZolpidem TartrateAmbien
How Zolpidem Tartrate interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Standardized Pomegranate Whole Fruit Extract + Zolpidem Tartrate interactionZonisamideZonegran, Zonisade
How Zonisamide interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Standardized Pomegranate Whole Fruit Extract + Zonisamide interactionZopicloneApo-Zopiclone, Co Zopiclone, Dom-Zopiclone, Imovane, Mylan-Zopiclone, Rhovane +1 more
How Zopiclone interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Standardized Pomegranate Whole Fruit Extract + Zopiclone interactionZuranoloneZurzuvae
How Zuranolone interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Standardized Pomegranate Whole Fruit Extract + Zuranolone interactionDrospirenone, Ethinyl Estradiol, LevomefolateBeyaz
How Drospirenone, Ethinyl Estradiol, Levomefolate interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Standardized Pomegranate Whole Fruit Extract + Drospirenone, Ethinyl Estradiol, Levomefolate interactionNefazodoneSerzone
How Nefazodone interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Standardized Pomegranate Whole Fruit Extract + Nefazodone interactionNilotinibTasigna
How Nilotinib interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Standardized Pomegranate Whole Fruit Extract + Nilotinib interactionPioglitazone, MetforminActoPlus Met
How Pioglitazone, Metformin interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Standardized Pomegranate Whole Fruit Extract + Pioglitazone, Metformin interactionRosiglitazone, GlimepirideAvandaryl
How Rosiglitazone, Glimepiride interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2C9.
Read the full Standardized Pomegranate Whole Fruit Extract + Rosiglitazone, Glimepiride interactionSimvastatin/ezetimibeVytorin
How Simvastatin/ezetimibe interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Standardized Pomegranate Whole Fruit Extract + Simvastatin/ezetimibe interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Whole and Complete Pomegranate with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
standardized Pomegranate whole fruit extract
Ace Inhibitors (Aceis)
Theoretically, taking pomegranate with ACEIs might increase the risk of adverse effects.
Pomegranate juice is thought to have ACE inhibitor-like effects.
Antihypertensive Drugs
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Consuming pomegranate juice can modestly lower blood pressure.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
In vitro, pomegranate juice inhibits CYP2D6. However, the clinical significance of this potential interaction in humans is not known.
Rosuvastatin (Crestor)
Theoretically, taking pomegranate with rosuvastatin might increase the risk of adverse effects.
In one case, a patient taking rosuvastatin 5 mg every other day in combination with ezetimibe 10 mg daily developed rhabdomyolysis after drinking pomegranate juice 200 mL twice weekly for 3 weeks. This patient had a history of elevated creatine kinase levels while not receiving any statin treatment. This suggests a possible underlying myopathy and predisposition to rhabdomyolysis.
Warfarin (Coumadin)
Theoretically, pomegranate might increase warfarin levels and increase the risk of bleeding. Also, discontinuing regular consumption of pomegranate juice might decrease warfarin levels.
In one case report, a patient had a stable, therapeutic bleeding time, as measured by international normalized ratio (INR), while taking warfarin in combination with pomegranate juice 2-3 times per week. The patient became subtherapeutic within about 10 days after discontinuing pomegranate juice, which required a warfarin dose increase. In another case report, a patient with a stable INR for over one year presented with an INR of 14. The patient noted no changes to medications or diet but did report consuming around 3 liters of pomegranate juice over the previous week. The patient's INR stabilized upon moderation of pomegranate juice consumption. The mechanism of this potential interaction is unclear.
Carbamazepine (Tegretol)
Theoretically, taking pomegranate with carbamazepine might increase the risk of adverse effects, although research suggests this interaction is unlikely to be clinically significant.
Animal research shows that pomegranate juice may inhibit cytochrome P450 3A4 (CYP3A4) metabolism of carbamazepine and increase levels of carbamazepine by 1.5 times without prolonging the elimination half-life. This suggests that pomegranate juice inhibits intestinal CYP3A4, but might not inhibit hepatic CYP3A4. However, some human research suggests that pomegranate does not significantly inhibit CYP3A4 drug metabolism in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2C9.
Some animal and in vitro research shows that pomegranate juice inhibits intestinal, but not hepatic, CYP2C9 isoenzyme activity. However, clinical research shows that neither pomegranate juice nor pomegranate extract have a significant effect on CYP2C9 activity in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Pomegranate contains several polyphenols that have individually been shown to inhibit CYP3A4. However, there is contradictory evidence about the effect of whole pomegranate juice on CYP3A4 activity. In vitro, pomegranate juice significantly inhibits the CYP3A4 enzyme, with comparable inhibition to grapefruit juice. In an animal model, pomegranate juice inhibits CYP3A4 metabolism of carbamazepine and increases levels of carbamazepine by 1.5 times; however, in human volunteers, drinking a single glass of pomegranate juice 240 mL or taking 200 mL daily for 2 weeks does not significantly affect levels of the CYP3A4 substrate midazolam after oral or intravenous administration. Another study in healthy volunteers shows that consuming pomegranate juice 300 mL three times daily for three days also does not significantly affect levels of simvastatin, a CYP3A4 substrate This suggests that pomegranate is unlikely to significantly affect levels of CYP3A4 substrates in humans.
Tolbutamide (Orinase)
Theoretically, pomegranate might increase levels of tolbutamide, although research suggests this interaction is unlikely to be clinically significant.
Animal research shows that pomegranate juice inhibits the cytochrome P450 2C9 (CYP2C9) metabolism of tolbutamide. Pomegranate juice increased tolbutamide levels by 1.2 times without prolonging the elimination half-life. This suggests that pomegranate juice inhibits intestinal CYP2C9, but might not inhibit hepatic CYP2C9. Despite this evidence, clinical research shows that neither pomegranate juice nor pomegranate extract have a significant effect on CYP2C9 activity in humans. This interaction does not appear to be clinically significant in humans.
Brand information
Manufacturer and brand details for Whole and Complete Pomegranate, from the product label.
Solgar
See all Solgar products- Name
- Solgar Vitamin and Herb
- City
- Leonia
- State
- N.J.
- ZipCode
- 07605
- Phone Number
- 1-877-765-4274
- Web Address
- www.solgar.com
Whole and Complete Pomegranate by Solgar: Common Questions
Does Whole and Complete Pomegranate by Solgar interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is pomegranate extract used for in this supplement?
Will this supplement lower my blood pressure?
Is it safe to take while pregnant or breastfeeding?
What are the side effects?
Can I take this if I'm on a statin for cholesterol?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Whole and Complete Pomegranate is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Whole and Complete Pomegranate’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Whole and Complete Pomegranate's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 27 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Pomegranate 27 references
- Igea JM, Cuesta J, Cuevas M, et al. Adverse reaction to pomegranate ingestion. Allergy 1991;46:472-4. DOI
- Gaig P, Bartolome B, Lleonart R, et al. Allergy to pomegranate (Punica granatum). Allergy 1999;54:287-8.
- Aviram M, Dornfeld L. Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis 2001;158:195-8. PubMed
- Valsecchi R, Reseghetti A, Leghissa P, et al. Immediate contact hypersensitivity to pomegranate. Contact Dermatitis 1998;38:44-5. PubMed
- Esmaillzadeh A, Tahbaz F, Gaieni I, et al. Concentrated pomegranate juice improves lipid profiles in diabetic patients with hyperlipidemia. J Med Food 2004;7:305-8. PubMed
- Aviram M, Rosenblat M, Gaitini D, et al. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clin Nutr 2004;23:423-33. DOI
- Hidaka M, Okumura M, Fujita K, et al. Effects of pomegranate juice on human cytochrome p450 3A (CYP3A) and carbamazepine pharmacokinetics in rats. Drug Metab Dispos 2005;33:644-8. PubMed
- Loren DJ, Seeram NP, Schulman RN, Holtzman DM. Maternal dietary supplementation with pomegranate juice is neuroprotective in an animal model of neonatal hypoxic-ischemic brain injury. Pediatr Res 2005;57:858-64. PubMed
- Kim ND, Mehta R, Yu W, et al. Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer. Breast Cancer Res Treat 2002;71:203-17. PubMed
- Sorokin AV, Duncan B, Panetta R, Thompson PD. Rhabdomyolysis associated with pomegranate juice consumption. Am J Cardiol 2006;98:705-6. PubMed
- Farkas D, Oleson LE, Zhao Y, et al. Pomegranate juice does not impair clearance of oral or intravenous midazolam, a probe for cytochrome P450-3A activity: comparison with grapefruit juice. J Clin Pharmacol 2007;47:286-94. PubMed
- Yeo C, Shon J, Liu K, et al. The effects of pomegranate juice on the pharmacokinetics of simvastatin in healthy Korean subjects (PI-63). Clin Pharmacol Ther 2006;79:23.
- Farkas D, Greenblatt DJ. Influence of fruit juices on drug disposition: discrepancies between in vitro and clinical studies. Expert Opin Drug Metab Toxicol 2008;4:381-93.
- Nagata M, Hidaka M, Sekiya H, et al. Effects of pomegranate juice on human cytochrome P450 2C9 and tolbutamide pharmacokinetics in rats. Drug Metab Dispos 2007;35:302-5. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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